Kidney Function and Urinary System Overview
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Questions and Answers

What is one of the key functions of the kidneys in maintaining the body's internal environment?

  • Producing bile for fat digestion
  • Regulating total water volume and solute concentration (correct)
  • Regulating body temperature
  • Releasing insulin for glucose metabolism
  • Which of the following is NOT a function of the kidneys?

  • Excreting metabolic wastes
  • Converting vitamin D to its active form
  • Secreting hormones that regulate growth (correct)
  • Producing erythropoietin
  • What structure primarily transports urine from the kidneys to the urinary bladder?

  • Collecting duct
  • Ureter (correct)
  • Renal pelvis
  • Urethra
  • Which of the following describes the renal medulla?

    <p>Deep to the cortex, darker with cone-shaped medullary pyramids (D)</p> Signup and view all the answers

    Which layer of supportive tissue is described as a fatty cushion surrounding the kidney?

    <p>Perirenal fat capsule (B)</p> Signup and view all the answers

    Where are the kidneys located in relation to the spinal column?

    <p>Superior lumbar region between T12 and L5 (C)</p> Signup and view all the answers

    What is the renal hilum?

    <p>The point where renal blood vessels, lymphatics, and nerves enter and exit the kidney (B)</p> Signup and view all the answers

    What is the approximate number of lobes present in one kidney?

    <p>8 (A)</p> Signup and view all the answers

    What is the correct sequence of urine flow through the structures of the kidney?

    <p>Papillae → Minor calyx → Major calyx → Renal pelvis → Ureter (C)</p> Signup and view all the answers

    Which part of the nephron is primarily responsible for urine filtration?

    <p>Glomerulus (D)</p> Signup and view all the answers

    What structure collects urine from minor calyces?

    <p>Major calyx (B)</p> Signup and view all the answers

    How do cortical nephrons differ from juxtamedullary nephrons?

    <p>Cortical nephrons cannot produce concentrated urine. (D)</p> Signup and view all the answers

    What is the primary function of the macula densa cells in the juxtaglomerular complex?

    <p>Sense NaCl content of filtrate (D)</p> Signup and view all the answers

    Which blood vessel carries blood away from the glomerulus?

    <p>Efferent arteriole (C)</p> Signup and view all the answers

    What percentage of cardiac output is delivered to the kidneys at rest?

    <p>20-25% (D)</p> Signup and view all the answers

    Where is most of the reabsorption and secretion in a nephron primarily located?

    <p>Proximal convoluted tubule (C)</p> Signup and view all the answers

    What defines the structure of the renal corpuscle?

    <p>A ball of capillaries and a surrounding capsule (C)</p> Signup and view all the answers

    Which statement accurately reflects urine production?

    <p>Urine is formed from the filtrate after processing in renal tubules. (A)</p> Signup and view all the answers

    What is the role of principal cells in the collecting duct?

    <p>They maintain water and Na+ balance. (B)</p> Signup and view all the answers

    What are peritubular capillaries primarily adapted for?

    <p>Absorption of water and solutes (D)</p> Signup and view all the answers

    Which process occurs first in urine formation?

    <p>Glomerular filtration (A)</p> Signup and view all the answers

    Functionally, what do vasa recta contribute to in the nephron?

    <p>Concentration of urine (C)</p> Signup and view all the answers

    What is the primary component of urine?

    <p>95% water (C)</p> Signup and view all the answers

    What might cause urine to have a cloudy appearance?

    <p>Urinary tract infection (A)</p> Signup and view all the answers

    What is the normal pH range of urine?

    <p>4.5 to 8.0 (C)</p> Signup and view all the answers

    What may indicate the presence of renal calculi?

    <p>Severe flank pain (B)</p> Signup and view all the answers

    Which part of the ureter is primarily responsible for preventing backflow of urine?

    <p>Ureteral valves (C)</p> Signup and view all the answers

    Which dietary factor can lead to an increase in urine pH?

    <p>Vegetarian diet (B)</p> Signup and view all the answers

    What is one common treatment for kidney stones?

    <p>Lithotripsy (C)</p> Signup and view all the answers

    What is the specific gravity range of urine?

