Podcast
Questions and Answers
Which of the following cellular processes is most directly affected by the accumulation of keratohyalin and lamellar granules within the stratum granulosum?
Which of the following cellular processes is most directly affected by the accumulation of keratohyalin and lamellar granules within the stratum granulosum?
- The synthesis of melanin for UV protection.
- The formation of the cornified cell envelope and epidermal water barrier. (correct)
- The sensation of light touch through Merkel cells.
- The regulation of immune responses via Langerhans cells.
A patient presents with a localized patch of skin exhibiting complete loss of melanocytes. This condition is best described as which of the following?
A patient presents with a localized patch of skin exhibiting complete loss of melanocytes. This condition is best described as which of the following?
- Vitiligo, characterized by partial or complete melanocyte loss. (correct)
- Carotenemia, induced by excessive carotene deposition.
- Nevus, indicating a benign overgrowth of melanocytes.
- Albinism, resulting from a genetic inability to produce melanin.
Which of the following statements accurately compares eccrine and apocrine sweat glands?
Which of the following statements accurately compares eccrine and apocrine sweat glands?
- Apocrine glands are distributed throughout the body, but eccrine glands are limited to specific regions like the axilla and groin.
- Apocrine glands produce a watery secretion to eliminate wastes, while eccrine glands produce viscous secretions containing lipids.
- Eccrine glands release sweat directly onto the skin surface, whereas apocrine gland secretions typically enter hair follicles. (correct)
- Eccrine glands primarily function in emotional stress response, while apocrine glands regulate body temperature.
In the context of deep wound healing, what is the primary role of fibroblasts during the maturation phase?
In the context of deep wound healing, what is the primary role of fibroblasts during the maturation phase?
If a patient is diagnosed with a condition affecting the reticular region of the dermis, which of the following would most likely be observed?
If a patient is diagnosed with a condition affecting the reticular region of the dermis, which of the following would most likely be observed?
Which of the following describes the correct chronological sequence of epidermal layers, starting from the most superficial layer to the deepest?
Which of the following describes the correct chronological sequence of epidermal layers, starting from the most superficial layer to the deepest?
How does the presence of epidermal ridges contribute to the function of the skin?
How does the presence of epidermal ridges contribute to the function of the skin?
What is the primary functional significance of the lamellated (Pacinian) corpuscles located within the hypodermis and sometimes the dermis?
What is the primary functional significance of the lamellated (Pacinian) corpuscles located within the hypodermis and sometimes the dermis?
What effect does aging have on the population and function of melanocytes, and how does this manifest in the integumentary system?
What effect does aging have on the population and function of melanocytes, and how does this manifest in the integumentary system?
In the context of wound healing in the epidermis, which cellular activity is most critical for the re-establishment of the epidermal barrier?
In the context of wound healing in the epidermis, which cellular activity is most critical for the re-establishment of the epidermal barrier?
A burn patient has damage extending through the epidermis and part of the dermis. While the patient has pain, the function of which structure still remains intact?
A burn patient has damage extending through the epidermis and part of the dermis. While the patient has pain, the function of which structure still remains intact?
How does the keratinization process contribute to the protective function of the skin?
How does the keratinization process contribute to the protective function of the skin?
Which component is NOT a derivative of the ectoderm?
Which component is NOT a derivative of the ectoderm?
What is the primary function of the vernix caseosa that protects the epidermis of a fetus?
What is the primary function of the vernix caseosa that protects the epidermis of a fetus?
What is the primary result of the skin's reduced immune-responsiveness to aging?
What is the primary result of the skin's reduced immune-responsiveness to aging?
How would severely decreased sweat production affect body temperature regulation?
How would severely decreased sweat production affect body temperature regulation?
What physiological change explains why aged skin is more prone to cracking?
What physiological change explains why aged skin is more prone to cracking?
In the context of skin grafts, what is the primary advantage of using an autograft compared to an allograft?
In the context of skin grafts, what is the primary advantage of using an autograft compared to an allograft?
If a newly developed topical medication is designed to enhance the skin's natural barrier function, which of the following components should it primarily target within the epidermis?
If a newly developed topical medication is designed to enhance the skin's natural barrier function, which of the following components should it primarily target within the epidermis?
