Podcast
Questions and Answers
Match the receptor type with its primary function:
Match the receptor type with its primary function:
Nociceptor = Detects pain and tissue damage Root Hair Plexus = Detects movement of hair Merkel Disc = Discriminative touch; precise object details Meissner’s Corpuscle = Detects gentle pressure and soft vibrations
Match the receptor type with its location in the skin:
Match the receptor type with its location in the skin:
Free Nerve Endings = Top of the dermis Merkel Disc = Bottom layer of the epidermis Meissner’s Corpuscle = Top of the dermis Root Hair Plexus = Around the hair follicle
Match the receptor type with its classification as tonic or phasic:
Match the receptor type with its classification as tonic or phasic:
Merkel Disc = Tonic receptor Meissner’s Corpuscle = Phasic receptor Nociceptor = Can exhibit both tonic and phasic properties Ruffini Corpuscle = Tonic receptor
Match the receptor type with its characteristic response to stimuli:
Match the receptor type with its characteristic response to stimuli:
Match the characteristic with the correct type of nerve ending receptor:
Match the characteristic with the correct type of nerve ending receptor:
Match the following receptors with what types of stimuli they respond to:
Match the following receptors with what types of stimuli they respond to:
Match the receptor type with its ability to provide detailed touch information on the skin:
Match the receptor type with its ability to provide detailed touch information on the skin:
Match the following with what stimulus intensity they respond to:
Match the following with what stimulus intensity they respond to:
Match the layer of the integument with its primary components:
Match the layer of the integument with its primary components:
Match the function of the integument with its mechanism:
Match the function of the integument with its mechanism:
Match the process with blood vessel behavior
Match the process with blood vessel behavior
Match the component of the surface film with its primary contribution:
Match the component of the surface film with its primary contribution:
Match the tissue type with its corresponding skin layer:
Match the tissue type with its corresponding skin layer:
Match the condition or state with the blood flow response in the skin:
Match the condition or state with the blood flow response in the skin:
Match the function of the integument with a chemical substance or process involved:
Match the function of the integument with a chemical substance or process involved:
Match the change in blood flow to skin with its effect on heat retention or loss:
Match the change in blood flow to skin with its effect on heat retention or loss:
Match the epidermal function with its corresponding description:
Match the epidermal function with its corresponding description:
Match the layer of the dermis with its main characteristic:
Match the layer of the dermis with its main characteristic:
Match the type of sensory receptor with the stimulus it detects:
Match the type of sensory receptor with the stimulus it detects:
Match the description with the appropriate term related to collagen fibers in the dermis:
Match the description with the appropriate term related to collagen fibers in the dermis:
Match the property of skin with its description:
Match the property of skin with its description:
Match the result of skin damage with its description:
Match the result of skin damage with its description:
Match the surgical procedure consideration with its consequence:
Match the surgical procedure consideration with its consequence:
Match the type of receptor with the kind of mechanical distortion it responds to:
Match the type of receptor with the kind of mechanical distortion it responds to:
Match each skin cancer type with its cell of origin:
Match each skin cancer type with its cell of origin:
Match each skin cancer type with its typical lesion description:
Match each skin cancer type with its typical lesion description:
Match each skin cancer type with its likelihood of metastasis:
Match each skin cancer type with its likelihood of metastasis:
Match each skin cancer type with the typical location on the body:
Match each skin cancer type with the typical location on the body:
Match each skin cancer with its relative mortality rate:
Match each skin cancer with its relative mortality rate:
Match each skin cancer type with a key distinguishing characteristic:
Match each skin cancer type with a key distinguishing characteristic:
Match the skin cancer with its primary risk factor from the list:
Match the skin cancer with its primary risk factor from the list:
Match the skin cancer with its appropriate treatment approach:
Match the skin cancer with its appropriate treatment approach:
Match each phase of tissue healing with its primary characteristic:
Match each phase of tissue healing with its primary characteristic:
Match the following inflammatory mediators with their primary action:
Match the following inflammatory mediators with their primary action:
Match the type of white blood cell (WBC) with its primary function during tissue repair:
Match the type of white blood cell (WBC) with its primary function during tissue repair:
Match each term related to tissue injury with its description:
Match each term related to tissue injury with its description:
Associate each event with its corresponding stage of the inflammatory response:
Associate each event with its corresponding stage of the inflammatory response:
Match each chemical cue with its specific role in chemotaxis during the inflammatory response:
Match each chemical cue with its specific role in chemotaxis during the inflammatory response:
Match the type of tissue repair with its description:
Match the type of tissue repair with its description:
Match the following cells with their primary role in tissue healing:
Match the following cells with their primary role in tissue healing:
Match the epidermal layer with its primary function:
Match the epidermal layer with its primary function:
Match the term with its correct definition related to skin structure:
Match the term with its correct definition related to skin structure:
Match the characteristic with the correct layer of the integument:
Match the characteristic with the correct layer of the integument:
Match the description with the skin layer it best describes:
Match the description with the skin layer it best describes:
Match the cell type with its primary role in the epidermis:
Match the cell type with its primary role in the epidermis:
Match the process with its role in epidermal structure:
Match the process with its role in epidermal structure:
Match the characteristics that occur during keratinization:
Match the characteristics that occur during keratinization:
Match the process in the epidermis with its effect on skin:
Match the process in the epidermis with its effect on skin:
Flashcards
Skin Layers
Skin Layers
Two layers: epidermis and dermis.