    <p>1.001 to 1.035 (A)</p> Signup and view all the answers

    What is the primary function of the urinary bladder?

    <p>Temporary storage of urine (A)</p> Signup and view all the answers

    Which layer is responsible for the contraction of the urinary bladder during urination?

    <p>Detrusor muscle (B)</p> Signup and view all the answers

    What type of sphincter is the internal urethral sphincter?

    <p>Involuntary smooth muscle (D)</p> Signup and view all the answers

    Which symptom is commonly associated with urinary tract infections (UTIs)?

    <p>Dysuria (C)</p> Signup and view all the answers

    Which condition occurs when the bladder is unable to expel urine?

    <p>Urinary retention (A)</p> Signup and view all the answers

    What is the typical length of the female urethra?

    <p>3-4 cm (B)</p> Signup and view all the answers

    Which type of incontinence is triggered by increased intra-abdominal pressure?

    <p>Stress incontinence (B)</p> Signup and view all the answers

    What is the primary cause of urinary tract infections in women?

    <p>Anatomy of the female urethra (B)</p> Signup and view all the answers

    By age 80, approximately what percentage of glomerular filtration rate (GFR) remains compared to young adults?

    <p>70% (A)</p> Signup and view all the answers

    What triggers the events during micturition?

    <p>Autonomic nervous system and somatic nervous system (C)</p> Signup and view all the answers

    What type of cell division is responsible for producing gametes?

    <p>Meiosis (D)</p> Signup and view all the answers

    Which cells are considered female gametes?

    <p>Secondary oocytes (D)</p> Signup and view all the answers

    What is the chromosome composition of human gametes?

    <p>23 chromosomes unpaired (B)</p> Signup and view all the answers

    During which process do gametes unite to initiate the formation of a new individual?

    <p>Fertilization (D)</p> Signup and view all the answers

    What function do sex chromosomes serve in humans?

    <p>They determine an individual's sex. (B)</p> Signup and view all the answers

    What distinguishes meiosis from mitosis?

    <p>Meiosis results in four genetically different cells. (A)</p> Signup and view all the answers

    What is the significance of crossing over during meiosis?

    <p>It creates genetic diversity among gametes. (D)</p> Signup and view all the answers

    What is the total chromosome number in a diploid human cell?

    <p>46 (B)</p> Signup and view all the answers

    What is the final stage of spermatogenesis called?

    <p>Spermiogenesis (C)</p> Signup and view all the answers

    Which cell type remains at the basal lamina as a stem cell during spermatogenesis?

    <p>Type A daughter cell (D)</p> Signup and view all the answers

    What structure forms above the nucleus of a spermatid during spermiogenesis?

    <p>Acrosome cap (B)</p> Signup and view all the answers

    What is the role of mitochondria in the mature spermatozoon?

    <p>To provide energy for tail movement (B)</p> Signup and view all the answers

    How many sperm are produced from one primary spermatocyte undergoing spermatogenesis?

    <p>4 (D)</p> Signup and view all the answers

    What characterizes a mature (large vesicular) follicle in ovarian follicle development?

    <p>Contains a secondary oocyte that has completed meiosis I (C)</p> Signup and view all the answers

    What happens to the primary oocyte in a primordial follicle?

    <p>It is arrested in the first meiotic prophase (B)</p> Signup and view all the answers

    What hormone is primarily secreted by granulosa cells during the maturation of ovarian follicles?

    <p>Estrogen (A)</p> Signup and view all the answers

    What is the fate of the corpus luteum after the oocyte is expelled during ovulation?

    <p>It degenerates and ceases hormone production (A)</p> Signup and view all the answers

    What is the typical outcome of female gametogenesis in terms of viable gametes produced?

    <p>Single viable secondary oocyte (A)</p> Signup and view all the answers

    During which phase of meiosis does crossing over occur?

    <p>Prophase I (A)</p> Signup and view all the answers

    How many chromosomes does each daughter cell have after Meiosis I?

    <p>23 chromosomes with two sister chromatids each (A)</p> Signup and view all the answers

    What is the primary result of independent assortment during meiosis?

    <p>Generation of genetic variation in gametes (A)</p> Signup and view all the answers

    What process occurs during Meiosis II?

