Information Retrieval in Evidence-Based Medicine
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Questions and Answers

What is the first step in the stepwise approach to answering DI questions?

  • Evaluate critical literature
  • Retrieve pertinent literature
  • Categorize quality of evidence
  • Define clinical question (correct)
  • Which of the following is a tertiary resource that can aid in initial information searches?

  • Lexi-comp (correct)
  • Embase
  • PubMed
  • Ovid
  • Why is it important to verify information using at least two resources?

  • To ensure all resources are primary
  • To identify discrepancies (correct)
  • To compare cost estimates
  • To simplify the research process
  • What characterizes primary resources in the context of information retrieval?

    <p>Original or new research (B)</p> Signup and view all the answers

    Which resource would you not typically use to find primary literature?

    <p>Micromedex (D)</p> Signup and view all the answers

    What is a recommended action if discrepancies are found between two resources?

    <p>Find another reputable resource for verification (B)</p> Signup and view all the answers

    Which of the following resources is classified as a tertiary resource?

    <p>Natural standard/natural medicines (B)</p> Signup and view all the answers

    What should be included in the evaluation of critical literature?

    <p>Understanding the quality of study design (B)</p> Signup and view all the answers

    What is a notable feature of the Sanford guide?

    <p>It has versions specifically for HIV. (C)</p> Signup and view all the answers

    Which textbook is known for its coverage of oncology?

    <p>DeVita’s (D)</p> Signup and view all the answers

    In evidence-based medicine, what is a background question?

    <p>A general inquiry seeking clinical information. (D)</p> Signup and view all the answers

    What is Access Medicine primarily used for?

    <p>To find clinical books and resources. (C)</p> Signup and view all the answers

    What do quick reference tabs in Access Medicine provide?

    <p>Concise overviews of disease states. (A)</p> Signup and view all the answers

    Which of the following best describes clinical pharmacology in the context described?

    <p>Searching by indication or adverse effect. (C)</p> Signup and view all the answers

    Which of the following is not a primary resource mentioned for literature evaluation?

    <p>Physician reviews of practices. (D)</p> Signup and view all the answers

    What type of resources can be found in Access Medicine under the clinical resources section?

    <p>Online books, flash cards, and NAPLEX resources. (A)</p> Signup and view all the answers

    What type of resources does ConsumerLab.com provide?

    <p>Testing of natural products and herbals (C)</p> Signup and view all the answers

    Which of the following is NOT a service provided by the FDA?

    <p>Lactation support resources (D)</p> Signup and view all the answers

    What essential report is published by the Centers for Disease Control and Prevention?

    <p>Morbidity and Mortality Weekly Report (MMWR) (C)</p> Signup and view all the answers

    What type of information can LactMed provide?

    <p>Drug levels in breast milk and potential infant effects (D)</p> Signup and view all the answers

    What is a primary role of the National Institutes of Health (NIH)?

    <p>Supporting public health initiatives (B)</p> Signup and view all the answers

    Which website is user-friendly and provides labeling information submitted by the FDA?

    <p>DailyMed (D)</p> Signup and view all the answers

    What does the Vaccine Adverse Event Reporting System (VAERS) monitor?

    <p>Adverse events following immunizations (B)</p> Signup and view all the answers

    Which of the following is an example of information provided by the FDA?

    <p>Drug safety and side effects (A)</p> Signup and view all the answers

    What feature allows for the quick navigation of guidelines?

    <p>Bolded or highlighted recommendations (A)</p> Signup and view all the answers

    What constitutes plagiarism according to the guidelines?

    <p>Paraphrasing an idea without proper citation (A)</p> Signup and view all the answers

    Which of the following resources is likely to provide a filter for guidelines during a literature search?

    <p>PubMed article type — guideline (A)</p> Signup and view all the answers

    When comparing multiple guidelines for disease states, which factor is NOT essential to consider?

    <p>The geographical origin of the guideline (A)</p> Signup and view all the answers

    When is it necessary to cite your sources?

    <p>When you paraphrase or summarize another's ideas (D)</p> Signup and view all the answers

    Which citation format must be used for journal abbreviations?

