Jaundice: Causes and Mechanisms

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What are the usual pigmented areas of the body where jaundice can be observed?

Skin, sclera, under tongue, and palate of mouth

What is the primary cause of prehepatic jaundice?

Increased breakdown of red blood cells

What is a possible cause of hemolytic anemia of the newborn?

Incompatibility between the mother's and fetus's Rh type

What is the term for the destruction of red blood cells?

Hemolysis

What are the three categories of jaundice causes?

Prehepatic, hepatic, and posthepatic

What is the result of excess destruction of red blood cells in hemolytic anemia?

Increased unconjugated bilirubin

What is the primary cause of physiologic jaundice in newborns?

Immaturity of the conjugating enzyme glucuronyl transferase

What is the hallmark sign of posthepatic jaundice?

Gray-colored stool

What is the main difference between pathologic and physiologic prehepatic jaundice?

The presence of erythroblastosis fetalis

What is the primary cause of hepatic jaundice?

Disease of the hepatocytes

What is the purpose of UV light therapy in the treatment of jaundice?

To convert unconjugated bilirubin to conjugated

What is the primary difference between prehepatic and posthepatic jaundice?

The type of bilirubin that accumulates in the blood

What is the most important thing to know when diagnosing jaundice?

The underlying mechanism of jaundice

Which of the following is characteristic of prehepatic jaundice?

High total serum bilirubin and high indirect bilirubin

What is a common cause of cholecystitis?

Irritation of stones inside the gallbladder or nearby ducts

What is the primary difference between conjugated and unconjugated bilirubin?

Conjugated bilirubin is soluble in water, while unconjugated bilirubin is insoluble

What is the primary indicator of posthepatic jaundice?

High total serum bilirubin and high direct bilirubin

What is a key feature of hepatic jaundice?

Normal or high total serum bilirubin and low direct bilirubin

Learn about the different causes and mechanisms of jaundice, including prehepatic, hepatic, and posthepatic jaundice. Understand the role of bilirubin and its impact on the body.

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