    <p>Separation of sister chromatids (C)</p> Signup and view all the answers

    What occurs during telophase I and cytokinesis?

    <p>Two new haploid cells are formed (A)</p> Signup and view all the answers

    What may result from nondisjunction during meiosis?

    <p>Gametes with an abnormal number of chromosomes (A)</p> Signup and view all the answers

    What is the primary function of spermatogonia in spermatogenesis?

    <p>Divide by mitosis to form new spermatogonial cells (C)</p> Signup and view all the answers

    In females, what do secondary oocytes mature into?

    <p>Haploid gametes (A)</p> Signup and view all the answers

    What is the result of successful crossing over during meiosis?

    <p>Increased genetic diversity (C)</p> Signup and view all the answers

    What is the outcome of meiosis in terms of the number of daughter cells produced?

    <p>Four haploid daughter cells (D)</p> Signup and view all the answers

    What happens during anaphase II of meiosis?

    <p>Sister chromatids separate and move to opposite poles (B)</p> Signup and view all the answers

    At what stage does the process of spermiogenesis occur during spermatogenesis?

    <p>After the formation of spermatids (A)</p> Signup and view all the answers

    What is a characteristic of fraternal twins compared to identical twins?

    <p>Different genetic combinations (C)</p> Signup and view all the answers

    Which cellular event defines the transition from meiosis I to meiosis II?

    <p>Separation of sister chromatids (C)</p> Signup and view all the answers

    What is the fate of the polar body formed during oogenesis?

    <p>It degenerates and has minimal cytoplasm. (D)</p> Signup and view all the answers

    During which phase of the ovarian cycle does the primary oocyte complete meiosis I?

    <p>Ovulation (D)</p> Signup and view all the answers

    What occurs to the secondary oocyte if it is not fertilized?

    <p>It breaks down within 24 hours. (B)</p> Signup and view all the answers

    Which hormone primarily stimulates the maturation of primordial follicles from puberty to menopause?

    <p>Follicle-stimulating hormone (FSH) (A)</p> Signup and view all the answers

    What is the status of primary oocytes in the ovaries before birth?

    <p>They are dormant and not yet developed into follicles. (B)</p> Signup and view all the answers

    Which method of contraception involves surgically cutting and tying off the uterine tubes?

    <p>Tubal ligation (D)</p> Signup and view all the answers

    What is a common risk factor for breast cancer that is associated with increased estrogen exposure?

    <p>Obesity (B)</p> Signup and view all the answers

    Which of the following sexually transmitted infections is caused by a bacterium and can be asymptomatic in many individuals?

    <p>Gonorrhea (A)</p> Signup and view all the answers

    What is the purpose of barrier methods in contraception?

    <p>Prevent sperm from reaching the uterine tubes (B)</p> Signup and view all the answers

    What does the morning-after pill primarily inhibit?

    <p>Ovulation (D)</p> Signup and view all the answers

    Which of the following is NOT a symptom commonly associated with chlamydia?

    <p>Gastrointestinal pain (C)</p> Signup and view all the answers

    In older males, what hormonal change primarily contributes to benign prostatic hyperplasia?

    <p>Increased estrogen (C)</p> Signup and view all the answers

    What are the flexible plastic structures inserted into the uterus called?

    <p>Intrauterine devices (IUD) (C)</p> Signup and view all the answers

    What is the primary treatment for endometriosis aimed at suppressing the growth of endometrial tissue?

    <p>Hormonal therapy (C)</p> Signup and view all the answers

    Which sexually transmitted infection is characterized by cyclic outbreaks of blister formation?

    <p>Genital herpes (B)</p> Signup and view all the answers

    Which procedure permanently prevents sperm from being able to exit the testis?

    <p>Vasectomy (D)</p> Signup and view all the answers

    What common breast cancer screening method is recommended for women over 40?

    <p>Mammography (B)</p> Signup and view all the answers

    What complication can arise in women due to untreated sexually transmitted infections?

    <p>Pelvic inflammatory disease (C)</p> Signup and view all the answers

    What is the characteristic feature of prostate cancer in its early stages?

