Podcast
Questions and Answers
Which drug is indicated for acute coronary syndromes (ACS) in combination with aspirin or in patients with recent myocardial infarction (MI), stroke, or peripheral arterial disease (PAD)?
Which drug is indicated for acute coronary syndromes (ACS) in combination with aspirin or in patients with recent myocardial infarction (MI), stroke, or peripheral arterial disease (PAD)?
- Durlaza
- Aspirin
- Rivaroxaban
- Clopidogrel (correct)
Which drug is a prodrug and its effectiveness depends on the conversion to an active metabolite, mainly by CYP450 2C19?
Which drug is a prodrug and its effectiveness depends on the conversion to an active metabolite, mainly by CYP450 2C19?
- Aspirin
- Rivaroxaban
- Clopidogrel (correct)
- Durlaza
Which drug is used with low-dose rivaroxaban to reduce the risk of major cardiovascular events such as MI and stroke?
Which drug is used with low-dose rivaroxaban to reduce the risk of major cardiovascular events such as MI and stroke?
- Durlaza
- Rivaroxaban
- Clopidogrel
- Aspirin (correct)
Which drug should not be used when rapid onset is needed, for example, in acute coronary syndrome (ACS) or pre-percutaneous coronary intervention (PCI)?
Which drug should not be used when rapid onset is needed, for example, in acute coronary syndrome (ACS) or pre-percutaneous coronary intervention (PCI)?
Which drug is indicated for those at risk of developing aspirin-associated gastric ulcers?
Which drug is indicated for those at risk of developing aspirin-associated gastric ulcers?
Which drug is used in single antiplatelet therapy (SAPT) for stable ischemic heart disease (SIHD) when there is a contraindication to aspirin?
Which drug is used in single antiplatelet therapy (SAPT) for stable ischemic heart disease (SIHD) when there is a contraindication to aspirin?
Which drug is the only P2Y12 inhibitor recommended in SIHD for dual antiplatelet therapy (DAPT)?
Which drug is the only P2Y12 inhibitor recommended in SIHD for dual antiplatelet therapy (DAPT)?
What is the classic symptom of stable angina?
What is the classic symptom of stable angina?
What is the medical emergency associated with unstable angina?
What is the medical emergency associated with unstable angina?
What can lead to misdiagnosis of stable angina in certain patient groups?
What can lead to misdiagnosis of stable angina in certain patient groups?
What is the term for chest pain caused by vasospasm of the coronary arteries?
What is the term for chest pain caused by vasospasm of the coronary arteries?
What is the main cause of decreased myocardial oxygen supply in stable ischemic heart disease?
What is the main cause of decreased myocardial oxygen supply in stable ischemic heart disease?
What type of angina can occur at rest and be caused by illicit drug use, particularly cocaine?
What type of angina can occur at rest and be caused by illicit drug use, particularly cocaine?
What is the term for chest pain that does not vary with position or respiration?
What is the term for chest pain that does not vary with position or respiration?
Which type of nitrates is recommended for all patients for fast relief of angina?
Which type of nitrates is recommended for all patients for fast relief of angina?
What is the main side effect associated with long-acting nitrates?
What is the main side effect associated with long-acting nitrates?
Which condition is a contraindication for short-acting nitrates?
Which condition is a contraindication for short-acting nitrates?
What is the recommended monitoring for long-acting nitrates?
What is the recommended monitoring for long-acting nitrates?
Which formulation of nitroglycerin requires a nitrate-free interval to prevent tolerance?
Which formulation of nitroglycerin requires a nitrate-free interval to prevent tolerance?
What is the main warning associated with nitroglycerin TL spray?
What is the main warning associated with nitroglycerin TL spray?
Which type of nitrates can aggravate angina caused by hypertrophic cardiomyopathy?
Which type of nitrates can aggravate angina caused by hypertrophic cardiomyopathy?
What is the main side effect associated with nitroglycerin SL powder?