Integument Layers
Integument Layers
Three layers: epidermis, dermis, and hypodermis.
Integument Purposes
Integument Purposes
Protection, excretion, temperature maintenance, vitamin D synthesis, and sensitivity.
Surface Film
Surface Film
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Vasodilation
Vasodilation
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Vasoconstriction
Vasoconstriction
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Vitamin D synthesis
Vitamin D synthesis
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Epidermis Tissue
Epidermis Tissue
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Hypodermis Fat Storage
Hypodermis Fat Storage
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Hypodermis Function
Hypodermis Function
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Hypodermis Blood Supply
Hypodermis Blood Supply
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Hypodermis Medical Use
Hypodermis Medical Use
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Keratinization Purpose
Keratinization Purpose
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Keratinocyte Movement
Keratinocyte Movement
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Keratinocyte Shape Change
Keratinocyte Shape Change
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Stratum Basale
Stratum Basale
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Epidermal Folds Significance
Epidermal Folds Significance
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Epidermal Ridges Function
Epidermal Ridges Function
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Fingerprints
Fingerprints
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Stretch Marks
Stretch Marks
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Reticular Layer Significance
Reticular Layer Significance
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Cleavage (Tension) Lines
Cleavage (Tension) Lines
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Mechanoreceptors
Mechanoreceptors
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Reticular Layer Structure
Reticular Layer Structure
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Nociceptors
Nociceptors
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Free Nerve Endings
Free Nerve Endings
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Nociceptor Function
Nociceptor Function
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Root Hair Plexus
Root Hair Plexus
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Merkel Disc
Merkel Disc
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Discriminative Touch
Discriminative Touch
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Tonic Receptors
Tonic Receptors
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Phasic Receptors
Phasic Receptors
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Basal Cell Carcinoma
Basal Cell Carcinoma
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Basal Cell Carinoma Lesion
Basal Cell Carinoma Lesion
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Squamous Cell Carcinoma
Squamous Cell Carcinoma
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Squamous Cell Carcinoma Lesion
Squamous Cell Carcinoma Lesion
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Malignant Melanoma
Malignant Melanoma
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Melanoma Lesion
Melanoma Lesion
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Metastatic Melanoma
Metastatic Melanoma
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Sarcoma
Sarcoma
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Inflammation
Inflammation
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Signs of Inflammation
Signs of Inflammation
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Vasodilation in Inflammation
Vasodilation in Inflammation
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Increased Vascular Permeability
Increased Vascular Permeability
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Diapedesis
Diapedesis
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Chemotaxis
Chemotaxis
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Phagocytosis in Inflammation
Phagocytosis in Inflammation
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Histamine's Role
Histamine's Role
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Study Notes
- Integument: Outermost covering of an animal, primarily the skin in vertebrates, serving as a protective barrier
- Skin (cutaneous membrane): Composed of two layers (epidermis and dermis)
- Integument: Consists of three layers (epidermis, dermis, and hypodermis)
- Skin helps protects underlying tissues and organs
- Excretes salts, water, and wastes in sweat such as urea, ammonia and uric acid
- Skin helps maintain normal body temperature by altering blood flow
- Vasodilation: Heat released from the body, increasing blood flow to the skin, may have pink or red appearance
- Vasoconstriction: Conserves heat in the body, decreasing blood flow to the skin, blood is sent to organs
- Skin synthesizes Vitamin D for calcium absorption in the intestine, important for hardening bones
- Nerves (nerve receptors) enable sensitivity to touch, pressure, pain, and temperature
Epidermis
- Type of tissue is stratified squamous epithelium, consists of 25-50 layers of keratinocytes
- Strata (layers) of the epidermis: Stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, and stratum basale
- Strata Germinativum: Contains two layers (basale and spinosum), the location of germ (stem) cells that produce new cells by mitosis
- The strata are present because of keratinization, a process where epidermal cells, called keratinocytes, mature and accumulate keratin as they move from the basale upward.
