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Questions and Answers
What is the maximum magnification power of an electron microscope?
What is the maximum magnification power of an electron microscope?
Which of the following characteristics is NOT common to all living things?
Which of the following characteristics is NOT common to all living things?
What is the typical magnification range for light microscopes used in biology labs?
What is the typical magnification range for light microscopes used in biology labs?
Which of the following is an essential function of living organisms as they grow and develop?
Which of the following is an essential function of living organisms as they grow and develop?
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Which type of microscope is specifically mentioned for examining larger objects like tissues?
Which type of microscope is specifically mentioned for examining larger objects like tissues?
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What ability allows living organisms to survive changes in their environment over time?
What ability allows living organisms to survive changes in their environment over time?
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Which of the following statement best describes the role of microscopes in medicine?
Which of the following statement best describes the role of microscopes in medicine?
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Which characteristic of living things refers to their ability to harness and use different forms of energy?
Which characteristic of living things refers to their ability to harness and use different forms of energy?
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What is the primary role of lysosomes within a cell?
What is the primary role of lysosomes within a cell?
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What keeps the interior of mitochondria acidic?
What keeps the interior of mitochondria acidic?
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Which structure within mitochondria is known for its folds?
Which structure within mitochondria is known for its folds?
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What is the primary function of mitochondria?
What is the primary function of mitochondria?
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Which component is NOT part of the endomembrane system?
Which component is NOT part of the endomembrane system?
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What type of cells are macrophages primarily associated with?
What type of cells are macrophages primarily associated with?
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What is produced through oxidative phosphorylation in mitochondria?
What is produced through oxidative phosphorylation in mitochondria?
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Which of the following correctly describes the composition of mitochondria?
Which of the following correctly describes the composition of mitochondria?
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What transition does dystrophin undergo in response to increased temperature?
What transition does dystrophin undergo in response to increased temperature?
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What is the relationship between fatty acid chain length and Tm (melting point)?
What is the relationship between fatty acid chain length and Tm (melting point)?
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Which component is responsible for anchoring proteins to the membrane surface through a covalent bond?
Which component is responsible for anchoring proteins to the membrane surface through a covalent bond?
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What effect do cis double bonds in unsaturated fatty acids have on fluidity?
What effect do cis double bonds in unsaturated fatty acids have on fluidity?
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What happens to the fluidity of membranes as the number of double bonds in fatty acids increases?
What happens to the fluidity of membranes as the number of double bonds in fatty acids increases?
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What structural feature of cholesterol enables it to interact with phospholipids in the membrane?
What structural feature of cholesterol enables it to interact with phospholipids in the membrane?
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Which type of muscular dystrophy is associated with genetic defects in dystrophin?
Which type of muscular dystrophy is associated with genetic defects in dystrophin?
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What occurs to the hydrophobic side chains at temperatures above the melting point, Tm?
What occurs to the hydrophobic side chains at temperatures above the melting point, Tm?
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What is the role of amino phospholipids in the cell membrane?
What is the role of amino phospholipids in the cell membrane?
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Which phospholipid is noted for containing a net negative charge?
Which phospholipid is noted for containing a net negative charge?
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What occurs during the lysis of the cell membrane?
What occurs during the lysis of the cell membrane?
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What is the significance of the hydrophobic carbon tails within the phospholipid bilayer?
What is the significance of the hydrophobic carbon tails within the phospholipid bilayer?
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Which phospholipid is specifically mentioned as being found only in the inner layer?
Which phospholipid is specifically mentioned as being found only in the inner layer?
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Which aspect does phosphatidylserine particularly contribute to in the membrane?
Which aspect does phosphatidylserine particularly contribute to in the membrane?
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What happens to the phospholipid bilayer when it spontaneously closes?
What happens to the phospholipid bilayer when it spontaneously closes?
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What is a key energetic preference of the phospholipid bilayer structure?
What is a key energetic preference of the phospholipid bilayer structure?
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What is a primary function of N-glycosidic bonds in glycoproteins?
What is a primary function of N-glycosidic bonds in glycoproteins?
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In what manner do membrane glycolipids function in cell recognition?
In what manner do membrane glycolipids function in cell recognition?
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What is a consequence of increased membrane fluidity?
What is a consequence of increased membrane fluidity?
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How might changes in membrane fluidity affect proteins with hydrophobic segments?
How might changes in membrane fluidity affect proteins with hydrophobic segments?
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What role does the carbohydrate moiety of glycoproteins play during cell division?
What role does the carbohydrate moiety of glycoproteins play during cell division?