What is the main side effect associated with nitroglycerin SL powder?
Which type of nitrates does not develop tolerance with SL/TL products?
Which type of nitrates does not develop tolerance with SL/TL products?
Which factor does not contribute to the risk of Ischemic Heart Disease (SIHD)?
Which factor does not contribute to the risk of Ischemic Heart Disease (SIHD)?
What is the recommended antiplatelet for SIHD treatment?
What is the recommended antiplatelet for SIHD treatment?
What is the purpose of a cardiac stress test in the context of SIHD?
What is the purpose of a cardiac stress test in the context of SIHD?
What is the goal of SIHD treatment?
What is the goal of SIHD treatment?
Which combination is FDA-approved for reducing the risk of cardiovascular events in patients with CAD?
Which combination is FDA-approved for reducing the risk of cardiovascular events in patients with CAD?
What is the purpose of antianginal treatment for SIHD?
What is the purpose of antianginal treatment for SIHD?
What is recommended for patients with SIHD to manage hypertension, heart failure, and diabetes?
What is recommended for patients with SIHD to manage hypertension, heart failure, and diabetes?
Unstable angina is not a type of acute coronary syndrome (ACS)
Unstable angina is not a type of acute coronary syndrome (ACS)
Prinzmetal's angina can only occur during physical exertion
Prinzmetal's angina can only occur during physical exertion
Chest pain caused by vasospasm of the coronary arteries is known as stable angina
Chest pain caused by vasospasm of the coronary arteries is known as stable angina
Myocardial oxygen supply is often decreased due to plaque buildup in the outer walls of the coronary arteries in stable ischemic heart disease (SIHD)
Myocardial oxygen supply is often decreased due to plaque buildup in the outer walls of the coronary arteries in stable ischemic heart disease (SIHD)
Long-acting nitrates are more effective than beta-blockers and calcium channel blockers in silent ischemia.
Long-acting nitrates are more effective than beta-blockers and calcium channel blockers in silent ischemia.
Clopidogrel is a direct-acting P2Y12 inhibitor.
Clopidogrel is a direct-acting P2Y12 inhibitor.
Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is recommended for all patients with stable ischemic heart disease (SIHD).
Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is recommended for all patients with stable ischemic heart disease (SIHD).
Aspirin should be used indefinitely in SIHD unless contraindicated.
Aspirin should be used indefinitely in SIHD unless contraindicated.
Yosprala and Durlaza should be used when rapid onset is needed, for example, in acute coronary syndrome (ACS) or pre-percutaneous coronary intervention (PCI).
Yosprala and Durlaza should be used when rapid onset is needed, for example, in acute coronary syndrome (ACS) or pre-percutaneous coronary intervention (PCI).
Prinzmetal's (variant) angina is preferred for treatment with beta-blockers.
Prinzmetal's (variant) angina is preferred for treatment with beta-blockers.
Omeprazole and esomeprazole are safe to use in combination with clopidogrel.
Omeprazole and esomeprazole are safe to use in combination with clopidogrel.
Clopidogrel is contraindicated in patients with active serious bleeding.
Clopidogrel is contraindicated in patients with active serious bleeding.
Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is reserved for those who have had placement of a drug-eluting stent for at least one month.
Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is reserved for those who have had placement of a drug-eluting stent for at least one month.
Clopidogrel is the only P2Y12 inhibitor recommended in SIHD.
Clopidogrel is the only P2Y12 inhibitor recommended in SIHD.
Yosprala is indicated for those at risk of developing aspirin-associated gastric ulcers.
Yosprala is indicated for those at risk of developing aspirin-associated gastric ulcers.
Aspirin should be used indefinitely in SIHD when there is a contraindication to aspirin.
Aspirin should be used indefinitely in SIHD when there is a contraindication to aspirin.
