Cardiovascular system - Part 1

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Questions and Answers

How many chambers does the human heart possess?

  • Two
  • Five
  • Four (correct)
  • Three

Which of the following describes the primary function of the atria?

  • Filtering waste products from the blood
  • Pumping blood to the rest of the body
  • Receiving blood from the body and lungs (correct)
  • Pumping blood to the lungs

Which valve prevents backflow of blood from the left ventricle into the left atrium?

  • Pulmonary valve
  • Mitral valve (correct)
  • Tricuspid valve
  • Aortic valve

Which layer of the heart wall is responsible for the heart's contractions?

<p>Myocardium (C)</p> Signup and view all the answers

During which phase of the cardiac cycle do the atria and ventricles relax and fill with blood?

<p>Diastole (D)</p> Signup and view all the answers

What is the function of the sinoatrial (SA) node?

<p>To initiate the electrical impulses that trigger heart contractions (D)</p> Signup and view all the answers

Which type of blood vessel carries blood away from the heart?

<p>Arteries (C)</p> Signup and view all the answers

What is the approximate blood pressure in the aorta during ventricular contraction (systole)?

<p>120 mmHg (A)</p> Signup and view all the answers

Which statement best describes the role of coronary arteries?

<p>They supply the heart muscle with oxygen-rich blood. (B)</p> Signup and view all the answers

During which part of the cardiac cycle does the majority of left ventricular perfusion occur?

<p>Diastole (B)</p> Signup and view all the answers

Which of the following best describes the pericardium's function?

<p>It provides a protective outer covering and lubrication for the heart. (B)</p> Signup and view all the answers

What is the significance of capillaries having very thin walls?

<p>To facilitate the exchange of compounds with surrounding tissues (B)</p> Signup and view all the answers

If the mitral valve is stenotic (narrowed), which chamber of the heart will experience increased pressure and workload?

<p>Left atrium (B)</p> Signup and view all the answers

Which of the following correctly sequences the flow of electrical impulses through the heart?

<p>SA node → AV node → Bundle of His → Purkinje fibers (C)</p> Signup and view all the answers

A patient's arterial blood pressure is consistently measured at 90/60 mmHg. Which of the following conditions is the patient most likely experiencing?

<p>Hypotension (B)</p> Signup and view all the answers

Occlusion of the left coronary artery is most likely to directly affect the function of which heart structure?

<p>Left ventricle (B)</p> Signup and view all the answers

A researcher discovers a novel drug that selectively inhibits the function of the Purkinje fibers. What effect would this drug likely have on the heart?

<p>Delayed ventricular contraction (D)</p> Signup and view all the answers

In a patient with severe aortic stenosis, which compensatory mechanism would the heart initially employ to maintain cardiac output?

<p>Ventricular hypertrophy (D)</p> Signup and view all the answers

A hypothetical toxin selectively targets and destroys mesothelial cells within the epicardium. What immediate physiological consequence would this likely induce?

<p>Reduced lubrication between the heart and pericardium (D)</p> Signup and view all the answers

If a drug is administered that selectively blocks L-type calcium channels in cardiac muscle cells, what direct effect would this have on cardiac function, assuming no other compensatory mechanisms?

<p>Decreased contractility due to reduced calcium influx during the plateau phase of the action potential. (C)</p> Signup and view all the answers

Approximately how many times does the human heart beat in one day?

<p>100,000 (D)</p> Signup and view all the answers

Which heart valve prevents the backflow of blood from the left ventricle into the left atrium?

<p>Mitral valve (C)</p> Signup and view all the answers

What is the primary role of the Sinoatrial (SA) node in the heart?

<p>To initiate the electrical impulses that trigger heart contractions. (C)</p> Signup and view all the answers

Which type of vessel is responsible for carrying blood away from the heart?

<p>Arteries (D)</p> Signup and view all the answers

What is the approximate blood pressure in the aorta during ventricular relaxation (diastole)?

<p>80 mmHg (B)</p> Signup and view all the answers

Coronary arteries play what critical role in the function of the heart?

<p>They provide oxygen and nutrients to the heart muscle. (D)</p> Signup and view all the answers

During which phase of the cardiac cycle does the majority (more than 85%) of left ventricular perfusion occur?

<p>Diastole (B)</p> Signup and view all the answers

Which of the following accurately describes the function of the pericardium?

<p>It provides a protective and lubricating enclosure for the heart. (D)</p> Signup and view all the answers

What structural feature of capillaries facilitates the exchange of substances with surrounding tissues?

