Laboratory Studies in Scleredema
8 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What should be obtained in scleredema patients to exclude group A streptococcal infection?

  • Throat culture (correct)
  • Serum cholesterol levels
  • Chest X-ray
  • Fasting blood glucose

Which test helps rule out diabetes mellitus in scleredema patients?

  • Immunofixation
  • Complete blood count
  • Antistreptolysin-O titers
  • Glycosylated hemoglobin (A1C) (correct)

In patients with scleredema, which paraprotein is most commonly identified?

  • IgG with a kappa light chain (correct)
  • IgM with a lambda light chain
  • IgA with a kappa light chain
  • IgE with a lambda light chain

What is the typical interval between the diagnosis of scleredema and detection of paraprotein?

<p>Median detection 2.5 years after diagnosis (A)</p> Signup and view all the answers

Which laboratory study should be performed to exclude a monoclonal gammopathy in scleredema patients?

<p>Serum protein electrophoresis (SPEP) (B)</p> Signup and view all the answers

Blood dyscrasias associated with scleredema typically appear how long after the onset of scleredema?

<p>Several years after onset (C)</p> Signup and view all the answers

Which test is used to detect a recent infection with group A streptococci in scleredema patients without apparent pharyngitis?

<p>Antistreptolysin-O (ASO) titers (B)</p> Signup and view all the answers

What is true about the occurrence of paraproteinemias in patients with scleredema?

<p>They can occur concurrently or after the diagnosis (B)</p> Signup and view all the answers

Study Notes

Laboratory Studies in Scleredema

  • Throat culture is recommended for scleredema patients to rule out group A streptococcal infection.
  • Antistreptolysin-O (ASO) titers should be measured to exclude recent infections with group A streptococci, especially in patients without evident pharyngitis.
  • Fasting blood glucose and glycosylated hemoglobin (A1C) should be assessed to exclude diabetes mellitus in scleredema patients.
  • Serum protein electrophoresis (SPEP) and immunofixation are important to identify or exclude monoclonal gammopathy in scleredema cases.
  • Both paraproteinemias and multiple myelomas have been reported in patients with scleredema, particularly type 2.
  • The most common paraprotein detected is IgG with kappa light chains, though IgA types can also be present.
  • Blood dyscrasias typically arise several years after scleredema onset, with detection of paraprotein potentially occurring before, concurrently, or after scleredema diagnosis.
  • A study found that paraproteinemia detection can be delayed, averaging up to 10 years post-scleredema diagnosis; other sources suggest a median detection of 2.5 years later.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Description

Explore the essential laboratory studies performed on scleredema patients to rule out various infections and conditions. This quiz covers tests such as throat cultures, ASO titers, blood glucose assessments, and serum protein electrophoresis. Enhance your understanding of the complexities involved in diagnosing scleredema.

More Like This

Scleroderma and Myositis Overview
18 questions
Scleroderma and Myositis Overview
18 questions
Esclerodermia y Morfea (Página 188)
15 questions
Lupus and Scleroderma Flashcards
11 questions
Use Quizgecko on...
Browser
Browser