Iron Kinetics and Heme Metabolism Anemias Quiz
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Questions and Answers

What is the primary cause of hemochromatosis?

  • Overconsumption of vitamin C
  • Mutations to the genes for the proteins of iron metabolism (correct)
  • Incorrect dietary intake of iron
  • Exposure to environmental toxins
  • In hereditary hemochromatosis, which gene mutation is typically involved?

  • HFE protein (correct)
  • Ferritin gene
  • Vitamin C gene
  • Superoxide gene
  • What is the ultimate cause of cell death in hemochromatosis?

  • Lysosomal enzyme depletion
  • Irreversible membrane damage (correct)
  • Mitochondrial dysfunction
  • Excessive ferritin production
  • How does free iron accumulation lead to cellular damage in hemochromatosis?

    <p>Initiates the generation of free radicals</p> Signup and view all the answers

    What role do vitamins E and C play in iron overload?

    <p>Moderate the effects and interrupt chain reactions</p> Signup and view all the answers

    At what age do individuals with classic hemochromatosis typically develop clinically evident disease?

    <p>40 to 60 years</p> Signup and view all the answers

    Which gender is more prone to phenotypic expression of tissue damage in hereditary hemochromatosis?

    <p>Men</p> Signup and view all the answers

    What is the initial cellular reaction to excess iron in hemochromatosis?

    <p>Form ferritin</p> Signup and view all the answers

    What is the degenerate and non-metabolically active form of ferritin that accumulates when cells exhaust storage capacity?

    <p>Hemosiderin</p> Signup and view all the answers

    How does ferrous iron contribute to cellular damage in hemochromatosis?

    <p>Initiates generation of superoxide and other free radicals</p> Signup and view all the answers

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