30 Questions
Which pathway is activated by blood trauma and involves collagen exposure?
Intrinsic Pathway
What plasma protein is the first to be activated in the Intrinsic Pathway when it contacts collagen fibers?
Factor XII
Which factor converts prothrombin to thrombin in the Final Common Pathway?
Factor X
What measurement technique is used to assess the activity of the Intrinsic Pathway?
PTT
Which pathway is hypothesized to demonstrate the interaction between cellular activity and coagulation proteins?
Cell-based Theory
What does Factor XIIa activate in the Intrinsic Pathway?
Factor XI
What is the main function of thrombin in the clotting cascade?
Convert fibrinogen to fibrin
Which factor forms a complex with VIIa to activate Factor X to Xa in the clotting cascade?
TF (Factor III)
What vitamin is required by the liver for the normal production of prothrombin and other clotting factors?
Vitamin K
In the clotting cascade, what initiates the Extrinsic Pathway?
Tissue Factor (TF)
What is the role of the TF/VIIa complex in the clotting cascade?
Activates Factor X to Xa
What is measured by PT and INR to assess the Extrinsic Pathway activation?
Prothrombin time
Which pathway is activated when coagulation is initiated outside of the intravascular space in the Classical Clotting Cascade?
Extrinsic pathway
What is the final common pathway in the Classical Clotting Cascade?
Thrombin generation
What is the main difference between the Classical and Contemporary Clotting Cascades?
Initiation location
What is the newer concept that hypothesizes why platelets and extrinsic/intrinsic pathways work interdependently?
Cell-based theory
Why is thrombin generated from the extrinsic pathway insufficient for providing sustained coagulation in the Classical Clotting Cascade?
Inadequate intrinsic pathway activation
Which component is needed outside of the intravascular space for the Extrinsic pathway to be activated in the Classical Clotting Cascade?
Cellular element
What is the primary function of thrombin in the clotting cascade?
Convert fibrinogen into fibrin strands
Which factor in the clotting cascade is responsible for stabilizing newly formed fibrin polymers?
Factor XIIIc
In the context of hemostasis, what condition may result from dysfunctional clotting mechanisms?
Thromboembolic disorders
In the fibrinolysis process, what converts plasminogen into plasmin to digest the fibrin meshwork?
Tissue plasminogen activator (TPA)
Which system actively breaks down a clot once its purpose, like sealing wounds, has been fulfilled?
Fibrinolysis system
Why is understanding the underlying principles of the clotting cascade valuable for medical professionals?
To diagnose and treat clotting disorders effectively
What initiates the Intrinsic Pathway of the clotting cascade?
Factor XII activation
Which factor forms a complex with tissue factor to activate Factor X in the clotting cascade?
Factor VIIa
What is the role of Factor XI in the clotting cascade?
Triggers activation of Factor XII
Which factor is activated by the TF/VIIa complex in the clotting cascade?
Factor X
In the Common Pathway, which factors interact with Factor Va and VIIIa?
IXa and VIIa
What does the activation of prekallikrein by Factor XII lead to in the Intrinsic Pathway?
Generation of kallikrein
Test your knowledge on the Intrinsic Pathway of blood clotting process, from Factor XII to thrombin activation. Learn about the activation cascade that leads to the formation of a blood clot.
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