Iron Kinetics and Heme Metabolism Anemias Quiz

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What is the primary cause of hemochromatosis?

Overconsumption of vitamin C

Mutations to the genes for the proteins of iron metabolism (correct)

Incorrect dietary intake of iron

Exposure to environmental toxins

In hereditary hemochromatosis, which gene mutation is typically involved?

HFE protein (correct)

Ferritin gene

Vitamin C gene

Superoxide gene

What is the ultimate cause of cell death in hemochromatosis?

Lysosomal enzyme depletion

Irreversible membrane damage (correct)

Mitochondrial dysfunction

Excessive ferritin production

How does free iron accumulation lead to cellular damage in hemochromatosis?

Initiates the generation of free radicals Signup and view all the answers

What role do vitamins E and C play in iron overload?

Moderate the effects and interrupt chain reactions Signup and view all the answers

At what age do individuals with classic hemochromatosis typically develop clinically evident disease?

40 to 60 years Signup and view all the answers

Which gender is more prone to phenotypic expression of tissue damage in hereditary hemochromatosis?

Men Signup and view all the answers

What is the initial cellular reaction to excess iron in hemochromatosis?

Form ferritin Signup and view all the answers

What is the degenerate and non-metabolically active form of ferritin that accumulates when cells exhaust storage capacity?

Hemosiderin Signup and view all the answers

How does ferrous iron contribute to cellular damage in hemochromatosis?

Initiates generation of superoxide and other free radicals Signup and view all the answers

Iron Kinetics and Heme Metabolism Anemias Quiz

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Questions and Answers

What is the primary cause of hemochromatosis?

In hereditary hemochromatosis, which gene mutation is typically involved?

What is the ultimate cause of cell death in hemochromatosis?

How does free iron accumulation lead to cellular damage in hemochromatosis?

What role do vitamins E and C play in iron overload?

At what age do individuals with classic hemochromatosis typically develop clinically evident disease?

Which gender is more prone to phenotypic expression of tissue damage in hereditary hemochromatosis?

What is the initial cellular reaction to excess iron in hemochromatosis?

What is the degenerate and non-metabolically active form of ferritin that accumulates when cells exhaust storage capacity?

How does ferrous iron contribute to cellular damage in hemochromatosis?

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