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Questions and Answers
What role does the macula densa play in the kidney's juxta-glomerular apparatus?
What role does the macula densa play in the kidney's juxta-glomerular apparatus?
Which structure is directly involved in monitoring blood flow in the afferent arteriole?
Which structure is directly involved in monitoring blood flow in the afferent arteriole?
What triggers the secretion of renin by granular cells?
What triggers the secretion of renin by granular cells?
What is the primary function of the smooth muscle cells associated with the afferent arteriole?
What is the primary function of the smooth muscle cells associated with the afferent arteriole?
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Which of the following best describes the relationship between NaCl transport and renin secretion?
Which of the following best describes the relationship between NaCl transport and renin secretion?
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Which metabolic wastes does the kidney excrete?
Which metabolic wastes does the kidney excrete?
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What role does renin play in the body's physiology?
What role does renin play in the body's physiology?
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What is the primary function of erythropoietin secreted by the kidneys?
What is the primary function of erythropoietin secreted by the kidneys?
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Which substance is converted to its active form by the kidneys?
Which substance is converted to its active form by the kidneys?
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What does the kidney do to help regulate acid-base balance in the body?
What does the kidney do to help regulate acid-base balance in the body?
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What stimulates the secretion of renin by the juxtaglomerular apparatus?
What stimulates the secretion of renin by the juxtaglomerular apparatus?
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Which prostaglandin acts as a vasodilator secreted by the kidneys?
Which prostaglandin acts as a vasodilator secreted by the kidneys?
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What effect does chronic renal disease have on bone health?
What effect does chronic renal disease have on bone health?
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What is the primary functional unit of the kidney?
What is the primary functional unit of the kidney?
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Which part of the nephron is responsible for filtration?
Which part of the nephron is responsible for filtration?
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What type of nephrons has glomeruli located closer to the medulla?
What type of nephrons has glomeruli located closer to the medulla?
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Which structure has a crucial role in urine concentration?
Which structure has a crucial role in urine concentration?
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How many nephrons are typically found in each kidney?
How many nephrons are typically found in each kidney?
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What is the main function of the renal tubules?
What is the main function of the renal tubules?
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Which type of nephron supplies the peritubular capillaries?
Which type of nephron supplies the peritubular capillaries?
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What feature distinguishes the proximal convoluted tubule from the distal convoluted tubule?
What feature distinguishes the proximal convoluted tubule from the distal convoluted tubule?
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In which part of the kidney are the juxtaglomerular apparatus located?
In which part of the kidney are the juxtaglomerular apparatus located?
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Which component of the nephron extends into the renal medulla?
Which component of the nephron extends into the renal medulla?
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What is the role of the loop of Henle?
What is the role of the loop of Henle?
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What is the primary function of the juxtaglomerular apparatus?
What is the primary function of the juxtaglomerular apparatus?
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Which vessel carries blood away from the glomerulus?
Which vessel carries blood away from the glomerulus?
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What aspect of homeostasis do the kidneys primarily help to maintain?
What aspect of homeostasis do the kidneys primarily help to maintain?
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Flashcards
What is a nephron?
What is a nephron?
The functional unit of the kidney, responsible for filtering blood and producing urine.
What is the renal corpuscle?
What is the renal corpuscle?
The filtration part of the nephron, composed of a ball of capillaries (glomerulus) and a surrounding capsule (Bowman's capsule).
What are the renal tubules?
What are the renal tubules?
The part of the nephron responsible for reabsorbing and secreting substances to fine-tune urine composition.
What are the proximal convoluted tubules (PCT)?
What are the proximal convoluted tubules (PCT)?
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What is the loop of Henle?
What is the loop of Henle?
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What are the distal convoluted tubules (DCT)?
What are the distal convoluted tubules (DCT)?
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What are the collecting tubules (CT)?
What are the collecting tubules (CT)?
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What is the juxtaglomerular apparatus?
What is the juxtaglomerular apparatus?
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What are juxtamedullary nephrons?
What are juxtamedullary nephrons?
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What are cortical nephrons?
What are cortical nephrons?
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What is the role of kidneys in maintaining homeostasis?
What is the role of kidneys in maintaining homeostasis?
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What is renal failure?
What is renal failure?
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How do kidneys contribute to electrolyte balance?
How do kidneys contribute to electrolyte balance?
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What is the role of the kidneys in pH regulation?
What is the role of the kidneys in pH regulation?
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What is the role of the kidneys in red blood cell production?
What is the role of the kidneys in red blood cell production?
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What is the role of the kidneys in calcium metabolism?
What is the role of the kidneys in calcium metabolism?
