Introduction to Muscle Tissue

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Questions and Answers

Which characteristic is not shared by all three types of muscle tissue (skeletal, cardiac, and smooth)?

  • Voluntary control via the nervous system (correct)
  • Contractibility to generate tension
  • Elasticity allowing return to original length
  • Excitability in response to stimuli

A patient has difficulty swallowing and controlling urination. Which function of skeletal muscle is most likely impaired?

  • Maintaining posture and body position
  • Producing skeletal movement
  • Maintaining body temperature
  • Regulating entering and exiting of material (correct)

Which connective tissue layer directly surrounds individual skeletal muscle fibers?

  • Perimysium
  • Endomysium (correct)
  • Epimysium
  • Fascicle

If a muscle is damaged, which specialized cells located between the endomysium and muscle fibers help in its repair?

<p>Satellite cells (A)</p> Signup and view all the answers

Which structure directly facilitates the transmission of electrical impulses from the sarcolemma into the interior of the muscle fiber?

<p>Transverse tubules (T-tubules) (B)</p> Signup and view all the answers

What is the primary role of the sarcoplasmic reticulum in muscle contraction?

<p>Storing and releasing calcium ions (D)</p> Signup and view all the answers

During muscle contraction, what prevents actin and myosin from interacting when the muscle is at rest?

<p>Tropomyosin (B)</p> Signup and view all the answers

Which event directly triggers the release of calcium ions from the sarcoplasmic reticulum, initiating muscle contraction?

<p>Arrival of an action potential along the T-tubules (A)</p> Signup and view all the answers

What is the primary role of creatine phosphate in muscle contraction?

<p>Regenerating ATP from ADP (A)</p> Signup and view all the answers

What is the function of acetylcholinesterase (AChE) in the neuromuscular junction?

<p>Breaking down acetylcholine (ACh) (C)</p> Signup and view all the answers

Why does rigor mortis occur after death?

<p>Lack of ATP prevents detachment of myosin from actin (C)</p> Signup and view all the answers

Which of the following best describes the sliding filament theory of muscle contraction?

<p>Actin and myosin filaments slide past each other, shortening the sarcomere. (B)</p> Signup and view all the answers

Which of the following events occurs first at the neuromuscular junction to initiate muscle contraction?

<p>Binding of acetylcholine to receptors on the sarcolemma. (D)</p> Signup and view all the answers

Which muscle type is responsible for involuntary movements within the digestive tract?

<p>Smooth muscle (B)</p> Signup and view all the answers

What is the role of the transverse tubules (T-tubules) in muscle contraction?

<p>To transmit action potentials deep into the muscle fiber (A)</p> Signup and view all the answers

Which of the following describes the function of the muscles of facial expression?

<p>They originate on the surface of the skull and move the skin. (C)</p> Signup and view all the answers

Which cranial nerve innervates the muscles of facial expression?

<p>Facial nerve (VII) (C)</p> Signup and view all the answers

What is the primary action of the external intercostal muscles during respiration?

<p>Elevating the ribs upward and anteriorly for inhalation (A)</p> Signup and view all the answers

Which muscle is primarily responsible for dividing the thoracic and abdominopelvic cavities?

<p>Diaphragm (B)</p> Signup and view all the answers

What is the linea alba?

<p>A median collagenous partition dividing the rectus abdominis (D)</p> Signup and view all the answers

Which group of muscles primarily moves the pectoral girdle and upper limb?

<p>Superficial layer of the back (C)</p> Signup and view all the answers

A patient is diagnosed with TMJ syndrome. Which group of muscles is most likely affected?

<p>Muscles of mastication (B)</p> Signup and view all the answers

Which of the following muscles constricts to decrease the volume of the thoracic cavity to facilitate forced expiration?

<p>Internal intercostals (B)</p> Signup and view all the answers

A patient experiences a herniation where part of the stomach protrudes through the diaphragm. What condition is likely indicated?

