Podcast
Questions and Answers
What is the role of an acid catalyst in the chemical modification of erythromycin?
What is the role of an acid catalyst in the chemical modification of erythromycin?
- Deactivating the hydroxyl group to prevent a nucleophilic attack
- Activating the hydroxyl group for a nucleophilic attack (correct)
- Inhibiting the formation of a ketal linkage
- Breaking down the erythromycin structure
What type of linkage is formed as a result of intramolecular nucleophilic attack in erythromycin?
What type of linkage is formed as a result of intramolecular nucleophilic attack in erythromycin?
- Cyclic ketal linkage (correct)
- Phosphodiester bond
- Disulfide bond
- Ester bond
How is the acid catalyst typically treated after its role in the chemical modification process with erythromycin?
How is the acid catalyst typically treated after its role in the chemical modification process with erythromycin?
- Regenerated for further use (correct)
- Disposed as waste
- Stored for future experiments
- Neutralized with a base
Which specific hydroxyl group in erythromycin is often selective for ketal formation?
Which specific hydroxyl group in erythromycin is often selective for ketal formation?
How does bacterial resistance to erythromycin and lincomycins occur?
How does bacterial resistance to erythromycin and lincomycins occur?
Which characteristic of erythromycin is affected when the enzyme is produced by resistant strains?
Which characteristic of erythromycin is affected when the enzyme is produced by resistant strains?
Which chemical modification of erythromycin is associated with a pKa value around 7.5?
Which chemical modification of erythromycin is associated with a pKa value around 7.5?
How do tetracyclines interfere with protein biosynthesis at the ribosomal level?
How do tetracyclines interfere with protein biosynthesis at the ribosomal level?
What is the main resistance mechanism of Gram-negative bacilli against macrolides like Erythromycin?
What is the main resistance mechanism of Gram-negative bacilli against macrolides like Erythromycin?
What is an alternative medical use of Erythromycin besides treating soft tissue infections?
What is an alternative medical use of Erythromycin besides treating soft tissue infections?
Which chemical group is esterified at the keto group site in Erythromycin?
Which chemical group is esterified at the keto group site in Erythromycin?
What is the major route of excretion for Erythromycin?
What is the major route of excretion for Erythromycin?
Which modification is made to increase lipid solubility and acid stability of Erythromycin for improved oral absorption?
Which modification is made to increase lipid solubility and acid stability of Erythromycin for improved oral absorption?
What feature distinguishes Azithromycin from other macrolides like Erythromycin?
What feature distinguishes Azithromycin from other macrolides like Erythromycin?
Why do Enterobacteriaceae family bacteria show pH-dependent sensitivities to Erythromycin?
Why do Enterobacteriaceae family bacteria show pH-dependent sensitivities to Erythromycin?
What aspect was modified in Azithromycin to increase its stability to acid-catalyzed degradation?
What aspect was modified in Azithromycin to increase its stability to acid-catalyzed degradation?
