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Questions and Answers
What is a characteristic of microorganisms?
What is a characteristic of microorganisms?
Which type of cells do bacteria belong to?
Which type of cells do bacteria belong to?
What does infection mean in a microbiological context?
What does infection mean in a microbiological context?
What source can human infections come from?
What source can human infections come from?
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In what manner can infections be transmitted?
In what manner can infections be transmitted?
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Which of the following describes an incubatory carrier?
Which of the following describes an incubatory carrier?
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What type of nucleic acid do viruses contain?
What type of nucleic acid do viruses contain?
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Why is it important to understand the differences between eukaryotic and prokaryotic cells?
Why is it important to understand the differences between eukaryotic and prokaryotic cells?
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Which factors increase the susceptibility to disease after infection?
Which factors increase the susceptibility to disease after infection?
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What is the infectious dose?
What is the infectious dose?
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What role do virulence factors play in microbial infection?
What role do virulence factors play in microbial infection?
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How can pathogens cause disease despite the host's immunity?
How can pathogens cause disease despite the host's immunity?
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What are common transmission routes for infectious agents?
What are common transmission routes for infectious agents?
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Which of the following is NOT a factor that affects disease progression after infection?
Which of the following is NOT a factor that affects disease progression after infection?
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Which statement about the transmission of microbes is correct?
Which statement about the transmission of microbes is correct?
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What is the significance of co-infection regarding disease occurrence?
What is the significance of co-infection regarding disease occurrence?
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What is the causative microbe of COVID-19?
What is the causative microbe of COVID-19?
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Who is the main source of infection in this family?
Who is the main source of infection in this family?
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What are methods of transmission of infection?
What are methods of transmission of infection?
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Is Mohamed a case or a carrier? What type of carrier is he?
Is Mohamed a case or a carrier? What type of carrier is he?
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What is one effective way to prevent the spread of COVID-19 in a community?
What is one effective way to prevent the spread of COVID-19 in a community?
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What distinguishes eukaryotic cells from prokaryotic cells?
What distinguishes eukaryotic cells from prokaryotic cells?
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What type of sources may lead to microbial infections in humans?
What type of sources may lead to microbial infections in humans?
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Which of the following is NOT a factor influencing the fate of an infection?
Which of the following is NOT a factor influencing the fate of an infection?
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Which of these is categorized as a living source of microbial infection?
Which of these is categorized as a living source of microbial infection?
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Microbes of medical importance do NOT include which of the following?
Microbes of medical importance do NOT include which of the following?
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Which factor is NOT associated with increased susceptibility to disease following infection?
Which factor is NOT associated with increased susceptibility to disease following infection?
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Which route of entry for pathogens is likely to increase the risk of disease production?
Which route of entry for pathogens is likely to increase the risk of disease production?
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What contributes to the virulence of certain bacteria?
What contributes to the virulence of certain bacteria?
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Which statement regarding the progression of infection to disease is correct?
Which statement regarding the progression of infection to disease is correct?
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What is a key characteristic of virulent microbes?
What is a key characteristic of virulent microbes?
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What role do co-infections play in disease production?
What role do co-infections play in disease production?
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In which stage of transmission might a microbe NOT lead to disease?
In which stage of transmission might a microbe NOT lead to disease?
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What does the term 'infectious dose' refer to?
What does the term 'infectious dose' refer to?
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What distinguishes microbial infection from human disease?
What distinguishes microbial infection from human disease?
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What plays a crucial role in determining the fate of an infection?
What plays a crucial role in determining the fate of an infection?
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What kind of source can lead to human microbial infections?
What kind of source can lead to human microbial infections?
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Which of the following is an example of a non-human living source of infection?
Which of the following is an example of a non-human living source of infection?
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Which group of microbes does NOT cause disease directly?
Which group of microbes does NOT cause disease directly?
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What is one method to mitigate the spread of infections in a community?
What is one method to mitigate the spread of infections in a community?
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What distinguishes a carrier from a patient in terms of infection?
What distinguishes a carrier from a patient in terms of infection?
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Which statement about the structure of prokaryotic cells is accurate?
Which statement about the structure of prokaryotic cells is accurate?
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How does age influence susceptibility to infection according to host factors?
How does age influence susceptibility to infection according to host factors?
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Which of these statements is true regarding microbial infections?
