18 Questions
What type of genetic disorders are caused by defects in one particular gene due to changes or mutations in the DNA?
Monogenetic disorders
What is the pattern of inheritance of autosomal dominant disorders?
Expressed in the heterozygous condition
Which type of inheritance does not differ between males and females?
Autosomal dominant
What is the term for the study of the inheritance of genetic disorders and diseases?
Mendelian inheritance
What is the name of the well-known autosomal dominant disorder that is an example of autosomal dominant inheritance?
Huntington's disease
How many pairs of non-sex chromosomes are there in humans?
22
What type of trait is depicted in the pedigree shown in Figure 4.35?
Autosomal recessive
What is the genotype of the unaffected male and female children in the fourth generation of the pedigree?
Homozygous dominant
What is the probability of the heterozygous male child in the fourth generation exhibiting the trait?
0%
What is the main purpose of pedigree analysis in genetics?
To predict the expression of a trait in future generations
What is the advantage of analyzing a pedigree in a family with a history of a genetic disorder?
It can provide information about the risk of disease inheritance and propagation
How many genotypes are possible for a family member in a pedigree, assuming a single autosomal recessive trait?
3
What is the condition in which an autosomal recessive disorder will most commonly occur?
When both parents carry the trait and the offspring receives the defective gene from each parent
What is the genotype of a person who is a carrier of an autosomal recessive disorder?
Rr
In a Punnett square, what is the probability of a child inheriting the allele for albinism (r) if both parents are carriers (Rr)?
25%
What is the difference between autosomal dominant and autosomal recessive inheritance?
Autosomal dominant is expressed in heterozygous conditions, while autosomal recessive is expressed in homozygous recessive conditions
What is the type of inheritance pattern shown by most forms of albinism in humans?
Autosomal recessive
What is the reason why both parents can be carriers of an autosomal recessive disorder but be unaffected themselves?
Because they are heterozygous and the normal allele is dominant
Analyzing the inheritance pattern of an autosomal recessive trait through a pedigree chart. Understand how the presence and absence of a trait are passed down through generations. Learn to interpret pedigree charts and identify the trait inheritance pattern.
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