Introduction to Hemostasis: Key Terms and Processes

The 1st stage in coagulation - Blood vessels contract to seal the wound and platelet fill the open space by forming a platelet plug.

2nd phase of hemostasis - Enzymatic reaction of plasma coagulation factors results in the production of an insoluble fibrin clot.

Injury 🡪 constriction of blood vessels (to reduce blood flow) 🡪 platelet adherence (to blood vessel wall) 🡪 platelet aggregation (aggregate/ come in contact to one another) 🡪 formation of platelet plug GENERAL PROCESS OF HEMOSTASIS 1.

GENERAL PROCESS OF HEMOSTASIS 2. Formation of ________ plug

GENERAL PROCESS OF HEMOSTASIS 3. Interaction of damaged blood vessels, platelets, and coagulation ________

NORMAL HEMOSTATIC BALANCE - In the body, coagulation and fibrinolysis must be balanced. If there is too much coagulation hypercoagulable state ____________ (formation of clot)

HEMOSTASIS is the series of cellular and humoral system that balances flow of blood within the circulation- cessation of blood flow.

THROMBOSIS is the formation of ______ in a blood vessel.

COAGULATION is the sequential ______ by which multiple plasma enzymes, cofactors, and other related substances interact in sequence to form an insoluble fibrin clot.

FIBRINOGEN is a plasma ______- converted to fibrin at the end of the coagulation cascade. Fibrin is the active form of fibrinogen that serves as the 'glue' to stop bleeding.