<p>Very thin walls (B)</p> Signup and view all the answers

If the tricuspid valve is stenotic (narrowed), which heart chamber will likely experience increased workload and pressure?

<p>Right atrium (C)</p> Signup and view all the answers

What is the expected range of pulmonary artery pressure?

<p>20/15 mmHg (B)</p> Signup and view all the answers

During the cardiac cycle, at what point do the atria and ventricles both relax and fill with blood?

<p>Diastole (A)</p> Signup and view all the answers

Which description accurately portrays the function of arteries?

<p>Carry oxygenated blood away from the heart. (B)</p> Signup and view all the answers

During ventricular systole, what happens to the coronary arteries?

<p>They are compressed, suppressing blood flow. (D)</p> Signup and view all the answers

What is the effect of arterial elastic recoil during diastole?

<p>It maintains arterial blood flow (A)</p> Signup and view all the answers

Predict the immediate outcome if the endocardium were damaged?

<p>Impaired heart chamber lining and valve function. (D)</p> Signup and view all the answers

A pharmacologist is developing a drug designed to selectively enhance the contractility of the myocardium. Which cellular mechanism should this drug primarily target to achieve the desired effect?

<p>Enhancing the function of L-type calcium channels in cardiac muscle cells. (C)</p> Signup and view all the answers

A researcher is investigating a novel genetic mutation that causes a significant reduction in the number of gap junctions present in the intercalated discs of cardiac muscle cells. Which of the following physiological consequences would most likely result from this mutation?

<p>Impaired coordinated contraction of the atria and ventricles (B)</p> Signup and view all the answers

What is the approximate arteriolar blood pressure at the point where arterioles connect to the capillaries?

<p>25 mmHg (B)</p> Signup and view all the answers

What is approximate blood pressure on the venous side of the capillaries?

<p>15 mmHg (C)</p> Signup and view all the answers

Which heart valve prevents backflow from the right ventricle into the right atrium?

<p>Tricuspid valve (A)</p> Signup and view all the answers

What is the primary function of the myocardium?

<p>To contract and pump blood (D)</p> Signup and view all the answers

During which phase of the cardiac cycle does ventricular filling primarily occur?

<p>Diastole (B)</p> Signup and view all the answers

The sinoatrial (SA) node initiates an electrical impulse at what rate?

<p>Regularly and independently (A)</p> Signup and view all the answers

Which vessels carry deoxygenated blood to the lungs?

<p>Pulmonary arteries (C)</p> Signup and view all the answers

What is the blood pressure during ventricular relaxation (diastole)?

<p>80 mmHg (D)</p> Signup and view all the answers

What physiological event impairs coronary artery blood flow?

<p>Ventricular contraction (B)</p> Signup and view all the answers

Which layer of the heart provides a protective outer covering?

<p>Pericardium (D)</p> Signup and view all the answers

What structural characteristic of capillaries facilitates gas exchange?

<p>Single-layered thin walls (B)</p> Signup and view all the answers

If a stenotic valve is present between the left atrium and left ventricle, which valve is this?

<p>Mitral (C)</p> Signup and view all the answers

What is the approximate blood pressure in arterioles just prior to reaching capillaries?

<p>65 mmHg (C)</p> Signup and view all the answers

What is the role of arterial elastic recoil during diastole?

<p>Maintaining arterial blood flow (D)</p> Signup and view all the answers

Damage to the endocardium would initially result in what immediate outcome?

<p>Impaired blood clotting within the heart (A)</p> Signup and view all the answers

A drug designed to selectively enhance myocardial contractility should target which cellular mechanism?

<p>Increased calcium availability in the cytoplasm (A)</p> Signup and view all the answers

A genetic mutation causes a significant reduction in the number of gap junctions present in the intercalated discs. What might result?

<p>Uncoordinated muscle contractions (A)</p> Signup and view all the answers

How many liters of blood does the heart pump through the body in one day?

<p>7,000 liters (A)</p> Signup and view all the answers

Which heart chamber receives blood from the lungs?

<p>Left atrium (C)</p> Signup and view all the answers

Which of the following indicates issues with central venous return (CVP)?

<p>0 mmHg (C)</p> Signup and view all the answers

A patient presents with heightened sympathetic tone. What changes indicate this state? (Select 2)

<p>Increased heart rate (C), Increased blood pressure (D)</p> Signup and view all the answers

The 'lub-DUB' sound of the heart is associated with what?

