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Questions and Answers
What is the role of cyclin-dependent kinases in the cell cycle?
What is the role of cyclin-dependent kinases in the cell cycle?
- To activate the cyclosome
- To phosphorylate the cyclin-binding proteins (correct)
- To stop the cell cycle at the third checkpoint
- To target the cyclins for degradation
What is the cell cycle regulated by in the G1 phase?
What is the cell cycle regulated by in the G1 phase?
- Mitogens
- Cyclin-dependent kinases (correct)
- Cyclin degradation
- Chromatids
What phase will the cell enter if mitogens are present?
What phase will the cell enter if mitogens are present?
- G0
- G2
- S (correct)
- G1
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Study Notes
- The cell cycle is stopped at the third checkpoint when chromatids are attached to the poles correctly.
- This checkpoint is regulated by cyclin degradation.
- The cyclin degradation pathway is activated by the cyclin-dependent kinases (M and S).
- The cyclin-dependent kinases in turn phosphorylate the cyclin-binding proteins (CBP), which then activate the cyclosome.
- The cyclosome then targets the cyclins for degradation.
- The cell can enter the G1 phase if there are no mitogens present, but will eventually enter the S phase if mitogens are present.
- The G1 phase is regulated by the cyclin-dependent kinases, and the cell will eventually enter the G0 phase if no mitogens are present.
- The cell can be held in the G1 phase by the cyclin-dependent kinases, and will eventually enter the G2 phase if mitogens are present.
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