Kidney Function: Reabsorption & Secretion
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Questions and Answers

What is the primary route of drug elimination from the body?

  • Through the kidneys (correct)
  • Through the intestines
  • Through the bile
  • Through the lungs
  • Which substances are typically not filtered by the glomerulus in the nephron?

  • Electrolytes
  • Proteins (correct)
  • Amino acids
  • Small molecules
  • After the ultrafiltrate enters Bowman's space, which structure does it pass through next?

  • Distal convoluted tubule
  • Loop of Henle
  • Proximal convoluted tubule (correct)
  • Collecting duct
  • What components are typically included in the ultrafiltrate formed in the nephron?

    <p>Water and glucose</p> Signup and view all the answers

    Which part of the nephron primarily focuses on the excretion of drugs?

    <p>Nephron</p> Signup and view all the answers

    What is the mechanism of action for liver microsomal enzyme (LME) inducers?

    <p>Stimulate or increase the activity of CYP</p> Signup and view all the answers

    What is a potential result of using LME inducers such as Rifampin?

    <p>Development of tolerance over time</p> Signup and view all the answers

    How do LME inhibitors affect drugs that are metabolized by the same enzyme?

    <p>They increase plasma levels, raising the risk of toxicity</p> Signup and view all the answers

    Which of the following is NOT considered a characteristic of LME inducers?

    <p>They inhibit enzyme activity temporarily</p> Signup and view all the answers

    Which of the following is an example of an LME inhibitor?

    <p>Ketoconazole</p> Signup and view all the answers

    What is the primary result of tubular reabsorption in the kidneys?

    <p>Transport of solutes and water into blood</p> Signup and view all the answers

    Which process directly involves the movement of solutes and water from tubular fluid to blood?

    <p>Tubular reabsorption</p> Signup and view all the answers

    What role do renal epithelial cells play in tubular secretion?

    <p>They secrete pharmaceuticals into the renal tubule.</p> Signup and view all the answers

    What is the correct sequence of events during the process of tubular reabsorption?

    <p>Tubular fluid → Interstitial fluid → Blood</p> Signup and view all the answers

    Which of the following does NOT occur during tubular secretion?

    <p>Transport of solutes to interstitial fluid</p> Signup and view all the answers

    What is the primary role of the liver in drug metabolism?

    <p>It processes lipophilic drugs for excretion.</p> Signup and view all the answers

    Which type of metabolic reaction is characterized by introducing or unmasking a polar functional group?

    <p>Oxidation reactions</p> Signup and view all the answers

    What is the role of prodrugs in drug metabolism?

    <p>They remain inactive until converted into their active form.</p> Signup and view all the answers

    Which tissue is NOT primarily involved in drug metabolism?

    <p>Brain</p> Signup and view all the answers

    What characterizes the cytochrome P450 system in drug metabolism?

    <p>It is involved in oxidation reactions to enhance solubility.</p> Signup and view all the answers

    Study Notes

    Reabsorption

    • Tubular reabsorption is the process by which solutes and water are removed from the tubule fluid and transported into interstitial fluid then into the blood.

    Tubular Secretion

    • Some drugs are secreted from renal epithelial cells into the lumen of renal tubule.

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    Description

    Explore the essential processes of tubular reabsorption and secretion in renal physiology. This quiz covers how solutes and water are reabsorbed from tubule fluid into the blood, as well as the secretion of drugs by renal epithelial cells. Test your knowledge of these critical kidney functions.

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