    <p>Asymptomatic (A)</p> Signup and view all the answers

    What occurs during the follicular phase of the ovarian cycle?

    <p>Primordial follicles are stimulated to mature by FSH and LH. (C)</p> Signup and view all the answers

    What triggers ovulation in the ovarian cycle?

    <p>A peak in LH secretion. (B)</p> Signup and view all the answers

    What does the corpus luteum primarily secrete during the luteal phase?

    <p>Progesterone and estrogen. (D)</p> Signup and view all the answers

    What occurs if the secondary oocyte is not fertilized?

    <p>Menstruation will begin as progesterone decreases. (D)</p> Signup and view all the answers

    Which phase of the uterine cycle aligns with the ovarian luteal phase?

    <p>Secretory phase. (C)</p> Signup and view all the answers

    During which phase of the ovarian cycle does the secondary oocyte reach metaphase II?

    <p>Follicular phase. (D)</p> Signup and view all the answers

    What is the typical age range for the onset of menopause?

    <p>45 to 55 years. (B)</p> Signup and view all the answers

    What signifies the end of the luteal phase?

    <p>Regression of the corpus luteum and decrease in hormones. (B)</p> Signup and view all the answers

    What hormone is secreted by a pre-embryo after fertilization?

    <p>Human chorionic gonadotropin (hCG). (D)</p> Signup and view all the answers

    Which type of cancer is the fifth most common in women?

    <p>Ovarian cancer. (A)</p> Signup and view all the answers

    What is the role of the corpus luteum if the oocyte is fertilized?

    <p>It maintains hormone secretion for pregnancy support. (C)</p> Signup and view all the answers

    What occurs during the menstrual phase of the uterine cycle?

    <p>The functional layer is shed during menstruation. (A)</p> Signup and view all the answers

    What characterizes the secretory phase of the uterine cycle?

    <p>Increased vascularization of the endometrium. (D)</p> Signup and view all the answers

    Flashcards

    Kidney Function

    Kidneys maintain internal balance by regulating water, solutes, and acid-base levels; excreting waste and producing hormones.

    Kidney Location

    Located in the superior lumbar region, between vertebrae T12 and L5; retroperitoneal.

    Renal Cortex

    Outermost region of the kidney; light-colored and granular.

    Renal Medulla

    Inside the cortex; darker, reddish-brown; composed of pyramids.

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    Renal Pyramid

    Cone-shaped structures in the renal medulla; base faces cortex, tip (papilla) faces kidney's interior.

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    Kidney Support Layers

    Renal fascia anchors, perirenal fat cushions, and fibrous capsule protects.

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    Urinary System Parts

    Kidneys, ureters, bladder, and urethra work together to filter and remove waste.

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    Kidney Hormones

    Kidneys produce erythropoietin for red blood cell production and renin for blood pressure regulation.

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    Renal Pelvis

    Funnel-shaped tube that collects urine from the kidneys and connects to the ureter.

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    Minor Calyx

    Cup-shaped structure that collects urine from the papillae of the kidney.

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    Major Calyx

    A larger structure that collects urine from minor calyces in the kidney.

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    Nephron

    The structural and functional unit of the kidney, responsible for filtering blood and forming urine. Over one million per kidney.

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    Renal Corpuscle

    The initial filtering unit within a nephron, consisting of a glomerulus and a glomerular capsule.

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    Glomerulus

    A ball of capillaries within the renal corpuscle where filtration of blood begins.

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    Glomerular Capsule

    The cup-shaped structure that surrounds the glomerulus in the renal corpuscle, receiving filtered fluid (filtrate).

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    Proximal Convoluted Tubule (PCT)

    The part of the renal tubule closest to the renal corpuscle; reabsorbs substances from the filtrate.

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    Nephron Loop

    The U-shaped portion of the renal tubule; involved in water and solute reabsorption and concentration.

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    Distal Convoluted Tubule (DCT)

    The part of the renal tubule farthest from the renal corpuscle; involved in fine-tuning reabsorption and secretion of specific substances.

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    Collecting Duct

    Receives filtrate from multiple nephrons, transporting to papillae, and adjusts urine concentration.

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    Cortical Nephrons

    Nephrons located almost entirely within the cortex, about 85% of total nephrons.

