Introduction to Genetics

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Questions and Answers

What defines a specific amino acid in a protein chain?

  • A specific hemoglobin change
  • A single nucleic acid
  • A sequence of proteins
  • A triplet of nucleotides (correct)

What consequence does a single mutation in DNA have?

  • It results in the same amino acid incorporation
  • It leads to an altered mRNA codon (correct)
  • It causes the protein to function better
  • It does not change the protein sequence

Which condition is a result of a mutation affecting hemoglobin?

  • Muscular dystrophy
  • Sickle-cell anemia (correct)
  • Cystic fibrosis
  • Hemophilia

How many different amino acids can be combined to create diverse proteins?

<p>20 (C)</p> Signup and view all the answers

What shape do normal red blood cells typically have?

<p>Round (A)</p> Signup and view all the answers

What advantage does recombinant DNA technology provide?

<p>It enables gene transfer across species. (B)</p> Signup and view all the answers

What is one reason model organisms are important in genetics research?

<p>Findings in model organisms can be applied to humans. (D)</p> Signup and view all the answers

Which statement best represents a concern regarding model organisms?

<p>Ethical considerations may be necessary. (A)</p> Signup and view all the answers

What was highlighted about genetic mechanisms across organisms?

<p>They are surprisingly similar. (A)</p> Signup and view all the answers

What was a characteristic of the first-generation model organisms?

<p>They were often complex and multi-cellular. (A)</p> Signup and view all the answers

What is the primary purpose of mitosis?

<p>To create two identical daughter cells (B)</p> Signup and view all the answers

What is the haploid number of chromosomes in a gamete compared to the diploid number?

<p>Half the diploid number (C)</p> Signup and view all the answers

What do homologous chromosomes represent?

<p>Chromosomes that exist in pairs (D)</p> Signup and view all the answers

Who is associated with the chromosome theory of inheritance?

<p>Walter Sutton and Theodor Boveri (C)</p> Signup and view all the answers

What is the karyotype of a cell?

<p>A numerical representation of the cell's chromosomes (D)</p> Signup and view all the answers

What does meiosis produce?

<p>Haploid daughter cells (C)</p> Signup and view all the answers

Which statement about Mendel's experiments is correct?

<p>He conducted experiments without knowledge of chromosomes (A)</p> Signup and view all the answers

What distinguishes the process of meiosis from mitosis?

<p>Meiosis produces gametes with half the chromosome number (B)</p> Signup and view all the answers

What function do restriction endonucleases serve in recombinant DNA technology?

<p>They cut DNA at specific sites. (D)</p> Signup and view all the answers

What is the role of DNA ligase in recombinant DNA technology?

<p>It joins two DNA fragments together. (C)</p> Signup and view all the answers

What is the primary outcome of DNA cloning?

<p>Preparation of large numbers of identical DNA molecules. (B)</p> Signup and view all the answers

How do restriction enzymes and DNA ligase work together in cloning?

<p>One cuts DNA fragments and the other joins them. (D)</p> Signup and view all the answers

What process is initiated by the discoveries in the 1970s related to recombinant DNA technology?

<p>Cloning. (C)</p> Signup and view all the answers

What do the terms 'cut and splice' refer to in recombinant DNA technology?

<p>The cutting and joining of DNA fragments. (D)</p> Signup and view all the answers

What are cloning vectors used for in DNA cloning?

<p>To transport DNA fragments into host cells. (A)</p> Signup and view all the answers

Which of the following is NOT a function of the enzymes mentioned in recombinant DNA technology?

<p>Amplifying DNA for sequencing. (B)</p> Signup and view all the answers

What is selective breeding?

<p>Choosing the best animals and crops to breed. (D)</p> Signup and view all the answers

What major theory did William Harvey contribute to biology?

<p>Embryos grow step by step. (A)</p> Signup and view all the answers

Who is known for discovering the structure of DNA?

<p>James Watson and Francis Crick (D)</p> Signup and view all the answers

What does the Central Dogma of molecular biology describe?

<p>The flow of genetic information: DNA → RNA → Protein. (C)</p> Signup and view all the answers

What is recombinant DNA technology used for?

<p>Changing how genes function. (C)</p> Signup and view all the answers

Which scientist is associated with the idea that male semen shapes the baby inside the mother?

<p>Aristotle (B)</p> Signup and view all the answers

What is the main focus of genomics?

