Podcast
Questions and Answers
Which species is primarily affected by papillomatosis?
Which species is primarily affected by papillomatosis?
What is the main causative agent of papillomatosis in cattle?
What is the main causative agent of papillomatosis in cattle?
What clinical signs are associated with bovine papillomatosis?
What clinical signs are associated with bovine papillomatosis?
How is Bovine Papillomavirus primarily transmitted?
How is Bovine Papillomavirus primarily transmitted?
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Which factor is linked to an increased cancer risk in cattle associated with BPV?
Which factor is linked to an increased cancer risk in cattle associated with BPV?
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What is a characteristic of equine sarcoids?
What is a characteristic of equine sarcoids?
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What is a key feature of the pathogenesis of Bovine Papillomavirus?
What is a key feature of the pathogenesis of Bovine Papillomavirus?
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In what way is the clinical acumen of veterinarians enhanced by learning about integumentary diseases across species?
In what way is the clinical acumen of veterinarians enhanced by learning about integumentary diseases across species?
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What is the main characteristic of Cowpox?
What is the main characteristic of Cowpox?
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Which of the following is a feature of Avian Pox?
Which of the following is a feature of Avian Pox?
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What is the primary mode of transmission for Papillomatosis?
What is the primary mode of transmission for Papillomatosis?
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Which virus family does Bovine Papillomavirus belong to?
Which virus family does Bovine Papillomavirus belong to?
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What is a characteristic symptom of Foot and Mouth Disease (FMD)?
What is a characteristic symptom of Foot and Mouth Disease (FMD)?
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Equine Sarcoid is most commonly associated with which type of virus?
Equine Sarcoid is most commonly associated with which type of virus?
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Which of the following control measures is specifically recommended for Cowpox?
Which of the following control measures is specifically recommended for Cowpox?
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Which virus is characterized by a brick-shaped structure and can also infect humans?
Which virus is characterized by a brick-shaped structure and can also infect humans?
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What are common clinical features of Lumpy Skin Disease (LSD)?
What are common clinical features of Lumpy Skin Disease (LSD)?
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Which breeds of cattle are reported to be more susceptible to Lumpy Skin Disease?
Which breeds of cattle are reported to be more susceptible to Lumpy Skin Disease?
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What is a primary control strategy for Lumpy Skin Disease?
What is a primary control strategy for Lumpy Skin Disease?
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Which virus family does the Foot and Mouth Disease (FMD) virus belong to?
Which virus family does the Foot and Mouth Disease (FMD) virus belong to?
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What symptom is characteristic of Vesicular Stomatitis?
What symptom is characteristic of Vesicular Stomatitis?
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How is Lymphocystis Disease transmitted in fish?
How is Lymphocystis Disease transmitted in fish?
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Which of the following best describes the economic impact of Lumpy Skin Disease?
Which of the following best describes the economic impact of Lumpy Skin Disease?
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What is the main reservoir for Cowpox Virus?
What is the main reservoir for Cowpox Virus?
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What complicates the recovery from Lumpy Skin Disease?
What complicates the recovery from Lumpy Skin Disease?
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What type of vaccine strategy is important for controlling outbreak of diseases like LSD?
What type of vaccine strategy is important for controlling outbreak of diseases like LSD?
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What is a characteristic feature of Foot and Mouth Disease (FMD)?
What is a characteristic feature of Foot and Mouth Disease (FMD)?
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Which of the following routes is NOT a transmission method for Vesicular Stomatitis?
Which of the following routes is NOT a transmission method for Vesicular Stomatitis?
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How can Orf virus potentially affect humans?
How can Orf virus potentially affect humans?
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What is the purpose of sample collection in diagnosing viral infections in animals?
What is the purpose of sample collection in diagnosing viral infections in animals?
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What primarily characterizes the biopsy results in equine sarcoids?
What primarily characterizes the biopsy results in equine sarcoids?
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Which viral proteins are implicated in the pathogenesis of equine sarcoids?
Which viral proteins are implicated in the pathogenesis of equine sarcoids?
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What is a significant challenge in controlling papillomavirus infections like equine sarcoids?
What is a significant challenge in controlling papillomavirus infections like equine sarcoids?
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What is the size range of viruses within the Poxviridae family?
What is the size range of viruses within the Poxviridae family?
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How do poxviruses replicate within host cells?
How do poxviruses replicate within host cells?