A patient reports excessive dryness and cracking of the skin, particularly on the hands, during winter. Which of the following would most effectively address this issue?
A patient reports excessive dryness and cracking of the skin, particularly on the hands, during winter. Which of the following would most effectively address this issue?
Which cellular event is most directly responsible for the formation of a callus in thick skin?
Which cellular event is most directly responsible for the formation of a callus in thick skin?
How does the structure of the dermis contribute to the skin's overall resilience and ability to withstand mechanical stress?
How does the structure of the dermis contribute to the skin's overall resilience and ability to withstand mechanical stress?
Following a laceration that damages both the epidermis and dermis, which sequence of events accurately describes the process of scar formation in deep wound healing?
Following a laceration that damages both the epidermis and dermis, which sequence of events accurately describes the process of scar formation in deep wound healing?
A dermatologist explains to a patient that their seborrheic dermatitis is linked to increased sebum production. This condition primarily involves the malfunction of what skin structure?
A dermatologist explains to a patient that their seborrheic dermatitis is linked to increased sebum production. This condition primarily involves the malfunction of what skin structure?
If a patient is diagnosed with a tumor originating from melanocytes, in which epidermal layer did this tumor most likely begin its development?
If a patient is diagnosed with a tumor originating from melanocytes, in which epidermal layer did this tumor most likely begin its development?
Why is the stratum lucidum only found in thick skin?
Why is the stratum lucidum only found in thick skin?
Why does skin wrinkle due to old age?
Why does skin wrinkle due to old age?
Which of the following explains why a person's hair turns gray as they age?
Which of the following explains why a person's hair turns gray as they age?
What are the accessory structure of the skin?
What are the accessory structure of the skin?
What determines the color of hair?
What determines the color of hair?
Why can striae or stretch marks appear?
Why can striae or stretch marks appear?
Which of the following skin sensations is not related to the cutaneous sensations?
Which of the following skin sensations is not related to the cutaneous sensations?
A yellow-orange pigment found in various layers of the skin would be:
A yellow-orange pigment found in various layers of the skin would be:
Which of the following are functions of hair?
Which of the following are functions of hair?
Dermatoglyphics is:
Dermatoglyphics is:
What is the role of melanin in the skin?
What is the role of melanin in the skin?
The primary function of sebum secreted by sebaceous glands is to do which of the following?
The primary function of sebum secreted by sebaceous glands is to do which of the following?
A free edge would be part of:
A free edge would be part of:
The dermis is composed of:
The dermis is composed of:
Why is the subcutaneous layer important for administering subcutaneous injections?
Why is the subcutaneous layer important for administering subcutaneous injections?
How does the subcutaneous layer contribute to thermoregulation?
How does the subcutaneous layer contribute to thermoregulation?
A patient experiences a superficial cut that bleeds. Which layer of the skin is involved?
A patient experiences a superficial cut that bleeds. Which layer of the skin is involved?
What characteristic of keratin contributes to the protective function of the epidermis and hair?
What characteristic of keratin contributes to the protective function of the epidermis and hair?
Why is it important to aspirate during intramuscular injections?
Why is it important to aspirate during intramuscular injections?
How does the distribution of subcutaneous fat contribute to body contour and shape?
How does the distribution of subcutaneous fat contribute to body contour and shape?
How do the structural properties of arteries assist in their function?
How do the structural properties of arteries assist in their function?
What is the primary role of veins in the circulatory system?
What is the primary role of veins in the circulatory system?
How does the integumentary system facilitate sensory perception?
How does the integumentary system facilitate sensory perception?
Based on the image, what is the relationship between the epidermis and the dermis?
Based on the image, what is the relationship between the epidermis and the dermis?
In a comparison between arteries and veins, which of the following characteristics is exclusive to veins?
In a comparison between arteries and veins, which of the following characteristics is exclusive to veins?
Which of the following statements accurately describes the oxygen content in blood vessels?
Which of the following statements accurately describes the oxygen content in blood vessels?
How does the shape and structure of arteries contribute to their function, compared to veins?
How does the shape and structure of arteries contribute to their function, compared to veins?
Which of the following best describes the primary role of keratinocytes in the epidermis?
