physiology 1404 lect 3
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Questions and Answers

What is the term for the amount of a substance filtered per unit time?

  • Secretion Rate
  • Reabsorption Rate
  • Filtered Load (correct)
  • Urinary Excretion Rate
  • Which process involves the movement of substances from the peritubular capillary blood into the tubules?

  • Urinary Excretion
  • Tubular Reabsorption
  • Tubular Secretion (correct)
  • Glomerular Filtration
  • What is the term for the balance between the amount of fluid and solutes reabsorbed in the proximal tubule and the amount filtered by the glomerulus?

  • Glomerulotubular Balance (correct)
  • Renal-Hepatic Balance
  • Proximal-Distal Balance
  • Tubuloglomerular Balance
  • In which segment of the nephron is isosmotic reabsorption of NaCl observed?

    <p>Late Proximal Tubule</p> Signup and view all the answers

    What is the term for the process by which substances are reabsorbed from the filtrate back into the bloodstream?

    <p>Reabsorption</p> Signup and view all the answers

    What is the term for the rate at which a substance is excreted in the urine?

    <p>Urinary Excretion Rate</p> Signup and view all the answers

    What is the primary function of transporters in the membranes of renal tubule epithelial cells?

    <p>Reabsorption and secretion of substances into the peritubular capillary blood</p> Signup and view all the answers

    Which of the following substances is NOT reabsorbed from the glomerular filtrate into the peritubular capillary blood?

    <p>K+</p> Signup and view all the answers

    What is the excretion rate of a substance equivalent to?

    <p>The amount of a substance excreted per unit time</p> Signup and view all the answers

    What is the purpose of measuring the filtered load and excretion rate of a substance?

    <p>To determine whether a substance has been reabsorbed or secreted</p> Signup and view all the answers

    What is the formula for calculating the filtered load of a substance?

    <p>GFR x [Px]</p> Signup and view all the answers

    What can be inferred if a substance is present in the urine?

    <p>It may have entered the renal tubule by either filtration or secretion</p> Signup and view all the answers

    Why would glucose molecules be excreted in the urine when the glucose concentration in the tubular fluid rises?

    <p>Because there are few remaining 'free' transporters to which they may re-attach</p> Signup and view all the answers

    What is the significance of Tm in the context of renal handling of glucose?

    <p>It is the maximum amount of glucose that can be reabsorbed in the tubules</p> Signup and view all the answers

    Why does glucosuria occur in uncontrolled diabetes mellitus?

    <p>Because the plasma glucose concentration exceeds Tm</p> Signup and view all the answers

    What is the effect of pregnancy on the renal handling of glucose?

    <p>It increases the filtered load of glucose</p> Signup and view all the answers

    What is the consequence of congenital abnormalities of the Na+ glucose cotransporter?

    <p>Decreased Tm</p> Signup and view all the answers

    What is the formula to calculate the amount of a substance filtered per unit time?

    <p>GFR x filterable plasma concentration of the substance</p> Signup and view all the answers

    What is the main characteristic of isosmotic reabsorption in the PT?

    <p>Solute and water reabsorption are coupled and proportional to each other</p> Signup and view all the answers

    What is the primary function of the Na+-K+ ATPase in the PT?

    <p>To pump Na+ out of the cell and maintain isosmolarity</p> Signup and view all the answers

    What is the effect of increased filtered load on reabsorption in the PT?

    <p>No change in reabsorption of isosmotic fluid</p> Signup and view all the answers

    What is the primary mechanism of glomerulotubular balance in the PT?

    <p>Balance between filtration and reabsorption</p> Signup and view all the answers

    What is the primary function of Starling's forces in the peritubular capillary?

    <p>To favor reabsorption of isosmotic fluid</p> Signup and view all the answers

    What is the percentage of the filtered load that is reabsorbed by the PT?

    <p>67%</p> Signup and view all the answers

    What is the primary function of the early distal tubule in terms of sodium reabsorption?

    <p>Reabsorption of sodium ions in an electro-neutral manner</p> Signup and view all the answers

    What is the effect of thiazide diuretics on the Na+-Cl- cotransporter in the early distal tubule?

    <p>They inhibit the transporter, causing a decrease in sodium reabsorption</p> Signup and view all the answers

    What is the primary function of principal cells in the late distal tubule and collecting duct?

    <p>Reabsorption of sodium ions and secretion of potassium ions</p> Signup and view all the answers

    What is the mechanism of sodium reabsorption in the late distal tubule and collecting duct?

    <p>Sodium ions diffuse through Na+ channels on the luminal membrane and are then pumped out of the cell by Na+-K+-ATPase</p> Signup and view all the answers

    What is the effect of aldosterone on sodium reabsorption in the late distal tubule and collecting duct?

    <p>It stimulates sodium reabsorption in the principal cells</p> Signup and view all the answers

    What is the effect of K+-sparing diuretics on sodium reabsorption in the late distal tubule and collecting duct?

    <p>They inhibit sodium reabsorption in the principal cells</p> Signup and view all the answers

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