Introduction to Medicinal Chemistry

<p>Ion-dipole bonding (C)</p> Signup and view all the answers

<p>Corwin Hansch (D)</p> Signup and view all the answers

<p>It measures the octanol/water coefficient. (B), It assesses the lipophilicity or hydrophilicity of a drug. (D)</p> Signup and view all the answers

<p>The part of a drug responsible for its biological activity (D)</p> Signup and view all the answers

<p>They provide less accurate data than other methods. (B)</p> Signup and view all the answers

<p>LogP greater than 5 (B)</p> Signup and view all the answers

<p>They are biologically equivalent in a certain system (B)</p> Signup and view all the answers

<p>Attraction between nearby covalent bonds. (D)</p> Signup and view all the answers

<p>It involves complex molecular interactions. (D)</p> Signup and view all the answers

<p>A cation with a π-cloud of an aromatic system (B)</p> Signup and view all the answers

<p>PSA less than 60Ų (C)</p> Signup and view all the answers

<p>Near equal molecular shapes. (D)</p> Signup and view all the answers

<p>Compound with a sulfur atom bonded to two oxygen atoms and a nitrogen (C)</p> Signup and view all the answers

<p>Conformational isomers can be interconverted easily without breaking bonds. (B)</p> Signup and view all the answers

<p>Lisinopril (D)</p> Signup and view all the answers

<p>It represents the maximum rate of substrate conversion by an enzyme (D)</p> Signup and view all the answers

<p>Decreases water solubility. (B)</p> Signup and view all the answers

<p>It has a property of being water-hating. (A)</p> Signup and view all the answers

<p>Their effects can be reversed by increasing substrate concentration (C)</p> Signup and view all the answers

<p>Different connectivity of atoms in the molecule (A)</p> Signup and view all the answers

<p>Ionic bonding (C)</p> Signup and view all the answers

<p>They compete for the substrate binding site. (B)</p> Signup and view all the answers

<p>HIV protease inhibitors (C)</p> Signup and view all the answers

<p>They can lead to allergic reactions. (D)</p> Signup and view all the answers

<p>They have a high affinity and may covalently attach to the enzyme. (C)</p> Signup and view all the answers

<p>They utilize the active site to covalently attach to enzyme residues. (B)</p> Signup and view all the answers

<p>They are classified as slow, tight-binding inhibitors. (B)</p> Signup and view all the answers

<p>They covalently attach to active site residues. (C)</p> Signup and view all the answers

<p>Competitive inhibitors (B)</p> Signup and view all the answers

Interaction between an ion and a polar molecule, usually a solvent like water.

Interaction between a positively charged ion and the electron cloud of an aromatic ring.

A group of atoms within a molecule that is responsible for its biological activity.

A molecule that can replace another molecule in a biological system without significantly altering the biological effect.

A functional group that is commonly found in drugs and typically contributes to their acidic properties.

A drug's maximum rate of reaction when fully saturated with substrate.

The substrate concentration at which the reaction rate is half of Vmax.

A molecule that binds to an enzyme and prevents it from reacting with its substrate.

A measurement of a drug's potency, where a lower IC50 value indicates greater potency. It represents the concentration required to inhibit a biological process by 50%.

Molecules that attack electron deficient sites (e.g., carbocations, carbonyl groups), readily donate electrons.

Molecules that readily accept electrons, often have a positive charge or a partially positive site.

A measure of a molecule's lipophilicity, indicating its preference for oil-like environments compared to water. It's a crucial factor in drug absorption and distribution in the body.

A type of interaction between molecules where electron clouds of nearby bonds influence each other, resulting in weak attractive forces. Often considered a type of hydrophobic interaction.

A type of enzyme inhibition where the inhibitor binds reversibly to the active site, competing with the substrate.

Inhibitors that mimic the transition state of the enzyme-substrate reaction, forming strong, stable interactions.

A type of interaction between molecules with permanent dipoles, involving a hydrogen atom bonded to a highly electronegative atom (like oxygen or nitrogen). In biological systems, it's crucial for protein folding and drug-receptor interactions.

Inhibitors that bind slowly but tightly, often forming covalent bonds with the enzyme.

A type of strong interaction between oppositely charged ions. It plays a vital role in stabilizing protein structures and drug interactions with biological targets.

A set of guidelines that predict a drug's potential for oral bioavailability. These rules focus on molecular properties like size, hydrogen bonding capability, and lipophilicity.

A type of irreversible inhibition where a molecule covalently binds to the active site of the enzyme.

Inhibition where a molecule utilizes the enzyme's mechanism to covalently attach to the enzyme.

A barrier composed of specialized cells that regulate the passage of substances from the bloodstream into the brain. It is essential for protecting the brain from harmful compounds.

A specific type of irreversible inhibition where the inhibitor binds to the enzyme through a Michael addition reaction.

The process of analyzing a disease state to identify potential targets and develop targeted therapies.

A computational method that links physico-chemical properties to biological activity.

A pathway in the body that regulates blood pressure, involving an enzyme called angiotensin-converting enzyme (ACE).

An enzyme that plays a key role in regulating blood pressure by converting angiotensin I to angiotensin II, a potent vasoconstrictor.

A drug that inhibits the action of angiotensin-converting enzyme (ACE), leading to lower blood pressure.

A graph used to analyze enzyme kinetics, plotting the inverse of reaction velocity against the inverse of substrate concentration.