Intro to Biology: Principles and Organization
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Questions and Answers

Given the central dogma of molecular biology, what post-translational regulatory mechanism would MOST directly and efficiently modulate protein activity in response to a transient environmental stimulus, bypassing transcriptional and translational machinery?

  • Ubiquitination followed by proteasomal degradation of the protein.
  • Allosteric modulation of an enzyme's active site by a small molecule effector. (correct)
  • Alternative splicing of pre-mRNA to generate protein isoforms with differing functions.
  • Epigenetic modification of histone tails to alter gene accessibility.

In the context of evolutionary developmental biology (Evo-Devo), which of the following scenarios would MOST likely lead to a macroevolutionary change, characterized by the emergence of a novel body plan feature?

  • A change in the expression pattern of a Hox gene affecting the spatial organization of segments along the anterior-posterior axis. (correct)
  • A frameshift mutation in a gene encoding a structural protein responsible for maintaining cell shape in epithelial tissues.
  • A synonymous mutation in a housekeeping gene responsible for ribosome biogenesis, resulting in slightly slower protein synthesis rates.
  • A point mutation in a coding region of a highly conserved metabolic enzyme, leading to a 5% reduction in its catalytic activity.

Considering the complexities of metabolic flux within a eukaryotic cell, what would be the MOST immediate consequence of a complete and irreversible inhibition of the malate-aspartate shuttle, assuming all other metabolic pathways remain functional?

  • Impaired transfer of cytosolic NADH equivalents into the mitochondria, reducing the efficiency of oxidative phosphorylation. (correct)
  • Complete cessation of glycolysis due to the buildup of cytosolic NADH and depletion of NAD+.
  • Accumulation of NADH in the mitochondrial matrix, leading to increased ATP production via oxidative phosphorylation.
  • Uncontrolled export of citrate from the mitochondria, leading to activation of lipogenesis and fatty acid synthesis.

In a hypothetical ecosystem where a keystone predator is extirpated, leading to a trophic cascade and subsequent loss of biodiversity, which of the following long-term effects is LEAST likely to occur?

<p>A rapid evolutionary adaptation in the remaining prey species to develop novel defense mechanisms. (B)</p> Signup and view all the answers

Given the intricacies of CRISPR-Cas9 genome editing technology, which scenario would present the MOST significant challenge in achieving precise and specific gene editing in a mammalian cell line?

<p>Minimizing off-target effects due to the guide RNA binding to unintended DNA sequences with high similarity to the target site. (D)</p> Signup and view all the answers

Considering the diverse mechanisms of epigenetic inheritance, which of the following scenarios would MOST likely result in a stable and heritable change in gene expression patterns across multiple generations, WITHOUT altering the underlying DNA sequence?

<p>Establishment of a self-sustaining feedback loop involving a transcription factor and a microRNA, maintained through cell divisions. (C)</p> Signup and view all the answers

In the context of systems biology, which approach would be MOST effective in elucidating the emergent properties arising from complex interactions within a signaling network, considering both spatial and temporal dynamics?

<p>Developing a computational model that integrates experimental data on protein-protein interactions, signaling kinetics, and spatial localization to simulate network behavior. (B)</p> Signup and view all the answers

Given the principles of allopatric speciation, which geographic scenario would MOST likely lead to the rapid divergence and reproductive isolation of two subpopulations of a previously panmictic species?

<p>A volcanic eruption creating a small, isolated island habitat far from the mainland population. (A)</p> Signup and view all the answers

Considering the intricacies of the eukaryotic proteome, which post-translational modification would MOST directly influence protein localization by acting as a 'zip code' targeting the protein to a specific cellular compartment?

<p>Acylation with a myristoyl or palmitoyl group. (D)</p> Signup and view all the answers

In the context of evolutionary game theory, which of the following strategies would be MOST likely to emerge as an evolutionarily stable strategy (ESS) in a population facing a resource scarcity scenario with frequent intergroup competition?

<p>A 'greenbeard' strategy where individuals cooperate selectively with others sharing a visible marker, while competing with those lacking the marker. (D)</p> Signup and view all the answers

Flashcards

Biology

The scientific study of life, including its structure, function, growth, origin, evolution, and distribution.

Cell Theory

All living organisms are composed of cells.

Gene Theory

Hereditary information is encoded in DNA and passed from parents to offspring.

Evolution

Life evolves over time through processes like natural selection.

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Homeostasis

Living organisms maintain a stable internal environment.

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Tissues

Groups of similar cells performing a specific function.

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Photosynthesis

Conversion of light energy into chemical energy (glucose) in plants and some bacteria.

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Cellular Respiration

Breakdown of glucose to generate ATP (energy currency of the cell).

