Podcast
Questions and Answers
What is the primary cause of hemochromatosis?
What is the primary cause of hemochromatosis?
- Overconsumption of vitamin C
- Mutations to the genes for the proteins of iron metabolism (correct)
- Incorrect dietary intake of iron
- Exposure to environmental toxins
In hereditary hemochromatosis, which gene mutation is typically involved?
In hereditary hemochromatosis, which gene mutation is typically involved?
- HFE protein (correct)
- Ferritin gene
- Vitamin C gene
- Superoxide gene
What is the ultimate cause of cell death in hemochromatosis?
What is the ultimate cause of cell death in hemochromatosis?
- Lysosomal enzyme depletion
- Irreversible membrane damage (correct)
- Mitochondrial dysfunction
- Excessive ferritin production
How does free iron accumulation lead to cellular damage in hemochromatosis?
How does free iron accumulation lead to cellular damage in hemochromatosis?
What role do vitamins E and C play in iron overload?
What role do vitamins E and C play in iron overload?
At what age do individuals with classic hemochromatosis typically develop clinically evident disease?
At what age do individuals with classic hemochromatosis typically develop clinically evident disease?
Which gender is more prone to phenotypic expression of tissue damage in hereditary hemochromatosis?
Which gender is more prone to phenotypic expression of tissue damage in hereditary hemochromatosis?
What is the initial cellular reaction to excess iron in hemochromatosis?
What is the initial cellular reaction to excess iron in hemochromatosis?
What is the degenerate and non-metabolically active form of ferritin that accumulates when cells exhaust storage capacity?
What is the degenerate and non-metabolically active form of ferritin that accumulates when cells exhaust storage capacity?
How does ferrous iron contribute to cellular damage in hemochromatosis?
How does ferrous iron contribute to cellular damage in hemochromatosis?
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