Which of these statements is true regarding microbial infections?
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In medical microbiology, what type of microbes is primarily studied?
In medical microbiology, what type of microbes is primarily studied?
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What is a significant reason for understanding the differences between eukaryotic and prokaryotic cells in medical microbiology?
What is a significant reason for understanding the differences between eukaryotic and prokaryotic cells in medical microbiology?
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Which type of carrier may not show any symptoms of disease while still being able to transmit infections?
Which type of carrier may not show any symptoms of disease while still being able to transmit infections?
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Which of the following factors is least likely to contribute to the transmission of infections in humans?
Which of the following factors is least likely to contribute to the transmission of infections in humans?
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What role do non-human sources play in human infectious diseases?
What role do non-human sources play in human infectious diseases?
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Which of the following accurately describes a characteristic of microorganisms?
Which of the following accurately describes a characteristic of microorganisms?
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In the context of infections, what does the term 'infectious dose' refer to?
In the context of infections, what does the term 'infectious dose' refer to?
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How may microbial infections indirectly damage human tissues?
How may microbial infections indirectly damage human tissues?
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Which statement best reflects the relationship between infection and disease?
Which statement best reflects the relationship between infection and disease?
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Study Notes
Microbiology - Introduction
- Microbiology is the study of microbes, which are living organisms too small to be seen without a microscope.
- Medical microbiology focuses on microbes causing disease in humans.
- Microbes of medical importance include bacteria, fungi, viruses, and protozoa.
- Bacteria are prokaryotic cells, while human cells are eukaryotic cells.
- Prokaryotic cells lack a nucleus and other membrane-bound organelles. Eukaryotic cells have a nucleus and other membrane-bound organelles.
- Microbes cause disease, but not all microbes cause disease in all cases. The host and microbe both factor into the possibility of disease.
Types of Microbes
- Bacteria are the most common cause of human disease.
- Bacteria are prokaryotic, meaning they lack a nucleus and other membrane-bound organelles.
- Viruses are not considered living cells, containing a single type of nucleic acid (DNA or RNA) surrounded by a protein coat.
- Fungi are eukaryotic organisms.
- Protozoa are single-celled eukaryotic organisms.
- Some bacteria have structures (e.g. pili) that help them attach to and invade cells.
- Some bacteria produce toxins (exotoxins, endotoxins) that contribute to the severity of disease.
- Viruses, fungi, and protozoa vary greatly in size and structure.
Microbial Infections
- Infections occur when microbes enter and interact with a host.
- Infection may or may not lead to disease.
- Infection-causing agents can include bacteria, viruses, fungi, or protozoa.
- The specific factors determine if the infection develops into disease.
Reservoirs of Infection
- Human sources: typical cases, atypical cases, carriers (incubatory, convalescent, contact)
- Non-human sources: animals (rabies, plague, swine flu, malaria), birds (avian flu), insects (malaria).
- Carriers may not show symptoms but can still transmit the infection, acting as reservoirs for disease.
- Reservoirs act as a source of the infectious agent for infection.
Portals of Exit of Microbes
- Respiratory tract: coughing, sneezing, talking.
- Gastrointestinal tract: feces, saliva.
- Skin: through breaks in skin.
- Genital tract: sexual contact.
- Blood: blood transfusions.
- From animals: bites, scratches, consumption of contaminated meat or milk.
Microbial Virulence
- Virulence is a microbe's ability to cause disease.
- Factors contributing to virulence include toxin production (toxigenic strains), invasiveness (ability to invade tissues), and ability to escape the immune response (e.g., by capsules, producing enzymes to protect the microbe).
Factors Affecting Fate of Infection
- Host factors: age, immune status, underlying medical conditions (diabetes, malignancy, some medications).
- Microbial factors: dose (infectious dose), route of entry, co-infection, virulence.
- Route of entry also influences if infection will develop into disease. Microbial factors, such as dose of infection, also determine the likely outcome.
- A pathogen needs to have the correct combination of factors to infect a host..
Clinical Case Study (Example)
- The case study describes a family affected by COVID-19.
- The case highlights the importance of hygiene and safety precautions to prevent disease transmission and progression. The example case can illustrate the role of human contact in disease transmission and progression. The source of COVID-19 infection was a family member, who then spread the virus to others, via respiratory droplets, or other common contact points.
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