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What marked the eradication of smallpox in public health history?
What marked the eradication of smallpox in public health history?
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Which species primarily serve as reservoirs for cowpox virus?
Which species primarily serve as reservoirs for cowpox virus?
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What clinical signs may indicate severe cowpox in felines?
What clinical signs may indicate severe cowpox in felines?
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What forms does avian pox present in, and what is a key characteristic of the wet form?
What forms does avian pox present in, and what is a key characteristic of the wet form?
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What is a primary method of transmission for avian pox?
What is a primary method of transmission for avian pox?
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Which of the following diseases is characterized by high morbidity but low mortality rates?
Which of the following diseases is characterized by high morbidity but low mortality rates?
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What clinical sign is commonly associated with lumpy skin disease?
What clinical sign is commonly associated with lumpy skin disease?
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What control measure can be effective against cowpox virus transmission?
What control measure can be effective against cowpox virus transmission?
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What is the primary cause of high mortality in the wet form of avian pox?
What is the primary cause of high mortality in the wet form of avian pox?
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What is the primary clinical outcome associated with Bovine Papillomavirus infection in cattle?
What is the primary clinical outcome associated with Bovine Papillomavirus infection in cattle?
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Which environmental factor is associated with an increased cancer risk in cattle infected with Bovine Papillomavirus?
Which environmental factor is associated with an increased cancer risk in cattle infected with Bovine Papillomavirus?
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What characteristic distinguishes equine sarcoids from other skin tumors in horses?
What characteristic distinguishes equine sarcoids from other skin tumors in horses?
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Which of the following transmission methods is most common for Bovine Papillomavirus?
Which of the following transmission methods is most common for Bovine Papillomavirus?
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What is an effective control measure to prevent the spread of Bovine Papillomavirus among cattle?
What is an effective control measure to prevent the spread of Bovine Papillomavirus among cattle?
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What is a primary characteristic of the lesions caused by equine sarcoids?
What is a primary characteristic of the lesions caused by equine sarcoids?
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Which aspect of veterinarians' education is enhanced through the study of integumentary diseases across various species?
Which aspect of veterinarians' education is enhanced through the study of integumentary diseases across various species?
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What is a common clinical sign associated with both Bovine Papillomavirus and equine sarcoids?
What is a common clinical sign associated with both Bovine Papillomavirus and equine sarcoids?
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What control measure is specifically advised to manage the transmission of Avian Pox?
What control measure is specifically advised to manage the transmission of Avian Pox?
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Which viral disease presents with vesicular lesions on the tongue and hooves in cloven-hoofed animals?
Which viral disease presents with vesicular lesions on the tongue and hooves in cloven-hoofed animals?
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What is a key transmission method for Cowpox Virus?
What is a key transmission method for Cowpox Virus?
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Which of the following best describes the structure of Bovine Papillomavirus?
Which of the following best describes the structure of Bovine Papillomavirus?
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What form of Cowpox infection primarily affects calves?
What form of Cowpox infection primarily affects calves?
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What is a characteristic symptom observed in Equine Sarcoid?
What is a characteristic symptom observed in Equine Sarcoid?
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Which family of viruses includes Avian Pox?
Which family of viruses includes Avian Pox?
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What is the recommended control measure for managing the spread of Foot and Mouth Disease (FMD)?
What is the recommended control measure for managing the spread of Foot and Mouth Disease (FMD)?
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What is a common clinical finding in animals affected by Lumpy Skin Disease?
What is a common clinical finding in animals affected by Lumpy Skin Disease?
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Which control strategy is crucial for managing outbreaks of Lumpy Skin Disease?
Which control strategy is crucial for managing outbreaks of Lumpy Skin Disease?
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Which breeds of cattle are particularly susceptible to Lumpy Skin Disease?
Which breeds of cattle are particularly susceptible to Lumpy Skin Disease?
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What is a significant risk associated with prolonged convalescence in Lumpy Skin Disease?
What is a significant risk associated with prolonged convalescence in Lumpy Skin Disease?
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Which of the following viral diseases share symptoms with Foot and Mouth Disease?
Which of the following viral diseases share symptoms with Foot and Mouth Disease?
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What economic impact can be expected from outbreaks of Lumpy Skin Disease?
What economic impact can be expected from outbreaks of Lumpy Skin Disease?
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What type of virus is responsible for causing Lumpy Skin Disease?