Long-acting nitrates can be used without a nitrate-free interval to prevent tolerance
Long-acting nitrates can be used without a nitrate-free interval to prevent tolerance
Ranolazine (Ranexa) can be used in combination with beta-blockers without risk of excessive bradycardia
Ranolazine (Ranexa) can be used in combination with beta-blockers without risk of excessive bradycardia
Short-acting nitrates have the potential to aggravate angina caused by hypertrophic cardiomyopathy
Short-acting nitrates have the potential to aggravate angina caused by hypertrophic cardiomyopathy
Nitrates do not develop tolerance with SL/TL products
Nitrates do not develop tolerance with SL/TL products
Isosorbide dinitrate should be dosed three times daily for a 14-hour nitrate-free interval
Isosorbide dinitrate should be dosed three times daily for a 14-hour nitrate-free interval
Isosorbide mononitrate should be dosed twice daily, 7 hours apart
Isosorbide mononitrate should be dosed twice daily, 7 hours apart
Nitroglycerin ER capsules should be taken with a 18-hour nitrate-free interval
Nitroglycerin ER capsules should be taken with a 18-hour nitrate-free interval
Isosorbide dinitrate is recommended for use in combination with hydralazine
Isosorbide dinitrate is recommended for use in combination with hydralazine
Nitrates are recommended for all patients for fast relief of angina
Nitrates are recommended for all patients for fast relief of angina
Nitrates have little to no clinical effects on heart rate or blood pressure
Nitrates have little to no clinical effects on heart rate or blood pressure
Nitroglycerin transdermal patch should be worn for 12-14 hours with a nitrate-free interval of 10-12 hours
Nitroglycerin transdermal patch should be worn for 12-14 hours with a nitrate-free interval of 10-12 hours
Nitrates are contraindicated in patients with liver cirrhosis and use of strong CYP3A4 inhibitors or inducers
Nitrates are contraindicated in patients with liver cirrhosis and use of strong CYP3A4 inhibitors or inducers
Coronary artery disease causes widening of arteries and increased blood flow to the heart
Coronary artery disease causes widening of arteries and increased blood flow to the heart
Myocardial oxygen demand decreases when the heart is working harder
Myocardial oxygen demand decreases when the heart is working harder
Annual influenza vaccine and pneumococcal vaccines are not recommended for patients with SIHD
Annual influenza vaccine and pneumococcal vaccines are not recommended for patients with SIHD
Low-dose rivaroxaban (Xarelto) in combination with aspirin is not FDA-approved for reducing the risk of cardiovascular events in patients with CAD
Low-dose rivaroxaban (Xarelto) in combination with aspirin is not FDA-approved for reducing the risk of cardiovascular events in patients with CAD
Antiplatelet and antianginal drug regimens are not used together for SIHD treatment
Antiplatelet and antianginal drug regimens are not used together for SIHD treatment
Aspirin is not the recommended antiplatelet for SIHD treatment
Aspirin is not the recommended antiplatelet for SIHD treatment
Non-drug treatments for SIHD include heart-healthy diet, exercise, and smoking cessation
Non-drug treatments for SIHD include heart-healthy diet, exercise, and smoking cessation
A high-intensity statin is not recommended for patients with SIHD
A high-intensity statin is not recommended for patients with SIHD
Antiplatelet treatment decreases myocardial oxygen demand or increases myocardial oxygen supply
Antiplatelet treatment decreases myocardial oxygen demand or increases myocardial oxygen supply
Patients with SIHD should not have hypertension, heart failure, and diabetes aggressively managed
Patients with SIHD should not have hypertension, heart failure, and diabetes aggressively managed
Cardiac stress test is not performed to assess the likelihood of CAD and diagnose SIHD
Cardiac stress test is not performed to assess the likelihood of CAD and diagnose SIHD
Risk factors for SIHD do not include physical inactivity
Risk factors for SIHD do not include physical inactivity
What is the classic symptom of stable angina?
What is the classic symptom of stable angina?
What type of angina can occur at rest and be caused by illicit drug use, particularly cocaine?
