Integumentary System: Skin Structure

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Questions and Answers

Which of the following cellular processes is most directly affected by the accumulation of keratohyalin and lamellar granules within the stratum granulosum?

  • The synthesis of melanin for UV protection.
  • The formation of the cornified cell envelope and epidermal water barrier. (correct)
  • The sensation of light touch through Merkel cells.
  • The regulation of immune responses via Langerhans cells.

A patient presents with a localized patch of skin exhibiting complete loss of melanocytes. This condition is best described as which of the following?

  • Vitiligo, characterized by partial or complete melanocyte loss. (correct)
  • Carotenemia, induced by excessive carotene deposition.
  • Nevus, indicating a benign overgrowth of melanocytes.
  • Albinism, resulting from a genetic inability to produce melanin.

Which of the following statements accurately compares eccrine and apocrine sweat glands?

  • Apocrine glands are distributed throughout the body, but eccrine glands are limited to specific regions like the axilla and groin.
  • Apocrine glands produce a watery secretion to eliminate wastes, while eccrine glands produce viscous secretions containing lipids.
  • Eccrine glands release sweat directly onto the skin surface, whereas apocrine gland secretions typically enter hair follicles. (correct)
  • Eccrine glands primarily function in emotional stress response, while apocrine glands regulate body temperature.

In the context of deep wound healing, what is the primary role of fibroblasts during the maturation phase?

<p>Synthesizing collagen fibers to form scar tissue and restore tissue strength. (C)</p> Signup and view all the answers

If a patient is diagnosed with a condition affecting the reticular region of the dermis, which of the following would most likely be observed?

<p>Visible stretch marks (striae) resulting from excessive skin stretching. (C)</p> Signup and view all the answers

Which of the following describes the correct chronological sequence of epidermal layers, starting from the most superficial layer to the deepest?

<p>Stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, stratum basale (D)</p> Signup and view all the answers

How does the presence of epidermal ridges contribute to the function of the skin?

<p>Providing a basis for fingerprints and increasing grip firmness. (D)</p> Signup and view all the answers

What is the primary functional significance of the lamellated (Pacinian) corpuscles located within the hypodermis and sometimes the dermis?

<p>Detection of sustained pressure and vibrations applied to the skin. (D)</p> Signup and view all the answers

What effect does aging have on the population and function of melanocytes, and how does this manifest in the integumentary system?

<p>A decreased number of functional melanocytes, resulting in gray hair and atypical skin pigmentation. (D)</p> Signup and view all the answers

In the context of wound healing in the epidermis, which cellular activity is most critical for the re-establishment of the epidermal barrier?

<p>Migration and division of basal epithelial cells to cover the wound area. (A)</p> Signup and view all the answers

A burn patient has damage extending through the epidermis and part of the dermis. While the patient has pain, the function of which structure still remains intact?

<p>The formation of fingerprints. (B)</p> Signup and view all the answers

How does the keratinization process contribute to the protective function of the skin?

<p>Preventing water loss and microbial invasion. (A)</p> Signup and view all the answers

Which component is NOT a derivative of the ectoderm?

<p>Dermis. (B)</p> Signup and view all the answers

What is the primary function of the vernix caseosa that protects the epidermis of a fetus?

<p>Protection from exposure to amniotic fluid. (B)</p> Signup and view all the answers

What is the primary result of the skin's reduced immune-responsiveness to aging?

<p>Increased susceptibility to pathological conditions. (C)</p> Signup and view all the answers

How would severely decreased sweat production affect body temperature regulation?

<p>The body would be less efficient at cooling down. (C)</p> Signup and view all the answers

What physiological change explains why aged skin is more prone to cracking?

<p>Dehydration of the skin. (A)</p> Signup and view all the answers

In the context of skin grafts, what is the primary advantage of using an autograft compared to an allograft?

<p>Eliminates concern for rejection since the tissue comes from the same individual. (D)</p> Signup and view all the answers

If a newly developed topical medication is designed to enhance the skin's natural barrier function, which of the following components should it primarily target within the epidermis?

<p>Lamellar granules in the stratum granulosum to improve lipid secretion. (B)</p> Signup and view all the answers

A patient reports excessive dryness and cracking of the skin, particularly on the hands, during winter. Which of the following would most effectively address this issue?