<p>Hiatal Hernia (A)</p> Signup and view all the answers

The Erector Spinae group consists of 3 muscles. What is the correct order from lateral to medial?

<p>Iliocostalis, Longissimus, Spinalis (A)</p> Signup and view all the answers

What is the result of increased mitochondrial biogenesis within a skeletal muscle fiber?

<p>Increased fatigue resistance (D)</p> Signup and view all the answers

How does the zone of overlap within the sarcomere contribute to muscle contraction?

<p>It is where thick and thin filaments bind to create muscle contractions (B)</p> Signup and view all the answers

What would happen if acetylcholinesterase (AChE) were inhibited at the neuromuscular junction?

<p>ACh would not be properly removed from the synaptic cleft so this would lead to prolonged muscle stimulation. (B)</p> Signup and view all the answers

What structural change in the sarcomere is directly responsible for muscle contraction, according to the sliding filament theory?

<p>The I band shortens. (B)</p> Signup and view all the answers

Why does the vertebral column require only a few flexor muscles?

<p>Body weight lies anterior to the column, flexing the spine using gravity. (C)</p> Signup and view all the answers

A newborn is diagnosed with Diastasis Recti. What anatomical structures would be directly involved in this condition?

<p>Rectus Abdominis Muscle &amp; Linea Alba (A)</p> Signup and view all the answers

A patient has damage to their 9th cranial nerve (glossopharyngeal). Which function is mostly likely affected?

<p>Initiation of swallowing (D)</p> Signup and view all the answers

What is the action of the superior oblique extra-ocular muscle?

<p>Moves the eye laterally and down (C)</p> Signup and view all the answers

What is the functional unit of the muscle fiber?

<p>Sarcomere (D)</p> Signup and view all the answers

A doctor is explaining that the patient has a muscular problem (strain) versus a ligamentous problem (sprain). What area of their body are they talking about?

<p>Lower Back (D)</p> Signup and view all the answers

What is the function of muscles in the pelvic floor?

<p>Primarily support the organs of the pelvic cavity, flex sacroccygeal joints and provide support for materials passing through the Urethra and anus (C)</p> Signup and view all the answers

What is the definition of myotomes?

<p>It is the group of muscles that a single spinal nerve root innervates. (D)</p> Signup and view all the answers

Which muscles control the position of the larynx, depress the mandible, and tense the floor of the mouth?

<p>Anterior muscles of the neck (A)</p> Signup and view all the answers

What causes muscle recoil after contraction?

<p>The epimysium, perimysium, and endomysium retract (B)</p> Signup and view all the answers

What is the purpose of intrafusal muscle fibers?

<p>Serves as specialized sensory organs to detect the amount and rate of change in muscle length (D)</p> Signup and view all the answers

Flashcards

Excitability (muscle tissue)

The ability to respond to stimulation, such as by the nervous system or hormones.

Contractibility

The ability to shorten actively and exert a pull or tension.

Extensibility

The ability to continue to contract over a range of resting lengths.

Elasticity

The ability of a muscle to return to its original length after contraction.

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Produce Skeletal movement

Move the body by pulling on bones of the skeleton.

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Maintain Posture

Constant muscle contractions maintain posture and body position.

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Support Soft Tissues

Layers of skeletal muscle support the weight of visceral organs and protect internal tissues.

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Regulate Entering and Existing of Material

Muscles encircle openings of the digestive and urinary tracts, providing voluntary control.

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Maintain Body Temperature

Muscle contractions require energy, converting some to heat and maintaining body temperature.

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Perimysium

The connective tissue that divides muscle into compartments, each containing a fascicle.

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Endomysium

A delicate network of reticular fibers that surrounds each skeletal muscle fiber.

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Fascicle

A bundle of muscle fibers within a muscle, surrounded by perimysium.

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Tendons

Cord-like or cable-like connective tissues connecting muscles to bones.

