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Intermediate Filaments Localization of Desmin

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Intermediate Filaments Localization of Desmin

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Questions and Answers

What is the role of integrins in cardiac function?

Mediate cell-cell interactions

Activate downstream signaling pathways

Bind to collagen (correct)

Form focal adhesions

Where do subsarcolemmal mitochondria (SSM) localize in cardiac muscle?

Between muscle fibers

Adjacent to the cell membrane (correct)

Around the nucleus

At the center of the muscle cells

Which protein plays a role in mechanotransduction at adherent junctions?

Focal adhesions

Cadherins (correct)

Integrins

Desmin

In what cellular component do intermediates filaments like Desmin localize in cardiac muscle?

Mitochondria (A) Signup and view all the answers

Which integrin binds to Fibronectin in the context of cardiac function?

a5b1 (C) Signup and view all the answers

What is the main role of focal adhesions in mechanotransduction?

Serve as signaling hubs for mechanotransduction (A) Signup and view all the answers

What is the main function of Desmin in cardiomyocytes?

Maintaining structural organization (A) Signup and view all the answers

Where is Desmin mainly localized within cardiomyocytes?

Mitochondria (D) Signup and view all the answers

What is the function of Integrins in cell-matrix interaction in cardiomyocytes?

Signal transduction (A) Signup and view all the answers

Which cytoskeleton protein has a slow dynamic compared to other fibers?

Desmin (D) Signup and view all the answers

What is the primary role of Intermediate filaments in cardiomyocytes?

Structural support (D) Signup and view all the answers

What is the impact of Desmin dysfunction on cardiac muscle function?

Impaired structural integrity (D) Signup and view all the answers

What is the primary role of cardiac fibroblasts?

Maintaining the extracellular matrix and providing structural support to the heart (A) Signup and view all the answers

What triggers cytoskeletal remodeling in cardiac fibroblasts?

Mechanical stimuli such as myocardial stretch and pressure overload (A) Signup and view all the answers

Which signaling pathways regulate cytoskeletal dynamics and fibroblast function in response to mechanical activation?

Integrins and focal adhesion kinases (A) Signup and view all the answers

What are ciliopathies?

Disorders related to defects in the structure or function of cilia (B) Signup and view all the answers

What is the role of desmin in cardiac muscle?

Providing structural support and maintaining the integrity of mitochondria (D) Signup and view all the answers

How do cytoskeletal abnormalities contribute to hypertension?

By affecting vascular smooth muscle cell contractility and vascular tone regulation (C) Signup and view all the answers