<p>Using emollients and moisturizers that replenish the skin's lipid and water content. (D)</p> Signup and view all the answers

Which cellular event is most directly responsible for the formation of a callus in thick skin?

<p>Accelerated keratinocyte production in response to increased cell division. (C)</p> Signup and view all the answers

How does the structure of the dermis contribute to the skin's overall resilience and ability to withstand mechanical stress?

<p>Extensive network of collagen and elastic fibers. (B)</p> Signup and view all the answers

Following a laceration that damages both the epidermis and dermis, which sequence of events accurately describes the process of scar formation in deep wound healing?

<p>Inflammation → angiogenesis → collagen synthesis by fibroblasts → epithelial cell migration. (C)</p> Signup and view all the answers

A dermatologist explains to a patient that their seborrheic dermatitis is linked to increased sebum production. This condition primarily involves the malfunction of what skin structure?

<p>Sebaceous glands. (B)</p> Signup and view all the answers

If a patient is diagnosed with a tumor originating from melanocytes, in which epidermal layer did this tumor most likely begin its development?

<p>in the stratum basale, where melanocytes are located (A)</p> Signup and view all the answers

Why is the stratum lucidum only found in thick skin?

<p>for more support and more layers (A)</p> Signup and view all the answers

Why does skin wrinkle due to old age?

<p>because the skin thickness decreases and the skin becomes less elastic (B)</p> Signup and view all the answers

Which of the following explains why a person's hair turns gray as they age?

<p>Hair tuns gray because there are less melanocytes. (D)</p> Signup and view all the answers

What are the accessory structure of the skin?

<p>hair, skin glands, and nails (C)</p> Signup and view all the answers

What determines the color of hair?

<p>the amount of melanin produced (A)</p> Signup and view all the answers

Why can striae or stretch marks appear?

<p>if a layer of dermis tissue is stretched too much (C)</p> Signup and view all the answers

Which of the following skin sensations is not related to the cutaneous sensations?

<p>smell (C)</p> Signup and view all the answers

A yellow-orange pigment found in various layers of the skin would be:

<p>Carotene (B)</p> Signup and view all the answers

Which of the following are functions of hair?

<p>sensing light touch and protection (A)</p> Signup and view all the answers

Dermatoglyphics is:

<p>the study of the patterns of epidermal ridges (B)</p> Signup and view all the answers

What is the role of melanin in the skin?

<p>protects against damage by ultraviolet radiation (A)</p> Signup and view all the answers

The primary function of sebum secreted by sebaceous glands is to do which of the following?

<p>prevent dehydration of hair and skin, and inhibit growth of certain bacteria (B)</p> Signup and view all the answers

A free edge would be part of:

<p>a nail (C)</p> Signup and view all the answers

The dermis is composed of:

<p>a connective tissue containing collagen and elastic fibers (B)</p> Signup and view all the answers

Why is the subcutaneous layer important for administering subcutaneous injections?

<p>It is rich in adipose tissue and has fewer blood vessels, allowing for slower, more sustained absorption. (A)</p> Signup and view all the answers

How does the subcutaneous layer contribute to thermoregulation?

<p>By containing blood vessels that can dilate or constrict to regulate heat loss. (A)</p> Signup and view all the answers

A patient experiences a superficial cut that bleeds. Which layer of the skin is involved?

<p>Dermis (D)</p> Signup and view all the answers

What characteristic of keratin contributes to the protective function of the epidermis and hair?

<p>Its tough, fibrous structure, providing strength and resistance to abrasion and water loss. (A)</p> Signup and view all the answers

Why is it important to aspirate during intramuscular injections?

<p>To avoid injecting the medication directly into a blood vessel. (A)</p> Signup and view all the answers

How does the distribution of subcutaneous fat contribute to body contour and shape?

<p>It varies by region and individual factors, influencing the body's silhouette. (B)</p> Signup and view all the answers

How do the structural properties of arteries assist in their function?

<p>Thick, strong walls enable them to withstand high blood pressure from the heart's pumping action. (B)</p> Signup and view all the answers

What is the primary role of veins in the circulatory system?