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Natural Selection

The process by which organisms with favorable traits are more likely to survive and reproduce.

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Biodiversity

The variety of life in an ecosystem or on Earth.

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Study Notes

  • Biology is the scientific study of life
  • It explores the structure, function, growth, origin, evolution, and distribution of living organisms

Core Principles of Biology

  • Cell theory: All living organisms are composed of cells
  • Gene theory: Hereditary information is encoded in DNA and passed from parents to offspring
  • Evolution: Life evolves over time through processes like natural selection
  • Homeostasis: Living organisms maintain a stable internal environment

Levels of Biological Organization

  • Molecules: Atoms combine to form molecules, such as DNA and proteins
  • Cells: The basic unit of life, containing organelles and carrying out life functions
  • Tissues: Groups of similar cells performing a specific function
  • Organs: Structures composed of different tissues working together
  • Organ systems: Groups of organs that cooperate to perform major bodily functions
  • Organisms: Individual living entities
  • Populations: Groups of individuals of the same species living in the same area
  • Communities: Populations of different species living and interacting in an area
  • Ecosystems: Communities of organisms interacting with their physical environment
  • Biosphere: The sum of all ecosystems on Earth

Chemistry of Life

  • Water: Essential for life due to its properties as a solvent, its high heat capacity, and its role in chemical reactions
  • Carbon: Forms the backbone of organic molecules due to its ability to form stable bonds with other atoms
  • Carbohydrates: Provide energy and structural support (e.g., sugars, starches, cellulose)
  • Lipids: Store energy, form cell membranes, and act as hormones (e.g., fats, oils, phospholipids)
  • Proteins: Perform a variety of functions, including catalyzing reactions, transporting molecules, and providing structural support (e.g., enzymes, antibodies)
  • Nucleic acids: Store and transmit genetic information (DNA and RNA)

Cell Structure and Function

  • Prokaryotic cells: Lack a nucleus and other membrane-bound organelles; found in bacteria and archaea
  • Eukaryotic cells: Contain a nucleus and other membrane-bound organelles; found in protists, fungi, plants, and animals
  • Cell membrane: Controls the movement of substances in and out of the cell
  • Nucleus: Contains the cell's DNA and controls cell activities
  • Ribosomes: Synthesize proteins
  • Endoplasmic reticulum (ER): Involved in protein and lipid synthesis
  • Golgi apparatus: Modifies, sorts, and packages proteins
  • Mitochondria: Generate energy through cellular respiration
  • Chloroplasts: Conduct photosynthesis in plant cells

Energy and Metabolism

  • Metabolism: The sum of all chemical reactions that occur within an organism
  • Enzymes: Catalyze biochemical reactions by lowering activation energy
  • Photosynthesis: Conversion of light energy into chemical energy (glucose) in plants and some bacteria
  • Cellular respiration: Breakdown of glucose to generate ATP (energy currency of the cell)
  • ATP (adenosine triphosphate): Primary energy carrier in cells

Genetics

  • DNA (deoxyribonucleic acid): Carries genetic information in the form of genes
  • Genes: Segments of DNA that code for proteins
  • Chromosomes: Structures made of DNA and protein that carry genes
  • DNA replication: Process of copying DNA before cell division
  • Transcription: Process of synthesizing RNA from a DNA template
  • Translation: Process of synthesizing proteins from an RNA template
  • Mutations: Changes in the DNA sequence that can lead to variations in traits

Cell Division

  • Mitosis: Cell division that results in two identical daughter cells; used for growth and repair
  • Meiosis: Cell division that results in four genetically different daughter cells (gametes); used for sexual reproduction

Evolution

  • Natural selection: The process by which organisms with favorable traits are more likely to survive and reproduce
  • Adaptation: Traits that enhance an organism's survival and reproduction in a specific environment
  • Genetic variation: Differences in genes among individuals within a population
  • Speciation: The process by which new species arise

Ecology

  • Populations: Groups of individuals of the same species living in the same area
  • Communities: Populations of different species interacting with each other
  • Ecosystems: Communities of organisms interacting with their physical environment
  • Biomes: Large-scale ecosystems characterized by specific climate conditions and dominant plant communities
  • Food chains and food webs: Show the flow of energy and nutrients through an ecosystem
  • Trophic levels: Position an organism occupies in a food chain (e.g., producers, consumers, decomposers)
  • Biodiversity: The variety of life in an ecosystem or on Earth
  • Conservation biology: The study of protecting and preserving biodiversity

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An overview of biology, the study of life, including cell theory, gene theory, evolution, and homeostasis. Explores the levels of biological organization from molecules and cells to organisms and populations.

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