<p>The closing of the heart valves. (D)</p> Signup and view all the answers

What is the name of the vessel type that facilitates the exchange of compounds to and from surrounding tissues?

<p>Capillaries (C)</p> Signup and view all the answers

Arteries transport blood in which direction?

<p>Away from the heart. (B)</p> Signup and view all the answers

What is the ultimate effect of contraction of the ventricles during systole on coronary arteries?

<p>Suppressed blood flow. (A)</p> Signup and view all the answers

What role does elastic recoil of the arteries play during diastole?

<p>It helps maintain arterial blood flow. (A)</p> Signup and view all the answers

Which of the following is a primary characteristic of the myocardium?

<p>Involuntary striated muscle. (D)</p> Signup and view all the answers

What would be the immediate likely effect of damage to the endocardium?

<p>Impaired lining of the heart chambers. (C)</p> Signup and view all the answers

What is the approximate blood pressure as blood enters capillaries from arterioles?

<p>25 mmHg (D)</p> Signup and view all the answers

In properly functioning circulatory systems, which location has a blood pressure closest to 0 mmHg?

<p>Large Vena Cava (C)</p> Signup and view all the answers

The heart beats approximately 100,000 times each day, pumping roughly how much blood?

<p>7,000 liters (C)</p> Signup and view all the answers

What is the function of the pulmonary valve?

<p>Prevents backflow from the right ventricle to the pulmonary artery (B)</p> Signup and view all the answers

Which zone receives oxygenated blood via the pulmonary artery?

<p>Lungs (C)</p> Signup and view all the answers

If the left coronary artery is occluded, which area will be most affected?

<p>Left ventricle (D)</p> Signup and view all the answers

Pulmonary artery pressure is normally what?

<p>20/15 mmHg (D)</p> Signup and view all the answers

During what state do the atria contract while ventricles relax?

<p>Atrial systole, ventricular diastole (B)</p> Signup and view all the answers

What is the nature of blood carried to the lungs via arteries?

<p>Deoxygenated (B)</p> Signup and view all the answers

Which of the following best describes the role of coronary sinus?

<p>Returns blood from cardiac muscle tissue to right atrium (B)</p> Signup and view all the answers

A novel drug increases the duration of diastole without changing heart rate. What effect it has on left ventricular perfusion?

<p>Increase in perfusion (B)</p> Signup and view all the answers

If a patient exhibits elevated CVP, what is the most probable issue?

<p>Blood pooling on venous side (C)</p> Signup and view all the answers

Through which valve does blood flow from the right atrium to the right ventricle?

<p>Tricuspid valve (A)</p> Signup and view all the answers

Which event occurs during the diastole phase of the cardiac cycle?

<p>The atria and ventricles relax and fill with blood. (B)</p> Signup and view all the answers

What role do the arteries play in the cardiovascular system?

<p>They carry oxygenated blood away from the heart to the body (except for the pulmonary artery). (B)</p> Signup and view all the answers

What is the approximate blood pressure in the aorta during systole?

<p>120 mmHg (B)</p> Signup and view all the answers

Which layer of the heart wall contains the involuntary striated muscle responsible for the heart's pumping action?

<p>Myocardium (B)</p> Signup and view all the answers

What is the mechanism by which arterial blood flow is maintained during diastole?

<p>The elastic recoil of the arteries helps to maintain pressure. (C)</p> Signup and view all the answers

Where does the heart receive its primary blood supply from?

<p>Coronary arteries (A)</p> Signup and view all the answers

Which of the following is NOT a function of the heart valves?

<p>Generating electrical impulses (D)</p> Signup and view all the answers

What is the approximate blood pressure in arterioles as blood enters the capillaries?

<p>25 mmHg (C)</p> Signup and view all the answers

During ventricular systole, what effect does the forceful contraction of the ventricles have on coronary arteries?

<p>It compresses the coronary arteries. (C)</p> Signup and view all the answers

What is the pressure in the vena cava?

<p>Close to 0 mmHg (A)</p> Signup and view all the answers

Why is the pulmonary circulation shorter than the systemic circulation?

<p>Because the lungs are located closer to the heart than the rest of the body. (D)</p> Signup and view all the answers

If a patient has a pulmonary artery pressure of 20/15 mmHg, what can be said of this patient?

<p>The patient is within normal range of pressures. (D)</p> Signup and view all the answers

Why are capillary walls very thin?

