Intervention Studies – Randomized Controlled Trials Advantages and Disadvantages

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What is the primary advantage of randomized controlled trials?

Improved control over exposure (correct)

Reduced compliance issues

Lower cost and better feasibility

Higher ethical standards

What is a major disadvantage of randomized controlled trials?

High cost and difficult feasibility (correct)

Low compliance issues

Reduced ethical concerns

Easy feasibility

What does it mean when a randomized controlled trial is referred to as 'double-blinded'?

Both the participant and the investigator are informed about who receives the treatment or procedure

Only the investigator is not informed about who receives the treatment or procedure

Both the participant and the investigator are not informed about who receives the treatment or procedure (correct)

Only the participant is not informed about who receives the treatment or procedure

What is the purpose of blinding in randomized controlled trials?

To prevent bias in analyzing results and outcomes Signup and view all the answers

What is the primary purpose of meta-analysis?

To synthesize the literature on a particular topic Signup and view all the answers

What determines the strength of a meta-analysis?

The number of studies it relies upon Signup and view all the answers

What ethical issue is associated with randomized controlled trials?

Lack of equipoise Signup and view all the answers

What minimizes observation bias in randomized controlled trials?

Randomization Signup and view all the answers

What is the role of an institutional review board?

To review and approve, amend, or terminate research Signup and view all the answers

Which requirement ensures that communities and individuals are selected based on scientific objectives?

Fair subject selection Signup and view all the answers

What is the purpose of informed consent in clinical research studies?

To inform individuals about the research and obtain their voluntary consent Signup and view all the answers

What is the main limitation of meta-analysis methods in clinical research?

They cannot control for bias in the original studies Signup and view all the answers

Which characteristic must a clinical research study have to meet the requirement of 'value'?

Enhancement of health or knowledge derived from the research Signup and view all the answers

What is the purpose of avoiding conflict of interest in clinical research?

To prevent financial or other conflicts from influencing research results Signup and view all the answers

Why is fair subject selection important in clinical research studies?

To ensure that communities and individuals are selected based on scientific objectives Signup and view all the answers

What is the purpose of independent review in clinical research studies?

Unaffiliated individuals must review the research and approve, amend, or terminate it Signup and view all the answers

Which characteristic must a clinical research study have to meet the requirement of 'scientific validity'?

Methodological rigor Signup and view all the answers

What is the main benefit of meta-analysis methods in clinical research?

They increase the power of an investigation Signup and view all the answers

Intervention Studies – Randomized Controlled Trials Advantages and Disadvantages

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