Podcast
Questions and Answers
What percentage of filtrate is typically reabsorbed in the proximal convoluted tubule?
What percentage of filtrate is typically reabsorbed in the proximal convoluted tubule?
- 90%
- 95%
- 70%
- 85% (correct)
What characterizes the ascending limb of the loop of Henlé?
What characterizes the ascending limb of the loop of Henlé?
- Wide and impermeable to water (correct)
- Narrow and permeable to water
- Thick walls and highly permeable to sodium
- Thin walls and impermeable to ions
The counter-current multiplier refers to which process in the loop of Henlé?
The counter-current multiplier refers to which process in the loop of Henlé?
- Water potential gradient established by opposing flows (correct)
- Filtration of liquid in opposite directions
- Enhanced absorption through parallel flow of liquids
- Exchange of oxygen and carbon dioxide
What is primarily responsible for the increased hydrostatic pressure within the glomerulus?
What is primarily responsible for the increased hydrostatic pressure within the glomerulus?
Which structure is specifically adapted to increase reabsorption surface area in the proximal convoluted tubule?
Which structure is specifically adapted to increase reabsorption surface area in the proximal convoluted tubule?
Which of the following is NOT a component that resists the movement of filtrate out of the glomerulus?
Which of the following is NOT a component that resists the movement of filtrate out of the glomerulus?
What type of cells line the walls of the glomerular capillaries?
What type of cells line the walls of the glomerular capillaries?
What is the main function of the distal convoluted tubule?
What is the main function of the distal convoluted tubule?
What role do mitochondria play in cells of the proximal convoluted tubule?
What role do mitochondria play in cells of the proximal convoluted tubule?
What substance is NOT typically filtered out during ultrafiltration in the nephron?
What substance is NOT typically filtered out during ultrafiltration in the nephron?
What is the primary function of the renal (Bowman's) capsule in the nephron?
What is the primary function of the renal (Bowman's) capsule in the nephron?
How much water is estimated to leave the body as urine from the daily intake?
How much water is estimated to leave the body as urine from the daily intake?
In the loop of Henlé, what is the significance of the hairpin shape?
In the loop of Henlé, what is the significance of the hairpin shape?
How do the kidneys maintain the body's calcium level?
How do the kidneys maintain the body's calcium level?
Which statement is correct about the glomerulus in mammals?
Which statement is correct about the glomerulus in mammals?
Which process describes the selective reabsorption in the nephron?
Which process describes the selective reabsorption in the nephron?
What is the primary role of podocytes in the kidney?
What is the primary role of podocytes in the kidney?
Which structure increases the surface area for reabsorption in the proximal convoluted tubule?
Which structure increases the surface area for reabsorption in the proximal convoluted tubule?
What is the function of the descending limb of the loop of Henlé?
What is the function of the descending limb of the loop of Henlé?
Where does most reabsorption occur within the nephron?
Where does most reabsorption occur within the nephron?
During ultrafiltration, what path does the filtrate take from the glomerulus?
During ultrafiltration, what path does the filtrate take from the glomerulus?
What substance is primarily active in endocytosis within tubule cells?
What substance is primarily active in endocytosis within tubule cells?
How does the concentration of sodium ions change as filtrate moves along the nephron?
How does the concentration of sodium ions change as filtrate moves along the nephron?
What feature differentiates the ascending limb from the descending limb of the loop of Henlé?
What feature differentiates the ascending limb from the descending limb of the loop of Henlé?
Flashcards
Ultrafiltration
Ultrafiltration
The process where blood is filtered in the kidneys, forcing fluids and small molecules out of the glomerulus and into Bowman's capsule. This is the first step in urine formation.
Selective Reabsorption
Selective Reabsorption
The process of reabsorbing useful substances - like water, glucose, and amino acids - back into the bloodstream from the nephron tubules, after ultrafiltration.
Afferent Arteriole
Afferent Arteriole
These are tiny blood vessels that bring blood into the glomerulus for filtration. They are wider than the efferent arterioles, which helps create pressure for ultrafiltration.