What type of virus is responsible for causing Lumpy Skin Disease?
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What is the primary transmission route of Vesicular Stomatitis?
What is the primary transmission route of Vesicular Stomatitis?
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Which of the following statements about Foot and Mouth Disease (FMD) is true?
Which of the following statements about Foot and Mouth Disease (FMD) is true?
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What is the purpose of developing breed-specific management strategies for susceptible cattle breeds?
What is the purpose of developing breed-specific management strategies for susceptible cattle breeds?
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Which of the following is a characteristic feature of Orf in animals?
Which of the following is a characteristic feature of Orf in animals?
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What complication may arise during the diagnosis of integumentary diseases in animals?
What complication may arise during the diagnosis of integumentary diseases in animals?
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Why is ongoing surveillance important in managing outbreaks of Lumpy Skin Disease?
Why is ongoing surveillance important in managing outbreaks of Lumpy Skin Disease?
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What mechanism do the viral proteins E5 and E6 primarily promote in dermal fibroblasts?
What mechanism do the viral proteins E5 and E6 primarily promote in dermal fibroblasts?
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Which unique feature distinguishes the replication of poxviruses from other DNA viruses?
Which unique feature distinguishes the replication of poxviruses from other DNA viruses?
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What is a key control measure to prevent the transmission of avian pox?
What is a key control measure to prevent the transmission of avian pox?
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Which animal is primarily linked to the transmission of cowpox virus?
Which animal is primarily linked to the transmission of cowpox virus?
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What clinical sign is specifically associated with the wet form of avian pox?
What clinical sign is specifically associated with the wet form of avian pox?
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What is a primary reason that cowpox is now rare in cattle in Europe?
What is a primary reason that cowpox is now rare in cattle in Europe?
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Which disease has a high morbidity but low mortality rate, particularly in cattle?
Which disease has a high morbidity but low mortality rate, particularly in cattle?
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What role do flies play in the transmission of lumpy skin disease?
What role do flies play in the transmission of lumpy skin disease?
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What is a significant characteristic of the disease progression in cowpox for cats?
What is a significant characteristic of the disease progression in cowpox for cats?
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What is a distinctive feature of the Poxviridae family concerning its virion structure?
What is a distinctive feature of the Poxviridae family concerning its virion structure?
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The presence of which lesions serves as a diagnostic indicator of cowpox infection?
The presence of which lesions serves as a diagnostic indicator of cowpox infection?
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What was an important historical achievement regarding smallpox eradication?
What was an important historical achievement regarding smallpox eradication?
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What specific interaction is key in the pathogenesis of equine sarcoids caused by BPV?
What specific interaction is key in the pathogenesis of equine sarcoids caused by BPV?
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What is one method highlighted for preventing contamination during outbreaks of lumpy skin disease?
What is one method highlighted for preventing contamination during outbreaks of lumpy skin disease?
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Study Notes
Integumentary Diseases Overview
- Integumentary diseases affect the skin and associated structures in various species, including mammals, birds, and fish.
- Veterinarians use their cross-species learning to diagnose and treat these diseases.
Viral Diseases Affecting the Integument
- Papillomatosis is caused by Bovine Papillomavirus (BPV).
- BPV infects keratinocytes and leads to epidermal hyperplasia causing warts.
- BPV transmission occurs through direct contact, fomites, and breeding.
- Equine sarcoids are raised, hairless masses commonly found on the head.
- Equine sarcoids are associated with BPV-1 and BPV-2, which infect dermal fibroblasts.
- The virus proteins E5 and E6 may interact with host cell proteins promoting fibroblast proliferation.
Poxviridae Family
- Poxviridae is a family of large, complex DNA viruses, ranging in size from 220–450 nm in length and 140–260 nm in width.
- The viruses possess linear double-stranded DNA (dsDNA) genomes.
- Replication occurs in the cytoplasm of host cells, which is unusual for DNA viruses.
Cowpox Virus
- Cowpox primarily affects the skin, leading to lesions on the teats and udders of cows.
- Cowpox virus replicates in the cytoplasm of host cells, leading to characteristic skin lesions and necrosis.
- Transmission occurs through direct contact with infected animals or contaminated equipment.
Avian Pox
- Avian pox presents in two forms: dry/cutaneous and wet/diphtheritic.
- The dry form is characterized by wart-like lesions on the comb, neck, face, and feet of birds.