Which of the following best describes the primary role of keratinocytes in the epidermis?
What is the functional significance of melanocytes within the epidermis?
What is the functional significance of melanocytes within the epidermis?
In what capacity do Langerhans cells function within the skin's defense mechanisms?
In what capacity do Langerhans cells function within the skin's defense mechanisms?
Which of the following describes how Merkel cells contribute to the sense of touch?
Which of the following describes how Merkel cells contribute to the sense of touch?
How does vitiligo affect skin pigmentation, and what causes this condition?
How does vitiligo affect skin pigmentation, and what causes this condition?
Which of the following is a key characteristic of albinism that distinguishes it from vitiligo?
Which of the following is a key characteristic of albinism that distinguishes it from vitiligo?
What purpose do epidermal ridges serve in the skin?
What purpose do epidermal ridges serve in the skin?
What is the primary function of Pacinian corpuscles located in the subcutaneous layer?
What is the primary function of Pacinian corpuscles located in the subcutaneous layer?
How do sebaceous glands contribute to the health and function of the skin?
How do sebaceous glands contribute to the health and function of the skin?
What is the primary mechanism by which eccrine sweat glands regulate body temperature?
What is the primary mechanism by which eccrine sweat glands regulate body temperature?
How do ceruminous glands protect the ear canal?
How do ceruminous glands protect the ear canal?
How do nails contribute to the functionality of fingers and toes?
How do nails contribute to the functionality of fingers and toes?
How does exposure to UV radiation or sunlight contribute to vitamin D production in the body?
How does exposure to UV radiation or sunlight contribute to vitamin D production in the body?
Which substance do sebaceous glands secrete, and what is its primary function?
Which substance do sebaceous glands secrete, and what is its primary function?
What is the role of hair in relation to light touch sensitivity?
What is the role of hair in relation to light touch sensitivity?
Which of the following characterizes the wall structure of arteries compared to veins?
Which of the following characterizes the wall structure of arteries compared to veins?
Where are apocrine sweat glands primarily located, and what is a distinctive characteristic of their secretions?
Where are apocrine sweat glands primarily located, and what is a distinctive characteristic of their secretions?
Which of the following is a vitamin D precursor found in fungi?
Which of the following is a vitamin D precursor found in fungi?
What part of the skin is technically not a layer?
What part of the skin is technically not a layer?
Which process helps form finger prints or footprints?
Which process helps form finger prints or footprints?
What do dermatoglyphics study?
What do dermatoglyphics study?
Which of the following materials is secreted by the ceruminous gland?
Which of the following materials is secreted by the ceruminous gland?
Which of the following best describes the role of thyroxinase in melanin production?
Which of the following best describes the role of thyroxinase in melanin production?
Albinism is primarily caused by the body's inability to perform what function?
Albinism is primarily caused by the body's inability to perform what function?
Which epidermal layer contains melanocytes, playing a key role in skin pigmentation?
Which epidermal layer contains melanocytes, playing a key role in skin pigmentation?
In the context of epidermal layers, which layer is characterized by cells that have begun to flatten and connect with each other, contributing to the skin's strength and flexibility?
In the context of epidermal layers, which layer is characterized by cells that have begun to flatten and connect with each other, contributing to the skin's strength and flexibility?
What is the primary characteristic of the stratum corneum?
What is the primary characteristic of the stratum corneum?
The stratum lucidum is found only in thick skin and provides what key function?
The stratum lucidum is found only in thick skin and provides what key function?
How can tension lines or lines of cleavage in the skin be best described?
How can tension lines or lines of cleavage in the skin be best described?
Which of the following is a key function of the papillary layer of the dermis?
Which of the following is a key function of the papillary layer of the dermis?
What type of tissue is primarily found in the papillary layer of the dermis, contributing to its flexibility and support?
What type of tissue is primarily found in the papillary layer of the dermis, contributing to its flexibility and support?
Why is understanding the direction of tension lines important?
Why is understanding the direction of tension lines important?
Which epidermal cell has an axon and is a two cell component?
Which epidermal cell has an axon and is a two cell component?
Within the epidermis, which layer contains cells filled with keratin that begin to die, thus forming a protective barrier?
Within the epidermis, which layer contains cells filled with keratin that begin to die, thus forming a protective barrier?
