Innate Immunity Defense Barriers
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Questions and Answers

What are the three lines of defense in the immune system?

  • First Line, Third Line, Fourth Line
  • Second Line, Third Line, Fourth Line
  • First Line, Second Line, Fourth Line
  • First Line, Second Line, Third Line (correct)

What is the first line of defense?

Physical and chemical barriers such as epithelial cell layers of the skin, mucosal tissues, and glandular tissues.

What is the second line of defense?

Cellular immune responses.

The skin is a part of the first line of defense.

<p>True (A)</p> Signup and view all the answers

Cellular immune responses are part of the third line of defense.

<p>False (B)</p> Signup and view all the answers

Dendritic cells present pathogens to lymphocytes in the third line of defense.

<p>True (A)</p> Signup and view all the answers

The first line of defense is the most specific defense mechanism.

<p>False (B)</p> Signup and view all the answers

Flashcards

What is immunology?

The study of how the host (our body) defends itself against foreign substances.

What is an antigen?

A foreign substance that triggers an immune response. It can be a microbe, a toxin, or even parts of a foreign cell.

What is immunity?

The state of being protected from a particular disease.

What is innate immunity?

The body's natural, non-specific defenses against infection. It's present from birth and acts immediately.

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What is adaptive immunity?

The body's specific, adaptive defenses against infection. It develops over time and remembers past encounters.

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What is the first line of defense in innate immunity?

The first line of defense against infection. Acts as a physical barrier to prevent pathogens from entering the body.

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What is the second line of defense in innate immunity?

The second line of defense against infection. Involves various cells and mechanisms that quickly identify and destroy pathogens.

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What is the third line of defense in innate immunity?

The third line of defense against infection. It's highly specific and involves B and T lymphocytes that target and destroy pathogens.

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What is phagocytosis?

The process by which certain cells in the immune system engulf and destroy pathogens. Think of a Pac-Man eating invaders.

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What are cytokines?

Chemical messengers that help coordinate the immune response. They attract immune cells to the site of infection and activate other immune cells.

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What are NK cells?

A type of cell that is present in innate immunity. These cells kill virus-infected cells and some tumor cells.

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What are dendritic cells?

A type of cell that is present in innate immunity. These cells capture pathogens and present them to T cells to trigger the adaptive immune response.

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What are B lymphocytes (B cells)?

A type of cell that is present in adaptive immunity. They are responsible for producing antibodies.

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What are T lymphocytes (T cells)?

A type of cell that is present in adaptive immunity. They directly kill infected cells and help activate other immune cells.

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What are antigen presenting cells (APCs)?

A type of cell that is present in adaptive immunity. They are responsible for presenting antigens to T cells to initiate the adaptive immune response.

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What are antibodies?

Proteins produced by B cells that bind to antigens and help neutralize them. Think of the immune system's missiles.

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What is immune memory?

The ability of the immune system to remember a prior exposure to an antigen and mount a faster and stronger response upon subsequent encounters.

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What is specificity in adaptive immunity?

The ability of the adaptive immune response to be highly specific to a particular antigen. Think of a lock and key.

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What is systemic in adaptive immunity?

The ability of the adaptive immune response to be effective throughout the entire body, not just at the site of infection.

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Why is lactic acid important in innate immunity?

Lactic acid inhibits growth of many microbes. Think of the sour environment of yogurt.

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How do cilia work in innate immunity?

Cilia in the respiratory tract help move pathogens out of the body by sweeping them up and out. Think of tiny hairs working together.

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Why is stomach acid important in innate immunity?

Stomach acid is very acidic, preventing many microbes from growing and surviving. Think of the acidic environment of vinegar.

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Why is urine important in innate immunity?

Urine serves to flush out pathogens from the urinary tract. Think of a flush.

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What is lysozyme?

Lysozyme is an enzyme that attacks the cell walls of bacteria, breaking them down. Think of a weapon that disarms the enemy.

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Why are normal flora important in innate immunity?

Normal flora are beneficial bacteria that compete with harmful pathogens for space and resources. It's like a natural defense force.

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Study Notes

Innate Immunity Defense Barriers

  • Innate immunity has multiple defense barriers
  • First Line: Physical and chemical barriers like skin, mucosal tissues (respiratory, digestive, urogenital), and glandular tissues (salivary, lacrimal, mammary)
  • Second Line: Cellular immune responses triggered by receptors recognizing pathogen components. White blood cells engulf and destroy microbes via phagocytosis. Cells produce antimicrobial substances and cytokines/chemokines to recruit cells and create inflammation.
  • Third Line: Dendritic cells present pathogens to lymphocytes, triggering adaptive immunity.

Innate Immunity Mechanisms

  • Examples of mechanisms and their functions:
    • Skin and mucous membranes: retard microbe entry
    • Lactic acid: inhibits microorganism growth
    • Cilia: remove pathogens from respiratory tract
    • Stomach acid (low pH): prevents pathogen growth
    • Urine: flushes pathogens from the body
    • Lysozyme: attacks pathogen cell walls
    • Normal flora: competes with pathogens, produces antimicrobial peptides
    • Cells: participate in phagocytosis (e.g., NK cells destroying target cells)
    • Pathogen recognition receptors (PRRs, e.g., Toll-like receptors): assist phagocytic cells in recognizing pathogens.

Adaptive Immunity

  • Adaptive (or acquired) immunity is a specific system protecting the body from microbes and abnormal cells. It's activated by foreign substances.
  • Characteristics:
    • Specific: for individual pathogens
    • Systemic: immunity isn't limited to infection site
    • Memory: increased response to repeated exposure to the same pathogen.
  • Comparison of Natural and Adaptive Immunity:
    Feature Natural Immunity Adaptive Immunity
    Specificity Non-specific Specific
    Response Time Rapid (minutes to hours) Slow (days to weeks)
    Memory No Yes
    Soluble Components Antimicrobial peptides and proteins Antibodies
    Major Cell Types Phagocytes, NK cells, dendritic cells T cells, B cells, APCs (antigen-presenting cells)

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Description

Explore the various defense barriers of innate immunity, including the physical and chemical aspects that serve as the first line of defense, as well as the cellular responses that occur when pathogens invade. This quiz also covers the mechanisms employed by the body to inhibit and eliminate infections. Test your knowledge about these crucial aspects of our immune system.

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