Interstitial Lung Disease Diagnosis

What does 'Probable UIP' refer to?

What does traction bronchiectasis/bronchiolectasis on CT indicate?

What makes applying UIP histopathological criteria challenging in TBLC?

What is more likely to show probable UIP pattern than definite UIP pattern compared to SLB?

What is considered an acceptable alternative to SLB for making histopathological diagnosis in ILD patients?

What is essential criterion for typical UIP-IPF pattern when seen with basal and peripheral predominance?

What was not reevaluated in 2018 IPF diagnosis guidelines?

What did the systematic review identify as a critical outcome in evaluating TBLC in ILD patients?

What combination of features is usually sufficient for probable UIP pattern on TBLC?

What makes the application of UIP histopathological criteria challenging in TBLC?

Histopathological Features of UIP and TBLC in Diagnosis of ILD

UIP diagnosis based on patchy dense fibrosis with architectural distortion, subpleural and paraseptal lung parenchyma predilection, fibroblast foci, and absence of features suggesting alternative diagnosis
"Probable UIP" refers to biopsies with some UIP findings in absence of features suggesting alternative diagnosis
Traction bronchiectasis/bronchiolectasis on CT indicates probable usual interstitial pneumonia pattern
TBLC makes applying UIP histopathological criteria challenging due to subpleural changes and potential sampling error
TBLC more likely to show probable UIP pattern than definite UIP pattern compared to SLB
Combination of patchy fibrosis, fibroblast foci, and absence of features usually sufficient for probable UIP pattern on TBLC
MDD results in comparable diagnostic agreement rates for SLB and TBLC in IPF patients
TBLC considered acceptable alternative to SLB for making histopathological diagnosis in ILD patients in experienced medical centers
2018 guidelines for diagnosis of IPF addressed TBLC in ILD patients, but failed to make consensus recommendation for or against TBLC
Honeycombing on CT is essential criterion for typical UIP-IPF pattern when seen with basal and peripheral predominance
SLB recommendation was not reevaluated in 2018 IPF diagnosis guidelines
Systematic review identified 40 studies evaluating TBLC in ILD patients, with diagnostic yield as critical outcome and varied study characteristics including sample size and procedure used

Test your knowledge on the histopathological features of usual interstitial pneumonia (UIP) and transbronchial lung cryobiopsy (TBLC) in the diagnosis of interstitial lung disease (ILD). Explore key criteria for UIP diagnosis, challenges in applying histopathological criteria with TBLC, and the comparison of TBLC and surgical lung biopsy (SLB) in ILD diagnosis.