Dermis
- Mostly made of dense irregular connective tissue with criss-cross collagen fibers, and a small amount of areolar connective tissue, and other components.
- Contains small blood vessels, nerve endings, hair follicles, glands, and lymph vessels
Hypodermis
- Other names include the subcutaneous layer and superficial fascia
- Its tissue is mainly areolar connective tissue and adipose connective tissue in varying amounts
- Acts as a foundation or support for the skin
- Stores from 15-50% of total body fat
- Attaches skin to muscle and bone
- Possesses a larger amount of areolar connective tissue than the dermis, making it the layer of the integument that provides blood for the epidermis
- Medicines can be injected due to its texture and rich blood supply
Keratinization of the Epidermis
- Takes 35 days on average
- Purpose of keratinization: Strengthen epidermis and makes it water-resistant
- Cell Location Change: Keratinocytes move from the basale upward to the corneum
- Cell Composition Change: Keratinocytes become encased in keratin, eventually dying as keratin replaces their living components
- Cell Shape Change: Keratinocytes start cuboidal/columnar but flatten to a squamous shape
Rapid Mitosis in Stratum Basale
- A single layer of columnar cells undergoes rapid mitosis, producing new cells every 14 to 19 days, containing most germ cells
- Cells are in a wavy line due to the dermal papillary layer
- Melanocytes are present for melanin production
- Merkel cells/discs: Act as receptors, stimulating nerves so that the brain knows when the skin is touched.
Desmosome Development in Stratum Spinosum
- Desmosome Formation: Intercellular cement/tough glue that holds cells together
- Cell shape stretches, giving a spiny or prickly appearance
- Limited Mitosis (small amount of cell division)
- Langerhans cells: Macrophages that clean bacteria, foreign materials, and damaged cells
Keratin Synthesis Begins in Stratum Granulosum
- Production of Keratohyaline: Gives cells a grainy appearance, which is the first step in keratin production
- Production of Lamellated granules: Make a waterproof for cells, preventing blood nutrients from reaching upper cell layers, as a result cells begin to die..
- Breakdown of Cell Contents occur with the nucleus and other cell components, which disintegrates because the cells die.
- Cells become thinner and flatter
Continued Keratin Synthesis in Stratum Lucidum
- Keratohyaline inside cells becomes eleidin, clear substance and second step in keratin production
Keratinization and Desquamation in Stratum Corneum
- Keratinization Completed: Eleidin turns into keratin, forming a hard envelope around the cell
- Desquamation: After 40-56 days, desmosome connections break and cells are shed off
Thick and Thin Skin Types
- Thick skin contains all five strata (stratum corneum is thick), there are no oil glands or hairs, and are only on palms and soles
- Thin skin lacks a stratum lucidum and each strata has fewer cell layers.
- Note: Thickness refers to the epidermis and the total skin thickness depends on the dermis
Papillary Layer (Superficial Layer) of the Dermis
- Areolar connective tissue with collagen fibers forms mounds (papillae), or folds, in the epidermis
- Strengthens the connection between the epidermis and dermis
- The papillae form friction ridges, giving a raised texture that assists in grasping objects and walking on slick surfaces
- Are useful as fingerprints in forensic science
Reticular Layer (Deep Layer) of the Dermis
- Bottom 80% of the dermis
- Consists of dense irregular connective tissue
- Provides overall strength and stretch to the skin
- The collagen fibers form patterns called Cleavage or Tension Lines mapped on the human body
- Surgeons must attempt to cut in the direction of collagen fibers to avoid bad scars.
