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Questions and Answers
What does the variable 'k' represent in the context of release kinetics?
What does the variable 'k' represent in the context of release kinetics?
In which pH environment was the highest 'k' value observed for the BA-CMC-5-T formulation?
In which pH environment was the highest 'k' value observed for the BA-CMC-5-T formulation?
The variable 'n' in the release kinetics is best defined as what?
The variable 'n' in the release kinetics is best defined as what?
What is the significance of the 'R2' value in the context of the release kinetic parameters?
What is the significance of the 'R2' value in the context of the release kinetic parameters?
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Among the formulations listed, which had the lowest SSR (Sum of Square Residual) at pH 4.0?
Among the formulations listed, which had the lowest SSR (Sum of Square Residual) at pH 4.0?
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The time of maximal rate of release (t2max) for the BA-CMC-5-T formulation at pH 7.0 is what?
The time of maximal rate of release (t2max) for the BA-CMC-5-T formulation at pH 7.0 is what?
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What does the term 'Mt' represent in the context of the provided data on thiamethoxam release?
What does the term 'Mt' represent in the context of the provided data on thiamethoxam release?
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At which pH level does the BA-CMC-7-T formulation show a release exponent 'n' closest to 0.31?
At which pH level does the BA-CMC-7-T formulation show a release exponent 'n' closest to 0.31?
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Among the formulations listed, which has the highest 'M1 max' value at pH 4.0?
Among the formulations listed, which has the highest 'M1 max' value at pH 4.0?
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Which pH condition demonstrated the lowest thiamethoxam release three days after application?
Which pH condition demonstrated the lowest thiamethoxam release three days after application?
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What is indicated when the release exponent value (n) is less than or near 0.5 in the Korsmeyer-Peppas model?
What is indicated when the release exponent value (n) is less than or near 0.5 in the Korsmeyer-Peppas model?
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Which formulation achieved the highest thiamethoxam release at pH 9.2 on the third day?
Which formulation achieved the highest thiamethoxam release at pH 9.2 on the third day?
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What can be inferred about B’s encapsulation in the hydrogel matrix based on the kinetics data?
What can be inferred about B’s encapsulation in the hydrogel matrix based on the kinetics data?
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Which model provided the best fit for the kinetics profile of B release from BA-CMCs?
Which model provided the best fit for the kinetics profile of B release from BA-CMCs?
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What effect does increasing the concentration of BA have on thiamethoxam release from the BA-CMCs?
What effect does increasing the concentration of BA have on thiamethoxam release from the BA-CMCs?
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Which statement accurately reflects the behavior of thiamethoxam release at different pH conditions?
Which statement accurately reflects the behavior of thiamethoxam release at different pH conditions?
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Which model was found not to fit well to the release data of B from BA-CMCs?
Which model was found not to fit well to the release data of B from BA-CMCs?
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Which formulation shows the highest release exponent (n) at pH 4.0?
Which formulation shows the highest release exponent (n) at pH 4.0?
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At pH 9.2, which formulation has the highest maximum release rate constant (k) from Gallagher-Corrigan method?
At pH 9.2, which formulation has the highest maximum release rate constant (k) from Gallagher-Corrigan method?
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What is the SSR value for BA-CMC-6 at pH 7.0?
What is the SSR value for BA-CMC-6 at pH 7.0?
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Which formulation demonstrates the lowest R2 value at pH 7.0 according to Korsmeyer-Peppas model?
Which formulation demonstrates the lowest R2 value at pH 7.0 according to Korsmeyer-Peppas model?
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Identify the formulation with the highest R2 value across all pH levels for the Gallagher-Corrigan method.
Identify the formulation with the highest R2 value across all pH levels for the Gallagher-Corrigan method.
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At pH 4.0, which formulation has the highest model-derived maximum release (M1 max)?
At pH 4.0, which formulation has the highest model-derived maximum release (M1 max)?
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What is the release exponent (n) for BA-CMC-4 at pH 9.2?
What is the release exponent (n) for BA-CMC-4 at pH 9.2?
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Which formulation has the lowest k value at pH 7.0 from Korsmeyer-Peppas?
Which formulation has the lowest k value at pH 7.0 from Korsmeyer-Peppas?
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Which formulation shows the largest difference in SSR between pH 4.0 and pH 9.2?
Which formulation shows the largest difference in SSR between pH 4.0 and pH 9.2?
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Identify the formulation at pH 4.0 with a rate constant (k) closest to 0.15 Day−1.
Identify the formulation at pH 4.0 with a rate constant (k) closest to 0.15 Day−1.
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Study Notes
Effect of pH on Release Kinetics of Thiamethoxam from BA-CMC-Ts
- The study investigates the release kinetics of thiamethoxam from various BA-CMC-Ts formulations at different pH levels (4.0, 7.0, and 9.2).
- The release kinetics were analyzed using three models: Korsmeyer-Peppas, First Order, and Gallagher-Corrigan.
- The Korsmeyer-Peppas model (Eq.(7)) did not provide a good fit for the release data, suggesting that the release mechanism is not solely driven by Fickian diffusion.
- Similarly, the First Order kinetic model (Eq.(8)) did not fit the release data well, indicating that thiamethoxam is tightly encapsulated within the hydrogel matrix.
- The Gallagher-Corrigan equation (Eq.(9)) showed the best fit for the release data from BA-CMCs, exhibiting high R2 values and low SSR compared to the other two models.
- This suggests that the Gallagher-Corrigan model accurately describes the release kinetics of thiamethoxam from the BA-CMC-Ts formulations.
Release Profile at Different pH Conditions
- At pH 4.0, the maximum release of thiamethoxam on the 3rd day was observed in BA-CMC-5 (62.03%), followed by BA-CMC-6 (52.49%) and BA-CMC-7 (41.68%).
- At pH 7.0, BA-CMC-Ts showed a larger release of thiamethoxam, with the maximum release occurring on the 3rd day in BA-CMC-5 (79.69%), followed by BA-CMC-6 (72.91%) and BA-CMC-7 (51.61%).
- At pH 9.2, the release rate was significantly higher due to increased ion swelling pressure and possible erosion effects of the hydrogel matrix. The maximum release on the 3rd day was achieved by BA-CMC-5 (86.45%), followed by BA-CMC-6 (78.26%) and BA-CMC-7 (63.97%).
Role of BA in Release Kinetics
- Increasing the concentration of BA in the BA-CMCs matrix leads to reduced thiamethoxam release rates.
- This indicates that BA enhances the crosslinking density of the BA-CMCs, resulting in a tighter encapsulation of thiamethoxam within the matrix.
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Description
This quiz explores the impact of pH on the release kinetics of thiamethoxam from BA-CMC-Ts formulations. It covers various kinetic models used for analysis, including Korsmeyer-Peppas, First Order, and Gallagher-Corrigan, discussing which model best fits the release data. Test your understanding of these concepts and their implications in formulation science.
