Intermediate Filaments Localization of Desmin
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Questions and Answers

What is the role of integrins in cardiac function?

  • Mediate cell-cell interactions
  • Activate downstream signaling pathways
  • Bind to collagen (correct)
  • Form focal adhesions
  • Where do subsarcolemmal mitochondria (SSM) localize in cardiac muscle?

  • Between muscle fibers
  • Adjacent to the cell membrane (correct)
  • Around the nucleus
  • At the center of the muscle cells
  • Which protein plays a role in mechanotransduction at adherent junctions?

  • Focal adhesions
  • Cadherins (correct)
  • Integrins
  • Desmin
  • In what cellular component do intermediates filaments like Desmin localize in cardiac muscle?

    <p>Mitochondria</p> Signup and view all the answers

    Which integrin binds to Fibronectin in the context of cardiac function?

    <p>a5b1</p> Signup and view all the answers

    What is the main role of focal adhesions in mechanotransduction?

    <p>Serve as signaling hubs for mechanotransduction</p> Signup and view all the answers

    What is the main function of Desmin in cardiomyocytes?

    <p>Maintaining structural organization</p> Signup and view all the answers

    Where is Desmin mainly localized within cardiomyocytes?

    <p>Mitochondria</p> Signup and view all the answers

    What is the function of Integrins in cell-matrix interaction in cardiomyocytes?

    <p>Signal transduction</p> Signup and view all the answers

    Which cytoskeleton protein has a slow dynamic compared to other fibers?

    <p>Desmin</p> Signup and view all the answers

    What is the primary role of Intermediate filaments in cardiomyocytes?

    <p>Structural support</p> Signup and view all the answers

    What is the impact of Desmin dysfunction on cardiac muscle function?

    <p>Impaired structural integrity</p> Signup and view all the answers

    What is the primary role of cardiac fibroblasts?

    <p>Maintaining the extracellular matrix and providing structural support to the heart</p> Signup and view all the answers

    What triggers cytoskeletal remodeling in cardiac fibroblasts?

    <p>Mechanical stimuli such as myocardial stretch and pressure overload</p> Signup and view all the answers

    Which signaling pathways regulate cytoskeletal dynamics and fibroblast function in response to mechanical activation?

    <p>Integrins and focal adhesion kinases</p> Signup and view all the answers

    What are ciliopathies?

    <p>Disorders related to defects in the structure or function of cilia</p> Signup and view all the answers

    What is the role of desmin in cardiac muscle?

    <p>Providing structural support and maintaining the integrity of mitochondria</p> Signup and view all the answers

    How do cytoskeletal abnormalities contribute to hypertension?

    <p>By affecting vascular smooth muscle cell contractility and vascular tone regulation</p> Signup and view all the answers

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