<p>To allow for efficient exchange of compounds with surrounding tissues (C)</p> Signup and view all the answers

What is the functional consequence of reduced elastic recoil in the aorta with aging?

<p>Increased diastolic blood pressure (B)</p> Signup and view all the answers

Which of the following is the most immediate and life-threatening consequence of a complete rupture of the chordae tendineae in the left ventricle?

<p>Pulmonary edema due to acute mitral regurgitation (B)</p> Signup and view all the answers

A genetic defect results in cardiac muscle cells with abnormally low levels of ATP. Which of the following aspects of cardiac function would be most directly impaired?

<p>Calcium reuptake into the sarcoplasmic reticulum (A)</p> Signup and view all the answers

A researcher is studying a novel drug that selectively enhances the contractility of the myocardium without affecting heart rate. Which cellular mechanism should this drug primarily target to achieve the desired effect?

<p>Enhancing the sensitivity of troponin to calcium ions (D)</p> Signup and view all the answers

In a scenario where a patient has a significantly prolonged PR interval on an electrocardiogram (ECG) but a normal QRS complex and QT interval, what specific anatomical structure is most likely malfunctioning to cause this conduction delay?

<p>Atrioventricular (AV) node (C)</p> Signup and view all the answers

What is the approximate volume of blood, in liters, that the heart pumps through the body in a day?

<p>7,000 litres (A)</p> Signup and view all the answers

Which heart valve is responsible for preventing the backflow of blood from the left ventricle into the left atrium?

<p>Mitral valve (C)</p> Signup and view all the answers

What is the primary function of the sinoatrial (SA) node?

<p>To initiate the electrical impulse that starts each heartbeat (D)</p> Signup and view all the answers

Coronary arteries are critical for the heart's function because they:

<p>Provide the heart muscle with its own blood supply (A)</p> Signup and view all the answers

Which of the following accurately describes the pericardium's function?

<p>Provides a protective outer covering for the heart (A)</p> Signup and view all the answers

What is the effect on blood pressure of increased elastic recoil?

<p>Decreased pulse pressure. (D)</p> Signup and view all the answers

Which location has a blood pressure closest to 0 mmHg?

<p>Vena cava (A)</p> Signup and view all the answers

What role do the coronary sinus and Thebesian veins play in the heart?

<p>They drain blood from the heart muscle into the right atrium. (B)</p> Signup and view all the answers

Predict the effect if the vagus nerve were severed?

<p>Elevated heart rate due to reduction of parasympathetic tone. (A)</p> Signup and view all the answers

During which phase of the cardiac cycle do the atria contract while the ventricles relax?

<p>Atrial systole (B)</p> Signup and view all the answers

During ventricular systole, what occurs in the coronary arteries?

<p>They are compressed, suppressing blood flow (B)</p> Signup and view all the answers

Which characteristic of capillaries facilitates the exchange of substances with surrounding tissues?

<p>Very thin walls (D)</p> Signup and view all the answers

What key role is fulfilled by the elastic recoil of arterial walls during diastole?

<p>Maintaining arterial blood flow (B)</p> Signup and view all the answers

What is the nature of blood being carried to the lungs via arteries?

<p>Deoxygenated (D)</p> Signup and view all the answers

What changes might indicate heightened sympathetic tone in a patient?

<p>Increased heart rate and increased blood pressure (B)</p> Signup and view all the answers

What is the most likely consequence if the endocardium is damaged?

<p>Compromised integrity of heart chambers (B)</p> Signup and view all the answers

Consider a patient who has a pulmonary artery pressure of 20/15 mmHg. What can you say about this patient?

<p>The patient has a normal pulmonary artery pressure (A)</p> Signup and view all the answers

A novel drug increases the duration of diastole without changing heart rate. What effect would you predict this drug to have on left ventricular perfusion?

<p>Increase perfusion, as coronary arteries fill during diastole (A)</p> Signup and view all the answers

A researcher discovers that the vagus nerve is severed in a study animal. What effect will this have?

<p>The heart rate will increase significantly. (D)</p> Signup and view all the answers

A 60-year-old patient presents with orthostatic hypotension. Reduced arterial elasticity is suspected of causing this issue. What impact has this likely had?

<p>Decreased ability to maintain blood flow during diastole. (D)</p> Signup and view all the answers

Which of the following best describes the function of the atrioventricular (AV) node?