    <p>American Medical Association (AMA) (A)</p> Signup and view all the answers

    What can be found in executive summaries of guidelines?

    <p>Shortened versions of guidelines without complete detail (D)</p> Signup and view all the answers

    Which section of tertiary resources might provide information on clinical guidelines?

    <p>Clinical practice guidelines in drug monographs (D)</p> Signup and view all the answers

    What is ‘sentence case’ in citation formatting?

    <p>Only capitalization of the first word and proper nouns (C)</p> Signup and view all the answers

    Why might someone choose one guideline over another in a clinical setting?

    <p>Evaluation of high-quality evidence and alignment with the patient population (A)</p> Signup and view all the answers

    If a scholarly article has more than six authors, how should they be cited?

    <p>Cite the first three followed by 'et al.' (B)</p> Signup and view all the answers

    What information is NOT typically required for citing a book?

    <p>ISBN number (D)</p> Signup and view all the answers

    What type of questions do guidelines often include to clarify their recommendations?

    <p>PICO questions (A)</p> Signup and view all the answers

    What is typically included alongside summary recommendations in guidelines?

    <p>Text for justification and additional detail (C)</p> Signup and view all the answers

    Which of the following actions does NOT require citation?

    <p>Discussing your personal experiences (D)</p> Signup and view all the answers

    When writing a paper, when should you format titles in sentence case?

    <p>For all titles, headings, and subheadings (A)</p> Signup and view all the answers

    What is the primary goal when summarizing guidelines?

    <p>To be concise and complete (D)</p> Signup and view all the answers

    Which of the following categories should be considered when reviewing literature to refine guideline recommendations?

    <p>Efficacy, safety, cost, and special populations (A)</p> Signup and view all the answers

    In clinical decision-making, guidelines should primarily be referenced for which purpose?

    <p>To assist and standardize clinical practice (D)</p> Signup and view all the answers

    When integrating landmark literature, it should be used to:

    <p>Support and supplement existing guideline knowledge (C)</p> Signup and view all the answers

    What should be included in the final recommendation derived from guidelines and literature?

    <p>A concise summary that combines multiple information sources (B)</p> Signup and view all the answers

    Which statement is true regarding the citation of guidelines in formal writing?

    <p>Most guidelines published in journals are cited as journal articles (B)</p> Signup and view all the answers

    How should guidelines be documented in day-to-day clinical practice?

    <p>Using an accepted shorthand (D)</p> Signup and view all the answers

    When summarizing guideline recommendations, what is a necessary skill to develop?

    <p>Combining multiple guideline statements succinctly (B)</p> Signup and view all the answers

    Flashcards

    DI question answering steps

    A systematic approach to addressing drug information (DI) questions, involving defining the question, retrieving relevant literature, evaluating the literature, categorizing evidence quality, and concluding with recommendations.

    Tertiary resources

    Starting point resources for background information on diseases, prevalence, mechanisms, and pharmacokinetics/pharmacodynamics; often used to understand the context of a clinical question.

    Secondary resources

    Resources that help find primary literature and research articles, like Ovid, PubMed, and Embase.

    Primary resources

    Original research articles and studies that are the foundation for evidence-based medical recommendations and drug information.

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    Verification of DI

    Crucial step of confirming the accuracy of drug information gathered from at least two different, reputable sources in case of discrepancies.

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    Clinical Pharmacology Resources

    Specialized resources like Lexi-comp and others providing information about drug interactions, compatibility, comparisons, adverse reactions, and more.

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    Electronic Tertiary Resources

    Digital resources like Lexi-comp, Micromedex, UpToDate, etc. that provide drug information, clinical guidelines, and evidence, for use in drug information.

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    Reputable DI Sources

    Trusted sources such as electronic tertiary databases, professional organizations (e.g., FDA, CDC), and review articles (e.g., Cochrane Database of Systematic Reviews) that provide accurate and reliable drug information.

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    ConsumerLab.com

    A website that tests natural products and herbs, requiring a paid subscription.

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    Medscape

    A free online resource for healthcare professionals, offering continuing education (CE) credits.

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    FDA

    A US government agency responsible for regulating food, drugs, medical devices, and more.