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    Juxtamedullary Nephrons

    Nephrons with long loops extending deep into the medulla, crucial for concentrated urine production.

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    Peritubular Capillaries

    Capillaries surrounding the renal tubules, responsible for reabsorbing substances from the filtrate.

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    Vasa Recta

    Long vessels parallel to nephron loops of juxtamedullary nephrons, supporting concentrated urine formation.

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    Urine composition

    Urine is primarily water (95%) and solutes (5%), including nitrogenous wastes like urea, uric acid, and creatinine.

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    Abnormal urine

    An abnormal color, cloudy appearance, or unusual odor in urine can indicate a health problem.

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    What does urine color tell us?

    Urine color is determined by urochrome, a pigment from hemoglobin breakdown. Deeper color means more concentrated urine.

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    Urine pH

    Urine is slightly acidic (around pH 6), but can vary based on diet and health.

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    Specific gravity of urine

    Specific gravity measures the density of urine compared to water. It ranges from 1.001 to 1.035 due to dissolved solutes.

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    Ureter function

    Ureters are tubes that transport urine from the kidneys to the bladder.

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    Kidney stones

    Kidney stones are crystals that form in the renal pelvis due to mineral buildup.

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    How are kidney stones treated?

    Most small stones pass naturally, but larger stones may require procedures like lithotripsy (shockwave therapy) to break them up.

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    Trigone

    A smooth triangular area inside the urinary bladder formed by the openings of the ureters and urethra. It's prone to holding onto infections.

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    Detrusor Muscle

    The three layers of smooth muscle that make up the bladder wall, responsible for contracting to expel urine.

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    Internal Urethral Sphincter

    An involuntary (smooth muscle) sphincter located at the junction of the bladder and urethra, preventing urine leakage.

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    External Urethral Sphincter

    A voluntary (skeletal muscle) sphincter surrounding the urethra as it passes through the pelvic floor, allowing conscious control of urination.

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    Urethritis

    Inflammation of the urethra, often caused by infection.

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    Cystitis

    Inflammation of the bladder, often caused by infection.

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    Pyelitis

    Inflammation of the renal pelvis, often caused by infection.

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    Micturition

    The process of urination or voiding, involving the coordinated contraction of the detrusor muscle, relaxation of the internal urethral sphincter, and conscious relaxation of the external urethral sphincter.

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    Stress Incontinence

    Involuntary leakage of urine due to increased pressure in the abdomen, often triggered by coughing, sneezing, or laughing.

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    Overflow Incontinence

    Involuntary leakage of urine due to the bladder overfilling and being unable to empty completely.

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    Gametes

    Sex cells, also known as sperm (male) and secondary oocytes (eggs) in females. They are haploid cells with 23 chromosomes each, capable of uniting during fertilization to form a new individual.

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    Meiosis

    A type of cell division specific to sex cells that produces four daughter cells genetically different from the parent cell. It involves two rounds of division, ensuring genetic diversity in offspring.

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    Homologous Chromosomes

    Matching pairs of chromosomes, one inherited from each parent. They carry genes for the same traits but may have different versions of those genes (alleles).

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    Crossing Over

    The exchange of genetic material between homologous chromosomes during meiosis. It creates new combinations of genes, increasing genetic diversity.

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    Autosomes

    Chromosomes that carry genes coding for cellular functions and most human characteristics, like eye color. There are 22 pairs of autosomes in humans.

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    Sex Chromosomes

    Chromosomes that determine an individual's sex. Females have two X chromosomes (XX) and males have one X and one Y chromosome (XY).

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    Haploid Cell

    A cell with only one set of chromosomes (n). Gametes (sex cells) are haploid to ensure offspring receive the correct number of chromosomes.

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    Spermatogenesis

    The process of producing sperm cells in the testes. It involves a series of stages starting with stem cells and ending with mature spermatozoa.

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    Spermiogenesis

    The final stage of spermatogenesis where spermatids differentiate into mature spermatozoa (sperm). This involves shedding excess cytoplasm, elongating the nucleus, forming an acrosome cap, and developing a tail.

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    Acrosome Cap

    A cap-like structure at the head of a sperm cell containing enzymes that help penetrate the secondary oocyte (egg) during fertilization.

