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Questions and Answers
What is the primary function of the capsid in a virus?
What is the primary function of the capsid in a virus?
- To facilitate the entry of the virus into the host cell
- To store energy for the virus
- To enclose and protect the nucleic acid genome (correct)
- To assist in the replication of the viral genome
Which of the following accurately describes enveloped viruses?
Which of the following accurately describes enveloped viruses?
- They have a lipid bilayer surrounding the capsid (correct)
- They can only infect bacteria
- They always exist in a lytic cycle
- They lack a capsid structure
Which type of viral genome consists of both single-stranded and double-stranded forms?
Which type of viral genome consists of both single-stranded and double-stranded forms?
- Viruses with complex structures
- Both DNA and RNA viruses (correct)
- DNA viruses only
- RNA viruses only
What differentiates a naked virus from an enveloped virus?
What differentiates a naked virus from an enveloped virus?
During which cycle does a virus integrate its genome into the host's DNA and remain latent?
During which cycle does a virus integrate its genome into the host's DNA and remain latent?
What does the term 'obligate intracellular parasites' indicate about viruses?
What does the term 'obligate intracellular parasites' indicate about viruses?
Which method of viral entry involves the virus tricking the host cell into engulfing it?
Which method of viral entry involves the virus tricking the host cell into engulfing it?
Which type of viral capsid structure is characterized by 20 equilateral triangles?
Which type of viral capsid structure is characterized by 20 equilateral triangles?
What is a common characteristic of all viruses?
What is a common characteristic of all viruses?
What role do glycoproteins fulfill in enveloped viruses?
What role do glycoproteins fulfill in enveloped viruses?
What is a defining characteristic of viruses that distinguishes them from living cells?
What is a defining characteristic of viruses that distinguishes them from living cells?
What component of a virus protects its genetic material?
What component of a virus protects its genetic material?
Which type of viral genome is characterized by having a single strand of nucleic acid?
Which type of viral genome is characterized by having a single strand of nucleic acid?
What distinguishes an enveloped virus from a naked virus?
What distinguishes an enveloped virus from a naked virus?
In which viral replication cycle does the viral DNA remain dormant within the host cell?
In which viral replication cycle does the viral DNA remain dormant within the host cell?
Which viral entry mechanism is characterized by the virus fusing with the host cell membrane?
Which viral entry mechanism is characterized by the virus fusing with the host cell membrane?
What term describes the exchange of genetic material between two different viruses within a host cell?
What term describes the exchange of genetic material between two different viruses within a host cell?
What type of virus structure involves viral proteins arranged in a way that forms a 20-sided shape?
What type of virus structure involves viral proteins arranged in a way that forms a 20-sided shape?
What best describes a bacteriophage's method of injecting genetic material into a host cell?
What best describes a bacteriophage's method of injecting genetic material into a host cell?
What is the purpose of glycoproteins found on the surface of some viruses?
What is the purpose of glycoproteins found on the surface of some viruses?
What component is unique to enveloped viruses and absent in naked viruses?
What component is unique to enveloped viruses and absent in naked viruses?
Which type of viral genome consists of either DNA or RNA but never both?
Which type of viral genome consists of either DNA or RNA but never both?
What structure protects the viral genetic material and helps it survive outside the host cell?
What structure protects the viral genetic material and helps it survive outside the host cell?
Which type of viral entry mechanism involves the use of host cell receptors for virus uptake?
Which type of viral entry mechanism involves the use of host cell receptors for virus uptake?
In which viral replication cycle do viruses proliferate and ultimately cause the host cell to lyse?
In which viral replication cycle do viruses proliferate and ultimately cause the host cell to lyse?
What is the process by which segmented viruses exchange genetic material?
What is the process by which segmented viruses exchange genetic material?
Which capsid structure is specifically arranged helically to form a tube-like appearance?
Which capsid structure is specifically arranged helically to form a tube-like appearance?
What type of viral genetic material is characterized by its double-stranded form?
What type of viral genetic material is characterized by its double-stranded form?
Which step is key in the transition from a lysogenic cycle to a lytic cycle?
Which step is key in the transition from a lysogenic cycle to a lytic cycle?
Which classification of viruses infects bacterial cells specifically?
Which classification of viruses infects bacterial cells specifically?
What is the primary feature that distinguishes a complex capsid structure from other types?
What is the primary feature that distinguishes a complex capsid structure from other types?
Which of the following accurately describes naked viruses?
Which of the following accurately describes naked viruses?
What characterizes the lytic cycle of viral replication?
What characterizes the lytic cycle of viral replication?
Which factor is NOT used to classify viruses?
Which factor is NOT used to classify viruses?
Which type of viral genome is defined as containing circular forms?
Which type of viral genome is defined as containing circular forms?