Sensory Receptors (Nerves) of the Dermis
- Receptor Types Grouped By Stimulus Detection:*
- Mechanoreceptors respond to any mechanical stimulus, such as touch, pressure, stretch, or vibration
- Nociceptors (pain receptors) respond to any intense stimulus that causes receptor
Receptor Types Grouped By Structure
- Free Nerve Ending Receptors: Neurons with "nude" endings
- Nociceptor: Detects mostly pain, but also temperature, itch, etc.
- Root Hair Plexus: Detects hair movement
- Merkel Disc: Unlike other receptors, this cell is located in the epidermis and they give detailed information about the object touching the skin
- Are Tonic Receptors: Remain active as long as 30 minutes
Encapsulated Nerve Ending Receptors
- Nerve cells covered in layers of connective tissue
- Meissner’s Corpuscles respond to gentle pressure and are found in of the dermis
- Give discriminative touch like the merkel disc
- Are Phasic Receptors which respond to an object on the skin, but stop responding shortly after
- Krause's End Bulb: Found in mucous membranes, as well as lips and tongue
- Pacinian Corpuscle: Layered connective tissue and responds to deep pressure. It is used to detect smooth versus rough texture. Gives vague information about the object touching the skin.
- Ruffini's Corpuscles: Mostly found in fingers and joints to monitor movements.
Skin Glands of the Dermis (and Hypodermis)
- Sudoriferous/Sweat Glands: Usually found in the dermis.
-
- Merocrine/eccrine glands are the most common type which regulates body temperature
Sebaceous/Oil Glands
- Sebaceous Glands: Sebum/oil is antifungal & antibacterial due to its slightly acidic pH (4-6 pH) and it the second part of the surface film/acid mantle
- May or may not be connected to hair follicles
- Prevents excessive water loss from skin
- Oil lubricates the hair and skin
Ceruminous/Wax Glands
- Wax is a combination of both cerumen and sebum
- Protects ear from dehydration
Accessory Structures of Dermis
- Hair Follicle: Tiny organ covering the hair and is the source of germ cells for hair growth
Hair Follicle Layers
- Dermal Root Sheath: Perimeter sheath; Made of collagen
- External Epithelial Root Sheath: all the strata
- Internal Epithelial Root Sheath: Has germinativum of the dermis where cell growth happens. These cells move to the MATRIX OF THE HAIR BULB to grow the hair.
- Hair Bulb: Round base section of hair follicle
- Hair matrix: This causes hair growth
- Hair papillae: Gives the Matrix blood supply
- Hair layers:
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- Cuticle outer most layer to ensure hairs do not mat
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- Cortex middle layer for melanocytes; largest layer
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- Medulla innermost largest, loose layer filled with air
- Arrector Pili Muscles: Tiny smooth muscles attached to the base of hairs (at hair bulb), which is used to release oil from sebaceous glands onto skin & hair.
Dermatoses as Skin Disorders
- Microbial disorders:
- Acne: Use Oil
- Impetigo: Blistering
- Tinea/ Mycoses: Fungal/yeast
- Seborrhea: oil irritated
- Warts: caused by virus
- Vascular and inflammatory disorders:
- Eczema - rash
- Decubitus ulcers- tissue damage
- Scleroderma- hard skin
- Psoriasis- autoimmune itching with excessive mitosis of skin cells.
- Rosacea- puffy cheeks
- vitiligo- immune disorder skin bleaching WBC
- Inflammation is defined as the body response to injury, as well as swelling
- Vasodilation: causing blood increase through the body
- Vascular Permeability: capillaries become temporary leaky.
- Chemotaxis: movement of WBC due to injury to the body
- Phagocytosis: Harmful material that digested in the body
- Skin growths can occur at anytime
- Basal Cell Cancers: less likely to metastasize and mostly cut out; originates in stratum basale
- Squamous Cell Carcinoma- red/scaly & quickly grows but can be radiated to not spread, originates in the Spinous layer.
- Malignant Melanoma- originates in melanocytes- from sun (not really skin cancer)
- Kaposi- originates in dermal with purplish color and is deadly when metastasizes to HIV patients but is rare
Burns
- First-degree: damage to epidermis or sunburn
- Second-degree: damage is blistering, but can be treated due to hurt
- Third-degree: complete destruction which there is destruction, yet it needs help to be removed with risk factors
- 2nd/3rd degree burns cause fluid to leak or damage bodily and require immediate care
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Description
Matching questions covering receptor types, functions, and locations in the skin. It also includes matching stimuli, intensity, and integument layers. The quiz assesses understanding of blood vessel behavior and skin's chemical contributions.