Innate Immunity Overview
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Questions and Answers

Which of the following is NOT a cell type involved in innate immunity?

  • Natural Killer cells
  • Mast cells
  • T cells (correct)
  • Macrophages
  • What is the primary function of phagocytes in innate immunity?

  • To produce antibodies
  • To engulf and destroy extracellular antigens (correct)
  • To activate complement proteins
  • To present antigens to T cells
  • Which of the following is a characteristic of innate immunity?

  • Specificity for individual antigens
  • Development of immunological memory
  • Rapid response to infection (correct)
  • Production of antibodies
  • What is the role of C-reactive protein (CRP) in innate immunity?

    <p>Promoting inflammation and complement activation (C)</p> Signup and view all the answers

    Which of the following is an example of an anatomical barrier in innate immunity?

    <p>Skin (C)</p> Signup and view all the answers

    Which of the following statements is TRUE about the cells of the immune system?

    <p>Both T cells and B cells are lymphocytes. (B)</p> Signup and view all the answers

    What is the role of resident flora in innate immunity?

    <p>They compete with pathogens for resources. (A)</p> Signup and view all the answers

    Which of the following is a characteristic of acute-phase reactants?

    <p>Their concentration increases rapidly in response to infection. (D)</p> Signup and view all the answers

    Which of the following cell types are classified as antigen presenting cells?

    <p>All of the above (D)</p> Signup and view all the answers

    What is the main function of CD8+ T cells?

    <p>To destroy infected cells (A)</p> Signup and view all the answers

    Which MHC class presents antigens to CD4+ T cells?

    <p>Class II MHC (D)</p> Signup and view all the answers

    What is the primary role of CD4+ T cells in the immune response?

    <p>Regulating immune responses and combating extracellular pathogens (A)</p> Signup and view all the answers

    Which of the following statements accurately describes the relationship between T cells and MHC molecules?

    <p>T cells recognize antigens only when presented in combination with MHC molecules (B)</p> Signup and view all the answers

    What is the primary role of natural killer cells in the immune system?

    <p>Destroying infected or cancerous cells (B)</p> Signup and view all the answers

    Which of the following cells are MOST responsible for the release of histamine, a key mediator of allergic reactions?

    <p>Basophils (B)</p> Signup and view all the answers

    Which of the following cells is primarily involved in the elimination of parasitic worms (helminths)?

    <p>Eosinophils (C)</p> Signup and view all the answers

    Which of the following cell types is the LEAST abundant in circulating blood?

    <p>Basophils (C)</p> Signup and view all the answers

    What is the primary function of MHC molecules in antigen presentation?

    <p>Displaying processed antigen fragments to T cells for recognition (A)</p> Signup and view all the answers

    Which of the following cell types is NOT considered an antigen-presenting cell (APC)?

    <p>Neutrophils (C)</p> Signup and view all the answers

    Which of the following cells is responsible for increasing vascular permeability, contributing to inflammation?

    <p>Mast cells (A)</p> Signup and view all the answers

    Which of the following is TRUE about macrophages?

    <p>They develop from monocytes in tissues and are long-lived (C)</p> Signup and view all the answers

    Where do B cells differentiate in mammals?

    <p>Bone marrow (D)</p> Signup and view all the answers

    What is the primary function of cytotoxic T cells?

    <p>Lyse virally infected cells (B)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of the adaptive immune system?

    <p>Rapid response to initial infection (B)</p> Signup and view all the answers

    Which of these cells are NOT considered phagocytes?

    <p>Mast cells (B)</p> Signup and view all the answers

    What type of T cell is involved in activating B cells during an adaptive immune response?

    <p>TH2 cells (B)</p> Signup and view all the answers

    Which of the following statements is TRUE regarding PRRs and PAMPs?

    <p>PAMPs are unique molecules found on pathogens. (A)</p> Signup and view all the answers

    What is the primary function of antibodies?

    <p>Recognize and bind to antigens (D)</p> Signup and view all the answers

    Which of the following statements accurately describes a thymocyte?

    <p>A progenitor T cell that has migrated to the thymus. (D)</p> Signup and view all the answers

    Flashcards

    Immune System Cells

    Cells arising from pluripotent stem cells, including lymphocytes and phagocytes.

    Lymphoid Lineage

    Produces lymphocytes; main types are T cells and B cells.

    Innate Immunity

    Generic, non-specific immune response without memory.

    Humoral Factors

    Components in innate immunity like complement proteins and CRP.

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    C-reactive Protein (CRP)

    Acute-phase reactant involved in opsonization and complement activation.

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    Phagocytes

    Cells that engulf and destroy extracellular antigens.

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    Resident Flora

    Nonpathogenic bacteria that live in and on our bodies, aiding immunity.

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    MHC Antigens

    Major Histocompatibility Complex; molecules that present antigens to T cells.

