18 Questions
What is the primary advantage of randomized controlled trials?
Improved control over exposure
What is a major disadvantage of randomized controlled trials?
High cost and difficult feasibility
What does it mean when a randomized controlled trial is referred to as 'double-blinded'?
Both the participant and the investigator are not informed about who receives the treatment or procedure
What is the purpose of blinding in randomized controlled trials?
To prevent bias in analyzing results and outcomes
What is the primary purpose of meta-analysis?
To synthesize the literature on a particular topic
What determines the strength of a meta-analysis?
The number of studies it relies upon
What ethical issue is associated with randomized controlled trials?
Lack of equipoise
What minimizes observation bias in randomized controlled trials?
Randomization
What is the role of an institutional review board?
To review and approve, amend, or terminate research
Which requirement ensures that communities and individuals are selected based on scientific objectives?
Fair subject selection
What is the purpose of informed consent in clinical research studies?
To inform individuals about the research and obtain their voluntary consent
What is the main limitation of meta-analysis methods in clinical research?
They cannot control for bias in the original studies
Which characteristic must a clinical research study have to meet the requirement of 'value'?
Enhancement of health or knowledge derived from the research
What is the purpose of avoiding conflict of interest in clinical research?
To prevent financial or other conflicts from influencing research results
Why is fair subject selection important in clinical research studies?
To ensure that communities and individuals are selected based on scientific objectives
What is the purpose of independent review in clinical research studies?
Unaffiliated individuals must review the research and approve, amend, or terminate it
Which characteristic must a clinical research study have to meet the requirement of 'scientific validity'?
Methodological rigor
What is the main benefit of meta-analysis methods in clinical research?
They increase the power of an investigation
Learn about the advantages and disadvantages of randomized controlled trials in intervention studies. Understand how this study design provides improved control over exposure and minimizes bias, but also comes with challenges such as high cost, compliance issues, and ethical concerns.
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