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    Spermatogonium

    A stem cell in the testes that divides mitotically to produce more spermatogonia or spermatocytes.

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    Primary Spermatocyte

    A cell that enters meiosis I, the first stage of cell division that reduces the chromosome number by half. It's formed from a spermatogonium.

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    Secondary Spermatocyte

    A cell produced during meiosis I, containing half the number of chromosomes as the primary spermatocyte. It will further divide in meiosis II.

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    Late Spermatid

    A cell that has undergone meiosis II and is almost ready to become a mature sperm cell. It has a nucleus, but lacks a tail or acrosome.

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    Follicle Cells

    Cells that surround and support the developing oocyte (egg) in the ovary. They play a crucial role in oocyte development.

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    Corpus Luteum

    A temporary endocrine gland formed from the remnants of a ruptured follicle after ovulation. It secretes hormones that prepare the uterus for pregnancy.

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    Antrum

    A fluid-filled space that develops within a secondary follicle in the ovary. The amount of fluid increases as ovulation approaches.

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    What is oogenesis?

    The process of egg cell (oocyte) maturation starting from a primary oocyte to a secondary oocyte, occurring in stages throughout a female's life.

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    What happens to primary oocytes before birth?

    Primordial germ cells, oogonia, divide by mitosis and then enter meiosis but become arrested in prophase I, becoming primary oocytes. They remain arrested until puberty.

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    What happens to primary oocytes during puberty?

    Primary follicles are stimulated by LH and FSH, maturing into secondary follicles with a primary oocyte. Usually only one matures fully and becomes a vesicular follicle.

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    What happens to the primary oocyte in the vesicular follicle?

    The primary oocyte completes meiosis I, forming a secondary oocyte with most of the cytoplasm and a smaller nonfunctional polar body that regresses.

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    What happens to the secondary oocyte after meiosis I?

    The secondary oocyte in the vesicular follicle enters metaphase II and becomes arrested again. It only completes meiosis if fertilized, otherwise it breaks down in 24 hours.

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    Endometriosis

    A condition where endometrial tissue grows outside the uterus, often on pelvic organs. This misplaced tissue responds to hormones and cannot be expelled normally, leading to pain and scarring.

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    Contraception

    Methods used to prevent pregnancy.

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    Abstinence

    The only 100% effective method of preventing pregnancy, involving refraining from sexual intercourse.

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    Barrier Method

    A contraception method that physically prevents sperm from reaching the egg. Examples include condoms, diaphragms, and spermicidal gels.

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    Intrauterine Device (IUD)

    A small device inserted into the uterus to prevent pregnancy. It can either release copper or synthetic progesterone, both of which interfere with implantation.

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    Oral Contraceptives

    Hormonal pills that prevent ovulation by suppressing the LH surge, effectively preventing pregnancy.

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    Tubal Ligation

    A surgical procedure where the fallopian tubes are cut and tied off, preventing sperm from reaching the egg.

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    Vasectomy

    An outpatient procedure where the vas deferens, the tube transporting sperm, is cut and tied off. This blocks sperm from leaving the testicles.

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    Breast Cancer Risk Factors

    Factors associated with an increased risk of developing breast cancer. Examples include family history, longer reproductive span, obesity, nulliparity, and genes like BRCA1 and BRCA2.

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    Benign Prostatic Hyperplasia (BPH)

    A noncancerous enlargement of the prostate gland commonly seen in older men. It's caused by hormonal changes and can compress the urethra, leading to frequent urination.

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    Prostate Cancer

    A malignant tumor of the prostate gland, more common in men over 50. It can be asymptomatic initially but later leads to urinary problems. It's screened with digital rectal exams and PSA tests.

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    Sexually Transmitted Infections (STIs)

    Infectious diseases spread through sexual contact. Many STIs cause no symptoms or go unnoticed, leading to complications like pelvic inflammatory disease.

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    Chlamydia

    A common STI caused by the bacterium Chlamydia trachomatis. It often shows no symptoms but can cause vaginal discharge, painful urination, and back pain.