- The wet form involves necrotic pseudomembranes in the oronasal region.
- Transmission occurs through mosquito bites or contact with scabs in the environment.
Lumpy Skin Disease
- Lumpy skin disease (LSD) is transmitted through shed skin, crusts, scabs, and flies.
- Clinical signs include fever, tachypnea, eyelid edema, and nasal discharge, followed by the development of cutaneous and oral mucosa nodules.
- Lumpy skin disease virus belongs to the Poxviridae family and is classified under the Capripoxvirus genus.
Key Viral Diseases in Livestock
- Bovine Lumpy Skin Disease: Variants include Sheeppox and Goatpox.
- Vesicular Stomatitis: Affects horses, cattle, and pigs, characterized by vesicular lesions.
- Foot and Mouth Disease (FMD): Highly contagious disease affecting cloven-hoofed animals.
- Orf: Causes lesions on the lips and muzzle of sheep and goats, zoonotic potential with lesions in humans.
Viral Characteristics and Pathogenesis
- Rhabdoviridae: Includes Vesicular Stomatitis Virus (VSV), characterized by a bullet-shaped, enveloped structure with linear -ssRNA.
- Picornaviridae: Includes FMD virus, non-enveloped with +ssRNA, known for its stability and ability to cause severe outbreaks.
- Poxviridae: Includes Orf virus, a dsDNA virus that can cause zoonotic infections.
Transmission and Control Measures
- Vesicular Stomatitis: Transmitted by arthropods and direct contact with infected animals or contaminated environments.
- FMD: Highly contagious, spread through secretions like saliva, milk, and vesicle fluid.
- Orf: Spread through direct contact and contaminated feeding troughs; zoonotic transmission is possible.
Case Studies and Historical Context
- UK FMD Outbreak (2001): Over 6 million livestock culled, costing approximately $13 billion.
- Vesicular Stomatitis: Notable outbreaks in the US affecting livestock and leading to economic losses, particularly in the equine industry.
- Orf: Zoonotic disease with lesions in humans, typically self-limiting.
Key Terms/Concepts
- Integumentary System: The organ system that includes the skin and its appendages.
- Papillomavirus: A family of viruses that can cause warts and lesions in various species.
- Poxviridae: A family of viruses that includes those causing diseases like cowpox and avian pox.
Diseases/Conditions
- Papillomatosis: A condition caused by bovine papillomavirus, characterized by warts on the skin, particularly in cattle.
- Equine Sarcoid: A type of skin tumor in horses associated with bovine papillomavirus, typically appearing as raised, hairless masses.
- Cowpox: A viral infection primarily affecting cattle, characterized by skin lesions and occasionally affecting humans and cats.
- Avian Pox: A viral disease in birds that presents in two forms: dry and wet, causing wart-like lesions.
- Foot and Mouth Disease (FMD): A highly contagious viral disease affecting cloven-hoofed animals, characterized by fever and vesicular lesions.
Key Clinical Signs
- Papillomatosis: Warts on the head and neck, particularly in calves and yearlings.
- Equine Sarcoid: Raised, hairless masses on the skin, commonly around the head and ears.
- Cowpox: Skin lesions on the udder and face of calves, with necrosis in epithelial cells.
- Avian Pox: Wart-like lesions on the comb, neck, and face of birds, with two forms presenting different symptoms.
- FMD: Vesicular lesions on the tongue and hooves, profuse salivation, and nasal discharge.
Key Transmission and Control Measures
- Papillomatosis: Transmitted through direct contact and fomites; control through hygiene and avoiding contact with infected animals.
- Equine Sarcoid: Transmission through contact with infected cattle; control measures include reducing contact and fly control.
- Cowpox: Transmitted by rodents and contaminated equipment; control through sanitation and rodent elimination.
- Avian Pox: Transmitted by mosquitoes and contact with scabs; control through vaccination and environmental management.
- FMD: Transmitted through secretions and excretions; control through quarantine, vaccination, and culling infected animals.