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    Monocytes

    White blood cells that can phagocytize pathogens and circulate in blood.

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    Macrophages

    Mature cells derived from monocytes, long-lived and effective at phagocytosis.

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    Neutrophils

    Majority of granulocytes, over 90%, primarily involved in phagocytosis.

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    Basophils

    Least common granulocytes, involved in allergic responses and releasing histamine.

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    Eosinophils

    Granulocytes that fight parasites, especially helminths, through IgE mediation.

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    Mast Cells

    Cells in connective tissues that regulate inflammatory responses and increase vascular permeability.

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    Natural Killer Cells

    Cells that destroy infected or transformed cells without prior antigen exposure.

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    Antigen Presenting Cells (APCs)

    Cells such as dendritic cells and macrophages that activate T-cells by presenting antigens.

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    T cells

    Immune cells that play roles in cell-mediated and humoral immunity, including CD4+ and CD8+ types.

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    CD4+ T cells

    Helper T cells that secrete cytokines to regulate immune responses and combat extracellular pathogens.

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    CD8+ T cells

    Killer T cells that destroy cells infected with intracellular pathogens or damaged cells.

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    Major Histocompatibility Complex (MHC)

    Self receptors that present processed antigens to T cells; classified as Class I and Class II.

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    Cytokines

    Signaling proteins released by CD4+ T cells that influence the activity of other immune cells.

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    PRRs

    Pathogen-Recognition Receptors on immune cells that detect PAMPs.

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    PAMPs

    Pathogen-associated molecular patterns unique to infectious organisms.

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    Adaptive Immunity

    Part of the immune system that adapts based on encountered antigens.

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    Cytotoxic T cells

    T cells that directly kill infected cells, specifically virally infected ones.

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    Memory response

    The rapid and stronger immune reaction upon re-encountering the same antigen.

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    Study Notes

    Innate Immunity

    • Innate responses are generally non-specific and generic.
    • Innate immune cells lack immunological memory.
    • Innate defenses include humoral factors, cells, anatomical barriers, resident flora, and secretions.

    Host Defenses in Innate Immunity

    • Humoral factors and Acute-Phase Reactants: Complement proteins, C-reactive protein (CRP), lactoferrin, lysozyme, pepsin (stomach acidity).
    • Anatomical barriers: Cilia, mucus, skin.
    • Resident flora: Many non-pathogenic bacteria.
    • Cells: Antigen-presenting cells (APCs), basophils, eosinophils, mast cells, natural killer cells, phagocytes.

    Types of Acute-Phase Reactants

    • C-reactive protein (CRP): Response time: 4-6 hours; Normal concentration: 0.5 mg/dL; Increase: 1000x; Function: Opsonization, complement activation.
    • Serum Amyloid A: Response time: 24 hours; Normal concentration: 5 mg/dL; Increase: 1000x; Function: Activates monocytes and macrophages.
    • Alpha1-antitrypsin: Response time: 24 hours; Normal concentration: 200-400 mg/dL; Increase: 2-5x; Function: Protease inhibitor.
    • Fibrinogen: Response time: 24 hours; Normal concentration: 200-400 mg/dL; Increase: 2-5x; Function: Clot formation.
    • Haptoglobin: Response time: 24 hours; Normal concentration: 40-290 mg/dL; Increase: 2-10x; Function: Binds hemoglobin.
    • Ceruloplasmin: Response time: 48-72 hours; Normal concentration: 20-40 mg/dL; Increase: 2x; Function: Binds copper and oxidizes iron.
    • Complement C3: Response time: 48-72 hours; Normal concentration: 60-140 mg/dL; Increase: 2x; Function: Opsonization, lysis.

    Cells of Innate Immunity

    • Phagocytes: Engulf extracellular antigens into vacuoles, destroying them. Monocytes in blood are phagocytic. Including but not limited to:
      • Monocytes: Circulate in the blood, have some phagocytic capability but not as effective as macrophages, can migrate to tissues but are short-lived.
      • Macrophages: Develop from blood monocytes in tissues, long-lived;
      • Neutrophils: Phagocytic; over 90% of circulating granulocytes.
    • Basophils: Least common granulocyte; release histamine and heparin.
    • Eosinophils: Granulocyte found mostly in tissues; Parasite fighter, release toxic proteins for helminths.
    • Mast cells and Basophils: Increase vascular permeability; reside in connective tissue and mucous membranes, regulate inflammatory response.
    • Natural killer (NK) cells: Destroy infected cells (e.g., viral, transformed). Found without exposure to antigens.

    Receptors: PRRs and PAMPS

    • Pathogen-Recognition Receptors (PRRs): On immune cells, recognize molecules (PAMPs) unique to infectious organisms.
    • PRRs are found on: Macrophages, dendritic cells, neutrophils, eosinophils, monocytes, mast cells, and epithelial cells.
    • Activation: PRRs bind to PAMPS, triggering phagocytic cell activation.
    • Example: Toll-like receptors (TLRs).

