Lecture 4

Play an AI-generated podcast conversation about this lesson

Which of the following is the definition of reproductive integrity in the context of cell survival curves?

The ability of cells to divide indefinitely and generate a large clone of cells (correct)

The loss of the capacity for sustained proliferation in proliferating cells

The loss of a specific function in differentiated cells

The inability of cells to divide and inhibit further growth

What is the dominant mechanism of cell death in most cells?

Mitotic death (correct)

Reproductive death

Loss of proliferative capacity

Apoptosis

What is the mean lethal dose for the loss of proliferative capacity in proliferating cells?

Less than 2 Gy (correct)

More than 100 Gy

2 Gy

Approximately 100 Gy

Which proteins monitor the cell cycle's progress and ensure accuracy?

Checkpoint Proteins Signup and view all the answers

What is the significance of the cell cycle?

Essential for growth, development, and tissue repair Signup and view all the answers

Which technique is used to produce synchronously dividing cell cultures?

Mitotic Harvest Technique Signup and view all the answers

Which phase of the cell cycle shows the greatest resistance to radiation?

Late S phase Signup and view all the answers

Which phase of the cell cycle is characterized by DNA replication?

S Phase Signup and view all the answers

What is the dose required to reduce the fraction of surviving cells to 37% in the effective dose-survival curve?

D0 Signup and view all the answers

What is the dose required to kill 90% of the population in the effective dose-survival curve?

D10 Signup and view all the answers

If a tumor contains 10^8 clonogenic cells, what total dose is required to give a 90% chance of tumor cure?

62.1 Gy Signup and view all the answers

Which phase of the cell cycle is most resistant to radiation?

DNA synthesis phase (S) Signup and view all the answers

What is the cycle time for resting mouse skin stem cells?

<blockquote> 200 hours </blockquote> Signup and view all the answers

Which phase of the cell cycle has the second peak of resistance to radiation?

G1 Signup and view all the answers

Which repair mechanism is more faithful and occurs after replication in the S phase?

Homologous recombinational repair Signup and view all the answers

Which of the following is NOT a mechanism of cell killing ?

Bystander effect Signup and view all the answers

Which of the following is a characteristic of apoptosis?

Cell shrinkage and fragmentation Signup and view all the answers

What is the equation for the surviving fraction in the multitarget model?

SF = exp(-αD - βD^2) Signup and view all the answers

What is the relationship between radiosensitivity and apoptosis in mammalian cells?

Radiosensitivity is directly correlated with apoptosis Signup and view all the answers

What does the α/β ratio in the linear-quadratic model indicate?

The width of the shoulder in the survival curve Signup and view all the answers

What is the role of autophagy in irradiated cells?

Autophagy promotes cell survival and generates nutrients and energy Signup and view all the answers

What is the cycle time for resting mouse skin stem cells?

<blockquote> 200 hours </blockquote> Signup and view all the answers

Which phase of the cell cycle is most resistant to radiation?

DNA synthesis phase (S) Signup and view all the answers

Which type of radiation displays a straight-line curve in the survival curve, approximating exponential cell killing?

X-rays Signup and view all the answers

Which repair mechanism is more faithful and occurs after replication in the S phase?

Homologous recombinational repair Signup and view all the answers

What is the plating efficiency in the unirradiated control dish if 100 cells were seeded and there are 70 colonies after 7 days?

70% Signup and view all the answers

What is the dose required to kill 90% of the population in the effective dose-survival curve?

63% Signup and view all the answers

What is the equation for the surviving fraction in the multitarget model?

$S = 1 - e^{-D/D_0}$ Signup and view all the answers

What is the relationship between radiosensitivity and apoptosis in mammalian cells?

Radiosensitivity decreases with increased apoptosis Signup and view all the answers

What is the significance of the cell cycle?

The cell cycle controls cell division Signup and view all the answers

Lecture 4

Podcast Beta

Questions and Answers

Which of the following is the definition of reproductive integrity in the context of cell survival curves?

What is the dominant mechanism of cell death in most cells?

What is the mean lethal dose for the loss of proliferative capacity in proliferating cells?

Which proteins monitor the cell cycle's progress and ensure accuracy?