<p>Delays the electrical signal, allowing the atria to fully contract before the ventricles. (D)</p> Signup and view all the answers

What is the role of the chordae tendineae?

<p>To prevent the atrioventricular valves from inverting during ventricular contraction. (A)</p> Signup and view all the answers

Which sequence accurately describes the direction of blood flow through the pulmonary circuit?

<p>Right ventricle → Pulmonary artery → Lungs → Pulmonary vein → Left atrium (D)</p> Signup and view all the answers

What is the primary mechanism by which the heart receives its own supply of oxygenated blood?

<p>Via the coronary arteries. (A)</p> Signup and view all the answers

Which of the following vessels typically has the lowest blood pressure?

<p>Vena cava (B)</p> Signup and view all the answers

During which phase of the cardiac cycle is blood pressure highest in the aorta?

<p>Ventricular systole (D)</p> Signup and view all the answers

Which of the following is a characteristic of veins, but not arteries?

<p>Contain valves to prevent backflow. (A)</p> Signup and view all the answers

What causes the 'lub' sound in the 'lub-DUB' heart sound?

<p>The closing of the atrioventricular valves. (B)</p> Signup and view all the answers

In a healthy individual at rest, which of the following is the most significant contributor to coronary blood flow?

<p>Aortic pressure during diastole. (B)</p> Signup and view all the answers

Which of the following best describes the state of the heart during diastole?

<p>Both the atria and ventricles are relaxed. (C)</p> Signup and view all the answers

What is the approximate blood pressure in the arterioles just before they enter the capillaries?

<p>25 mmHg (D)</p> Signup and view all the answers

Which layer of the heart is composed of involuntary striated muscle responsible for the heart's contractile function?

<p>Myocardium (C)</p> Signup and view all the answers

What is the approximate central venous pressure (CVP) in the vena cava near the heart?

<p>0 mmHg (B)</p> Signup and view all the answers

Which of the following correctly pairs a heart valve with its function?

<p>Pulmonary valve: prevents backflow from the pulmonary artery to the right ventricle (C)</p> Signup and view all the answers

A patient with a genetic defect has abnormally low levels of elastin in their arterial walls. What would be the most likely consequence of this condition?

<p>Widened pulse pressure (B)</p> Signup and view all the answers

During ventricular systole, how are the coronary arteries affected and what is the primary source of myocardial perfusion?

<p>Coronary arteries are compressed, limiting blood flow; aortic pressure during diastole (C)</p> Signup and view all the answers

A novel drug selectively targets and inhibits the function of mesothelial cells within the visceral pericardium. What immediate physiological consequence would this likely induce?

<p>Increased risk of cardiac tamponade. (A)</p> Signup and view all the answers

A researcher is studying a population with a high incidence of a genetic mutation that results in non-functional gap junctions in cardiac muscle cells. Which of the following physiological changes would they most likely observe in the affected individuals?

<p>Discoordinated atrial and ventricular contractions. (C)</p> Signup and view all the answers

Imagine the sinoatrial (SA) node ceases to function in a patient. What compensatory mechanism would likely take over, and what would be the expected consequence on heart rate?

<p>The atrioventricular (AV) node would take over, decreasing heart rate. (D)</p> Signup and view all the answers

Which heart valve is responsible for preventing the backflow of blood from the right ventricle into the pulmonary artery?

<p>Pulmonary valve (B)</p> Signup and view all the answers

What is the role of the arterioles in the cardiovascular system?

<p>Connect arteries to capillaries (A)</p> Signup and view all the answers

What is the approximate blood pressure in the large vena cava?

<p>0 mmHg (C)</p> Signup and view all the answers

Contraction of the ventricles during systole has what effect on coronary arteries?

<p>Compresses the arteries and suppresses blood flow (A)</p> Signup and view all the answers

Elastic recoil in the arteries plays what role during diastole?

<p>Maintains arterial blood flow (C)</p> Signup and view all the answers

If the left coronary artery becomes occluded, what is the most likely direct consequence?

<p>Impaired function of the left ventricle (C)</p> Signup and view all the answers

Which of the following lists accurately depict the direction of the blood flow? (1) Arteries, (2) Arterioles, (3) Capillaries, (4) Venules and (5) Veins.

<p>(1)→(2)→(3)→(4)→(5) (B)</p> Signup and view all the answers

A patient has a pulmonary artery pressure of 20/15 mmHg. What does this indicate?

<p>Normal pulmonary artery pressure (B)</p> Signup and view all the answers

What immediate effect would damage to the endocardium have?

