18 Questions
What is the role of integrins in cardiac function?
Bind to collagen
Where do subsarcolemmal mitochondria (SSM) localize in cardiac muscle?
Adjacent to the cell membrane
Which protein plays a role in mechanotransduction at adherent junctions?
Cadherins
In what cellular component do intermediates filaments like Desmin localize in cardiac muscle?
Mitochondria
Which integrin binds to Fibronectin in the context of cardiac function?
a5b1
What is the main role of focal adhesions in mechanotransduction?
Serve as signaling hubs for mechanotransduction
What is the main function of Desmin in cardiomyocytes?
Maintaining structural organization
Where is Desmin mainly localized within cardiomyocytes?
Mitochondria
What is the function of Integrins in cell-matrix interaction in cardiomyocytes?
Signal transduction
Which cytoskeleton protein has a slow dynamic compared to other fibers?
Desmin
What is the primary role of Intermediate filaments in cardiomyocytes?
Structural support
What is the impact of Desmin dysfunction on cardiac muscle function?
Impaired structural integrity
What is the primary role of cardiac fibroblasts?
Maintaining the extracellular matrix and providing structural support to the heart
What triggers cytoskeletal remodeling in cardiac fibroblasts?
Mechanical stimuli such as myocardial stretch and pressure overload
Which signaling pathways regulate cytoskeletal dynamics and fibroblast function in response to mechanical activation?
Integrins and focal adhesion kinases
What are ciliopathies?
Disorders related to defects in the structure or function of cilia
What is the role of desmin in cardiac muscle?
Providing structural support and maintaining the integrity of mitochondria
How do cytoskeletal abnormalities contribute to hypertension?
By affecting vascular smooth muscle cell contractility and vascular tone regulation
Explore the schematic representation of the desmin intermediate filament scaffold and its interactome in cardiac muscle, including its localization in mitochondria. Dive into the ultrastructural observations of mitochondrial alterations in cardiac muscle and the impact of KO-Desmin.
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