Efferent Arteriole
Efferent Arteriole
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Glomerulus
Glomerulus
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Bowman's Capsule
Bowman's Capsule
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Glomerular Filtrate
Glomerular Filtrate
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Peritubular Capillaries
Peritubular Capillaries
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Proximal Convoluted Tubule
Proximal Convoluted Tubule
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Loop of Henlé
Loop of Henlé
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Descending Limb
Descending Limb
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Ascending Limb
Ascending Limb
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Distal Convoluted Tubule
Distal Convoluted Tubule
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Counter-current Multiplier
Counter-current Multiplier
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Microvilli
Microvilli
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Mitochondria
Mitochondria
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Podocytes
Podocytes
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Basement Membrane (in the kidney)
Basement Membrane (in the kidney)
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Foot-like processes of podocytes
Foot-like processes of podocytes
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Proximal Convoluted Tubule (PCT)
Proximal Convoluted Tubule (PCT)
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Microvilli (in the PCT)
Microvilli (in the PCT)
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Ultrafiltration in the kidney
Ultrafiltration in the kidney
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Study Notes
Kidney Function - Ultrafiltration and Selective Reabsorption
- Kidneys regulate blood composition, maintaining a constant water potential, removing wastes (e.g., urea), regulating minerals, and blood pressure. Red blood cell production is also regulated.
- Blood enters the kidney through the renal artery, branching into millions of arterioles. Each arteriole leads to a renal (Bowman's) capsule, forming a glomerulus (capillary network).
- The glomerulus's afferent arteriole (incoming) is wider than the efferent arteriole (outgoing), creating hydrostatic pressure. This forces water, glucose, mineral ions, and other small molecules (up to 68000 relative molecular mass) into the renal capsule. This filtration under pressure is ultrafiltration.
- Filtrate is prevented from fully leaving by capillary endothelium, basement membrane, epithelial cells of renal capsule, intracapsular pressure, and glomerulus' low water potential.
- Specialized podocytes in the renal capsule have "feet" (podocyte) allowing fluid to pass between, not through them. The glomerular capillaries have large spaces (100 nm) between their cells.
- Filtrate is similar to blood plasma except for plasma proteins.
The Glomerulus - a Unique Capillary Bed
- The glomerulus is unique. This is an arteriole supplying blood, and another draining it (efferent arteriole), unlike other capillary beds.
- This structure is important for creating the hydrostatic pressure necessary for ultrafiltration to occur.
- The efferent arteriole further divides into peritubular capillaries, draining into a venule, away from the glomerulus.
- The efferent arteriole merging into further capillaries increases hydrostatic pressure within the glomerulus.
Selective Reabsorption
- Nearly 85% of filtrate is reabsorbed into the blood in the proximal convoluted tubule, because molecules smaller or below 68000 relative molecular mass are filtered out and many are essential to the body's functions.
- About 180 dm³ of water enter the nephrons daily, with only 1 dm³ exiting as urine.
- Reabsorption of water in the proximal convoluted tubule is 85%.
The Loop of Henle
- The loop of Henle, a hairpin-shaped structure in the medulla, is crucial for concentrating urine. It creates conditions (i.e high ion concentration, low water potential) for water reabsorption in the distal convoluted tubule.
- The descending limb is thin-walled, highly permeable to water.
- The ascending limb is thick-walled, impermeable to water.
- Sodium ions are actively pumped out of the ascending limb into the interstitial region. This creates a concentration gradient.
- Water passively moves out of the descending limb, lowering filtrate water potential.
- The loop acts as a counter-current multiplier, establishing a gradient in the interstitial fluid of the kidney, necessary for the further reabsorption of water in the collecting duct.
Distal Convoluted Tubule
- The distal convoluted tubule, controls water and salt balance, and adjusts pH by selectively reabsorbing ions.
- This reabsorption is hormone-regulated.
- Microvilli and mitochondria allow rapid reabsorption in the distal tubule.
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