<p>Disruption of blood flow and potential clot formation (A)</p> Signup and view all the answers

Imagine the sinoatrial (SA) node ceases to function in a patient. What compensatory mechanism would most likely take over, and what would be the expected consequence on heart rate?

<p>The atrioventricular (AV) node would take over, decreasing heart rate (A)</p> Signup and view all the answers

The right atrium receives blood from what?

<p>Vena cavae (B)</p> Signup and view all the answers

What is the approximate blood pressure in arterioles just before they reach the capillaries?

<p>65 mmHg (A)</p> Signup and view all the answers

Which of the following is the most accurate description of the role of the coronary sinus?

<p>Drains deoxygenated blood from the myocardium (C)</p> Signup and view all the answers

What is unique to pulmonary arteries?

<p>Carry deoxygenated blood (B)</p> Signup and view all the answers

During what phase of the cardiac cycle is the majority of left ventricular myocardial perfusion achieved?

<p>Ventricular diastole (C)</p> Signup and view all the answers

A novel drug selectively increases the duration of diastole without changing heart rate. Predict the effect of this drug on left ventricular perfusion.

<p>Increased left ventricular perfusion (A)</p> Signup and view all the answers

Why the pulmonary pressures always need to be lower than systemic pressures? (Select 2)

<p>The pulmonary circulation is shorter (A), The right ventricle does not need to overcome high resistance to eject blood (C)</p> Signup and view all the answers

During which phase of the cardiac cycle do the atria contract?

<p>Atrial systole (B)</p> Signup and view all the answers

What is the purpose of the heart's four valves?

<p>To ensure unidirectional blood flow (B)</p> Signup and view all the answers

Which of the following is the outer layer of the heart wall?

<p>Epicardium (B)</p> Signup and view all the answers

What functional characteristic is associated with the sinoatrial node?

<p>Initiation of heart's electrical impulses (B)</p> Signup and view all the answers

Where do veins carry blood?

<p>Back to the heart (A)</p> Signup and view all the answers

Which of the following events reduces coronary artery blood flow to the left ventricle?

<p>Ventricular contraction (systole) (A)</p> Signup and view all the answers

How many liters of blood does the heart pump on average each day?

<p>7,000 liters (C)</p> Signup and view all the answers

How is arterial blood flow maintained during diastole?

<p>Elastic recoil in the arteries (B)</p> Signup and view all the answers

What is the role of capillaries in the cardiovascular system?

<p>Exchanging compounds with surrounding tissues (A)</p> Signup and view all the answers

Which artery carries deoxygenated blood?

<p>Pulmonary artery (D)</p> Signup and view all the answers

Which of the following describes the sequence of electrical conduction in the heart, starting from the initiation of the impulse?

<p>SA node → AV node → Bundle of His → Purkinje fibers (B)</p> Signup and view all the answers

Considering the effects of ventricular contraction on coronary arteries, which statement is most accurate?

<p>Systole decreases blood flow; diastole increases blood flow. (A)</p> Signup and view all the answers

A pharmaceutical company is developing a drug to treat hypertension by vasodilation. Which type of blood vessel should this drug primarily target?

<p>Arterioles (B)</p> Signup and view all the answers

In individuals with significant aortic valve stenosis, what is the expected long-term compensatory change in the heart's structure?

<p>Hypertrophy of the left ventricle (B)</p> Signup and view all the answers

Arteries are described as carrying blood away from the heart, which of the following is the specific functional feature is directly responsible for assisting this process?

<p>Elastic recoil aiding in blood propulsion (A)</p> Signup and view all the answers

A patient is diagnosed with a condition that impairs the function of mesothelial cells in the pericardium. What is the most immediate and direct consequence of this impairment on cardiac function?

<p>Increased friction between cardiac muscle layers (A)</p> Signup and view all the answers

A researcher is studying a novel genetic mutation that selectively impairs the function of gap junctions in cardiac muscle cells. Which of the following physiological consequences would most likely result from this mutation?

<p>Reduced rate of action potential propagation through the myocardium (C)</p> Signup and view all the answers

How many liters of blood, approximately, does the heart pump through the body in a day?

<p>7,000 liters (A)</p> Signup and view all the answers

Which type of blood vessel carries blood back to the heart?

<p>Veins (C)</p> Signup and view all the answers

What is the approximate blood pressure on the venous side of capillaries?