What type of angina can occur at rest and be caused by illicit drug use, particularly cocaine?
What is the term for chest pain that does not vary with position or respiration?
What is the term for chest pain that does not vary with position or respiration?
What is the term for chest pain caused by vasospasm of the coronary arteries?
What is the term for chest pain caused by vasospasm of the coronary arteries?
Which enzyme is responsible for the conversion of clopidogrel to its active metabolite, and what genetic variation can affect this conversion?
Which enzyme is responsible for the conversion of clopidogrel to its active metabolite, and what genetic variation can affect this conversion?
What is the duration of dual antiplatelet therapy (DAPT) with aspirin and clopidogrel for patients with a drug-eluting stent, according to the text?
What is the duration of dual antiplatelet therapy (DAPT) with aspirin and clopidogrel for patients with a drug-eluting stent, according to the text?
What is the main drug interaction to avoid when using clopidogrel, and what are the potential consequences of this interaction?
What is the main drug interaction to avoid when using clopidogrel, and what are the potential consequences of this interaction?
What is the recommended daily dose of aspirin in a dual antiplatelet therapy (DAPT) regimen?
What is the recommended daily dose of aspirin in a dual antiplatelet therapy (DAPT) regimen?
What is the preferred type of beta-blockers for use in stable ischemic heart disease (SIHD), and why are beta-blockers without intrinsic sympathomimetic activity (ISA) preferred?
What is the preferred type of beta-blockers for use in stable ischemic heart disease (SIHD), and why are beta-blockers without intrinsic sympathomimetic activity (ISA) preferred?
What is the clinical benefit of calcium channel blockers in the treatment of stable ischemic heart disease?
What is the clinical benefit of calcium channel blockers in the treatment of stable ischemic heart disease?
What is the main risk associated with the use of long-acting nitrates?
What is the main risk associated with the use of long-acting nitrates?
What is the indication for Yosprala, and when should it not be used?
What is the indication for Yosprala, and when should it not be used?
What type of angina is preferred for treatment with calcium channel blockers?
What type of angina is preferred for treatment with calcium channel blockers?
What is the main warning associated with clopidogrel, and what is the recommended action regarding CYP2C19 genotype testing?
What is the main warning associated with clopidogrel, and what is the recommended action regarding CYP2C19 genotype testing?
What are the potential adverse effects that should be monitored in patients taking aspirin or clopidogrel?
What are the potential adverse effects that should be monitored in patients taking aspirin or clopidogrel?
What is the recommended duration of dual antiplatelet therapy (DAPT) for patients with a bare metal stent, according to the text?
What is the recommended duration of dual antiplatelet therapy (DAPT) for patients with a bare metal stent, according to the text?
What are the risk factors for SIHD?
What are the risk factors for SIHD?
What is the recommended antiplatelet for SIHD?
What is the recommended antiplatelet for SIHD?
What is the alternative to aspirin for antiplatelet treatment in SIHD?
What is the alternative to aspirin for antiplatelet treatment in SIHD?
What non-drug treatments are recommended for SIHD?
What non-drug treatments are recommended for SIHD?
What is the FDA-approved combination for reducing the risk of cardiovascular events in patients with CAD?
What is the FDA-approved combination for reducing the risk of cardiovascular events in patients with CAD?
What is the goal of SIHD treatment?
What is the goal of SIHD treatment?
What type of treatment decreases myocardial oxygen demand or increases myocardial oxygen supply in SIHD?
What type of treatment decreases myocardial oxygen demand or increases myocardial oxygen supply in SIHD?
What is the recommended statin intensity for patients with SIHD?
What is the recommended statin intensity for patients with SIHD?
What vaccines are recommended for patients with SIHD?
What vaccines are recommended for patients with SIHD?
What is the only P2Y12 inhibitor recommended for SIHD dual antiplatelet therapy (DAPT)?
What is the only P2Y12 inhibitor recommended for SIHD dual antiplatelet therapy (DAPT)?
