Introduction to Genomics I Lecture 1

Lecture 1: Introduction to Genomics

• Course: Introduction to Genomics I (PY5131)
• Instructor: Dr. AK Snabaitis
• Learning Objectives (for Introduction to Genomics):
  • Define "human genome"
  • Understand genomic disorders
  • Explain DNA and chromosome structure
  • Describe chromosomal disorders
• Genomics:
  • The complete set of genetic material in an organism.
  • Studies the structure of genes and their location in the genome.
  • Includes gene expression mechanisms.
  • Also explores proteomics, studying protein expression and modification.
• Human Genome:
  • Sequenced in 2003.
  • Contains approximately 3 billion base pairs.
  • Estimated to have around 30,000 genes.
  • Only ~10% of mammalian DNA encodes genes; the rest is non-coding.
• Genomic Applications:
  • Pharmacogenomics: Combining genomics with pharmaceuticals to create individualized therapies. This involves analyzing an individual's genome to understand their response to drugs and identify specific gene variants for tailored treatments.
  • Understanding Diseases:
    • Identifying the inherited basis for congenital diseases.
    • Understanding the risk of developing cancer and neurological disorders.
    • Predicting chances of developing specific diseases.
• Types of Mutations:
  • Germline Mutations: Occur in the germline (sex cells), potentially affecting all cells.
  • Somatic Mutations: Occur in somatic cells (body cells) and don't affect future generations; can still cause diseases.

This quiz covers the foundational concepts of the human genome and genomic disorders as introduced in Lecture 1 of the course 'Introduction to Genomics I'. You'll explore DNA structure, chromosomal disorders, and applications such as pharmacogenomics, providing a comprehensive understanding of genomic science and its implications.