<p>15 mmHg (B)</p> Signup and view all the answers

What is the role of the valves in the heart?

<p>To prevent backflow of blood (B)</p> Signup and view all the answers

Which layer of the heart wall is the outermost?

<p>Epicardium (A)</p> Signup and view all the answers

What is the function of the sinoatrial (SA) node in the heart's electrical system?

<p>To initiate electrical impulses (C)</p> Signup and view all the answers

Which of the following best describes diastole?

<p>A period of relaxation and filling of the heart (B)</p> Signup and view all the answers

What is the function of capillaries?

<p>Allow exchange of compounds with surrounding tissues (C)</p> Signup and view all the answers

Which heart valve is located between the left atrium and left ventricle?

<p>Mitral valve (D)</p> Signup and view all the answers

What is the term for the thin fibrous sac that surrounds the heart?

<p>Pericardium (A)</p> Signup and view all the answers

What causes the 'lub-DUB' heart sounds?

<p>The closing of the heart valves (C)</p> Signup and view all the answers

Which of the following contributes to maintaining arterial blood flow during diastole?

<p>Elastic recoil in the arteries (D)</p> Signup and view all the answers

How do veins differ structurally from arteries?

<p>Veins have valves (B)</p> Signup and view all the answers

Which of the following best describes the function of the pulmonary artery?

<p>Carries deoxygenated blood to the lungs (B)</p> Signup and view all the answers

What is the approximate arteriolar blood pressure where they join the capillaries?

<p>25 mmHg (C)</p> Signup and view all the answers

Pulmonary artery pressure that exceeds 20/15 mmHg might suggests what about the systemic pressure?

<p>The patient likely has normal systemic pressure. (A)</p> Signup and view all the answers

Which of the following accurately represents the sequence of electrical conduction in the ventricles?

<p>AV node -&gt; Bundle of His -&gt; Purkinje fibers (A)</p> Signup and view all the answers

What would be the effect of administering a drug that selectively enhances the contractility of the myocardium cells without affecting heart rate?

<p>Increased stroke volume (D)</p> Signup and view all the answers

How is the heart's activity coordinated?

<p>By electrical impulses (B)</p> Signup and view all the answers

Which of the following is most associated with contraction of the ventricles compressing the coronary arteries?

<p>Suppresses blood flow (A)</p> Signup and view all the answers

When comparing pulmonary circulation to systemic circulation, which statement applies?

<p>It is shorter (C)</p> Signup and view all the answers

In a scenario where the sinoatrial (SA) node fails, what happens?

<p>The atrioventricular (AV) node may take over. (D)</p> Signup and view all the answers

Why is the pulmonary circulation's pressure lower than systemic circulation's pressure?

<p>To prevent edema in the lungs (B)</p> Signup and view all the answers

What action is associated with the 'lub-DUB' sounds of the heart?

<p>The closing of heart valves. (D)</p> Signup and view all the answers

Which heart structure receives blood from the systemic circulation?

<p>Right Atrium (A)</p> Signup and view all the answers

Why is the precise coordination of heart muscle contractions crucial?

<p>To ensure efficient and timely blood ejection. (B)</p> Signup and view all the answers

A cardiologist observes that a patient's left ventricle is receiving insufficient blood supply due to the compression of coronary arteries. During which phase of the cardiac cycle is this compression most pronounced?

<p>Ventricular Systole (D)</p> Signup and view all the answers

Consider an experimental scenario where the interstitial fluid within the pericardial sac is selectively replaced with a viscous gel. Assuming no immediate compensatory mechanisms, what direct effect would this alteration most likely have on cardiac function?

<p>Reduced cardiac output owing to impeded ventricular expansion and contraction. (D)</p> Signup and view all the answers

Flashcards

Cardiovascular System

The cardiovascular system is responsible for circulating blood, containing oxygen and nutrients, throughout the body.

Heart's Daily Workload

The heart beats approximately 100,000 times a day, circulating about 7,000 liters of blood.

Heart Chambers

The heart has four chambers: two atria (which receive blood) and two ventricles (which discharge blood).

Heart Valves

These ensure blood flows in one direction. They include the aortic, mitral, tricuspid, and pulmonary valves.

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Aortic Valve

Located between the left ventricle and aorta, it allows blood to exit the heart.

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Mitral Valve

Located between the left atria and left ventricle, it prevents backflow during ventricular contraction.

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Tricuspid Valve

Located between the right atria and right ventricle, it ensures that blood flows in the correct direction.

