Kim Pharmaceutics Exam Objectives
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Questions and Answers

What determines the membrane permeability of drug substances?

  • Compound size (correct)
  • Bioavailability
  • Chemical formula
  • Physical appearance

    • What is the characteristic of amorphous solid forms?

  • Repetition in three-dimensional lattice units
  • Definite melting points
  • Long-range order
  • Random molecular arrangement (correct)

    • Which type of solid form involves molecules or atoms arranged in repetition in a three-dimensional lattice?

  • Crystalline (correct)
  • Solvates
  • Polymeric
  • Cocrystals

    • What is the defining characteristic of polymorphism in drug formulation?

    <p>Different physical properties despite identical composition</p> Signup and view all the answers

    What is a prodrug in relation to drug transformation?

    <p>Inactive form that needs activation</p> Signup and view all the answers

    Which type of solid form can accommodate other molecules to form salts?

    <p>Crystalline</p> Signup and view all the answers

    What is the primary function of excipients in drug formulations?

    <p>To serve as the vehicle or medium for the active drug substance</p> Signup and view all the answers

    Which of the following excipients is commonly used as a thickening agent or to form topical gels?

    <p>Carbomer</p> Signup and view all the answers

    What was the issue observed with the delavirdine mesylate tablets when exposed to high relative humidity?

    <p>The tablets exhibited poor dissolution</p> Signup and view all the answers

    Which of the following is a physicochemical property used to test chemical substances?

    <p>Both melting point depression and vapor pressure</p> Signup and view all the answers

    What is the phenomenon of melting point depression?

    <p>The reduction of the melting point of a material with a reduction in its size</p> Signup and view all the answers

    Which of the following statements about vapor pressure is true?

    <p>It does not depend on the presence of other vapors in the air</p> Signup and view all the answers

    What is the definition of a dosage form?

    <p>The physical form of a dose of drug</p> Signup and view all the answers

    What is required before a new drug can be distributed and used?

    <p>Obtaining approval from the FDA after filing a New Drug Application (NDA)</p> Signup and view all the answers

    What did the Durham-Humphrey Amendment of 1951 establish?

    <p>The distinction between prescription and over-the-counter drugs</p> Signup and view all the answers

    Which of the following is NOT one of the major federal enactments related to drug regulation and control?

    <p>The Controlled Substances Act of 1970</p> Signup and view all the answers

    What is the purpose of the Investigational New Drug (IND) application?

    <p>To initiate clinical trials for a new drug</p> Signup and view all the answers

    What is the definition of a dosage regimen?

    <p>The frequency at which drug doses are given</p> Signup and view all the answers

    What is the main purpose of the Kefauver-Harris Amendments of 1962?

    <p>To require proof of both safety and effectiveness for FDA approval</p> Signup and view all the answers

    What did the Comprehensive Drug Abuse Prevention and Control Act of 1970 establish?

    <p>5 schedules for drugs subject to use</p> Signup and view all the answers

    What are some characteristics of a goal drug according to the text?

    <p>Optimal duration, convenient administration, no side effects, minimal dosage, minimal dosing frequency</p> Signup and view all the answers

    What does cGMP stand for in relation to pharmaceuticals?

    <p>Current Good Manufacturing Practice</p> Signup and view all the answers

    What does cGMP regulate in the pharmaceutical industry?

    <p>Packaging, labeling, and storage of pharmaceuticals</p> Signup and view all the answers

    What is the role of USP/NF as mentioned in the text?

    <p>Establishing standards for drugs and their ingredients</p> Signup and view all the answers

    Which of the following is an advantage of transdermal drug delivery?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is a disadvantage of transdermal drug delivery?

    <p>All of the above</p> Signup and view all the answers

    What is the primary reason transdermal drug delivery can improve bioavailability?

    <p>It avoids first-pass metabolism in the liver</p> Signup and view all the answers

    Which characteristic is most important for a drug to be suitable for traditional transdermal delivery?

    <p>Low molecular weight and high lipophilicity</p> Signup and view all the answers

    Which of the following is NOT a characteristic of drugs suitable for traditional transdermal delivery?

    <p>High molecular weight</p> Signup and view all the answers

    What is the primary benefit of the controlled and sustained release profile provided by transdermal drug delivery?

    <p>Improved patient compliance</p> Signup and view all the answers

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