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    CDC

    The US center for diseases control and prevention, providing public health information and resources.

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    NIH

    The US government's primary agency for biomedical and public health research.

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    LactMed

    A NIH resource providing information on drugs and chemicals' effects during breastfeeding.

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    DailyMed

    A user-friendly website provided by the National Library of Medicine, featuring FDA-submitted drug labeling/package inserts.

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    TOXNET

    A NIH database containing various resources related to toxicology, including household product and chemical data.

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    Sanford Guide

    A widely used resource for antibiotics and their corresponding infections.

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    Top Discipline Textbooks

    Key resources in general medicine (Cecil's), oncology (DeVita's), internal medicine (Harrison's), and infectious disease (Mandell's).

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    Evidence-Based Medicine

    The development of recommendations based on a critical analysis of primary literature.

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    Background Questions

    General clinical information questions (e.g., spleen function, carbapenem mechanism, furosemide side effects).

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    Access Medicine

    An online collection of medical books, including drug information, flashcards, and resources, found in library resources (e.g.AccessPharmacy).

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    Clinical Trials Reviews

    Evaluations of clinical trials, studies, and guidelines to assess the validity of approaches, results, and recommendations.

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    Quick Reference

    A concise overview of diseases, diagnosis, and treatment, accessible through online resources.

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    Clinical Pharmacology Search

    Searching for information on medications by indication or adverse effects.

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    Guideline Website Tab

    Most guideline organizations have a dedicated tab on their website for browsing guidelines. This allows easy access to their recommendations.

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    Guideline Update Info

    Websites may provide additional information about guidelines, including upcoming updates, corrections to published versions, and concise summaries.

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    Finding Unfamiliar Guidelines

    You can find specific guidelines using search filters in databases like PubMed or EMBASE, or by consulting tertiary resources.

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    Multiple Guidelines for One Disease

    Different organizations might publish guidelines for the same disease. Choose one based on quality, target audience, and PICO questions.

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    Guideline Formatting

    Guidelines are typically organized for easy navigation, with bolded recommendations and often include summary tables or PICO-based organization.

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    Executive Summary

    Many guidelines offer short, quick-reference executive summaries, separated from the full guideline text.

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    Referencing a Guideline

    When citing a guideline, follow the prescribed format or consult the guideline's own citation instructions.

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    Recommendation Justification

    Each guideline recommendation includes associated text providing reasoning and additional detail to support the suggestion.

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    Plagiarism

    Using someone else's work without proper attribution, including directly copying, paraphrasing, or using ideas without citation.

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    When to Cite

    You must cite your sources when using factual information, direct quotes, summaries, paraphrases, interpretations, conclusions, or distinctive structures from other sources.

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    AMA Style

    The American Medical Association (AMA) manual of style is a set of guidelines for formatting citations and references in medical publications.

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    Journal Abbreviations

    Use the correct abbreviations for journals according to the National Library of Medicine (NLM) journal of abbreviations.

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    Sentence Case

    Capitalize the first letter of the first word and proper nouns in titles, headings, and subheadings.

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    Scholarly Article Citation

    Include author names, article title, journal abbreviation, publication year, volume number, page numbers, and supplement information if needed.

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    Book Citation

    Include author names, italicized book title, publication year, publisher, and city of publication.

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    Author Limits

    For articles or books with more than six authors, list only the first three authors and add "et al."

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    Why cite guidelines?

    Guidelines provide evidence-based recommendations and support clinical decision-making. Citing them shows your decision-making is informed and ethical.

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    AMA format for guidelines

    When referencing guidelines formally, use APA format for website-only guidelines and journal article format for published guidelines.

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    What's the purpose of summarizing guidelines?

    To extract and condense the most relevant guidelines recommendations for a specific problem or question.

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    Patient-specific information

    Beyond guidelines, adding a patient's individual needs, drug interactions, or preferences can tailor recommendations.

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    Landmark literature

    Highly influential research with strong impact in a field, often cited frequently and providing significant insights.

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    How do guidelines and landmark literature work together?

    Guidelines provide the framework, and landmark literature can supplement and provide deeper insights, making a stronger case.

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    Why consider efficacy, safety, cost, and special populations?