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Which type of glycoprotein is primarily involved with the oxygen of serine?
Which type of glycoprotein is primarily involved with the oxygen of serine?
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How do cell surface glycolipids potentially interact with pathogens?
How do cell surface glycolipids potentially interact with pathogens?
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What happens during the movement of cells through capillaries regarding glycoproteins?
What happens during the movement of cells through capillaries regarding glycoproteins?
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Study Notes
Introduction to Cell Biology
- Living things require cellular organization, reproduction, growth and development, energy transformation and utilization, homeostasis, response to environment, and adaptation.
- Living things evolve over time.
- Microscopes are essential for medicine; allow us to see cells and pathogens.
- Electron microscopes magnify 10,000,000x, Light microscopes magnify 1000x, and Dissecting microscopes magnify 100x.
Cell Structure and Organelles
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Lysosomes are cellular organelles that remove broken organelles and pathogens
- They do this by degrading unwanted biomolecules.
- Their acidic interior is maintained by an H+ pump.
- Macrophages are a specific type of white blood cell that break down pathogens and toxins.
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Mitochondria are responsible for producing ATP.
- They contain two membranes: an outer and an inner membrane.
- The inner membrane has folds called cristae, which increase its surface area.
- The space between the two membranes is called the intermembrane space, and the inside of the inner membrane is called the matrix.
- The ATP is produced by oxidative phosphorylation.
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Endomembrane System is a structure with different shapes that are made of membranes including:
- Plasma membrane, nuclear envelope, and the endoplasmic reticulum
- The endomembrane system plays a role in making and modifying proteins and lipids.
Membrane Fluidity
-
Proteins can move and rotate in the membrane
- The flexibility of the membrane allows the cell to:
- Divide
- Deform
- Fuse with vesicles
- The flexibility of the membrane allows the cell to:
-
The membrane fluidity is influenced by temperature and the fatty acid composition.
- High temperatures increase the fluidity of the membrane.
- Unsaturated fatty acids with cis double bonds reduce the membrane's rigidity.
- Increased saturation and chain length increase rigidity and decrease fluidity.
- Cholesterol can increase fluidity in low temperatures and decrease fluidity at high temperatures.
Membrane Structure
- The plasma membrane is a phospholipid bilayer.
- The phospholipid bilayer is a spontaneous structure that is stable because the hydrophilic head and hydrophobic tail structure minimizes the exposure of hydrophobic tails to water, which is energetically unfavorable.
- The structure of the phospholipid bilayer also allows for a closed compartment to form, which allows for organelle structure.
- It has both hydrophilic and hydrophobic components.
- Phosphatidylethanolamine and Phosphatidylserine are found on the inner side of the bilayer and contribute to the membrane potential.
- Phosphatidylinositol is found exclusively on the inner side of the bilayer.
Membrane Proteins
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Integral Membrane Proteins
- They have both hydrophilic and hydrophobic regions.
- They are embedded in the phospholipid bilayer.
- Their function may reside either inside or outside the membrane.
- If their function is in the hydrophilic region, changes in membrane fluidity have little effect.
- If their function is in the hydrophobic region, changes in membrane fluidity may have significant effects.
- Some integral membrane proteins contain attached lipid groups for increased stability.
-
Peripheral Membrane Proteins
- They only associate with one leaflet of the membrane.
- They are bound to the inner or outer surface of the membrane.
- They are not embedded in the bilayer but are associated with it.
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Lipid-Anchored Proteins
- They are bound to the inner or outer side of the membrane.
- They are attached to the membrane lipid bilayer with modifications such as glycosylphosphatidylinositol (GPI) anchors.
Membrane Carbohydrates
-
Glycoproteins
- They are carbohydrate-linked proteins.
- They can have N-glycosidic and O-glycosidic bonds with specific amino acids:
- N-glycosidic bonds can be attached to the amide nitrogen of an asparagine side chain.
- O-glycosidic bonds can be attached to the oxygen of a serine or threonine side chain.
- They can serve as cell recognition markers and limit their movement in the membrane.
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Glycolipids
- They are carbohydrate-linked lipids.
- Their variable carbohydrate make-up can serve as binding sites for viruses, bacterial toxins, and cell recognition markers.
- They can serve as specific recognition molecules for cell-cell interactions
- The blood types A, B, and O are determined by the carbohydrate composition of the glycolipids.
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Description
Test your knowledge on the fundamentals of cell biology, including the characteristics of living organisms, cellular structures, and organelles. This quiz covers essential topics such as lysosomes, mitochondria, and the importance of microscopes in cell studies.