W9: Krebs Cycle and Oxidative Phosphorylation

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What is the main purpose of the Krebs Cycle?

Generate NADH for the citric acid cycle

Convert pyruvate to lactate

Convert glucose to energy after glycolysis (correct)

Produce ATP directly

Where does the energy for ATP synthesis in oxidative phosphorylation come from?

NADH and FADH2 from glycolysis

Formation of citric acid in the Krebs Cycle

Conversion of glucose into pyruvate

Protons crossing the inner mitochondrial membrane via ATPase (correct)

What is the preparatory step for the Krebs Cycle?

Production of NADH for energy transport

Conversion of pyruvate to lactate

Formation of pyruvate

Formation of Acetyl CoA (correct)

Which molecule is deficient in dietary thiamine deficiency, leading to the accumulation of pyruvate?

Acetyl CoA Signup and view all the answers

What role does NADH and FADH2 play in the electron transport chain?

Transport energy to the electron transport chain Signup and view all the answers

Where does the Krebs Cycle take place in the cell?

Mitochondrial matrix Signup and view all the answers

What is the initial compound that combines with acetyl CoA to enter the Krebs cycle?

Oxaloacetic acid Signup and view all the answers

Which enzyme complex deficiency can lead to lactic acidosis similar to what is observed in alcoholics?

Pyruvate dehydrogenase deficiency Signup and view all the answers

What are the main products generated from the Krebs cycle per cycle for each glucose molecule metabolized?

2 ATP, 3 NADH, 1 FADH2 Signup and view all the answers

Which nutrient deficiency is commonly observed in alcoholics and contributes to the development of metabolic disturbances?

Thiamine Signup and view all the answers

What compound is progressively oxidized through a series of enzyme-catalyzed reactions in the Krebs cycle?

Citric acid Signup and view all the answers

Which compound is NOT directly generated from the Krebs cycle per cycle?

Glucose Signup and view all the answers

What is the role of citrate synthetase in the Krebs cycle?

To convert acetyl-CoA to citrate Signup and view all the answers

What is the effect of fluoroacetate on the Krebs cycle?

It blocks the Krebs cycle completely Signup and view all the answers

What is the net ATP yield from the Krebs cycle?

2 ATP Signup and view all the answers

What is the role of oxaloacetic acid in the Krebs cycle?

To combine with acetyl-CoA to form citrate Signup and view all the answers

What is the result of arsenic binding to inorganic phosphate?

It depletes ATP stores Signup and view all the answers

What is the current ATP yield from glycolysis and the Krebs cycle?

2 ATP Signup and view all the answers

During oxidative phosphorylation, what is the total ATP yield from 10 NADH and 2 FADH2?

38 ATP Signup and view all the answers

What is the primary regulator of oxidative phosphorylation?

ADP level Signup and view all the answers

How many ATP molecules are generated per NADH during oxidative phosphorylation?

3 ATP Signup and view all the answers

What is the effect of high ATP levels on citrate synthetase?

It is inhibited Signup and view all the answers

What is the effect of adding ADP to mitochondria?

The rate of oxygen consumption increases Signup and view all the answers

What is the role of FADH2 in oxidative phosphorylation?

It generates 2 ATP Signup and view all the answers

What is the allosteric inhibitor of citrate synthase?

ATP Signup and view all the answers

What is the primary driver of the Electron Transport Chain (ETC) and oxidative phosphorylation?

Level of ADP Signup and view all the answers

What is the byproduct of oxidative phosphorylation that drives the Electron Transport Chain?

Water Signup and view all the answers

What is the substrate for citrate synthase in the citric acid cycle?