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Kidney's Excretory Function
Kidney's Excretory Function
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Gluconeogenesis in the Kidney
Gluconeogenesis in the Kidney
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Kidney's Role in Blood Pressure Regulation
Kidney's Role in Blood Pressure Regulation
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Erythropoietin (EPO)
Erythropoietin (EPO)
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Renin
Renin
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Prostaglandins in Kidney Function
Prostaglandins in Kidney Function
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Kidney's Role in Vitamin D Metabolism
Kidney's Role in Vitamin D Metabolism
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Kidney's Role in Acid-Base Balance
Kidney's Role in Acid-Base Balance
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Juxtaglomerular Apparatus (JGA)
Juxtaglomerular Apparatus (JGA)
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Granular Cells
Granular Cells
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Macula Densa
Macula Densa
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Tubuloglomerular Feedback (TGF)
Tubuloglomerular Feedback (TGF)
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Study Notes
Renal Module Information
- Course code: IMP-07- 20318
- Phase: I
- Year/semester: 2nd year / Semester 3 (2022-2023)
Lecture 1: Endocrine Function of the Kidney
- Functional unit of the kidney: nephron
- Nephron structure: glomerulus, Bowman's capsule, proximal convoluted tubule (PCT), loop of Henle, distal convoluted tubule (DCT), collecting tubules (CT)
- Renal corpuscle: filtering part of nephron, contains glomerulus and Bowman's capsule
- Glomerulus: ball of capillaries, filters blood
- Bowman's capsule: blind end of tubule that surrounds glomerulus, collects filtrate
- PCT: highly coiled in cortex, reabsorbs materials, has luminal brush border
- Loop of Henle: U-shaped, in medulla, important for concentration of urine
- DCT: highly coiled, in cortex, reabsorbs or secretes substances
- Collecting tubules: cross medulla, where final urine concentration occurs
Tutorial 1: Endocrine Function of the Kidney
- Intended Learning Outcomes (ILOs):
- Describe functions of renal system.
- Identify types of nephrons and functions of each type.
- Describe Juxtaglomerular apparatus and its significance.
Structure of the Urinary System
- Key components: Renal artery, Renal vein, Kidney, Aorta, Ureter, Urinary bladder, Urethra, Vena cava
Kidney Structure
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Kidney composed of 6-18 lobes
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Each lobe formed of a pyramid of medulla, covered with cortex
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Renal cortex: outer layer of the kidney
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Renal medulla: inner layer of the kidney
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Renal pelvis: funnel-shaped structure that collects urine
Nephron Details
- Nephron: functional unit of the kidney
- Each kidney has one million nephrons.
- Only 1/4 of kidney nephrons can carry the function
- Excessive loss of nephrons will cause issues.
Nephron Anatomy
- Renal corpuscle (filtering part)
- Renal tubule (reabsorption and secretion part)
- Proximal convoluted tubule (PCT)
- Loop of Henle
- Distal convoluted tubule (DCT)
- Collecting tubules
Renal Corpuscle More Details
- Glomerulus: Ball of capillaries, filters blood, located within Bowman's capsule.
- Bowman's capsule: Expanded blind end of tubule that surrounds the glomerulus, collects the filtrate
Renal Tubules
- Proiximal Convoluted Tubule (PCT), Loop of Henle, Distal Convoluted Tubule (DCT), Collecting Tubules (CT)
- PCT: Highly coiled, cortex, reabsorbs substances, has brush border
- Loop of Henle: U-shaped, medulla, concentrations of urine, thin descending/thick ascending
- DCT: highly coiled, cortex, reabsorbs or secretes substances
- Collecting tubules: Cross medulla, final urine concentration
Nephron Types
- Cortical nephrons: 80%, glomeruli close to surface. Loop of Henle short
- Juxtamedullary nephrons: 20%, glomeruli near medulla, long loop of Henle, important for concentrating urine
Kidney Functions
- Homeostasis of ECF: (H2O, electrolytes, volume, pH, and osmolarity)
- Excretion of metabolic wastes: (urea, uric acid, creatinine) and foreign compounds (e.g., drugs)
- Gluconeogenesis: Kidney synthesizes glucose from amino acids during prolonged fasting
- Regulation of arterial blood pressure through renin secretion
- Endocrine functions: secreting erythropoietin and renin, converting Vit D into active form, secreting prostaglandins (PGA2 and PGE); vasodilator, vasoconstrictors
- Acid-base regulation: elimination of acids from protein metabolism, regulates buffer stores in the body
Renin
- Hormone secreted by Juxtaglomerular apparatus, important for salt conservation
- Secreted in response to low NaCL, low ECF volume, low ABP
- Acts on angiotensinogen to produce angiotensin I, then angiotensin II, ultimately stimulating aldosterone secretion
Factors Stimulating Renin Secretion
- Renal ischemia
- Hypotension
- Hemorrhage
- Sympathetic stimulation
- Increased blood catecholamine levels
Factors Inhibiting Renin Secretion
- Increased blood pressure
- Increased blood volume
- Increased Cl or Na reabsorption across macula densa
- Angiotensin II
- Vasopressin (ADH) and aldosterone
Erythropoietin
- Hormone secreted by peritubular capillaries in response to hypoxia.
- Stimulates red bone marrow to produce RBCs.
- Kidney plays a vital role in erythropoiesis.
- Kidney secretes 85% of erythropoietin in the body.
Prostaglandins
- Kidney secretes PGE2 and PGI2
- Acts locally to help autoregulate glomerular filtration rate and renal blood flow.
Regulation of 1,25 dihydroxy vit D3 Production
- Regulation of 1,25-dihydroxy vitamin D3 production by kidney activity of 1α-hydroxylase enzyme which converts 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol.
- Kidney plays a crucial role in calcium homeostasis and bone formation, so problems with chronic renal issues can cause weakened, decalcified bones.
Juxtaglomerular Apparatus (JGA) Details
- Components: Macula densa, granulated cells
- Macula densa: modified cells in DCT, monitor flow rate (NaCl & adenosine in DCT, and impacts afferent arteriole.
- Granular cells: modified cells in wall of afferent arteriole, monitors flow in arteriole and secretes renin.
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Description
Test your knowledge on the role of the macula densa, the juxtaglomerular apparatus, and the various hormones and substances secreted by the kidneys. This quiz covers important physiological mechanisms involved in filtering blood, regulating blood pressure, and maintaining the body's overall homeostasis.