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Questions and Answers

What is the primary function of osteoclasts in bone physiology?

  • To destroy old bone tissue (correct)
  • To store calcium in bones
  • To build new bone tissue
  • To maintain bone health

Which of the following is NOT a function of bone?

  • Support the body
  • Protect vital organs
  • Store minerals
  • Regulate body temperature (correct)

What advantage does trabecular bone have over compact bone?

  • Lighter weight and more surface area (correct)
  • Higher density
  • Increased strength under pressure
  • More flexibility

What role does synovial fluid play in joint function?

<p>Acts as a lubricant between joint surfaces (C)</p> Signup and view all the answers

Which part of the body contains ossicles that contribute to sound transmission?

<p>Middle ear (A)</p> Signup and view all the answers

What happens to bone strength when osteocytes die due to poor blood supply?

<p>Bone strength gradually decreases (B)</p> Signup and view all the answers

Which of the following elements is primarily stored in bones for the body's use?

<p>Calcium (A)</p> Signup and view all the answers

Which of the following statements about bone remodeling is true?

<p>It is a continuous process of bone resorption and formation. (C)</p> Signup and view all the answers

What property of trabecular bone allows it to absorb more energy compared to compact bone?

<p>Greater flexibility (A)</p> Signup and view all the answers

At what stress level does bone typically break, according to the provided information?

<p>120 N/mm² (D)</p> Signup and view all the answers

According to Hooke's law, how does strain change in relation to stress at the beginning of deformation?

<p>Strain is proportional to stress (D)</p> Signup and view all the answers

What is the significance of Young's modulus in the context of bone mechanics?

<p>It is the ratio of stress to strain during the elastic deformation (D)</p> Signup and view all the answers

Which type of fracture is indicated by a spiral fracture in the tibia?

<p>Shear (twisting) fracture (C)</p> Signup and view all the answers

What phenomenon has been suggested to play a role in bone growth and repair?

<p>Piezoelectricity (C)</p> Signup and view all the answers

What is the calculated amount of shortening in a leg bone when supporting a body weight of 700 N?

<p>0.15 mm (D)</p> Signup and view all the answers

When a bone is subjected to bending stresses, where do these stresses primarily occur?

<p>In the central portions of long bones (B)</p> Signup and view all the answers

What is the primary organic component of bone that contributes to its flexibility?

<p>Collagen (B)</p> Signup and view all the answers

Which statement correctly describes the difference between compact bone and trabecular bone?

<p>Compact bone is stronger than trabecular bone due to its structure. (B)</p> Signup and view all the answers

How can bone mineral be described based on its composition?

<p>It constitutes 60% of bone's weight and 40% of its volume. (B)</p> Signup and view all the answers

What does the large surface area of bone mineral crystals facilitate?

<p>Rapid interaction with chemicals in the blood. (B)</p> Signup and view all the answers

What is the result when collagen is removed from a bone?

<p>Only the mineral remains, which is fragile. (C)</p> Signup and view all the answers

What happens to bone structure when a bone tumor is present?

<p>Bone is destroyed gradually like a structured building. (D)</p> Signup and view all the answers

Which chemical element is used to identify bone tumors not yet visible on x-rays?

<p>Fluorine-14 (D)</p> Signup and view all the answers

In what way is trabecular bone advantageous compared to compact bone?

<p>It enables better blood flow and nutrient delivery. (D)</p> Signup and view all the answers

What is the primary consequence of rheumatoid arthritis on joint structure?

<p>Overproduction of synovial fluid (C)</p> Signup and view all the answers

How does the viscosity of synovial fluid change under stress?

<p>It decreases under large shear stress (B)</p> Signup and view all the answers

Which substances contribute to the lubricating properties of synovial fluid?

<p>Hyaluronic acid and mucopolysaccharides (D)</p> Signup and view all the answers

What is a key feature of articular cartilage?

<p>It is rubbery and can deform under stress (D)</p> Signup and view all the answers

What role does the porous nature of articular cartilage play in joint lubrication?

<p>It allows other lubricating materials to be squeezed in during stress (B)</p> Signup and view all the answers

What is the relationship between bone mineral mass and osteoporosis?

<p>Lower than normal bone mineral mass is a striking feature of osteoporosis (B)</p> Signup and view all the answers

Why is a precise technique needed to measure bone mineral mass?

