Questions and Answers
What initiates the intrinsic pathway of blood coagulation?
Which factors are primarily involved in the extrinsic pathway?
Which factor plays a central role in both the intrinsic and extrinsic pathways?
What is the function of prothrombinase in the coagulation process?
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Which requirement is necessary for the formation of prothrombin activator?
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Which factor is NOT considered a clotting factor?
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The combination of which factors is required to amplify the clotting process in the intrinsic pathway?
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What is the first factor activated in the common pathway of coagulation?
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Study Notes
Intrinsic Pathway
- Activated by factors already present in blood; characterized as a slow pathway.
- Begins with activation of Hageman factor (Factor XII) by exposed collagen.
- Factor XII activates Plasma Thromboplastin Antecedent (Factor XI), which then activates Factor IX.
- Factors IX and VIII work together to amplify the clotting process, leading to the activation of Factor X.
- Key factors involved in order: Factor XII, Factor XI, Factor IX, Factor VIII, Factor X.
Extrinsic Pathway
- Triggered by factors external to blood; functions as a faster pathway.
- Initiated when Thromboplastin (Factor III) from damaged tissue enters the bloodstream.
- The presence of Factor III activates Factor VII.
- Factors III and VII work together to activate Factor X.
- Key factors involved: Factor III, Factor VII, Factor X.
Convergence of Pathways
- Both intrinsic and extrinsic pathways converge to form a common pathway leading to blood coagulation.
- Factor X is central to initiating the common pathway.
- Factor X, in combination with Factor V, forms prothrombin activator/prothrombinase.
- Prothrombinase converts prothrombin to thrombin, assisted by calcium ions.
- Thrombin then converts fibrinogen to fibrin, forming the clot.
Requirements for Common Pathway
- Essential components include Factor X, Factor V, Prothrombinase, Prothrombin, Thrombin, Fibrinogen, and Fibrin.
List of Blood Clotting Factors
- Factor I: Fibrinogen
- Factor II: Prothrombin
- Factor III: Tissue Factor
- Factor IV: Calcium
- Factor V: Labile Factor (Proaccelerin)
- Factor VI: Not a clotting factor
- Factor VII: Stable Factor (Proconvertin)
- Factor VIII: Antihemophilic Factor A
- Factor IX: Antihemophilic Factor B (Christmas Factor)
- Factor X: Stuart-Prower Factor
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Description
This quiz explores the intrinsic pathway of blood coagulation, detailing the activation sequence of various factors starting from Factor XII to Factor X. Learn how these factors interact and amplify the clotting process. Perfect for students studying hematology or related subjects.
