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Ketogenesis and Metabolism Quiz

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Questions and Answers

What initiates the process of ketogenesis in the liver?

Decreased fatty acid oxidation in the liver

Increase in glucose supply to the liver

Increased utilization of acetyl-CoA by the TCA cycle

Increased supply of free fatty acids due to lipolysis (correct)

Which process is directly inhibited to promote ketogenesis?

Utilization of acetyl-CoA by the TCA cycle (correct)

Beta-oxidation of fatty acids

Lipolysis of triacylglycerols

Transport of free fatty acids to the liver

What is the primary building block for the production of ketone bodies?

Glucose

Acetyl-CoA (correct)

Triacylglycerols

Fatty acids

What role do ketone bodies serve in the body when glucose is scarce?

They serve as an alternative energy source Signup and view all the answers

What is the fate of acyl-CoA in the liver during ketogenesis?

It undergoes beta-oxidation to form acetyl-CoA Signup and view all the answers

What happens to the ratio of anti-insulin to insulin in cases of starvation and severe uncontrolled diabetes?

It increases significantly. Signup and view all the answers

What role does fatty acyl-CoA play in fatty acid metabolism during starvation?

It activates CPT-1 to allow fatty acyl-CoA to enter mitochondria. Signup and view all the answers

How does β-oxidation affect the TCA cycle under conditions of starvation?

It inhibits glycolysis and subsequently the TCA cycle. Signup and view all the answers

What is the consequence of the high NADH/NAD ratio during gluconeogenesis?

Oxaloacetate is converted to malate for cytosolic transport. Signup and view all the answers

What metabolic shift occurs due to decreased glucose oxidation in starvation?

Diverting acetyl-CoA towards ketogenesis. Signup and view all the answers