Which of the following statements correctly describes the relationship between the epidermis and the dermis?
Which of the following statements correctly describes the relationship between the epidermis and the dermis?
In the context of melanin production, what is the primary consequence of a deficiency in the enzyme thyroxinase?
In the context of melanin production, what is the primary consequence of a deficiency in the enzyme thyroxinase?
Which epidermal layer is the deepest and where new keratinocytes are produced?
Which epidermal layer is the deepest and where new keratinocytes are produced?
Which layer do melanocytes that produce pigment locate?
Which layer do melanocytes that produce pigment locate?
Which layer contains cells converting to die, and form a protective barrier?
Which layer contains cells converting to die, and form a protective barrier?
Which of the following is the primary function of the dermis?
Which of the following is the primary function of the dermis?
Which layer is the most superficial part in the skin?
Which layer is the most superficial part in the skin?
Which of the following layers has nerve endings and corpuscles of touch?
Which of the following layers has nerve endings and corpuscles of touch?
Which epidermal layer is composed of dead keratinocytes?
Which epidermal layer is composed of dead keratinocytes?
Which epidermal layer is not present on eyelids?
Which epidermal layer is not present on eyelids?
The junction of stratum spinosum and stratum granulosum is found:
The junction of stratum spinosum and stratum granulosum is found:
Which connective tissues have collagen and elastic fibers?
Which connective tissues have collagen and elastic fibers?
What are the 4 major layers of the epidermis?
What are the 4 major layers of the epidermis?
Flashcards
Integumentary System
Integumentary System
The system including skin, hair, nails and glands, as well as blood vessels, muscles and nerves.
Dermatology
Dermatology
Medical field focused on diagnosing and treating integumentary system disorders.
Cutaneous Membrane
Cutaneous Membrane
The skin; body's largest organ by surface area and weight.
Epidermis
Epidermis
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Dermis
Dermis
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Subcutaneous (Hypodermis)
Subcutaneous (Hypodermis)
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Keratinocytes
Keratinocytes
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Melanocytes
Melanocytes
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Langerhans Cells
Langerhans Cells
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Merkel Cells
Merkel Cells
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Stratum Basale
Stratum Basale
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Stratum Spinosum
Stratum Spinosum
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Stratum Granulosum
Stratum Granulosum
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Stratum Lucidum
Stratum Lucidum
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Stratum Corneum
Stratum Corneum
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Keratinization
Keratinization
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Papillary Region
Papillary Region
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Dermal Papillae
Dermal Papillae
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Reticular Region
Reticular Region
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Lines of Cleavage
Lines of Cleavage
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Epidermal Ridges
Epidermal Ridges
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Dermatoglyphics
Dermatoglyphics
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Melanin
Melanin
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Nevus (Mole)
Nevus (Mole)
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Albinism
Albinism
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Vitiligo
Vitiligo
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Carotene
Carotene
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Subcutaneous Layer
Subcutaneous Layer
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Pili
Pili
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Hair Shaft
Hair Shaft
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Hair Root
Hair Root
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Hair Follicle
Hair Follicle
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Sebaceous (Oil) Glands
Sebaceous (Oil) Glands
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Sudoriferous (Sweat) Glands
Sudoriferous (Sweat) Glands
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Eccrine Sweat Glands
Eccrine Sweat Glands
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Apocrine Glands
Apocrine Glands
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Ceruminous Glands
Ceruminous Glands
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Nails
Nails
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Thin (hairy) Skin
Thin (hairy) Skin
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Thick (hairless) skin
Thick (hairless) skin
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Integument
Integument
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Subcutaneous Layer (Hypodermis)
Subcutaneous Layer (Hypodermis)
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Binding and anchoring (Subcutaneous layer)
Binding and anchoring (Subcutaneous layer)
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Fat Storage (Subcutaneous layer)
Fat Storage (Subcutaneous layer)
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Blood Vessels and Nerves (Subcutaneous layer)
Blood Vessels and Nerves (Subcutaneous layer)
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Keratin
Keratin
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Arteries
Arteries
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Veins
Veins
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90% of Insulin
90% of Insulin
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Aspirating
Aspirating
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Arteries (oxygen content)
Arteries (oxygen content)
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Veins (oxygen content)
Veins (oxygen content)
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Arteries (wall structure)
Arteries (wall structure)
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Veins (wall structure)
Veins (wall structure)
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Pulmonary Artery
Pulmonary Artery
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Fingerprints/Footprints
Fingerprints/Footprints
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Pacinian Corpuscles
Pacinian Corpuscles
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Hair
Hair
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Sebaceous Glands
Sebaceous Glands
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Sebum
Sebum
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Apocrine Sweat Glands
Apocrine Sweat Glands
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Cerumen
Cerumen
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Vitamin D Production
Vitamin D Production
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Cholecalciferol (Vit D3)
Cholecalciferol (Vit D3)
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Ergosterol
Ergosterol
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Thyroxin
Thyroxin
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Papillary Layer
Papillary Layer
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Areolar Connective Tissue
Areolar Connective Tissue
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Thyroxinase
Thyroxinase
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Study Notes
- Albinism is a genetic condition causing the body to be unable to produce or properly store melanin due to gene mutations.