<p>To carry deoxygenated blood back to the heart for re-oxygenation. (B)</p> Signup and view all the answers

How does the integumentary system facilitate sensory perception?

<p>By housing sensory receptors that detect stimuli like temperature, pain, and touch. (D)</p> Signup and view all the answers

Based on the image, what is the relationship between the epidermis and the dermis?

<p>The epidermis is the outer, thinner layer, while the dermis is the inner, thicker layer. (C)</p> Signup and view all the answers

In a comparison between arteries and veins, which of the following characteristics is exclusive to veins?

<p>Contain valves to prevent backflow (B)</p> Signup and view all the answers

Which of the following statements accurately describes the oxygen content in blood vessels?

<p>The pulmonary artery carries deoxygenated blood from the heart. (A)</p> Signup and view all the answers

How does the shape and structure of arteries contribute to their function, compared to veins?

<p>Arteries have a round, thick-walled structure that remains open under pressure. (D)</p> Signup and view all the answers

Which of the following best describes the primary role of keratinocytes in the epidermis?

<p>Producing a protein that toughens the skin (B)</p> Signup and view all the answers

What is the functional significance of melanocytes within the epidermis?

<p>Producing pigment to protect against UV radiation (C)</p> Signup and view all the answers

In what capacity do Langerhans cells function within the skin's defense mechanisms?

<p>Detecting and fighting harmful germs and alerting the immune system (B)</p> Signup and view all the answers

Which of the following describes how Merkel cells contribute to the sense of touch?

<p>Connecting with nerve endings to sense light touch and pressure (B)</p> Signup and view all the answers

How does vitiligo affect skin pigmentation, and what causes this condition?

<p>The immune system attacks melanocytes, leading to patches of lighter skin. (B)</p> Signup and view all the answers

Which of the following is a key characteristic of albinism that distinguishes it from vitiligo?

<p>It is a genetic condition present from birth that affects pigmentation throughout the body. (B)</p> Signup and view all the answers

What purpose do epidermal ridges serve in the skin?

<p>Generating fingerprints and footprints for identification (B)</p> Signup and view all the answers

What is the primary function of Pacinian corpuscles located in the subcutaneous layer?

<p>Detecting deep pressure and vibrations (B)</p> Signup and view all the answers

How do sebaceous glands contribute to the health and function of the skin?

<p>By secreting sebum to prevent dehydration (D)</p> Signup and view all the answers

What is the primary mechanism by which eccrine sweat glands regulate body temperature?

<p>Cooling the body through sweat evaporation (A)</p> Signup and view all the answers

How do ceruminous glands protect the ear canal?

<p>By producing cerumen to trap foreign particles (A)</p> Signup and view all the answers

How do nails contribute to the functionality of fingers and toes?

<p>Protecting tips and aiding in gripping (C)</p> Signup and view all the answers

How does exposure to UV radiation or sunlight contribute to vitamin D production in the body?

<p>The skin synthesizes colecalciferol from cholesterol upon exposure to UV radiation. (A)</p> Signup and view all the answers

Which substance do sebaceous glands secrete, and what is its primary function?

<p>Sebum, to prevent dehydration of hair and skin (C)</p> Signup and view all the answers

What is the role of hair in relation to light touch sensitivity?

<p>It amplifies light touch and is considered a form of protection. (B)</p> Signup and view all the answers

Which of the following characterizes the wall structure of arteries compared to veins?

<p>Arteries have thick, muscular, and elastic walls to withstand high pumping pressure. (C)</p> Signup and view all the answers

Where are apocrine sweat glands primarily located, and what is a distinctive characteristic of their secretions?

<p>Axillae and groin, producing a thicker sweat that can cause body odor (C)</p> Signup and view all the answers

Which of the following is a vitamin D precursor found in fungi?

<p>Ergosterol. (B)</p> Signup and view all the answers

What part of the skin is technically not a layer?

<p>Subcutaneous layer (A)</p> Signup and view all the answers

Which process helps form finger prints or footprints?

<p>Epidermal Ridges (B)</p> Signup and view all the answers

What do dermatoglyphics study?

<p>Fingerprints (B)</p> Signup and view all the answers

Which of the following materials is secreted by the ceruminous gland?