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    Genital Herpes

    An STI caused by the herpes simplex virus, resulting in cyclical outbreaks of blisters in the genital and anal regions. There's no cure, but antiviral medications can manage symptoms.

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    Gonorrhea

    An STI caused by the bacterium Neisseria gonorrhoeae, spread through sexual contact or from mother to baby during childbirth.

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    Follicular Phase

    The first phase of the ovarian cycle (days 1-13), where primary follicles develop into secondary follicles, with one becoming a mature vesicular follicle. It involves the production of estrogen and the completion of meiosis I by the primary oocyte.

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    Ovulation

    The release of a secondary oocyte from the mature vesicular follicle. It usually occurs on day 14 of the ovarian cycle, triggered by a surge in LH.

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    Luteal Phase

    The final phase of the ovarian cycle (days 15-28) where the remaining follicle cells form the corpus luteum, a temporary endocrine gland that secretes progesterone and estrogen. It prepares the uterine lining for pregnancy.

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    Menopause

    The cessation of menstrual cycles for a year or longer in women, typically occurring between ages 45-55. It signifies the end of a woman's reproductive capacity.

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    Pre-Embryo

    A fertilized secondary oocyte that implants in the uterine wall and starts secreting hCG, mimicking LH and maintaining the corpus luteum.

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    Human Chorionic Gonadotropin (hCG)

    A hormone produced by the pre-embryo, mimicking LH and stimulating the corpus luteum to continue producing progesterone and estrogen.

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    Cervical Cancer

    A common malignancy of the female reproductive system, often linked to HPV infection. Early detection through Pap smears is crucial for timely treatment.

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    Pap Smear

    A screening test for cervical cancer, involving collecting epithelial cells from the cervix and examining them for abnormal growth.

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    Uterine Cycle

    The cyclical changes in the endometrial lining of the uterus, influenced by estrogen and progesterone. It typically lasts 28 days, but can vary.

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    Menstrual Phase

    The first phase of the uterine cycle (days 1-5) where the functional layer of the endometrium is shed, causing menstrual bleeding.

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    Proliferative Phase

    The second phase of the uterine cycle (days 6-14) where a new functional layer of endometrium develops, influenced by rising estrogen levels.

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    Secretory Phase

    The third phase of the uterine cycle (days 15-28) where the uterine lining is further prepared for implantation by increasing progesterone levels from the corpus luteum.

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    Ovarian Cycle and Uterine Cycle Relationship

    The ovarian and uterine cycles are closely synchronized. The menstrual phase corresponds to the follicular phase, the proliferative phase to the follicular phase and ovulation, and the secretory phase to the luteal phase.

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    Study Notes

    Kidney Function

    • Kidneys are major excretory organs, maintaining internal body environment by regulating water volume and solute concentration in blood, ion concentrations in extracellular fluids, and long-term acid-base balance.
    • They excrete metabolic wastes, toxins, and drugs.
    • Kidneys produce erythropoietin (regulates red blood cell production) and renin (regulates blood pressure).
    • They convert vitamin D to its active form and carry out gluconeogenesis as needed.

    Urinary System Components

    • Ureters: Transport urine from kidneys to bladder.
    • Urinary bladder: Temporarily stores urine.
    • Urethra: Transports urine out of the body.

    Kidney Location and Structure

    • Retroperitoneal, in superior lumbar region between T12 and L5.
    • Right kidney is lower than left due to liver position.
    • Adrenal gland sits atop each kidney.
    • Kidney has convex lateral surface and concave medial surface with renal hilum (where vessels, nerves, and ureters enter/exit).
    • Three supportive tissue layers surround the kidney:
      • Renal fascia: Anchoring outer layer of dense fibrous connective tissue.
      • Perirenal fat capsule: Fatty cushion.
      • Fibrous capsule: Transparent capsule preventing infection spread.