- People with albinism have very pale skin, hair, and eyes from birth, with a lack of melanin throughout the body.
- In albinism, little to no melanin is produced, increasing sensitivity to sunlight and the risk of eye problems.
- Albinism is present at birth and persists throughout life.
- In most cases (95-99%), albinism results from a deficiency in the enzyme tyrosinase, which is needed to create melanin from the amino acid tyrosine.
- Individuals with this genetic disease cannot metabolize tyrosine to create melanin.
- Keratinocytes feature keratinocyte filaments, also known as broomsticks.
- Merkel cells feature axons.
- Merkel cells are two-cell components.
- Melanocytes may have cellular extensions, sometimes called "paa", or granules.
- Langerhans cells have many nuclei.
- Epidermis has four major layers, varying in thickness in different parts of the body.
- Epidermis is thickest on the sole of the foot, which has 5 layers.
- Epidermis is thinnest on the scrotum and eyelids, which only have 4 layers.
Epidermis Layers
- The stratum basale (stratum germinativum) is the deepest layer where new skin cells (keratinocytes) are produced.
- The stratum basale (stratum germinativum) also location of melanocytes (cells that produce pigment).
- The first layer of above the dermis is the stratum basale.
- The stratum spinosum, also known as the "spiny layer", is where cells begin to flatten.
- The stratum spinosum provides strength and flexibility to the skin through connections between cells.
- The stratum granulosum contains cells filled with keratin and beginning to die, forming a protective barrier as they move upwards.
- Stratum granulosum is the darkest and most tinted layer of the skin.
- The stratum lucidum is found only in thick skin, such as palms and soles.
- The stratum lucidum is a thin, clear layer that reduces friction.
- The stratum lucidum appears white in color.
- The stratum corneum is the outermost layer, composed of dead, flattened cells that provide a tough, protective barrier.
- The stratum corneum is thick in the epidermis, except if found on the eyelids.
- The stratum corneum consists of dead keratinocytes and is the most superficial layer.
- The stratum corneum is located in the stratum spinosum and the junction of the stratum granulosum, where two layers are joined together.
Dermis
- The dermis has an important function in the skin, containing collagen and elastic fibers.
- The dermis has two layers: the papillary layer (the most superficial part) and the reticular/deeper layer.
- The dermal papillae is the inner/deeper layer
- The dermis consists of areolar connective tissue, collagen and elastic fibers and has nerve endings called corpuscles of touch and also free nerve endings.
- Areolar connective tissue is a type of loose connective tissue which is flexible and supports, cushions and adds elasticity to the skin.
- The dermis nourishes the epidermis and allows for the movement of nutrients, waste and immune cells.
Lines of Cleavage
- Lines of cleavage, also known as tension lines, are patterns in the skin which show the direction in which collagen fibers are arranged.
- Lines of cleavage indicate how the skin is naturally stretched and moved.
- These lines are typically running in certain directions, especially in areas like the back, arms, and chest.
- Lines of cleavage follow the underlying collagen fibers' direction, helping the skin stay strong and flexible.
- Lines of cleavage aren't visible in normal conditions but can be seen when the skin is stretched or injured.
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