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Aponeuroses

Flat, sheet-like tendons.

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Sarcoplasm

The cytoplasm of a muscle fiber.

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Sarcolemma

The cell membrane of a muscle fiber.

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Sarcoplasmic Reticulum

A network of tubules, vesicles, and cisternae within muscle cells for storing calcium ions.

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Myofibrils

Cylindrical structures within muscle cells made of actin and myosin.

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Myofilaments

Protein filaments (actin and myosin) that constitute myofibrils.

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Sarcomere

The basic functional unit of muscle fiber, composed of actin and myosin filaments.

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Z line (Z disc)

End of the sarcomere.

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A band

Includes the M line, H band and zone of overlap.

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I band

The region between the A band and the Z line which only contains actin filaments.

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Tropomyosin

A protein that covers active sites on actin, preventing actin-myosin interaction when the muscle is at rest

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Troponin

Binds to tropomyosin and regulates muscle contraction by moving tropomyosin away from active sites on actin when calcium is present.

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Sarcopenia

Age-related loss of muscle mass and function

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Muscle Hypertrophy

Increase in muscle size due to an increase in the size (not number) of muscle fibers

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Sliding Filament Theory

Muscle contraction explained by the sliding of actin and myosin filaments.

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Sliding occurs

Filaments slide past each other when myosin heads bind to active sites on actin.

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Motor Neuron

It releases chemicals at synapses to communicate with muscle fibers, triggering contraction.

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Acetylcholine (ACh)

A neurotransmitter released by motor neurons to stimulate muscle contraction.

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Synaptic Cleft

The space between a motor neuron's synaptic terminal and the muscle fiber's motor end plate.

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Acetylcholinesterase (AChE)

An enzyme in the synaptic cleft that breaks down acetylcholine to stop muscle stimulation.

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Myotomes

The group of muscles innervated by a single spinal nerve root

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Rigor Mortis

Stiffness of muscles after death due to lack of ATP and calcium buildup.

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Axial Musculature functions

Move head, vertebral column, and rib cage for breathing.

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Muscles of Head and Neck

Facial, oculomotor, mastication, pharynx, and anterior neck muscles.

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Extra-ocular Muscles

Move the eyes, innervated by cranial nerves III, IV, and VI.

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Muscles of Mastication

Temporalis, masseter, pterygoids; move the mandible at the temporomandibular joint.

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Muscles of the Vertebral Column

Trapezius, latissimus dorsi, erector spinae, deep layer muscles.

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Muscles of Anterior Torso

Oblique and rectus muscles: scalenes, intercostals, abdominal muscles.

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Study Notes

Introduction to Muscle Tissue

  • Muscle tissue is one of the four primary tissue types in the body.
  • It consists of muscle fibers, which are elongate cells capable of contracting along their longitudinal axis.
  • There are three types of muscle tissue: skeletal, cardiac, and smooth.
  • Skeletal muscle moves the body by pulling on bones.
  • Cardiac muscle pushes blood through the circulatory system.
  • Smooth muscle pushes fluids and solids along the digestive tract and performs varied functions in other systems.
  • Muscle tissues share four basic properties: excitability, contractibility, extensibility, and elasticity.
  • Excitability is the ability to respond to stimulation. Skeletal muscles normally respond to stimulation by the nervous system. Cardiac and smooth muscles respond to the nervous system and circulating hormones.
  • Contractibility is the ability to shorten actively and exert a pull or tension.
  • Extensibility is the ability to continue to contract over a range of resting lengths.
  • Elasticity is the ability of a muscle to rebound toward its original length after a contraction.

Functions of Skeletal Muscle

  • Skeletal muscles are contractile organs attached to bones of the skeleton directly or indirectly.
  • Functions of skeletal muscle include producing skeletal movement, maintaining posture and body position, supporting soft tissues, regulating entering and exiting of material and maintaining body temperature.