<p>Cerumen (B)</p> Signup and view all the answers

Which of the following best describes the role of thyroxinase in melanin production?

<p>Thyroxinase converts thyroxin into melanin. (B)</p> Signup and view all the answers

Albinism is primarily caused by the body's inability to perform what function?

<p>Produce or properly store melanin. (A)</p> Signup and view all the answers

Which epidermal layer contains melanocytes, playing a key role in skin pigmentation?

<p>Stratum basale (D)</p> Signup and view all the answers

In the context of epidermal layers, which layer is characterized by cells that have begun to flatten and connect with each other, contributing to the skin's strength and flexibility?

<p>Stratum spinosum (C)</p> Signup and view all the answers

What is the primary characteristic of the stratum corneum?

<p>It is composed of dead, flattened cells. (D)</p> Signup and view all the answers

The stratum lucidum is found only in thick skin and provides what key function?

<p>Reducing friction (B)</p> Signup and view all the answers

How can tension lines or lines of cleavage in the skin be best described?

<p>They are patterns indicating the predominant direction of collagen fibers. (A)</p> Signup and view all the answers

Which of the following is a key function of the papillary layer of the dermis?

<p>Nourishing the epidermis (C)</p> Signup and view all the answers

What type of tissue is primarily found in the papillary layer of the dermis, contributing to its flexibility and support?

<p>Areolar connective tissue (C)</p> Signup and view all the answers

Why is understanding the direction of tension lines important?

<p>It indicates how the skin naturally stretches and moves, affecting surgical incisions. (C)</p> Signup and view all the answers

Which epidermal cell has an axon and is a two cell component?

<p>Merkel cell (A)</p> Signup and view all the answers

Within the epidermis, which layer contains cells filled with keratin that begin to die, thus forming a protective barrier?

<p>Stratum granulosum (D)</p> Signup and view all the answers

Which of the following statements correctly describes the relationship between the epidermis and the dermis?

<p>The epidermis is avascular and relies on the dermis for nutrient supply. (A)</p> Signup and view all the answers

In the context of melanin production, what is the primary consequence of a deficiency in the enzyme thyroxinase?

<p>Inability to convert thyroxin into melanin (B)</p> Signup and view all the answers

Which epidermal layer is the deepest and where new keratinocytes are produced?

<p>Stratum basale (A)</p> Signup and view all the answers

Which layer do melanocytes that produce pigment locate?

<p>Stratum basale (C)</p> Signup and view all the answers

Which layer contains cells converting to die, and form a protective barrier?

<p>Stratum granulosum (A)</p> Signup and view all the answers

Which of the following is the primary function of the dermis?

<p>Contains collagen and elastic fibers. (D)</p> Signup and view all the answers

Which layer is the most superficial part in the skin?

<p>Papillary layer (C)</p> Signup and view all the answers

Which of the following layers has nerve endings and corpuscles of touch?

<p>Papillary layer (C)</p> Signup and view all the answers

Which epidermal layer is composed of dead keratinocytes?

<p>Stratum corneum (C)</p> Signup and view all the answers

Which epidermal layer is not present on eyelids?

<p>Stratum lucidum (A)</p> Signup and view all the answers

The junction of stratum spinosum and stratum granulosum is found:

<p>where 2 layers come together (D)</p> Signup and view all the answers

Which connective tissues have collagen and elastic fibers?

<p>Areolar connective tissue (D)</p> Signup and view all the answers

What are the 4 major layers of the epidermis?

<p>corneum, lucidum, granulosum, basale (C)</p> Signup and view all the answers

Flashcards

Integumentary System

The system including skin, hair, nails and glands, as well as blood vessels, muscles and nerves.

Dermatology

Medical field focused on diagnosing and treating integumentary system disorders.

Cutaneous Membrane

The skin; body's largest organ by surface area and weight.

Epidermis

Outer, thinner layer of the skin made of epithelial tissue.

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Dermis

Inner, thicker layer of the skin containing connective tissue.

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Subcutaneous (Hypodermis)

Layer beneath dermis that attaches skin to tissues and organs.

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Keratinocytes

Skin cells producing keratin, a protective protein.

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Melanocytes

Cells that produce melanin to protect against UV radiation.