<p>Bone mineral mass decreases slowly, making detection difficult (B)</p> Signup and view all the answers

What does the coefficient of friction in a joint relate to?

<p>The weight pressing on the joint (C)</p> Signup and view all the answers

What is a major drawback of using traditional x-rays for measuring bone mineral density?

<p>Traditional x-rays are nonlinear with respect to x-ray energy. (C)</p> Signup and view all the answers

Which component is NOT part of the improved photon absorptiometry technique?

<p>A broad energy source (B)</p> Signup and view all the answers

In the formula $BM (g/cm^2) = K log (I_0/I)$, what does $K$ represent?

<p>The constant that relates intensity to bone mineral density (D)</p> Signup and view all the answers

How does the in vivo activation technique measure calcium in the body?

<p>By quantifying emitted gamma rays unique to radioactive isotopes (C)</p> Signup and view all the answers

What is one of the key improvements made in photon absorptiometry over traditional x-ray techniques?

<p>Utilization of a scintillation equivalent material detector (A)</p> Signup and view all the answers

Which source of radiation is specifically mentioned as suitable for photon absorptiometry?

<p>Iodine 125 (D)</p> Signup and view all the answers

What problem does a narrow beam solve in the context of photon absorptiometry?

<p>It minimizes scatter and improves measurement accuracy. (C)</p> Signup and view all the answers

What characteristic of conventional x-ray techniques makes them less effective for quantitative measurements?

<p>They do not accurately reflect non-linear absorption rates. (A)</p> Signup and view all the answers

Flashcards

Major components of bone

Bone is mainly composed of inert tissue and osteocytes (cells).

Trabecular bone advantage

Trabecular bone is lighter and more flexible than compact bone.

X-ray image bone mineral mass problems

X-ray measurements of bone mineral mass are affected by factors like thickness, bone density and positioning.

Bone fracture types

Different types of bone fractures can be diagnosed using an X-ray image (e.g., hairline fractures, complete breaks).

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Synovial fluid function

Lubricates joints to reduce friction allowing smooth movement.

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Bone support function

Bones, along with muscles, provide structural support to the body.

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Bone locomotion function

Bone joints allow for movement of one bone relative to another.

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Bone chemical storage

Bones store minerals like calcium for the body's use.

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Bone Composition

Bone is made up of two main components: collagen (organic) and bone mineral (inorganic), plus water.

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Collagen in Bone

Collagen is the organic component of bone, making up about 40% of bone's weight and 60% of its volume. It gives bone flexibility.

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Bone Mineral

Bone mineral, mostly calcium hydroxyapatite, is the inorganic component of bone, comprising about 60% of bone's weight and 40% of its volume. It provides bone's strength.

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Bone Mineral Structure

Bone mineral crystals are rod-shaped, with diameters of 20-70 nm and lengths of 50-100 nm. This structure gives a large surface area.

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Bone Strength Variations

Compact bone is stronger than trabecular bone due to its dense structure. Trabecular bone, found at the ends of long bones, is weaker.

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Trabecular Bone Location

Trabecular bone is found in the ends of long bones.

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X-ray Absorption in Bone

Bones absorb X-rays better than surrounding soft tissue due to calcium's heavy nucleus.

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Bone Tumor Detection

Bone tumors can be detected using radioactive fluorine (14F), that is injected into the body.

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Trabecular bone

A type of bone tissue with a porous, lattice-like structure, providing strength with less material than compact bone.

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Trabecular bone's strength

Trabecular bone efficiently resists compressive forces, like those at the ends of bones, but is not strong against bending, a common force in long bones.

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Young's Modulus (Y)

A measure of a material's stiffness; it's the ratio of stress to strain in the material's initial linear portion.

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Bone under tension

When a bone is stretched, it elongates progressively until it breaks. The elongation follows a specific curve.

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Bone fracture

A break in the bone. Its healing can be influenced by things like immobilization and perhaps even electrical impulses.

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Compressive force

A force that pushes inward on a material.

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Tensile force

A force that pulls outward on a material.

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Bone fracture repair

The process by which the body fixes a broken bone. Growth and repair are influenced by many factors, including electrical fields.

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X-ray limitations for bone density

Traditional x-rays are not ideal for accurately measuring bone mineral density due to factors like heterogeneous beam energy, scattered radiation, and film's non-linear response.

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Photon absorptiometry

A technique using a precise, narrow beam of x-rays or gamma rays to measure bone density by analyzing the amount of radiation absorbed and transmitted through bone. This overcomes the limitations of traditional X-rays.