Virus Name Family Characteristics
- Bovine Papillomavirus Papillomaviridae dsDNA, circular genome, causes papillomatosis in cattle
- Cowpox Virus Poxviridae dsDNA, brick-shaped, can infect humans and cats
- Avian Pox Virus Poxviridae dsDNA, enveloped, affects all bird species
- Vesicular Stomatitis Virus Rhabdoviridae -ssRNA, causes lesions similar to FMD
- Foot and Mouth Disease Virus Picornaviridae +ssRNA, non-enveloped, affects cloven-hoofed animals
- Orf Virus Poxviridae dsDNA, sometimes enveloped
- Lymphocystis Disease Virus Non-enveloped, linear dsDNA, 186 kb
- Vesicular Stomatitis Virus Enveloped, linear -ssRNA
- Papillomaviridae family: Non-enveloped, circular dsDNA, ~8 kb
Problem-Solving Steps
- To diagnose integumentary diseases in animals, follow these steps:
- Clinical Observation: Note the clinical signs and lesions present on the animal.
- History Taking: Gather information on the animal's history, including exposure to other animals and environmental factors.
- Sample Collection: Collect samples from lesions for laboratory analysis (e.g., PCR, histopathology).
- Laboratory Testing: Perform tests to identify the causative agent (e.g., viral cultures, serology).
- Diagnosis: Analyze the results to confirm the diagnosis based on clinical signs and laboratory findings.
- Treatment Plan: Develop a treatment plan based on the diagnosis, considering control measures and potential zoonotic risks.
Introduction to Integumentary Diseases
- Integumentary diseases affect the skin and associated structures, impacting various species
- Veterinarians must be able to identify and diagnose skin diseases across species
- Learning about integumentary diseases in various taxa allows for understanding evolutionary and pathological similarities and differences
Papillomavirus Infections
- Papillomatosis is caused by Bovine Papillomavirus (BPV) and affects primarily cattle, especially calves and yearlings
- BPV infects keratinocytes, leading to epidermal hyperplasia and the formation of warts
- Warts are typically found on the head and neck of infected animals
- Transmission occurs through direct contact, fomites, and breeding
- Control measures include disinfection of equipment and minimizing contact with infected animals
- BPV has multiple strains that can cause various lesions, including fibropapillomas
- BPV is associated with bladder cancer in certain regions
- Bracken fern consumption has been linked to increased cancer risk in cattle
Equine Sarcoid
- Equine Sarcoid is a skin tumor in horses caused by BPV-1 and BPV-2
- Sarcoids appear as raised, hairless masses, typically found on the head, especially around the eyes and ears.
- The lesions are locally aggressive but do not metastasize, however they can regrow or form new lesions.
- BPV-1 and BPV-2 infect dermal fibroblasts, leading to neoplastic changes
- Equine Sarcoid is not contagious as BPV replication is incomplete in sarcoid lesions
- Control measures include minimizing contact with infected cattle and managing fly populations
Poxviridae Family
- Poxviridae is a family of large, complex DNA viruses that infect vertebrates and invertebrates.
- Poxviridae family members have a brick-shaped morphology and a linear dsDNA genome.
- Poxviruses are unique in their replication occurring in the cytoplasm of host cells, which is unusual for DNA viruses.
- Poxviridae members can produce both enveloped and non-enveloped virions.
Cowpox Virus
- Cowpox primarily affects the skin and causes lesions on the teats and udders of cows
- Cowpox lesions are characterized by cytoplasmic inclusions in infected epithelial cells
- Cowpox is now rare in cattle; most cases occur in domestic cats and humans
- Transmission occurs through direct contact with infected animals or contaminated equipment
- Cowpox lesions in cats can be severe, resulting in widespread skin lesions and potential lung infection
Avian Pox
- Avian Pox presents in two forms: dry and wet
- The dry form is characterized by wart-like lesions on the comb, neck, face, and feet of birds
- The wet form involves necrotic pseudomembranes in the oronasal region
- Transmission occurs through mosquito bites or contact with scabs in the environment
- Mortality rates can reach 50% in severe cases, particularly in the wet form
- Survivors of the dry form can fully heal
Lumpy Skin Disease
- Lumpy skin disease (LSD) is transmitted through shed skin, crusts, scabs, and flies
- Clinical signs include fever, tachypnea, eyelid edema, and nasal discharge, followed by the development of cutaneous and oral mucosa nodules
- The disease can persist for weeks, with lesions ulcerating and healing with substantial scarring
- Certain breeds, such as Jersey and Guernsey, are more susceptible to LSD
- Control strategies include vaccination, vector control, and biosecurity measures
Overview of Viral Diseases
- Bovine Lumpy Skin Disease (LSD): Affects cattle and causes significant economic losses
- Vesicular Stomatitis: Affects horses, cattle, and pigs, characterized by vesicular lesions that resemble Foot-and-Mouth Disease (FMD)
- Foot and Mouth Disease (FMD): Highly contagious disease affecting cloven-hoofed animals, leading to severe economic impacts globally
Viral Characteristics and Pathogenesis
- Rhabdoviridae: Contains Vesicular Stomatitis Virus (VSV), characterized by a bullet-shaped, enveloped structure with a linear -ssRNA genome.