    Adaptive Immunity

    • Adaptive immunity adapts to the encountered antigens.
    • Key players: Phagocytes (innate), B cells (lymphocytes), antibodies (adaptive) when the antigen is extracellular.
    • B cell activation requires specific CD4+ T cells (TH2) and their cytokines.
    • Characterized by a more rapid, stronger memory response.

    Lymphocytes

    • Two types: T cells and B cells.
    • T cells: Differentiate in the thymus.
    • B cells: Differentiate in mammals (fetal liver, spleen, and adult bone marrow); in avians differentiate in the bursa of Fabricius.

    Cells of Adaptive Immunity

    • B cells and Plasma cells: Produce antibodies (anamnestic or secondary immune response).
    • CD4+ T cells: Produce cytokines that enhance cytotoxic molecule production in phagocytes (TH1), regulate antigen-presenting cell activation (innate), and induce NK cell proliferation (innate).
    • Cytotoxic T cells: Lyse infected cells (virally infected cells).

    B Cells

    • B cell antigen-specific receptor is an antibody molecule on the B cell surface.
    • Recognizes whole antigens without antigen processing.
    • Membrane immunoglobulin.

    T Cell Thymocyte

    • Progenitor T cells migrate to the thymus to become mature T cells, called thymocytes.
    • Some seed secondary lymphoid tissue, while others recirculate between blood and lymphoid tissue until they encounter antigens.
    • Leave the thymus as CD4+ T or CD8+ T cells.

    T Cells

    • Take part in cell-mediated and humoral immunity.
    • In humoral immunity, antibodies play a subordinate role.
    • Important for all other aspects of immunity.

    T Cells Classification

    • CD4+ T cells: Main function: secreting cytokines needed for regulating all immune responses and combating extracellular pathogens (Helper T cells).
    • CD8+ T cells: Main role: destroying infected (intracellular pathogens) cells (Killer T cells or Cytotoxic T cells).

    T Cells and MHC

    • T cells recognize ("non-self") pathogens by detecting processed antigens presented in conjunction with "self" MHC (major histocompatibility complex) molecules.
    • Antigen-presenting cells:
      • Dendritic cells
      • Macrophages
      • B cells
    • CD8+ T cells: Recognize antigens coupled to Class I MHC molecules (self).
    • CD4+ T cells: Recognize antigens coupled to Class II MHC molecules (self).
    • Class I MHC: found on variety of cell types.
    • Class II MHC: primarily found on antigen-presenting cells.

    CD8+ T Cell

    • Kill cells infected with intracellular pathogens or those that are otherwise damaged or dysfunctional.

    CD4+ T Cell

    • Release cytokines that influence the activities of various cell types.
    • Cytokines produced enhance macrophage's microbicidal function and killer T cell activity.

    Adaptive Immunity: Humoral and Cellular Responses

    • T cell receptors only recognize antigens presented on MHC molecules.
    • Cellular immunity involves killing infected cells.
    • Humoral immunity involves antibody production.

    Regulatory T Cells (Tregs)

    • Suppressor T cells produce chemicals (cytokines) to "turn off" other immune system cells when an infection is brought under control.

    Normal IR: Process of Inflammation

    • Body's overall response to tissue injury (physical, chemical, or infectious).
    • Cardinal signs:
      • Rubor (redness): vasodilation.
      • Calor (heat): increased blood flow.
      • Tumor (swelling): increased fluid/exudate.
      • Dolor (pain): stimulation of nerve endings.

    Initiation of Local Inflammatory Response

    • Tissue damage and bacteria activate resident sentinel cells to release chemoattractants and vasoactive factors.
    • This triggers increased blood flow and capillary permeability.
    • Permeable capillaries allow fluid (exudate) and cells to flow into the affected area.
    • Phagocytes and antibacterial substances destroy bacteria.
    • Neutrophils and other phagocytes migrate to the site of inflammation.

    Hypersensitivity

    • Four types, all involving initial sensitization.
    • Type I (Allergy): IgE-mediated; immediate response.
    • Type II (Cytotoxic): IgG or IgM-mediated cell destruction.
    • Type III (Immune Complex): Immune complexes depositing, triggering complement activation.
    • Type IV (Delayed): Cell-mediated; T-cells activated, leading to inflammatory response.

    Diseases Manifesting Delayed Type Hypersensitivity

    • Chronic diseases in humans linked to infectious agents (e.g., tuberculosis, leprosy, leishmaniasis).
    • Also linked to Deep fungal infections and helminthic infections.
    • Activate T cells and macrophages.

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    Description

    Explore the fundamentals of innate immunity, focusing on non-specific responses and various defense mechanisms. Learn about humoral factors, anatomical barriers, and the role of different immune cells. This quiz covers essential concepts and components critical to understanding the body's first line of defense.

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