<p>The study of all genes in an organism. (A)</p> Signup and view all the answers

What role do proteins play in an organism?

<p>They create traits such as hair color. (C)</p> Signup and view all the answers

What is one application of biotechnology-derived genetic testing?

<p>Prenatal diagnosis (B)</p> Signup and view all the answers

Which of the following is NOT a benefit of biotechnology in agriculture?

<p>Rapid growth rate of crops (D)</p> Signup and view all the answers

What does genomics primarily study?

<p>The structure, function, and evolution of genes (C)</p> Signup and view all the answers

Which of the following is a characteristic of proteomics?

<p>Studies the interactions of proteins under certain conditions (C)</p> Signup and view all the answers

What is a common trait shared by all life, according to the content?

<p>A common origin (B)</p> Signup and view all the answers

Which process involves the cloning of livestock?

<p>Somatic cell nuclear transfer (A)</p> Signup and view all the answers

Which statement about bioinformatics is accurate?

<p>It integrates data to analyze biological information (A)</p> Signup and view all the answers

What is one goal of genetic modification in crop plants?

<p>Enhanced resistance to environmental stress factors (D)</p> Signup and view all the answers

Flashcards

Codon

A sequence of three nucleotides (adenine, guanine, cytosine, thymine) in DNA that codes for a specific amino acid.

DNA Mutation

A change in the nucleotide sequence of DNA that can alter the amino acid sequence of a protein.

Hemoglobin

A type of protein found in red blood cells that carries oxygen throughout the body.

Sickle Cell Anemia

A genetic disease caused by a mutation in the gene that codes for hemoglobin, leading to misshapen red blood cells.

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Protein Synthesis

The process by which a sequence of DNA is used to create a protein.

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Mitosis

The process of cell division that results in two daughter cells, each with the same number of chromosomes as the parent cell.

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Meiosis

The process of cell division that results in four daughter cells, each with half the number of chromosomes as the parent cell.

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Chromosome number

The number of chromosomes in a cell or organism.

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Diploid cell (2n)

A cell that contains two sets of chromosomes, one from each parent.

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Haploid cell (n)

A cell that contains one set of chromosomes.

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Homologous chromosomes

Pairs of chromosomes that carry genes for the same traits and have the same structure.

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Karyotype

A visual representation of the complete set of chromosomes in a cell.

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Chromosome theory of inheritance

The theory that states that genes are located on chromosomes and that the behavior of chromosomes during meiosis explains the patterns of inheritance.

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DNA Cloning

A technique used to produce multiple copies of a specific DNA molecule, like a gene.

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Restriction Enzymes

Enzymes that cut DNA at specific sequences, like molecular scissors.

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DNA Ligase

An enzyme that joins two pieces of DNA together, acting like a molecular glue.

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Cloning Vector

A DNA molecule that can carry a foreign DNA fragment into a host cell, like a DNA delivery vehicle.

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Recombinant DNA Technology

The process of combining DNA from different sources to create a new, recombinant DNA molecule.

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Era of Cloning

The era marked by the advent of recombinant DNA technology, allowing for the manipulation and cloning of genes.

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DNA Fragment Isolation

A technique used to isolate and amplify specific DNA fragments from a larger DNA sample.

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Recombinant DNA Applications

The use of recombinant DNA technology to produce new products or modify existing ones.

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Genomics

A field of biology that focuses on studying the complete set of genes and their interactions within an organism.

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Proteomics

A field of biology that focuses on studying the complete set of proteins and their interactions within a cell or organism.

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Bioinformatics

A field of biology that uses computational tools to analyze large datasets, particularly in genetics and genomics.

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GMOs

Genetically modified organisms. These are organisms that have been altered through genetic engineering techniques.

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Biotechnology

A technology involving the use of living organisms or their components to create products useful to humans.

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Genetic Modification

The process of altering the genetic makeup of an organism to enhance desirable traits, like disease resistance or increased yield.

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Cloning

The process of creating a genetically identical copy of an existing organism.

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Evolutionary Genomics

The study of the evolutionary relationships between different organisms.

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Why study model organisms?

The study of model organisms, like mice, helps us understand human genetics and diseases.

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Model organisms in medical research.

Model organisms help researchers understand human diseases and pave the way for treatments.

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Ethical considerations in model organism use.

Model organisms should be ethically sound, meaning their use does not raise ethical concerns.

