30 Questions
What is the main purpose of the Krebs Cycle?
Convert glucose to energy after glycolysis
Where does the energy for ATP synthesis in oxidative phosphorylation come from?
Protons crossing the inner mitochondrial membrane via ATPase
What is the preparatory step for the Krebs Cycle?
Formation of Acetyl CoA
Which molecule is deficient in dietary thiamine deficiency, leading to the accumulation of pyruvate?
Acetyl CoA
What role does NADH and FADH2 play in the electron transport chain?
Transport energy to the electron transport chain
Where does the Krebs Cycle take place in the cell?
Mitochondrial matrix
What is the initial compound that combines with acetyl CoA to enter the Krebs cycle?
Oxaloacetic acid
Which enzyme complex deficiency can lead to lactic acidosis similar to what is observed in alcoholics?
Pyruvate dehydrogenase deficiency
What are the main products generated from the Krebs cycle per cycle for each glucose molecule metabolized?
2 ATP, 3 NADH, 1 FADH2
Which nutrient deficiency is commonly observed in alcoholics and contributes to the development of metabolic disturbances?
Thiamine
What compound is progressively oxidized through a series of enzyme-catalyzed reactions in the Krebs cycle?
Citric acid
Which compound is NOT directly generated from the Krebs cycle per cycle?
Glucose
What is the role of citrate synthetase in the Krebs cycle?
To convert acetyl-CoA to citrate
What is the effect of fluoroacetate on the Krebs cycle?
It blocks the Krebs cycle completely
What is the net ATP yield from the Krebs cycle?
2 ATP
What is the role of oxaloacetic acid in the Krebs cycle?
To combine with acetyl-CoA to form citrate
What is the result of arsenic binding to inorganic phosphate?
It depletes ATP stores
What is the current ATP yield from glycolysis and the Krebs cycle?
2 ATP
During oxidative phosphorylation, what is the total ATP yield from 10 NADH and 2 FADH2?
38 ATP
What is the primary regulator of oxidative phosphorylation?
ADP level
How many ATP molecules are generated per NADH during oxidative phosphorylation?
3 ATP
What is the effect of high ATP levels on citrate synthetase?
It is inhibited
What is the effect of adding ADP to mitochondria?
The rate of oxygen consumption increases
What is the role of FADH2 in oxidative phosphorylation?
It generates 2 ATP
What is the allosteric inhibitor of citrate synthase?
ATP
What is the primary driver of the Electron Transport Chain (ETC) and oxidative phosphorylation?
Level of ADP
What is the byproduct of oxidative phosphorylation that drives the Electron Transport Chain?
Water
What is the substrate for citrate synthase in the citric acid cycle?
Acetyl CoA
What is the purpose of O2 in oxidative phosphorylation?
To accept electrons and form water
What is the effect of adding ADP to the mitochondrial reaction?
It increases the rate of oxygen consumption
Test your knowledge on the Krebs cycle and oxidative phosphorylation with this quiz by Dr. Bronwen Dalziel. Learn about the key concepts and processes involved in cellular respiration. This quiz is based on materials copyrighted by the University of Western Sydney.
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