What is the only P2Y12 inhibitor recommended for SIHD single antiplatelet therapy (SAPT) when there is a contraindication to aspirin?
What is the only P2Y12 inhibitor recommended for SIHD single antiplatelet therapy (SAPT) when there is a contraindication to aspirin?
What drug is used with low-dose rivaroxaban to reduce the risk of major cardiovascular events in CAD?
What drug is used with low-dose rivaroxaban to reduce the risk of major cardiovascular events in CAD?
What is the purpose of long-acting nitrates in stable ischemic heart disease (SIHD) treatment?
What is the purpose of long-acting nitrates in stable ischemic heart disease (SIHD) treatment?
What is the main contraindication for nitroglycerin SL tablet (Nitrostat)?
What is the main contraindication for nitroglycerin SL tablet (Nitrostat)?
What is the recommended monitoring for nitroglycerin SL powder (GoNitro)?
What is the recommended monitoring for nitroglycerin SL powder (GoNitro)?
What is the safety concern associated with nitroglycerin TL spray (NitroMist, Nitrolingual)?
What is the safety concern associated with nitroglycerin TL spray (NitroMist, Nitrolingual)?
What is the purpose of nitrate-free interval in long-acting nitrates?
What is the purpose of nitrate-free interval in long-acting nitrates?
What is the recommended dosing schedule for nitroglycerin ointment 2% (Nitro-Bid)?
What is the recommended dosing schedule for nitroglycerin ointment 2% (Nitro-Bid)?
When are long-acting nitrates used?
When are long-acting nitrates used?
What is the recommended monitoring for nitroglycerin SL tablet (Nitrostat)?
What is the recommended monitoring for nitroglycerin SL tablet (Nitrostat)?
What is the main safety concern associated with nitroglycerin SL powder (GoNitro)?
What is the main safety concern associated with nitroglycerin SL powder (GoNitro)?
What is the main warning associated with long-acting nitrates?
What is the main warning associated with long-acting nitrates?
What is the main contraindication for nitroglycerin TL spray (NitroMist, Nitrolingual)?
What is the main contraindication for nitroglycerin TL spray (NitroMist, Nitrolingual)?
What are the recommended conditions for which short-acting nitrates should not be used?
What are the recommended conditions for which short-acting nitrates should not be used?
Flashcards
Coronary Artery Disease (CAD)
Coronary Artery Disease (CAD)
Narrowing of the coronary arteries, reducing blood flow to the heart.
Myocardial Oxygen Demand
Myocardial Oxygen Demand
The amount of oxygen the heart muscle needs.
Risk Factors for SIHD
Risk Factors for SIHD
Conditions increasing the chance of Ischemic Heart Disease, including hypertension, smoking, dyslipidemia, diabetes, obesity, and physical inactivity.
