Ionic Basis of Ventricular Action Potential
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Questions and Answers

What is the term used to describe the time period during which a cell is unexcitable to stimulation?

  • Absolute refractory period (correct)
  • Relative refractory period
  • Supranormal period
  • Effective refractory period

Which type of fibers can spontaneously generate action potentials without neural input?

  • Atrial fibers
  • SA Node fibers (correct)
  • Purkinje fibers
  • Ventricular fibers

What is a key difference between the resting membrane potential of the SA Node and the Atrial, Ventricular, and Purkinje fibers?

  • Stable resting membrane potential
  • Unstable resting membrane potential (correct)
  • Long duration of action potential
  • Sustained plateau

During which period does stimulation produce a weak action potential that propagates more slowly than usual?

<p>Relative refractory period (C)</p> Signup and view all the answers

Which type of stimulus can trigger an action potential during the supranormal period?

<p>Weaker-than-normal stimulus (A)</p> Signup and view all the answers

What distinguishes the ERP (effective refractory period) from the ARP (absolute refractory period)?

<p>Localized depolarisation that does not propagate (D)</p> Signup and view all the answers

Which phase of the cardiac action potential is characterized by the movement of the membrane potential towards the resting potential?

<p>Phase 3 (B)</p> Signup and view all the answers

Which type of potassium current is responsible for maintaining the resting membrane potential?

<p>I$_K1$ (C)</p> Signup and view all the answers

What is the primary difference between the delayed rectifier potassium currents I$_Ks$ and I$_Kr$?

<p>I$_Ks$ is a slow current, while I$_Kr$ is a rapid current (D)</p> Signup and view all the answers

What is the primary ionic mechanism responsible for the repolarization phase (phase 3) of the ventricular action potential?

<p>Decrease in the inward calcium current (I$_Ca$) and increase in the outward potassium currents (I$_Ks$, I$_Kr$) (B)</p> Signup and view all the answers

Which phase of the cardiac action potential is characterized by a stable membrane potential?

<p>Phase 4 (D)</p> Signup and view all the answers

Which phase of the SA node action potential is characterized by repolarization?

<p>Phase 3 (B)</p> Signup and view all the answers

Which type of potassium current is responsible for the transient outward phase (phase 1) of the cardiac action potential?

<p>I$_to$ (B)</p> Signup and view all the answers

What ion current contributes to the slow depolarization in Phase 4 of the SA node action potential?

<p>Inward Na+ current (D)</p> Signup and view all the answers

Which phase of the SA node action potential accounts for the automaticity of SA node cells?

<p>Phase 4 (D)</p> Signup and view all the answers

What sets the heart rate in relation to the SA node action potential?

<p>Rate of phase 4 depolarization (D)</p> Signup and view all the answers

What is the most negative value of the membrane potential in the SA node action potential?

<p>~ -65 mV (B)</p> Signup and view all the answers

In the SA node action potential, what brings the membrane potential to threshold for Ca2+ channels to open?

<p>Inward Na+ current (B)</p> Signup and view all the answers

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