Kinetics of Thiamethoxam Release Study
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Kinetics of Thiamethoxam Release Study

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Questions and Answers

What does the variable 'k' represent in the context of release kinetics?

  • Time of maximal rate of release
  • Maximum fraction released
  • Coefficient of determination
  • First order rate constant (correct)

    • In which pH environment was the highest 'k' value observed for the BA-CMC-5-T formulation?

  • pH 4.0
  • pH 7.0 (correct)
  • pH 9.2
  • None of the above

    • The variable 'n' in the release kinetics is best defined as what?

  • Sum of square residual
  • Rate constant
  • Time of maximal rate
  • Release exponent (correct)

    • What is the significance of the 'R2' value in the context of the release kinetic parameters?

    <p>It represents the precision of the linear regression fit.</p> Signup and view all the answers

    Among the formulations listed, which had the lowest SSR (Sum of Square Residual) at pH 4.0?

    <p>BA-CMC-6-T</p> Signup and view all the answers

    The time of maximal rate of release (t2max) for the BA-CMC-5-T formulation at pH 7.0 is what?

    <p>8.09 days</p> Signup and view all the answers

    What does the term 'Mt' represent in the context of the provided data on thiamethoxam release?

    <p>Fraction of drug release at time t</p> Signup and view all the answers

    At which pH level does the BA-CMC-7-T formulation show a release exponent 'n' closest to 0.31?

    <p>pH 7.0</p> Signup and view all the answers

    Among the formulations listed, which has the highest 'M1 max' value at pH 4.0?

    <p>BA-CMC-5-T</p> Signup and view all the answers

    Which pH condition demonstrated the lowest thiamethoxam release three days after application?

    <p>pH 4.0</p> Signup and view all the answers

    What is indicated when the release exponent value (n) is less than or near 0.5 in the Korsmeyer-Peppas model?

    <p>Release follows Fickian diffusion.</p> Signup and view all the answers

    Which formulation achieved the highest thiamethoxam release at pH 9.2 on the third day?

    <p>BA-CMC-5</p> Signup and view all the answers

    What can be inferred about B’s encapsulation in the hydrogel matrix based on the kinetics data?

    <p>B was tightly encapsulated resulting in a reduced release rate.</p> Signup and view all the answers

    Which model provided the best fit for the kinetics profile of B release from BA-CMCs?

    <p>Gallagher-Corrigan equation</p> Signup and view all the answers

    What effect does increasing the concentration of BA have on thiamethoxam release from the BA-CMCs?

    <p>Decreases the release rate.</p> Signup and view all the answers

    Which statement accurately reflects the behavior of thiamethoxam release at different pH conditions?

    <p>Higher pH levels lead to increased diffusion due to swelling.</p> Signup and view all the answers

    Which model was found not to fit well to the release data of B from BA-CMCs?

    <p>First order kinetic model</p> Signup and view all the answers

    Which formulation shows the highest release exponent (n) at pH 4.0?

    <p>BA-CMC-4</p> Signup and view all the answers

    At pH 9.2, which formulation has the highest maximum release rate constant (k) from Gallagher-Corrigan method?

    <p>BA-CMC-3</p> Signup and view all the answers

    What is the SSR value for BA-CMC-6 at pH 7.0?

    <p>0.008</p> Signup and view all the answers

    Which formulation demonstrates the lowest R2 value at pH 7.0 according to Korsmeyer-Peppas model?

    <p>BA-CMC-4</p> Signup and view all the answers

    Identify the formulation with the highest R2 value across all pH levels for the Gallagher-Corrigan method.

    <p>BA-CMC-3</p> Signup and view all the answers

    At pH 4.0, which formulation has the highest model-derived maximum release (M1 max)?

    <p>BA-CMC-5</p> Signup and view all the answers

    What is the release exponent (n) for BA-CMC-4 at pH 9.2?

    <p>0.003</p> Signup and view all the answers

    Which formulation has the lowest k value at pH 7.0 from Korsmeyer-Peppas?

    <p>BA-CMC-7</p> Signup and view all the answers

    Which formulation shows the largest difference in SSR between pH 4.0 and pH 9.2?

    <p>BA-CMC-5</p> Signup and view all the answers

    Identify the formulation at pH 4.0 with a rate constant (k) closest to 0.15 Day−1.

    <p>BA-CMC-3</p> Signup and view all the answers

    Study Notes

    Effect of pH on Release Kinetics of Thiamethoxam from BA-CMC-Ts

    • The study investigates the release kinetics of thiamethoxam from various BA-CMC-Ts formulations at different pH levels (4.0, 7.0, and 9.2).
    • The release kinetics were analyzed using three models: Korsmeyer-Peppas, First Order, and Gallagher-Corrigan.
    • The Korsmeyer-Peppas model (Eq.(7)) did not provide a good fit for the release data, suggesting that the release mechanism is not solely driven by Fickian diffusion.
    • Similarly, the First Order kinetic model (Eq.(8)) did not fit the release data well, indicating that thiamethoxam is tightly encapsulated within the hydrogel matrix.
    • The Gallagher-Corrigan equation (Eq.(9)) showed the best fit for the release data from BA-CMCs, exhibiting high R2 values and low SSR compared to the other two models.
    • This suggests that the Gallagher-Corrigan model accurately describes the release kinetics of thiamethoxam from the BA-CMC-Ts formulations.

    Release Profile at Different pH Conditions

    • At pH 4.0, the maximum release of thiamethoxam on the 3rd day was observed in BA-CMC-5 (62.03%), followed by BA-CMC-6 (52.49%) and BA-CMC-7 (41.68%).
    • At pH 7.0, BA-CMC-Ts showed a larger release of thiamethoxam, with the maximum release occurring on the 3rd day in BA-CMC-5 (79.69%), followed by BA-CMC-6 (72.91%) and BA-CMC-7 (51.61%).
    • At pH 9.2, the release rate was significantly higher due to increased ion swelling pressure and possible erosion effects of the hydrogel matrix. The maximum release on the 3rd day was achieved by BA-CMC-5 (86.45%), followed by BA-CMC-6 (78.26%) and BA-CMC-7 (63.97%).

    Role of BA in Release Kinetics

    • Increasing the concentration of BA in the BA-CMCs matrix leads to reduced thiamethoxam release rates.
    • This indicates that BA enhances the crosslinking density of the BA-CMCs, resulting in a tighter encapsulation of thiamethoxam within the matrix.

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    Description

    This quiz explores the impact of pH on the release kinetics of thiamethoxam from BA-CMC-Ts formulations. It covers various kinetic models used for analysis, including Korsmeyer-Peppas, First Order, and Gallagher-Corrigan, discussing which model best fits the release data. Test your understanding of these concepts and their implications in formulation science.

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