Gross Anatomy of Skeletal Muscles

  • Greek words sarkos (“flesh”) and mys (“muscle”) are prefixes to terms of the muscular system.
  • The perimysium divides the muscle into fascicles, which contain bundles of muscle fibers.
  • The perimysium contains blood vessels and nerves that supply each fascicle.
  • The endomysium is a network of reticular fibers that surrounds each skeletal muscle fiber.
  • The endomysium binds muscle fibers to each other and supports capillaries.
  • Satellite cells, which function in the repair of damaged tissue, lie between the endomysium and muscle fibers.
  • Connective tissue fibers of the endomysium and perimysium are interwoven, and those of the perimysium blend into the epimysium.
  • Collagen fibers of the epimysium, perimysium, and endomysium may converge to form a fibrous connection of the muscle to bone, skin, or another muscle.
  • These connections form tendons (thick cords or cables) or aponeuroses (flattened sheets).

Microanatomy of Skeletal Muscle Fibers

  • Skeletal muscle fibers (myocytes) differ from other cells.
  • They are very large, with a diameter of 100 µm and a length exceeding 12-16 inches.
  • The sarcoplasm (cytoplasm) contains hundreds to thousands of myofibrils.
  • Each myofibril is a cylindrical structure 1–2 µm in diameter and as long as the entire cell.
  • The sarcolemma is the cell membrane of a skeletal muscle fiber.
  • The sarcoplasmic reticulum (SR) is a network of tubules, vesicles, and cisternae.
  • The sarcoplasmic reticulum (SR) stores calcium ions needed for muscle contraction.
  • Mitochondria and glycogen granules are scattered among the myofibrils.
  • A typical skeletal muscle fiber has hundreds of mitochondria.
  • The entire cell shortens when a myofibril contracts.
  • Mitochondrial biogenesis is the process by which new mitochondria are formed in the cell.
  • There are two types of skeletal muscle fibers: extrafusal and intrafusal.
  • Extrafusal muscle fibers make up the large mass of skeletal muscle tissue that contract.
  • Intrafusal muscle fibers are skeletal muscle fibers that serve as specialized sensory organs (proprioceptors that detect the amount and rate of change in fiber length).

Myofibrils and Myofilaments

  • Myofibrils consist of bundles of myofilaments, which are protein filaments primarily made of actin and myosin.
  • Actin filaments are “thin filaments."
  • Myosin filaments are “thick filaments."
  • Myosin heads are known as cross-bridges, connecting thick and thin filaments during muscle contraction.
  • Actin and myosin are organized in repeating hexagonal units called sarcomeres.

Sarcomere Organization

  • Sarcomeres give the muscle a striated appearance.
  • Thick and thin filaments within a myofibril are organized in sarcomeres.
  • Myofibrils are arranged parallel to the long axis of the cell, with their sarcomeres lying side by side.
  • Each myofibril consists of approximately 10,000 sarcomeres.
  • Sarcomeres are the smallest functional units of the muscle fiber.
  • Interactions between thick and thin filaments of sarcomeres cause skeletal muscle fiber contractions.
  • The Z line delineates the ends of the sarcomere.
  • Thick filaments lie in the center of the sarcomere called the M line.
  • The H zone contains exclusively myosin filaments.
  • The A band includes the M line, H band, and zone of overlap (thick and thin filaments).
  • The region between the A band and the Z line is part of the I band, which contains only actin filaments.
  • The zone of overlap is where the thin filaments pass between the thick filaments.
  • Thin filaments (actin) also contain tropomyosin (covers active sites) and troponin (holds tropomyosin in place).
  • Sarcopenia is age related loss of muscle mass and function.
  • Muscle Hypertrophy is an increase in the amount of cell subunits known as the myofilaments.