What is the significance of the cell cycle?

Which technique is used to produce synchronously dividing cell cultures?

Which phase of the cell cycle shows the greatest resistance to radiation?

Which phase of the cell cycle is characterized by DNA replication?

What is the dose required to reduce the fraction of surviving cells to 37% in the effective dose-survival curve?

What is the dose required to kill 90% of the population in the effective dose-survival curve?

If a tumor contains 10^8 clonogenic cells, what total dose is required to give a 90% chance of tumor cure?

Which phase of the cell cycle is most resistant to radiation?

What is the cycle time for resting mouse skin stem cells?

Which phase of the cell cycle has the second peak of resistance to radiation?

Which repair mechanism is more faithful and occurs after replication in the S phase?

Which of the following is NOT a mechanism of cell killing ?

Which of the following is a characteristic of apoptosis?

What is the equation for the surviving fraction in the multitarget model?

What is the relationship between radiosensitivity and apoptosis in mammalian cells?

What does the α/β ratio in the linear-quadratic model indicate?

What is the role of autophagy in irradiated cells?

What is the cycle time for resting mouse skin stem cells?

Which phase of the cell cycle is most resistant to radiation?

Which type of radiation displays a straight-line curve in the survival curve, approximating exponential cell killing?

Which repair mechanism is more faithful and occurs after replication in the S phase?

What is the plating efficiency in the unirradiated control dish if 100 cells were seeded and there are 70 colonies after 7 days?

What is the dose required to kill 90% of the population in the effective dose-survival curve?

What is the equation for the surviving fraction in the multitarget model?

What is the relationship between radiosensitivity and apoptosis in mammalian cells?

What is the significance of the cell cycle?

More Quizzes Like This

Lecture 4

Lecture 4 - Face & Neck; Scalp, mastication, TMJ, Neck Vasculature...

Lecture 4-5

Lecture 4b

Upgrade to continue

Lecture 4

Podcast Beta

Questions and Answers

Which of the following is the definition of reproductive integrity in the context of cell survival curves?

What is the dominant mechanism of cell death in most cells?

What is the mean lethal dose for the loss of proliferative capacity in proliferating cells?

Which proteins monitor the cell cycle's progress and ensure accuracy?

What is the significance of the cell cycle?

Which technique is used to produce synchronously dividing cell cultures?

Which phase of the cell cycle shows the greatest resistance to radiation?

Which phase of the cell cycle is characterized by DNA replication?

What is the dose required to reduce the fraction of surviving cells to 37% in the effective dose-survival curve?

What is the dose required to kill 90% of the population in the effective dose-survival curve?

If a tumor contains 10^8 clonogenic cells, what total dose is required to give a 90% chance of tumor cure?

Which phase of the cell cycle is most resistant to radiation?

What is the cycle time for resting mouse skin stem cells?

Which phase of the cell cycle has the second peak of resistance to radiation?

Which repair mechanism is more faithful and occurs after replication in the S phase?

Which of the following is NOT a mechanism of cell killing ?

Which of the following is a characteristic of apoptosis?

What is the equation for the surviving fraction in the multitarget model?

What is the relationship between radiosensitivity and apoptosis in mammalian cells?

What does the α/β ratio in the linear-quadratic model indicate?

What is the role of autophagy in irradiated cells?

What is the cycle time for resting mouse skin stem cells?

Which phase of the cell cycle is most resistant to radiation?

Which type of radiation displays a straight-line curve in the survival curve, approximating exponential cell killing?

Which repair mechanism is more faithful and occurs after replication in the S phase?

What is the plating efficiency in the unirradiated control dish if 100 cells were seeded and there are 70 colonies after 7 days?

What is the dose required to kill 90% of the population in the effective dose-survival curve?

What is the equation for the surviving fraction in the multitarget model?

What is the relationship between radiosensitivity and apoptosis in mammalian cells?

What is the significance of the cell cycle?

More Quizzes Like This

Lecture 4

Lecture 4 - Face &amp; Neck; Scalp, mastication, TMJ, Neck Vasculature...

Lecture 4-5

Lecture 4b

Lecture 4 - Face & Neck; Scalp, mastication, TMJ, Neck Vasculature...