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Pulmonary Valve

Located between the right ventricle and pulmonary artery, it directs blood to lungs.

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Endocardium

A thin layer of tissue that lines the heart's chambers and valves.

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Myocardium

Involuntary striated muscle that makes up the bulk of the heart.

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Epicardium

The outer layer consisting of mesothelial cells.

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Pericardium

A thin fibrous sheath that encloses the whole heart and contains interstitial fluid for lubrication.

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Diastole

The phase when the atria and ventricles relax and fill with blood.

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Systole

The phase when the atria contract (atrial systole) and push blood into the ventricles.

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Heart's Electrical System

Specialized tissue that coordinates the heart's activity via electrical impulses.

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Sinoatrial (SA) Node

The 'heart pacemaker' that initiates electrical impulses.

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Atrioventricular (AV) Node

This node delays the signal, allowing atria to fully contract before ventricles.

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Bundle of His & Purkinje Fibers

These carry the electrical signal to cause ventricular contraction.

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Arteries

These carry blood away from the heart, either to the to the lungs (deoxygenated) or the rest of the body (oxygenated).

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Veins

These carry deoxygenated blood back to the heart.

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Study Notes

Key Facts About The Heart

  • The heart beats approximately 100,000 times each day.
  • The heart pumps 7,000 litres of blood through the body in a 24-hour period.

Heart Chambers

  • The heart has four chambers.
  • There are two atria, which receive blood.
  • There are two ventricles, which discharge blood.

Heart Valves

  • The heart contains four valves that ensures blood flows in one direction.
  • The aortic valve allows blood to flow from the left ventricle to the aorta.
  • The mitral valve allows blood to flow from the left atria to the left ventricle.
  • The tricuspid valve allows blood to flow from the right atria to the right ventricle.
  • The pulmonary valve allows blood to flow from the right ventricle to the pulmonary artery.
  • Heart sounds are described as "lub-DUB".

Heart Structure

  • The heart wall has three tissue layers covered by a thin protective coating called the pericardium.
  • The endocardium is a thin tissue layer that lines the heart chambers and valves.
  • The myocardium is an involuntary striated muscle that makes up most of the heart's bulk.
  • The epicardium is the outer layer and consists of mesothelial cells.
  • The pericardium is a thin, fibrous sheath enclosing the heart that contains interstitial fluid for lubrication.

Heart Function (Diastole and Systole)

  • Each heartbeat consists of two parts: diastole and systole.
  • During diastole, the atria and ventricles relax and fill with blood.
  • During systole, the atria contract and push blood into the ventricles.
  • As the atria relax, the ventricles contract and pump blood out of the heart.

Heart's Electrical System

  • Heart muscles must contract in a coordinated manner.
  • The heart's activity is coordinated by electrical impulses.
  • The sinoatrial node (heart pacemaker) starts the process.
  • The atrioventricular node (gate) is next.
  • Finally, the Bundle of His & Purkinje fibers contract the ventricles.

Blood Vessels

  • Arteries transport blood away from the heart to the rest of the body (oxygenated) or to the lungs (deoxygenated through the pulmonary artery).
  • Veins return deoxygenated blood back to the heart, increasing in size closer to the heart.
  • Capillaries connect the smallest arteries (arterioles) to the smallest veins (venules).
  • The capillaries have very thin walls to allow compound exchange to and from tissues.

Blood Pressure

  • Pressure in the aorta after ventricular contraction (systole) is 120 mmHg, dropping to 80 mmHg during diastole (ventricular relaxation).
  • Arterial blood flow is maintained during diastole because of elastic recoil in the arteries.
  • Pulmonary circulation is shorter than systemic.
  • Pulmonary artery pressure is 20/15 mmHg.
  • Arteriole blood pressure is about 65 mmHg, reducing to 25 mmHg where they join capillaries.
  • Blood pressure on the venous side of capillaries is about 15 mmHg.
  • Pressure in the large vena cava is close to 0 mmHg (CVP).

Coronary Circulation

  • The heart requires a rich blood supply from the left and right coronary arteries derived from the aortic sinus.
  • Cardiac muscle has capillaries and blood returned to the right atrium through the coronary sinus.
  • The left ventricle is supplied mostly by the left coronary artery therefore occlusion in coronary artery disease can lead to serious damage.
  • During systole, contraction of ventricles compresses the coronary arteries which suppresses blood flow, so most of left ventricular perfusion occurs during diastole.

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