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Genetic similarity between model organisms and humans.

Model organisms often share genetic similarities with humans, making them valuable for studying human biology.

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Selective Breeding

The process of selecting and breeding organisms with desirable traits to produce offspring with those enhanced traits.

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Hippocrates' Theory of Inheritance

His theory stated that traits were carried by body fluids and that these fluids interacted to influence the offspring's characteristics.

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Aristotle's Theory of Inheritance

He believed that male semen contained a 'heat' element that shaped the baby's form inside the mother.

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Cell Theory

This theory states that all living things are composed of basic units called cells. It revolutionized biology.

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Mendel's Pea Experiments

Mendel studied pea plants to understand how traits are passed down. He discovered dominant and recessive traits.

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Chromosomes

Tiny structures within cells that carry genes, the units of heredity responsible for determining traits.

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DNA

A long molecule that contains the genetic instructions for building and maintaining an organism. Found in the nucleus of cells.

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Central Dogma of Molecular Biology

A process where DNA is copied into RNA, and RNA is then used to create proteins. These proteins ultimately determine traits.

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Study Notes

Introduction to Genetics

  • Genetics is the study of heredity and how traits are passed from parents to offspring.
  • Genes are instructions that determine an organism's traits.
  • Genes are composed of DNA, a long molecule that carries genetic information.
  • DNA structure is a double helix with base pairs (A-T, C-G).

History of Genetics

  • Early scholars (Hippocrates, Aristotle) had ideas about heredity, but lacked scientific evidence.
  • William Harvey proposed epigenesis (structures develop later).
  • Schleiden and Schwann developed the cell theory.
  • Louis Pasteur disproved spontaneous generation.
  • Darwin proposed the theory of evolution by natural selection, but didn't understand the genetic basis.
  • Gregor Mendel's experiments with pea plants laid the foundation for modern genetics (studied inheritance). Mendel's work was later correlated with observations of chromosomes in meiosis.

Genetic Mechanisms

  • Chromosomes carry genes.
  • Homologous chromosomes, pairs of chromosomes, determine diploid numbers.
  • The karyotype is the chromosome complement of a cell.
  • Mitosis produces two diploid daughter cells with identical genetic information.
  • Meiosis produces four haploid gametes with half the genetic information of the parent cell.
  • Alleles (variants of a gene) create variation.
  • Genotype refers to the set of alleles for a given trait, and phenotype refers to the expression of the genotype.

DNA: The Carrier of Genetic Information

  • DNA's structure: double helix.
  • DNA is composed of nucleotides with a sugar, phosphate, and a nitrogenous base (A,T,C,G).
  • Nucleotide base pairing (A-T, and G-C) are complementary.
  • DNA carries genetic information that determines traits.
  • DNA is transcribed into RNA (mRNA) to carry the message from the nucleus to the ribosomes.
  • RNA translates mRNA into proteins (amino acids), creating the phenotype.

Recombinant DNA Technology

  • Restriction enzymes cut DNA at specific sites.
  • DNA ligase joins pieces of DNA.
  • Recombinant DNA technology allows for the combination of DNA from different sources and the creation of genetically modified organisms (GMOs).
  • Cloning makes many identical copies of a piece of DNA.
  • Genomic libraries are collections of cloned DNA segments.

The Impact of Biotechnology

  • Biotechnology in health care: Genetic testing, and disease diagnosis.
  • Biotechnology in agriculture: Modification & genetic improvement of crops (GMOs).

Genomics, Proteomics, and Bioinformatics

  • Genomics: Study of genomes (all genetic material).
  • Proteomics: Study of proteins.
  • Bioinformatics: Use of computational tools to analyze genetic data.
  • Model organisms are used to study human diseases (simple to understand and reproduce).
  • Human Genome Project mapped human genes.

Modern Genetic Approaches

  • Forward genetics: Identifying genes in mutants.
  • Reverse genetics: Determining gene function from known DNA sequences.
  • Gene knockouts: Determining gene function by removing a gene.
  • Model organisms (ex. fruit flies, bacteria, and mice) are used to understand human issues and genetics.

The Age of Genetics

  • Human Genome Project: Mapped or sequenced the entire human genome.
  • Sequencing costs continue to decrease.
  • Rapid technological advancements continue to accelerate the understanding of genetics.
  • Ethical concerns and public policy decisions surrounding genetics remain important.

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