Cardiac Stress Test
Cardiac Stress Test
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Treatment Goals for SIHD
Treatment Goals for SIHD
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Antiplatelet Drugs
Antiplatelet Drugs
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Aspirin
Aspirin
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Clopidogrel (Plavix)
Clopidogrel (Plavix)
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Antianginal Drugs
Antianginal Drugs
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Non-drug Treatments
Non-drug Treatments
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High-intensity Statin
High-intensity Statin
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Hypertension
Hypertension
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Heart Failure
Heart Failure
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Diabetes
Diabetes
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Influenza Vaccine
Influenza Vaccine
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Pneumococcal Vaccines
Pneumococcal Vaccines
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SIHD Treatment Regimen
SIHD Treatment Regimen
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Low-dose Rivaroxaban (Xarelto)
Low-dose Rivaroxaban (Xarelto)
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Study Notes
Ischemic Heart Disease (SIHD) and its Treatment
- Coronary artery disease (CAD) causes narrowing of arteries and reduced blood flow to the heart
- Myocardial oxygen demand increases when the heart is working harder due to increased heart rate, contractility, or left ventricular wall tension
- Risk factors for SIHD include hypertension, smoking, dyslipidemia, diabetes, obesity, and physical inactivity
- Cardiac stress test is performed to assess the likelihood of CAD and diagnose SIHD
- Treatment goals for SIHD are to improve function, prevent future cardiovascular events, and reduce the risk of cardiovascular death
- Antiplatelet and antianginal drug regimens are used together for SIHD treatment
- Aspirin is the recommended antiplatelet; clopidogrel (Plavix) is used as an alternative
- Non-drug treatments for SIHD include heart-healthy diet, exercise, smoking cessation, and alcohol limitation
- Low-dose rivaroxaban (Xarelto) in combination with aspirin is FDA-approved for reducing the risk of cardiovascular events in patients with CAD
- Antianginal treatment decreases myocardial oxygen demand or increases myocardial oxygen supply
- Patients with SIHD should be treated with a high-intensity statin and have hypertension, heart failure, and diabetes aggressively managed
- Annual influenza vaccine and pneumococcal vaccines are recommended for patients with SIHD
Ischemic Heart Disease (SIHD) and its Treatment
- Coronary artery disease (CAD) causes narrowing of arteries and reduced blood flow to the heart
- Myocardial oxygen demand increases when the heart is working harder due to increased heart rate, contractility, or left ventricular wall tension
- Risk factors for SIHD include hypertension, smoking, dyslipidemia, diabetes, obesity, and physical inactivity
- Cardiac stress test is performed to assess the likelihood of CAD and diagnose SIHD
- Treatment goals for SIHD are to improve function, prevent future cardiovascular events, and reduce the risk of cardiovascular death
- Antiplatelet and antianginal drug regimens are used together for SIHD treatment
- Aspirin is the recommended antiplatelet; clopidogrel (Plavix) is used as an alternative
- Non-drug treatments for SIHD include heart-healthy diet, exercise, smoking cessation, and alcohol limitation
- Low-dose rivaroxaban (Xarelto) in combination with aspirin is FDA-approved for reducing the risk of cardiovascular events in patients with CAD
- Antianginal treatment decreases myocardial oxygen demand or increases myocardial oxygen supply
- Patients with SIHD should be treated with a high-intensity statin and have hypertension, heart failure, and diabetes aggressively managed
- Annual influenza vaccine and pneumococcal vaccines are recommended for patients with SIHD
Ischemic Heart Disease (SIHD) and its Treatment
- Coronary artery disease (CAD) causes narrowing of arteries and reduced blood flow to the heart
- Myocardial oxygen demand increases when the heart is working harder due to increased heart rate, contractility, or left ventricular wall tension
- Risk factors for SIHD include hypertension, smoking, dyslipidemia, diabetes, obesity, and physical inactivity
- Cardiac stress test is performed to assess the likelihood of CAD and diagnose SIHD
- Treatment goals for SIHD are to improve function, prevent future cardiovascular events, and reduce the risk of cardiovascular death
- Antiplatelet and antianginal drug regimens are used together for SIHD treatment
- Aspirin is the recommended antiplatelet; clopidogrel (Plavix) is used as an alternative
- Non-drug treatments for SIHD include heart-healthy diet, exercise, smoking cessation, and alcohol limitation
- Low-dose rivaroxaban (Xarelto) in combination with aspirin is FDA-approved for reducing the risk of cardiovascular events in patients with CAD
- Antianginal treatment decreases myocardial oxygen demand or increases myocardial oxygen supply
- Patients with SIHD should be treated with a high-intensity statin and have hypertension, heart failure, and diabetes aggressively managed
- Annual influenza vaccine and pneumococcal vaccines are recommended for patients with SIHD
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Test your knowledge of Ischemic Heart Disease (SIHD) and its Treatment with this quiz. Explore the risk factors, diagnostic methods, and treatment options, including drug regimens and non-drug interventions, to improve patient outcomes and reduce cardiovascular risks.