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Langerhans Cells

Cells involved in immune responses, arising from red bone marrow.

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Merkel Cells

Cells functioning in touch sensation with tactile discs.

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Stratum Basale

Deepest layer where continuous cell division occurs.

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Stratum Spinosum

Layer of 8-10 layers of keratinocytes.

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Stratum Granulosum

Layer with keratohyalin and lamellar granules; varies in thickness.

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Stratum Lucidum

Layer only in thick skin on fingertips, palms, and soles.

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Stratum Corneum

Outermost layer of dead keratinocytes.

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Keratinization

Process of accumulating protective keratin in skin cells.

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Papillary Region

Outer region of dermis with areolar connective tissue.

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Dermal Papillae

Dermal projections with capillary loops.

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Reticular Region

Deeper region of dermis with dense irregular connective tissue.

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Lines of Cleavage

Lines indicating predominant direction of collagen fibers in the skin.

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Epidermal Ridges

Contours forming fingerprints and footprints; increase grip.

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Dermatoglyphics

Study of epidermal ridge patterns like fingerprints.

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Melanin

Yellow-red or brown-black pigment produced by melanocytes.

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Nevus (Mole)

Localized overgrowth of melanocytes.

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Albinism

Inherited inability to produce melanin.

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Vitiligo

Condition of partial or complete melanocyte loss in patches.

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Carotene

Yellow-orange pigment found in the stratum corneum.

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Subcutaneous Layer

Layer not part of skin that attaches to underlying tissue.

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Pili

Hairs that have functions such as protection and sensing light touch.

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Hair Shaft

Part of the hair projecting above the skin surface.

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Hair Root

Hair part that penetrates into the dermis.

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Hair Follicle

Structure surrounding the hair root.

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Sebaceous (Oil) Glands

Glands connected to hair follicles that secrete sebum.

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Sudoriferous (Sweat) Glands

Glands secreting sweat for cooling and waste removal.

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Eccrine Sweat Glands

Sweat glands for cooling the body.

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Apocrine Glands

Sweat glands in axilla, groin, and beard areas that open into hair follicles.

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Ceruminous Glands

Modified sweat glands in the ear canal producing earwax.

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Nails

Hard keratinized epidermal cells on ends of fingers and Toes.

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Thin (hairy) Skin

Covers all body regions except palms, palmar surfaces of digits, and soles

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Thick (hairless) skin

Covers the palms, palmar surfaces of digits, and soles

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Integument

Outer protective covering of an organism; includes skin, hair, nails, sweat glands, and sensory receptors.

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Subcutaneous Layer (Hypodermis)

Deepest layer of the skin, connecting it to muscles and organs; cushions, insulates, and stores energy.

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Binding and anchoring (Subcutaneous layer)

Anchors skin to underlying tissues, contains collagen and elastin fibers.

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Fat Storage (Subcutaneous layer)

Rich in adipose tissue; cushions, insulates, and acts as an energy reserve.

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Blood Vessels and Nerves (Subcutaneous layer)

Contains blood vessels and nerves; supplies nutrients and aids thermoregulation.

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Keratin

Tough, fibrous protein that protects hair from damage and provides strength.

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Arteries

Red; carries oxygen-rich blood from the heart.

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Veins

Blue, carry oxygen-poor blood back to the heart.

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90% of Insulin

Administered subcutaneously, easiest administration, not IV.

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Aspirating

Pulling back the plunger during an Intramuscular (IM) injection to check for blood.

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Arteries (oxygen content)

Usually carries oxygenated blood, except for the pulmonary artery.

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Veins (oxygen content)

Usually carries deoxygenated blood, except for the pulmonary veins.

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Arteries (wall structure)

Thick, muscular, and elastic walls to withstand high pressure.

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Veins (wall structure)

Thinner walls with valves to prevent backflow.

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Pulmonary Artery

Carries oxygen-poor blood from the heart to the lungs.

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Fingerprints/Footprints

The shape formed by epidermal papillae; unique to each person.

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Pacinian Corpuscles

Detects pressure and vibrations in the subcutaneous layer.

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Hair

Accessory structures for protection, reduction of heat loss, and sensing light touch.