What distinguishes enveloped viruses from naked viruses in terms of structure?
What distinguishes enveloped viruses from naked viruses in terms of structure?
In viral entry, which mechanism involves exploiting host cell receptors?
In viral entry, which mechanism involves exploiting host cell receptors?
During which cycle does a virus replicate without killing the host cell?
During which cycle does a virus replicate without killing the host cell?
What is a common method by which bacteriophages inject their genetic material into host cells?
What is a common method by which bacteriophages inject their genetic material into host cells?
Which of the following statements about glycoproteins in viruses is TRUE?
Which of the following statements about glycoproteins in viruses is TRUE?
What is the structure that consists of a viral genome protected by a protein coat?
What is the structure that consists of a viral genome protected by a protein coat?
Which of the following best describes the lytic cycle?
Which of the following best describes the lytic cycle?
What main factor is NOT used in the classification of viruses?
What main factor is NOT used in the classification of viruses?
Which type of viruses contain a lipid bilayer membrane?
Which type of viruses contain a lipid bilayer membrane?
What is a common characteristic of segmented viral genomes?
What is a common characteristic of segmented viral genomes?
What occurs during the lysogenic cycle of a virus?
What occurs during the lysogenic cycle of a virus?
Which characteristic defines helical viruses?
Which characteristic defines helical viruses?
Which method does a naked virus use to enter a host cell?
Which method does a naked virus use to enter a host cell?
What describes the role of glycoproteins within the viral envelope?
What describes the role of glycoproteins within the viral envelope?
What mechanism is primarily responsible for genetic exchange between viruses?
What mechanism is primarily responsible for genetic exchange between viruses?
What best describes the structure of a virus?
What best describes the structure of a virus?
In which type of capsid structure are proteins arranged in a helical formation?
In which type of capsid structure are proteins arranged in a helical formation?
What characteristic describes a virus with a lipid envelop?
What characteristic describes a virus with a lipid envelop?
Which viral infection method is common for enveloped viruses?
Which viral infection method is common for enveloped viruses?
What type of virus specifically targets bacteria?
What type of virus specifically targets bacteria?
Which term describes the phase where a virus replicates and causes the host cell to burst?
Which term describes the phase where a virus replicates and causes the host cell to burst?
What components are found in the nucleocapsid of a virus?
What components are found in the nucleocapsid of a virus?
What method do viruses commonly use to enter host cells?
What method do viruses commonly use to enter host cells?
What is NOT a criterion used for classifying viruses?
What is NOT a criterion used for classifying viruses?
What best defines the viral genome?
What best defines the viral genome?
What defines viruses as obligate intracellular parasites?
What defines viruses as obligate intracellular parasites?
Which best describes the composition of a virus's nucleocapsid?
Which best describes the composition of a virus's nucleocapsid?
What is a distinguishing feature of RNA viruses compared to DNA viruses?
What is a distinguishing feature of RNA viruses compared to DNA viruses?
What feature differentiates complex viruses from helical and icosahedral viruses?
What feature differentiates complex viruses from helical and icosahedral viruses?
Which method of viral entry involves interaction with specific receptors on the host cell's surface?
Which method of viral entry involves interaction with specific receptors on the host cell's surface?
During which viral cycle does the host cell eventually burst to release new virions?
During which viral cycle does the host cell eventually burst to release new virions?
What primary factor classifies viruses when considering their genome composition?
What primary factor classifies viruses when considering their genome composition?
What characterizes enveloped viruses compared to naked viruses?
What characterizes enveloped viruses compared to naked viruses?
Which of the following best describes glycoproteins found on enveloped viruses?
Which of the following best describes glycoproteins found on enveloped viruses?
Which viral attribute is essential for identifying the type of host a virus can infect?
Which viral attribute is essential for identifying the type of host a virus can infect?
Which mechanism of genetic exchange involves the combination of genetic material from segmented viruses?
Which mechanism of genetic exchange involves the combination of genetic material from segmented viruses?
What is complementation in the context of viral interactions?
What is complementation in the context of viral interactions?
What is NOT a characteristic of the lytic cycle?
What is NOT a characteristic of the lytic cycle?
Which of the following best describes phenotypic mixing?
Which of the following best describes phenotypic mixing?
What role does recombination play in viral genetics?
What role does recombination play in viral genetics?
Which best describes the condition of a dormant virus in the lysogenic cycle?
Which best describes the condition of a dormant virus in the lysogenic cycle?
What is the potential impact of reassortment in viruses?
What is the potential impact of reassortment in viruses?
What distinguishes lytic viruses from lysogenic viruses?
What distinguishes lytic viruses from lysogenic viruses?
What is an example of a virus that utilizes complementation?
What is an example of a virus that utilizes complementation?