    Kidney Internal Anatomy

    • Renal cortex: Superficial region, light-colored and granular appearance.
    • Renal medulla: Deep to cortex, darker, reddish-brown appearance, composed of medullary pyramids.
      • Pyramid base faces cortex, tip (papilla) faces internal space.
      • Pyramids are separated by renal columns, extensions of cortical tissue.
      • Lobe: Medullary pyramid and surrounding cortical tissue (approx. 8 per kidney).
    • Renal pelvis: Funnel-shaped tube continuous with the ureter leaving the hilum.
      • Branches of pelvis form 2-3 major calyces, which subdivide to form several minor calyces.
      • Minor calyces: cup-shaped collecting urine from papillae.
      • Major calyces: Collect urine from minor calyces and drain into renal pelvis.
      • Urine flow: Papillae to minor calyx to major calyx to renal pelvis to ureter.

    Kidney Blood Supply

    • Kidneys have a rich blood supply as they cleanse blood and adjust composition.
    • Renal arteries branch from the abdominal aorta, delivering ~1/4 of total cardiac output (~1200 mL/min) to kidneys at rest.
    • Blood flow: Renal artery -> segmental -> interlobar -> arcuate -> cortical radiate arteries.
    • Blood flows through microscopic vessels before draining into veins.
    • Venous flow: Cortical radiate -> arcuate -> interlobar -> renal veins.
    • Renal veins drain into the inferior vena cava.

    Nephron Structure

    • Nephrons are the functional units (over 1 million per kidney) that form urine.
    • Each nephron has two main parts: renal corpuscle and renal tubule.
    • Most of the corpuscle and tubule reside in the cortex.

    Renal Corpuscle

    • Glomerulus: Ball of capillaries with fenestrated endothelium, allowing filtrate (plasma-derived fluid) formation.
    • Glomerular capsule: Cup-shaped hollow structure around glomerulus.
      • Parietal layer: Simple squamous epithelium.
      • Visceral layer: Podocytes clinging to glomerular capillaries.

    Renal Tubule

    • Proximal convoluted tubule: Close to corpuscle, confined to cortex, and has dense microvilli increasing surface area; reabsorption and secretion occur there.
    • Nephron loop: U-shaped structure with descending and ascending limbs.
    • Distal convoluted tubule: Farthest from corpuscle, confined to cortex, fewer microvilli (more secretion than reabsorption).
      • Distal convoluted tubule drains into collecting duct.
    • Collecting duct: Receives filtrate from many nephrons, runs through medullary pyramids, and gives them striped appearance. Fuses to deliver urine through papillae to minor calyces.

    Nephron Classes

    • Cortical nephrons: Primarily in cortex, constituting 85% of nephrons.
    • Juxtamedullary nephrons: Have long loops that deeply invade medulla, crucial for concentrated urine production.

    Nephron Capillary Beds

    • Renal tubules are associated with glomerulus and peritubular capillaries/vasa recta.
    • Glomerulus: Specialized for filtration, fed/drained by arterioles (afferent enters, efferent leaves).
    • Peritubular capillaries: Clinging to renal tubules in cortex, low-pressure and porous for water/solute absorption (arise from efferent arterioles and empty into venules).
    • Vasa recta: Long vessels parallel to nephron loops of juxtamedullary nephrons in medulla, crucial for concentrated urine.

    Juxtaglomerular Complex (JGC)

    • Each nephron has one JGC, involving modified portions of distal ascending limb of nephron loop and afferent arteriole.
    • Important in regulating filtrate formation rate and blood pressure.
    • Macula densa: Tall cells of ascending limb that detect NaCl content in filtrate (chemoreceptors).
    • Granular cells: Enlarged, smooth muscle cells of afferent arteriole acting as mechanoreceptors sensing blood pressure; contain renin-containing secretory granules.

    Kidney Physiology

    • Kidneys filter entire plasma volume ~60 times/day (~180 L processed daily).
    • Consume 20-25% of body's resting oxygen.
    • Filtrate is blood plasma minus proteins; urine is produced from filtrate.
    • Urine formation/blood adjustment involves three processes:
      • Glomerular filtration: Produces cell/protein-free filtrate.
      • Tubular reabsorption: Returns > 99% of filtrate substances to blood.
      • Tubular secretion: Selectively moves substances from blood to filtrate.

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    Description

    This quiz covers the essential functions of the kidneys as excretory organs, their role in maintaining the body's internal environment, and the components of the urinary system. It also explores the anatomy of kidneys, including their location and structure. Test your knowledge on these critical aspects of human physiology.

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