Muscle Contraction Theory and Process

  • The sliding filament theory explains the mechanism for muscle contraction.
  • The trigger for contraction is the presence of calcium ions, and the contraction requires ATP.
  • Sliding occurs when myosin heads of thick filaments bind to active sites on thin filaments.
  • Skeletal muscle cells transport calcium ions into the terminal cisternae of the sarcoplasmic reticulum. Electrical events at the sarcolemmal surface cause a contraction by triggering the release of calcium ions from the terminal cisternae.
  • The electrical impulse is distributed by the transverse tubules that extend deep into the sarcoplasm of the muscle fiber.
  • When an electrical impulse travels along a nearby T tubule, the terminal cisternae become permeable to calcium ions.
  • Calcium ions diffuse into the zone of overlap and bind to troponin.
  • Troponin changes shape and alters the position of the tropomyosin strand, exposing active sites on the actin molecules.
  • Cross-bridge binding then occurs, and the contraction begins.
  • The change in calcium permeability at the terminal cisternae is temporary, so additional impulses must be conducted along the T tubules.
  • When electrical stimulation ends, the sarcoplasmic reticulum will recapture the calcium ions.
  • The troponin–tropomyosin complex covers the active sites, and the contraction ends.
  • The binding and breakdown of ATP prepares the myosin head for binding to an active site on actin.
  • Once a cross-bridge forms, the myosin head pivots and pulls the thin filament toward the center of the sarcomere.
  • Another ATP must bind to the myosin head for it to detach and reload for another cycle.
  • Muscle fibers will eventually stop contracting as they run out of ATP.
  • Creatine is naturally produced in the human body and is transported in the blood for use by muscles.
  • Creatine phosphate (phosphocreatine or PCr) helps to supply energy to cells, primarily muscle, by increasing the formation of ATP.

Neural Control of Muscle Fiber Contraction

  • Chemicals released by the motor neuron at the neuromuscular junction alter the transmembrane potential of the sarcolemma.
  • This change initiates contraction by triggering the release of calcium ions by the sarcoplasmic reticulum.
  • Each skeletal muscle fiber is controlled by a motor neuron inside the central nervous system.
  • The axon of the motor neuron extends to the neuromuscular junction of that muscle fiber.
  • The expanded tip of the axon is called the synaptic terminal.
  • The synaptic terminal contains mitochondria and synaptic vesicles filled with acetylcholine (ACh).
  • Acetylcholine is a neurotransmitter, a chemical released by a neuron to communicate with another cell.
  • The ACh released binds to receptor sites on the motor end plate, initiating a change in the local transmembrane potential.
  • This change results in the generation of an electrical impulse (action potential) that sweeps over the surface of the sarcolemma and into each T tubule.
  • The synaptic cleft separates the synaptic terminal from the motor end plate.
  • The synaptic cleft contains acetylcholinesterase (AChE), which breaks down molecules of ACh.
  • Action potentials will continue to be generated until acetylcholinesterase removes the bound ACh.
  • Myotomes are groups of muscles that a single spinal nerve root innervates.
  • Rigor mortis occurs after death when muscles run out of ATP and the sarcoplasmic riticulum(SR) is unable to remove calcium ions triggering ongoing contraction due to cross bridges not detaching

Muscle Recoil

  • Muscles return to normal length after contraction via muscle recoil.
  • This is due to epimysium, perimysium, and endomysium retracting.
  • Muscle recoil is also aided by antagonists and gravity.

Muscle Contraction Summary

  • At the neuromuscular junction (NMJ), ACh released by the synaptic terminal binds to receptors on the sarcolemma.
  • The SR releases stored calcium ions, increasing the calcium concentration of the sarcoplasm in and around the sarcomeres.
  • Calcium ions bind to troponin, producing a change in the orientation of the troponin–tropomyosin complex that exposes active sites on the thin (actin) filaments.
  • Myosin cross-bridges form when myosin heads bind to active sites.
  • Cycles of cross-bridge binding, pivoting, and detachment occur, powered by the hydrolysis of ATP.
  • Action potential generation ceases as ACh is broken down by acetylcholinesterase (AChE).
  • The SR reabsorbs calcium ions, and the concentration of calcium ions in the sarcoplasm declines.