- Picornaviridae: Contains FMD virus, non-enveloped with +ssRNA, known for its stability and ability to cause severe outbreaks
- Poxviridae: Contains Orf virus, a dsDNA virus that can cause zoonotic infections
Transmission and Control Measures
- Vesicular Stomatitis: Transmitted by arthropods and direct contact with infected animals or contaminated environments.
- FMD: Highly contagious, spread through secretions like saliva, milk, and vesicle fluid; can persist in carriers for extended periods.
- Orf: Spread through direct contact and contaminated feeding troughs.
Important Facts:
- Bovine Papillomavirus (BPV) Strains: BPV-1 BPV-2, BPV-3, BPV-4, BPV-5, BPV-6, BPV-8, BPV-9, BPV-10
- Cowpox Virus: dsDNA, 222 kb, brick-shaped
- Avian Pox Virus: Enveloped, linear dsDNA, brick-shaped
- Foot and Mouth Disease Virus: Non-enveloped, +ssRNA, 8.3 kb
- Orf Virus: dsDNA, sometimes enveloped
- Lymphocystis Disease Virus: Non-enveloped, linear dsDNA, 186 kb
- Vesicular Stomatitis Virus: Enveloped, linear -ssRNA
- Papillomaviridae family: Non-enveloped, circular dsDNA, ~8 kb
Problem-Solving Steps
- Clinical Observation: Note the clinical signs and lesions present on the animal
- History Taking: Gather information on the animal’s history, including exposure to other animals and environmental factors
- Sample Collection: Collect samples from lesions for laboratory analysis (e.g., PCR, histopathology)
- Laboratory Testing: Perform tests to identify the causative agent (e.g., viral cultures, serology)
- Diagnosis: Analyze the results to confirm the diagnosis based on clinical signs and laboratory findings
- Treatment Plan: Develop a treatment plan based on the diagnosis, considering control measures and potential zoonotic risks
Key Terms
- Integumentary System: The organ system made up of the skin and its appendages, serving as a protective barrier for the body
- Papillomavirus: A family of viruses that cause warts and lesions in various species
- Poxviridae: A family of viruses that cause diseases like cowpox and avian pox, characterized by their complex structure and ability to infect vertebrates and invertebrates
Diseases/Conditions
- Papillomatosis: Condition caused by bovine papillomavirus
- Equine Sarcoid: Type of skin tumor in horses
- Cowpox: Viral infection that primarily affects cattle
- Avian Pox: Viral disease in birds
- Foot and Mouth Disease: Highly contagious viral disease affecting even-toed ungulates
Key Clinical Signs
- Papillomatosis: Warts on the head and neck
- Equine Sarcoid: Raised, hairless masses on the skin, common around the head and ears
- Cowpox: Skin lesions on the udder and face of calves, with necrosis in epithelial cells
- Avian Pox: Wart-like lesions on the comb, neck, and face of birds
- FMD: Vesicular lesions on the tongue and hooves, profuse salivation, and nasal discharge
Transmission and Control Measures
- Papillomatosis: Transmitted through direct contact and fomites; control through hygiene and avoiding contact with infected animals
- Equine Sarcoid: Transmission through contact with infected cattle; control measures include reducing contact and fly control.
- Cowpox: Transmitted by rodents and contaminated equipment; control through sanitation and rodent elimination.
- Avian Pox: Transmitted by mosquitoes and contact with scabs; control through vaccination and environmental management
- FMD: Transmitted through secretions and excretions; control through quarantine, vaccination, and culling infected animals
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Description
This quiz covers the essential aspects of integumentary diseases affecting various species, including the impact of viral infections such as Bovine Papillomavirus and Equine Sarcoids. Additionally, it explores the characteristics of the Poxviridae family of viruses. Test your knowledge on the diagnosis and treatment methods used by veterinarians.