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Introduction to Cancer: Types and Causes

Learn the basics of cancer, including its definition as uncontrolled cell growth, the difference between benign and malignant tumors, and the main types such as Carcinoma. Explore how cancer is caused by harmful genetic variations accumulated over time.

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Questions and Answers

What is the main cause of cancer according to the text?

An accumulation of detrimental variation in the genome over a lifetime

Which type of cancer originates from connective tissue found in bones, tendons, cartilage, muscle, and fat?

Sarcoma

What is the most common risk factor for lung cancer according to the text?

Exposure to chemicals such as radon and asbestos

Which cancer is disproportionately more common among Orthodox Jewish women?

<p>Breast cancer</p> Signup and view all the answers

What type of cancer originates in epithelial tissue found in the internal and external lining of the body?

<p>Carcinoma</p> Signup and view all the answers

What percentage of lung cancer deaths in men are likely caused by smoking according to the text?

<p>70%</p> Signup and view all the answers

What is a common risk factor for colon cancer according to the text?

<p>High-fiber and low red meat diet</p> Signup and view all the answers

How do cancer cells differ from normal human cells in terms of replicative immortality?

<p>Cancer cells can greatly exceed the Hayflick's limit due to telomerase activity</p> Signup and view all the answers

Which gene plays a central role in controlling cell growth and is discussed in the text?

<p>p53 Tumor Suppressor Gene</p> Signup and view all the answers

What is a characteristic of cancer cells related to genome instability?

<p>Ability to continue dividing despite abnormal number of chromosomes or mutations</p> Signup and view all the answers

Why do most cancer cells avoid normal growth suppressor signals at the G1 checkpoint?

<p>To continue proliferating</p> Signup and view all the answers

What is the significance of the two-hit hypothesis in cancer-inducing genes?

<p>Both copies of the gene must be affected for the gene to induce cancer</p> Signup and view all the answers

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