Ionizing Radiation in Pharmaceutical Sterilization

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Questions and Answers

What is the direct action of ionizing radiation on microorganisms?

  • Interaction with target regions in molecules (correct)
  • Absorption of radiation by water
  • Production of free radicals
  • Excitation of mold spores

How does a single ionization in sensitive regions of molecules affect microorganisms?

  • Increases microbial resistance
  • Promotes microbial reproduction
  • Stimulates microbial growth
  • Causes inactivation of the molecule (correct)

What is the role of water in indirect action of ionizing radiation?

  • Transfer of energy to solute molecules
  • Production of free radicals (correct)
  • Excitation of mold spores
  • Direct interaction with target regions

How does ionizing radiation cause harm at the molecular level?

<p>By causing direct inactivation of molecules (D)</p> Signup and view all the answers

What is the primary source of energy imparted in dilute solutions exposed to radiation?

<p>Water (B)</p> Signup and view all the answers

How does ionizing radiation cause microbial death through indirect action?

<p>By absorption by water and production of free radicals (C)</p> Signup and view all the answers

What is considered the major subject of cellular damage?

<p>DNA (D)</p> Signup and view all the answers

What makes free radicals extremely reactive?

<p>Having an unpaired electron in their inner orbitals (D)</p> Signup and view all the answers

What can be broken in free radical reactions?

<p>Any chemical bond (D)</p> Signup and view all the answers

How does oxygen influence free radical formation?

<p>By enabling the creation of more stable free radical species (D)</p> Signup and view all the answers

What is the effect of transfer of a free radical to a biological molecule?

<p>It causes bond breakage or inactivation of key functions (B)</p> Signup and view all the answers

What does the organic peroxy radical do in terms of transferring radicals?

<p>It causes damage at each encounter by transferring radicals from molecule to molecule (C)</p> Signup and view all the answers

Why is DUR important when optimizing radiation doses for irradiation-sensitive materials?

<p>To minimize degradation of the product (A)</p> Signup and view all the answers

What advantage does radiation sterilization have in terms of temperature independence?

<p>It is efficient at both ambient and sub-zero temperatures (C)</p> Signup and view all the answers

What is a key benefit of radiation sterilization in terms of chemical usage?

<p>It does not require any volatile or toxic chemicals (A)</p> Signup and view all the answers

In what aspect is radiation sterilization especially flexible?

<p>Can sterilize products in any phase and with varying characteristics (A)</p> Signup and view all the answers

What contributes to the time efficiency of e-beam sterilization?

<p>Completion within seconds to minutes (C)</p> Signup and view all the answers

What advantage does radiation sterilization offer in terms of packaging?

<p>Final packaging can be maintained during processing (A)</p> Signup and view all the answers

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