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Sebaceous Glands

Attached directly to hair follicle; secrete sebum

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Sebum

Material secreted by sebaceous glands to prevent dehydration.

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Apocrine Sweat Glands

Located in armpits and groin; produce thicker sweat that can cause body odor.

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Cerumen

Helps protect the ear by trapping dirt, contains antimicrobial properties.

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Vitamin D Production

Needs UV radiation or sunlight to be activated.

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Cholecalciferol (Vit D3)

Vitamin D in humans and mammals.

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Ergosterol

Vitamin D in Fungi

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Thyroxin

Amino acid needed to create melanin.

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Papillary Layer

Superficial region of the dermis, consisting of areolar connective tissue.

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Areolar Connective Tissue

A type of loose connective tissue; contains collagen and elastic fibers.

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Thyroxinase

Deficiency in this enzyme causes lack of melanin at a rate of (95%/98%/99%).

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Study Notes

  • Albinism is a genetic condition causing the body to be unable to produce or properly store melanin due to gene mutations.
  • People with albinism have very pale skin, hair, and eyes from birth, with a lack of melanin throughout the body.
  • In albinism, little to no melanin is produced, increasing sensitivity to sunlight and the risk of eye problems.
  • Albinism is present at birth and persists throughout life.
  • In most cases (95-99%), albinism results from a deficiency in the enzyme tyrosinase, which is needed to create melanin from the amino acid tyrosine.
  • Individuals with this genetic disease cannot metabolize tyrosine to create melanin.
  • Keratinocytes feature keratinocyte filaments, also known as broomsticks.
  • Merkel cells feature axons.
  • Merkel cells are two-cell components.
  • Melanocytes may have cellular extensions, sometimes called "paa", or granules.
  • Langerhans cells have many nuclei.
  • Epidermis has four major layers, varying in thickness in different parts of the body.
  • Epidermis is thickest on the sole of the foot, which has 5 layers.
  • Epidermis is thinnest on the scrotum and eyelids, which only have 4 layers.

Epidermis Layers

  • The stratum basale (stratum germinativum) is the deepest layer where new skin cells (keratinocytes) are produced.
  • The stratum basale (stratum germinativum) also location of melanocytes (cells that produce pigment).
  • The first layer of above the dermis is the stratum basale.
  • The stratum spinosum, also known as the "spiny layer", is where cells begin to flatten.
  • The stratum spinosum provides strength and flexibility to the skin through connections between cells.
  • The stratum granulosum contains cells filled with keratin and beginning to die, forming a protective barrier as they move upwards.
  • Stratum granulosum is the darkest and most tinted layer of the skin.
  • The stratum lucidum is found only in thick skin, such as palms and soles.
  • The stratum lucidum is a thin, clear layer that reduces friction.
  • The stratum lucidum appears white in color.
  • The stratum corneum is the outermost layer, composed of dead, flattened cells that provide a tough, protective barrier.
  • The stratum corneum is thick in the epidermis, except if found on the eyelids.
  • The stratum corneum consists of dead keratinocytes and is the most superficial layer.
  • The stratum corneum is located in the stratum spinosum and the junction of the stratum granulosum, where two layers are joined together.

Dermis

  • The dermis has an important function in the skin, containing collagen and elastic fibers.
  • The dermis has two layers: the papillary layer (the most superficial part) and the reticular/deeper layer.
  • The dermal papillae is the inner/deeper layer
  • The dermis consists of areolar connective tissue, collagen and elastic fibers and has nerve endings called corpuscles of touch and also free nerve endings.
  • Areolar connective tissue is a type of loose connective tissue which is flexible and supports, cushions and adds elasticity to the skin.
  • The dermis nourishes the epidermis and allows for the movement of nutrients, waste and immune cells.

Lines of Cleavage

  • Lines of cleavage, also known as tension lines, are patterns in the skin which show the direction in which collagen fibers are arranged.
  • Lines of cleavage indicate how the skin is naturally stretched and moved.
  • These lines are typically running in certain directions, especially in areas like the back, arms, and chest.
  • Lines of cleavage follow the underlying collagen fibers' direction, helping the skin stay strong and flexible.
  • Lines of cleavage aren't visible in normal conditions but can be seen when the skin is stretched or injured.

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