Intrinsic Pathway of Blood Clotting Process
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Questions and Answers

Which pathway is activated by blood trauma and involves collagen exposure?

  • Cell-based Pathway
  • Extrinsic Pathway
  • Intrinsic Pathway (correct)
  • Common Pathway
  • What plasma protein is the first to be activated in the Intrinsic Pathway when it contacts collagen fibers?

  • Factor XII (correct)
  • Factor XI
  • Factor IX
  • Factor VIII
  • Which factor converts prothrombin to thrombin in the Final Common Pathway?

  • Factor XII
  • Factor X (correct)
  • Factor VIII
  • Factor IX
  • What measurement technique is used to assess the activity of the Intrinsic Pathway?

    <p>PTT</p> Signup and view all the answers

    Which pathway is hypothesized to demonstrate the interaction between cellular activity and coagulation proteins?

    <p>Cell-based Theory</p> Signup and view all the answers

    What does Factor XIIa activate in the Intrinsic Pathway?

    <p>Factor XI</p> Signup and view all the answers

    What is the main function of thrombin in the clotting cascade?

    <p>Convert fibrinogen to fibrin</p> Signup and view all the answers

    Which factor forms a complex with VIIa to activate Factor X to Xa in the clotting cascade?

    <p>TF (Factor III)</p> Signup and view all the answers

    What vitamin is required by the liver for the normal production of prothrombin and other clotting factors?

    <p>Vitamin K</p> Signup and view all the answers

    In the clotting cascade, what initiates the Extrinsic Pathway?

    <p>Tissue Factor (TF)</p> Signup and view all the answers

    What is the role of the TF/VIIa complex in the clotting cascade?

    <p>Activates Factor X to Xa</p> Signup and view all the answers

    What is measured by PT and INR to assess the Extrinsic Pathway activation?

    <p>Prothrombin time</p> Signup and view all the answers

    Which pathway is activated when coagulation is initiated outside of the intravascular space in the Classical Clotting Cascade?

    <p>Extrinsic pathway</p> Signup and view all the answers

    What is the final common pathway in the Classical Clotting Cascade?

    <p>Thrombin generation</p> Signup and view all the answers

    What is the main difference between the Classical and Contemporary Clotting Cascades?

    <p>Initiation location</p> Signup and view all the answers

    What is the newer concept that hypothesizes why platelets and extrinsic/intrinsic pathways work interdependently?

    <p>Cell-based theory</p> Signup and view all the answers

    Why is thrombin generated from the extrinsic pathway insufficient for providing sustained coagulation in the Classical Clotting Cascade?

    <p>Inadequate intrinsic pathway activation</p> Signup and view all the answers

    Which component is needed outside of the intravascular space for the Extrinsic pathway to be activated in the Classical Clotting Cascade?

    <p>Cellular element</p> Signup and view all the answers

    What is the primary function of thrombin in the clotting cascade?

    <p>Convert fibrinogen into fibrin strands</p> Signup and view all the answers

    Which factor in the clotting cascade is responsible for stabilizing newly formed fibrin polymers?

    <p>Factor XIIIc</p> Signup and view all the answers

    In the context of hemostasis, what condition may result from dysfunctional clotting mechanisms?

    <p>Thromboembolic disorders</p> Signup and view all the answers

    In the fibrinolysis process, what converts plasminogen into plasmin to digest the fibrin meshwork?

    <p>Tissue plasminogen activator (TPA)</p> Signup and view all the answers

    Which system actively breaks down a clot once its purpose, like sealing wounds, has been fulfilled?

    <p>Fibrinolysis system</p> Signup and view all the answers

    Why is understanding the underlying principles of the clotting cascade valuable for medical professionals?

    <p>To diagnose and treat clotting disorders effectively</p> Signup and view all the answers

    What initiates the Intrinsic Pathway of the clotting cascade?

    <p>Factor XII activation</p> Signup and view all the answers

    Which factor forms a complex with tissue factor to activate Factor X in the clotting cascade?

    <p>Factor VIIa</p> Signup and view all the answers

    What is the role of Factor XI in the clotting cascade?

    <p>Triggers activation of Factor XII</p> Signup and view all the answers

    Which factor is activated by the TF/VIIa complex in the clotting cascade?

    <p>Factor X</p> Signup and view all the answers

    In the Common Pathway, which factors interact with Factor Va and VIIIa?

    <p>IXa and VIIa</p> Signup and view all the answers

    What does the activation of prekallikrein by Factor XII lead to in the Intrinsic Pathway?

    <p>Generation of kallikrein</p> Signup and view all the answers

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