What is the primary function of the viral nucleocapsid?
What is the primary function of the viral nucleocapsid?
Which of the following correctly describes the characteristics of naked viruses?
Which of the following correctly describes the characteristics of naked viruses?
What type of host do bacteriophages specifically infect?
What type of host do bacteriophages specifically infect?
What is a key characteristic of the lytic cycle in viral multiplication?
What is a key characteristic of the lytic cycle in viral multiplication?
Which method allows enveloped viruses to enter host cells?
Which method allows enveloped viruses to enter host cells?
What aspect of viral classification does genome geometry refer to?
What aspect of viral classification does genome geometry refer to?
Which viral feature aids in binding to receptor sites on host cells?
Which viral feature aids in binding to receptor sites on host cells?
What distinguishes a complex virus from helical and icosahedral viruses?
What distinguishes a complex virus from helical and icosahedral viruses?
Which statement accurately reflects the replication process of viruses?
Which statement accurately reflects the replication process of viruses?
What describes the process by which some viruses can remain dormant in host cells?
What describes the process by which some viruses can remain dormant in host cells?
What mechanism involves the exchange of segments of a viral genome between two virions?
What mechanism involves the exchange of segments of a viral genome between two virions?
Which method allows a defective virus to gain missing components from a functional virus?
Which method allows a defective virus to gain missing components from a functional virus?
What is the purpose of phenotypic mixing in viruses?
What is the purpose of phenotypic mixing in viruses?
Which characteristic about viruses is true regarding their classification?
Which characteristic about viruses is true regarding their classification?
What does recombination in viruses refer to?
What does recombination in viruses refer to?
What is a major distinction between lytic and lysogenic cycles in viruses?
What is a major distinction between lytic and lysogenic cycles in viruses?
Which viral exchange mechanism does not involve the direct exchange of genetic material?
Which viral exchange mechanism does not involve the direct exchange of genetic material?
What type of viruses use reassortment as a mechanism for genetic exchange?
What type of viruses use reassortment as a mechanism for genetic exchange?
What role does capsid protein exchange play in phenotypic mixing?
What role does capsid protein exchange play in phenotypic mixing?
Which of the following statements is NOT true about viruses?
Which of the following statements is NOT true about viruses?
What defines the primary structure of a virus?
What defines the primary structure of a virus?
Which of the following accurately describes the lytic cycle of viral replication?
Which of the following accurately describes the lytic cycle of viral replication?
How are viruses classified based on their genome composition?
How are viruses classified based on their genome composition?
What is a key characteristic of naked viruses?
What is a key characteristic of naked viruses?
What mechanism do envelope viruses primarily use to enter host cells?
What mechanism do envelope viruses primarily use to enter host cells?
Which viral structure is described as having proteins arranged in a tube-like form?
Which viral structure is described as having proteins arranged in a tube-like form?
What occurs during the process of recombination in viruses?
What occurs during the process of recombination in viruses?
What distinguishes a icosahedral virus from a helical virus?
What distinguishes a icosahedral virus from a helical virus?
What is the primary consequence of a virus using the lytic cycle?
What is the primary consequence of a virus using the lytic cycle?
In which replication cycle does viral genetic material integrate into the host's genome?
In which replication cycle does viral genetic material integrate into the host's genome?
Flashcards
Obligate intracellular parasite
Obligate intracellular parasite
A virus that needs a host cell to replicate.
Virus Genome
Virus Genome
Either DNA or RNA, but never both, that carries the genetic instructions of a virus.
Capsid
Capsid
The protein coat that protects a virus's genome.
Helical Capsid
Helical Capsid
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Icosahedral Capsid
Icosahedral Capsid
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Lytic Cycle
Lytic Cycle
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Lysogenic Cycle
Lysogenic Cycle
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Enveloped Virus
Enveloped Virus
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Naked Virus
Naked Virus
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Viral Replication
Viral Replication
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What are viruses considered?
What are viruses considered?
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What is a viral genome?
What is a viral genome?
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What is a capsid?
What is a capsid?
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What is a nucleocapsid?
What is a nucleocapsid?
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What is an envelope?
What is an envelope?
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What are RNA viruses?
What are RNA viruses?
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What is a helical capsid?
What is a helical capsid?
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What is an icosahedral capsid?
What is an icosahedral capsid?
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What is a bacteriophage?
What is a bacteriophage?
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What is the lytic cycle?
What is the lytic cycle?
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Nucleocapsid
Nucleocapsid
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Envelope
Envelope
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Glycoproteins
Glycoproteins
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Bacteriophage
Bacteriophage
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Viral Recombination
Viral Recombination
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Viral Reassortment
Viral Reassortment
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What is a virus?
What is a virus?
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What makes up a virus?