Axial Musculature

  • Axial musculature moves the head, vertebral column, and rib cage for breathing.

Muscles of Facial Expression

  • Muscles of facial expression originate on the surface of the skull.
  • They move the skin when they contract.
  • These muscles are innervated by the seventh cranial nerve (facial nerve).
  • The largest group of facial muscles is associated with the mouth.
  • Smaller groups of muscles control movements of the eyebrows, eyelids, scalp, nose, and external ear.

Extra-ocular Muscles

  • Six extra-ocular muscles originate on the surface of the orbit and control the position of each eye.
  • The extra-ocular muscles are innervated by the third (oculomotor), fourth (trochlear), and sixth (abducens) cranial nerves.
  • There are 4 rectus muscles: superior, inferior, medial, and lateral.
  • Also, there are inferior and superior oblique muscles

Muscles of the Tongue

  • The muscles of the tongue insert on the tongue and have names ending in -glossus.

Muscles of Mastication

  • The muscles of mastication move the mandible at the temporomandibular joint.

Muscles of the Pharynx

  • The paired pharyngeal muscles are important in the initiation of swallowing and innervated by the ninth (glossopharyngeal) and tenth (vagus) cranial nerves.

Anterior Muscles of the Neck

  • The anterior muscles of the neck control the position of the larynx, depress the mandible, tense the floor of the mouth, and provide a stable foundation for muscles of the tongue and pharynx.
  • Scalene muscles are of interest in class.

Muscles of the Vertebral Column

  • Muscles of the back form three layers: superficial, intermediate, and deep.
  • The superficial muscles include the trapezius and latissimus dorsi, which move the pectoral girdle and upper limb.
  • The intermediate layer includes spinal extensors and lateral flexors which are "I Like Sphagetti": Iliocostalis, Longissimus, and Spinalis.
  • The deep layer interconnects and stabilizes the vertebrae to produce extension or rotation of the vertebral column.
  • Vertebral column muscles include many extensors but few flexors due to location of body weight.

Muscles of the Anterior Thorax and Abdominal Muscles

  • Two classes of muscles are seen in the anterior torso area: Oblique and Rectus.
  • Oblique muscles compress structures or rotate the vertebral column.
  • Rectus muscles are flexors of the vertebral column.
  • The external intercostal muscles aid in inhalation by pulling the ribs up and anteriorly.
  • The internal intercostal muscles aid in forced expiration by forcing the ribs toward one another.
  • Both sets of intercostal muscles are important in costal breathing.
  • The abdomen consists basically of four muscles: the external and internal oblique muscles, the rectus abdominis muscle, and transversus abdominis muscles.
  • The rectus abdominis extends from the xiphoid process to the pubic symphysis.
  • It is divided longitudinally by the linea alba.
  • Transverse tendinous inscriptions divide this muscle into four repeated segments.
  • Diastasis recti is a gap between the two sides of the rectus abdominis muscle.
  • Diastasis recti is caused by the stretching of the linea alba.
  • The transversus abdominis muscles aid in forced expiration and offer support to the abdominal and posterolateral region.

Diaphragm

  • The term diaphragm refers to any muscular sheet that forms a wall.
  • The diaphragm partitions or separates the abdominopelvic and thoracic cavities.
  • Its contraction increases the volume of the thoracic cavity to promote inspiration.
  • Its relaxation decreases the volume to facilitate expiration.
  • Hiatal Hernia mimics heart attacks.

Muscles of the Pelvic Floor

  • Muscles of the pelvic floor extend from the sacrum and coccyx to the ischium and pubis.
  • Three main functions of muscles of the pelvic floor include supporting pelvic organs, flexing the sacrum and coccyx, and controlling urination and defecation.
  • Muscular sphincters surround structures and permit voluntary control of urination and defecation.

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