    Evaluating literature thoroughly ensures you understand a drug's effectiveness, potential dangers, financial impact, and impact on unique groups.

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    The final recommendation

    Combines guideline recommendations, relevant literature, and patient factors for a personalized, informed clinical decision.

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    Study Notes

    Information Search and Retrieval: Review of DI Resources

    • A stepwise approach to answering drug information (DI) questions involves defining the clinical question, retrieving pertinent literature, evaluating critical literature, categorizing the quality of evidence, and developing a conclusion and recommendation.
    • Tertiary resources serve as starting points, providing background information on diseases, prevalence, mechanisms, PK/PD, and references.
    • Secondary resources, like Ovid, PubMed, and Embase, are tools to find primary literature.
    • Primary resources include original or new research and form the foundations of recommendations.
    • To verify information, consult at least two resources, and if discrepancies arise, consult a third reputable source.
    • Electronic tertiary resources include Lexi-comp, Clinical Pharmacology, Facts & Comparisons - eAnswers, Micromedex, Natural Standard/Natural Medicines, AHFS (part of Lexi), E-textbooks (AccessPharmacy & AccessMedicine), and others like UpToDate, DynaMed, Cochrane databases of systematic reviews, MDConsult, NIH Office of Dietary Supplements, Pharmacist's Letter, and Medscape.

    Food and Drug Administration (FDA) Resources

    • FDA resources include the Center for Drug Evaluation and Research (CDER) and the Center for Disease Control and Prevention (CDC), with clinical trials information available online.
    • Resources about clinical pharmacology include drug interactions, IV compatibility, product comparisons, and adverse reactions.
    • Monographs, international brand names, do not crush lists, and information about tablet identification and clinical calculators are available.
    • Micromedex, Lexi-comp, and similar resources are available for information on drugs and supplements.
    • Information on natural medicines, including natural standard, natural medicine, likely/possibly/insufficient evidence scales, interactions, monographs, and nutrition/lactation information is available.

    Additional Resources and Topics

    • Patient's entire medication review
    • Natural products are not FDA-approved.
    • Review of drug monographs for brand and generic drugs, tablet identification (with images), toxicology, interactions, and IV compatibility.
    • Drug facts and comparison reviews include class reviews, monographs, interactions, tablet identification, manufacturer index, and black box warnings.
    • Access Pharmacy and Access Medicine provide 80 key pharmacy reference texts, blogs, quick references, drug information, drug therapy cases, and study resources.
    • AccessMedicine includes textbooks by disease states with patient handouts on diseases, drug monographs, international names, pricing, and patient handouts in English and Spanish.
    • Calculators for medical data are available, including online databases for biological products and drug product pricing and packaging.
    • Resources like UpToDate and DynaMed provide background information on disease states, treatment options, and guidelines.
    • Cochrane database provides systematic reviews, and various other resources regarding specific topics.

    Evaluating Information and Citations

    • All information should be evaluated, especially for its currency and accuracy.
    • Plagiarism is presenting someone else's words or ideas as your own without proper acknowledgment.
    • Properly citing sources is essential for academic work and avoiding plagiarism. -Information regarding when to cite sources is provided.
    • Correct citation formats are critical to ensure proper acknowledgment of sources. -Information and guidance on sentence case and capitalization style for titles and headings is provided. -Various resources and examples regarding scholarly articles and book chapters, different formatting styles, and package inserts are provided.

    Clinical Guidelines and Landmark Literature

    • Clinical guidelines are systematically developed statements to support clinicians and patients with decisions about health care in specific circumstances.
    • Guidelines have components such as background and etiology, diagnostic criteria and testing, assessing disease states, treatment recommendations, and monitoring.
    • Guidelines provide concise summaries, consistency in practice, and support for patient management protocols and formulary decisions.
    • Guidelines often involve partnerships between professional associations, government organizations, and managed care organizations.

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    EBM I - Exam 1 PDF

    Description

    Test your knowledge on the fundamentals of information retrieval in evidence-based medicine. This quiz covers the types of resources available, including primary and tertiary resources, and their significance in clinical practice. Enhance your understanding of critical literature evaluation and the features of essential medical guides.

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