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Monoenergetic source in Photon Absorptiometry

A source generating x-rays or gamma rays of a single, specific energy to ensure consistent absorption by bone.

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Narrow beam in Photon Absorptiometry

A focused beam of radiation to minimize scattering and ensure accurate measurements.

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Scintillation detector in Photon Absorptiometry

A sensitive detector converting radiation into light pulses, used for precise measurement of bone density.

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Bone Mineral Mass (BM) formula

The amount of bone mineral (BM) at any point in the beam is proportional to the logarithm of the ratio of incident intensity (Io) to transmitted intensity (I), represented by the formula: BM (g/cm2) = K log (Io/I), where K is a constant.

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In vivo activation

A technique measuring bone mineral density by exposing the body to neutrons, which converts calcium and other elements into radioactive forms emitting gamma rays, providing information about bone mineral content.

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Gamma rays in In vivo activation

Radioactive calcium emits specific energy gamma rays detectable in In vivo activation, indicating the quantity of calcium in the body.

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Synovial Fluid's Role

Synovial fluid acts as a lubricant in joints, reducing friction and allowing smooth movement.

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Synovial Membrane Function

The synovial membrane encloses the joint and produces and retains the lubricating synovial fluid.

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Articular Cartilage's Properties

Articular cartilage is a smooth, rubbery material covering the joint surfaces, providing a low-friction surface for movement.

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Articular Cartilage's Lubrication

Articular cartilage absorbs synovial fluid, providing additional lubrication, especially under stress.

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Synovial Fluid Viscosity

Synovial fluid's viscosity (thickness) changes under pressure, becoming less viscous (thinner) for better lubrication.

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Synovial Fluid Composition

Hyaluronic acid and mucopolysaccharides are key components giving synovial fluid its lubricating properties.

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Osteoporosis Measurement

Measuring bone mineral mass is crucial for diagnosing osteoporosis, as low bone density is a key characteristic.

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Bone Mineral Mass Importance

Bone strength relies heavily on the amount of bone mineral present, highlighting why accurate measurement is essential for osteoporosis diagnosis.

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Study Notes

Physics of Skeleton

  • The skeletal system is of interest to medical physicists and engineers due to the complex static and dynamic forces encountered during various bodily functions.
  • Bone has at least six key functions: support, locomotion, protection of organs, storage of chemical elements, nourishment, and sound transmission.
  • Bones are composed primarily of calcium hydroxyapatite, which absorbs x-rays more effectively than surrounding soft tissue. This is why bones are easily visible on x-rays.
  • Bone is also composed of collagen, the organic component.
  • Trabecular bone, with its thin thread-like structure, is found in the ends of long bones, and is weaker than compact bone, but better at absorbing shock and impact.
  • Compact bone is primarily in the central shaft of long bones, providing strength and support essential for forces in walking, running, and jumping.
  • Bone is a living tissue that undergoes constant remodeling, with specialized cells (osteoclasts) removing old bone and (osteoblasts) building new bone.
  • Synovial fluid lubricates the joints, preventing friction and wear and tear.
  • Diseases like rheumatoid arthritis can cause overproduction of synovial fluid, leading to swollen joints.
  • Problems like difficulties in x-ray measurement of bone mineral mass include heterogeneous beam energies, much scattered radiation, and poor film detector properties.
  • An improved technique, photon absorptiometry, was developed, using gamma sources and scintillation detectors to overcome limitations of conventional x-rays.
  • A radioisotope, like iodine 25 or americium 241, can be used as a radiation source in vivo activation to measure bone mineral mass.

Bone Strength and Fracture

  • Bone strength depends on the amount of bone mineral present.
  • Osteoporosis is characterized by low bone mineral mass, increasing the risk for fractures.
  • Bones can withstand a significant amount of tension before fracturing.
  • Fractures commonly occur due to shear or tension forces rather than compression.
  • The body repairs bone fractures relatively quickly if the region is immobilized.

Measurement of Bone Mineral

  • Methods for measuring bone mineral mass in vivo include x-ray techniques and in-vivo activation.
  • X-ray imaging techniques have limitations, such as having a heterogeneous beam, significant scatter, and a poor film detector.
  • In-vivo activation uses energetic neutrons to convert calcium into radioactive forms, which emit gamma rays used in bone mineral mass assessments.

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