Kidney Function: NFP and GFR

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Questions and Answers

What does the term Net Filtration Pressure (NFP) refer to?

  • The osmotic pressure in Bowman's Capsule
  • The pressure in the renal tubules
  • The pressure that inhibits filtration
  • The pressure that promotes filtration (correct)

What is the formula for calculating NFP?

NFP = HPgc - (OPgc + HPcs)

What does glomerular filtration rate (GFR) represent?

The amount of filtrates formed in all renal corpuscles of both kidneys combined

What is the average GFR rate?

<p>125 ml/min</p> Signup and view all the answers

To maintain homeostasis of body fluids, the kidneys need to

<p>maintain a relatively constant GFR</p> Signup and view all the answers

If GFR is too high, what happens to needed substances?

<p>They pass through the renal tubule too quickly to be reabsorbed</p> Signup and view all the answers

If GFR is too low, what happens to filtrate components?

<p>They are reabsorbed and certain waste products are not adequately secreted</p> Signup and view all the answers

GFR is directly related to what other factor?

<p>NFP</p> Signup and view all the answers

What does HPgc stand for?

<p>Hydrostatic pressure of blood in glomerulus</p> Signup and view all the answers

What is the value of HPgc?

<p>55 mm Hg</p> Signup and view all the answers

What does HPcs stand for?

<p>Hydrostatic pressure of fluid in Bowman's Capsule</p> Signup and view all the answers

What is the value of HPcs?

<p>15 mm Hg</p> Signup and view all the answers

What does OPgc stand for?

<p>Osmotic pressure of plasma proteins in blood</p> Signup and view all the answers

What is the value of OPgc?

<p>30 mm Hg</p> Signup and view all the answers

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Study Notes

Net Filtration Pressure (NFP)

  • Net Filtration Pressure (NFP) is the total pressure that promotes the filtration process in the kidneys.
  • NFP formula: NFP = HPgc - (OPgc + HPcs), where each variable represents different pressures involved in filtration.

Glomerular Filtration Rate (GFR)

  • Glomerular filtration rate (GFR) measures the amount of filtrate produced by all renal corpuscles in both kidneys.
  • On average, GFR is 125 ml/min, indicating the kidney's capacity for filtration.

Importance of GFR

  • The kidneys must maintain a relatively constant GFR to ensure homeostasis of body fluids.
  • A GFR that is too high results in essential substances passing through the renal tubule too quickly, reducing reabsorption.
  • Conversely, if GFR is too low, many filtrate components are reabsorbed, impairing waste elimination.

Relationship Between NFP and GFR

  • GFR is directly related to NFP; changes in NFP will affect the filtration rate in the kidneys.

Hydrostatic and Osmotic Pressures

  • HPgc (Hydrostatic Pressure of Glomerulus) is the pressure exerted by blood in the glomerulus, facilitating fluid outflow; value is 55 mm Hg.
  • HPcs (Hydrostatic Pressure in Bowman's Capsule) opposes glomerular filtration by resisting fluid movement; value is 15 mm Hg.
  • OPgc (Osmotic Pressure of Glomerular Capillary) is due to plasma proteins in blood, pulling fluid back towards the glomerulus; value is 30 mm Hg.

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