What makes up a virus?
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What is a viral capsid?
What is a viral capsid?
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How do viruses classify?
How do viruses classify?
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How do bacteriophages enter cells?
How do bacteriophages enter cells?
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What is the lysogenic cycle?
What is the lysogenic cycle?
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How do viruses exchange genetic material?
How do viruses exchange genetic material?
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What makes a virus different from living organisms?
What makes a virus different from living organisms?
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What is the function of a viral envelope?
What is the function of a viral envelope?
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What are the two main viral replication cycles?
What are the two main viral replication cycles?
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How does a virus enter its host cell?
How does a virus enter its host cell?
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Types of viral capsid structures
Types of viral capsid structures
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Viral classification by genome
Viral classification by genome
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What are bacteriophages?
What are bacteriophages?
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How do viruses use their host's machinery?
How do viruses use their host's machinery?
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What is viral recombination?
What is viral recombination?
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What makes viruses non-living?
What makes viruses non-living?
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Complementation
Complementation
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Phenotypic Mixing
Phenotypic Mixing
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What are the two main viral infection strategies?
What are the two main viral infection strategies?
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How does viral recombination occur?
How does viral recombination occur?
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What is the significance of viral reassortment?
What is the significance of viral reassortment?
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What is the difference between complementation and phenotypic mixing?
What is the difference between complementation and phenotypic mixing?
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What is a segmented genome?
What is a segmented genome?
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What is a defective virus?
What is a defective virus?
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How does viral recombination differ from reassortment?
How does viral recombination differ from reassortment?
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What is the significance of phenotypic mixing?
What is the significance of phenotypic mixing?
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Why are viruses considered obligate intracellular parasites?
Why are viruses considered obligate intracellular parasites?
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What are the different ways viruses can exchange genetic material?
What are the different ways viruses can exchange genetic material?
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Study Notes
Introduction to Virology
- Viruses are considered obligate intracellular parasites: they require a host cell to replicate.
- They blur the line between living and non-living entities: they are not cells, but they can replicate and make proteins once inside a host cell.
- Viruses are essentially genome packages made up of:
- Nucleic acid genome: either DNA or RNA, but never both.
- Protein coat (capsid): encloses the genome and protects it.
- Nucleocapsid: capsid and genetic material together.
- Envelope (optional): a lipid membrane surrounding the capsid.
- Glycoproteins: on the envelope, used for binding to host cells.
Virus Classification
- Genome Composition:
- Type of Nucleic Acid: DNA viruses or RNA viruses.
- Number of Strands: Single-stranded or double-stranded DNA or RNA (but only one type at a time).
- Genome Geometry: Linear or circular.
- Capsid Structure:
- Helical: Capsomers (proteins) arranged in a helical structure, forming a tube-like shape. Example: Tobacco mosaic virus.
- Icosahedral: Capsomers form 20 equilateral triangles, creating a 20-sided diamond shape. Example: Poliovirus.
- Complex: Combination of helical and icosahedral structures.
- Presence of an Envelope:
- Naked viruses: Lack an envelope.
- Enveloped viruses: Possess a lipid bilayer envelope surrounding the capsid. Example: Influenza.
- Type of Host:
- Viruses can infect various organisms. Example: Bacteriophages (viruses that infect bacteria).
- Method of Action: This can influence how a virus enters its host cell:
- Tail Injection: Some viruses, particularly bacteriophages, have tail structures that inject their genetic material into a cell.
- Direct Fusion: Enveloped viruses can fuse their lipid bilayer with the host cell membrane.
- Receptor-Mediated Endocytosis: Naked or enveloped viruses can enter through host cell receptors, tricking the cell into engulfing them.
Viral Replication Cycles
- Lytic Cycle:
- The virus uses the host cell's machinery to replicate and produce new viral particles.
- Eventually, the host cell bursts (lyses) and releases the newly formed viruses.
- Lysogenic Cycle:
- The viral genome integrates into the host cell's genome and remains dormant (latent).
- The host replicates its own genetic material, including the viral genome, producing more infected cells.
- Under certain triggers, the latent viral genome can enter the lytic cycle, leading to virus production.
Viral Genetic Exchange
- Recombination: Two viruses exchange genetic material within a host cell.
- Reassortment: Only in viruses with segmented genomes (e.g., influenza, bunyaviruses, orthomyxoviruses, arenaviruses, reoviruses), different segments of genetic material are exchanged between two viruses. This can lead to pandemics and epidemics.
- Complementation: A functional virus provides missing components to a defective virus. Example: Hepatitis B providing an antigen to Hepatitis D.
- Phenotypic Mixing: Two functional viruses exchange protein capsids, allowing for the transfer of viral characteristics even if the genetic material remains unchanged.
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