Inhaled Anticholinergics: Muscarinic Antagonists
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Questions and Answers

A client with COPD is prescribed ipratropium. Which instruction should the nurse emphasize regarding the medication's use?

  • Discontinue the medication if you experience any blurred vision.
  • Use this medication as a rescue inhaler during acute breathing difficulties.
  • Administer the medication only when experiencing a productive cough.
  • Suck on hard candy or frequently sip water to relieve dry mouth. (correct)

A client with a history of glaucoma is prescribed ipratropium. What specific instruction should the nurse provide to ensure client safety?

  • Increase fluid intake to prevent urinary retention.
  • Avoid taking the medication at night to prevent sleep disturbances.
  • Schedule frequent eye exams to monitor for glaucoma progression. (correct)
  • Monitor blood pressure regularly due to potential hypertensive effects.

A client is prescribed both ipratropium and a beta2-adrenergic agonist. What is the most important nursing consideration regarding these medications?

  • Instruct the client to alternate the use of each inhaler daily.
  • Monitor for decreased effectiveness of either medication.
  • Administer the beta2-adrenergic agonist first, followed by ipratropium 30 minutes later.
  • Ensure the primary care provider adjusts the dosage of one of the medications. (correct)

Which pre-existing condition should prompt a nurse to exercise caution when administering ipratropium?

<p>Prostatic hyperplasia (A)</p> Signup and view all the answers

A client reports difficulty urinating after starting ipratropium. What action should the nurse take first?

<p>Notify the primary care provider about the change in urinary elimination. (D)</p> Signup and view all the answers

How do inhaled anticholinergics counteract bronchoconstriction in clients with COPD?

<p>By blocking acetylcholine at muscarinic receptors in the parasympathetic nervous system. (B)</p> Signup and view all the answers

A client with a history of narrow-angle glaucoma is prescribed inhaled ipratropium. Which intervention is most important?

<p>Monitoring the client for increased intraocular pressure. (D)</p> Signup and view all the answers

Why is it important to offer water and hard candy to clients using inhaled anticholinergics?

<p>To counteract the adverse effect of dry mouth. (D)</p> Signup and view all the answers

When administering multiple inhalants, including an anticholinergic, what is the recommended waiting period after administering the anticholinergic before giving the next inhalant?

<p>5 minutes. (D)</p> Signup and view all the answers

What is the primary difference in the mechanism of action between beta2-adrenergic agonists and anticholinergics in treating airflow disorders?

<p>Beta2-adrenergic agonists stimulate the sympathetic system, while anticholinergics block the parasympathetic system. (C)</p> Signup and view all the answers

Which adverse effect of inhaled anticholinergics requires monitoring urinary elimination patterns, especially in older adults?

<p>Urinary retention (B)</p> Signup and view all the answers

A client reports an unpleasant aftertaste after using their inhaled anticholinergic. What action should the nurse recommend?

<p>Rinsing the mouth with water after administration. (D)</p> Signup and view all the answers

Which of the following is the prototype medication for short-acting muscarinic antagonists (SAMA)?

<p>Ipratropium (C)</p> Signup and view all the answers

Flashcards

Inhaled Anticholinergics: Use

Inhaled anticholinergics are bronchodilators used for COPD, not rescue meds for acute asthma.

Inhaled Anticholinergics: Dry Mouth Relief

Suck on hard candy and sip water.

Inhaled Anticholinergics: Monitoring

Regular eye exams for glaucoma and report urinary changes.

Ipratropium: Cautions

Glaucoma, prostatic hyperplasia, bladder neck obstruction, or urinary retention.

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Inhaled Anticholinergics: Interactions

Beta2-adrenergic agonists enhance bronchodilation.

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Anticholinergics

Medications used for airflow disorders that relieve bronchoconstriction and reduce secretions, especially in COPD.

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Ipratropium

Short-acting muscarinic antagonist (SAMA) used as a rescue inhaler for quick relief.

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Umeclidinium, Tiotropium, Aclidinium, Revefenacin

Long-acting muscarinic antagonists (LAMAs) used for long-term management of airflow disorders.

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Anticholinergic Action

These medications inhibit acetylcholine at muscarinic receptors, causing bronchodilation.

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Anticholinergic Adverse Effects

Dry mouth, pharyngeal irritation, increased intraocular pressure (glaucoma), urinary retention, tachycardia.

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Anticholinergic Interventions

Provide water/candy for dry mouth, monitor for glaucoma and urinary retention.

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Anticholinergic Administration

Administer via inhaler/nebulizer, follow instructions, wait 5 min between other inhalants, rinse mouth after use.

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Parasympathetic System

Bronchoconstriction of the bronchi and bronchioles through acetylcholine.

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Study Notes

  • Inhaled anticholinergics (muscarinic antagonists) treat airflow disorders.
  • These medications relieve bronchoconstriction and reduce secretions in COPD patients.
  • Medication selection is based on whether it’s for fast relief or long-term management.

Prototype and Other Medications

  • Ipratropium is the prototype short-acting anticholinergic or muscarinic antagonists (SAMA) medication.
  • Umeclidinium, tiotropium, aclidinium, and revefenacin are long-acting muscarinic antagonists (LAMA).

Expected Pharmacologic Action

  • Anticholinergics affect the parasympathetic system, while beta2-adrenergic agonists affect the sympathetic system.
  • The parasympathetic system uses acetylcholine to cause bronchoconstriction.
  • Inhaled anticholinergics inhibit acetylcholine's action at the muscarine receptor.
  • Anticholinergics block the muscarine receptor, inhibiting acetylcholine, resulting in bronchodilation.

Adverse Drug Reactions

  • Adverse reactions are usually local, like dry mouth and pharyngeal irritation.
  • Increased intraocular pressure can occur in those with narrow-angle glaucoma if systemic absorption is abundant.
  • Other adverse reactions include urinary retention, tachycardia, headache, dizziness, blurred vision, epistaxis, bronchospasms, and hypotension.

Interventions

  • Provide water and hard candy to ease dry mouth discomfort.
  • Offer glaucoma testing and monitor urinary elimination patterns, especially in older adults.

Administration

  • Administer via inhaler or nebulizer, following instructions, dosage limits, and schedule.
  • Maintain the prescribed time between puffs.
  • Wait at least 5 minutes after giving the anticholinergic before administering other inhalants.
  • Provide water for rinsing the mouth due to unpleasant aftertaste.

Safety Alert

  • Inhaled anticholinergics are not rescue medications for acute asthma exacerbations.
  • They are labeled for use as bronchodilators for COPD.

Client Instructions

  • Review possible side effects and ways to alleviate discomfort.
  • Suggest sucking on hard candy and sipping water for dry mouth.
  • Remind clients to have regular eye exams for glaucoma.
  • Tell them to report any changes in urinary elimination to their provider.

Contraindications and Precautions

  • Use caution when giving ipratropium to clients who have glaucoma, prostatic hyperplasia, bladder neck obstruction, or urinary retention.
  • Closely monitor for worsening of these conditions.

Interactions

  • Beta2-adrenergic agonists can enhance bronchodilation effects.
  • The primary care provider should adjust the dosage of one of the medications if they are taken concurrently.

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Description

Inhaled anticholinergics, or muscarinic antagonists, treat airflow disorders by relieving bronchoconstriction and reducing secretions, especially in COPD. Drug selection depends on the need for quick relief versus long-term control. Prototype SAMA is ipratropium, while umeclidinium and others are LAMAs.

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