Inflammatory Mediators Quiz

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Questions and Answers

Which cells are among the richest sources of histamine?

  • Mast cells (correct)
  • T cells
  • Macrophages
  • Eosinophils

What triggers the release of histamine from mast cells?

  • Binding of antibodies to T cells
  • Activation of B cells
  • Activation of macrophages
  • Binding of antibodies to mast cells (correct)

What is the effect of histamine on arterioles and venules?

  • Causes constriction of arterioles and decreases the permeability of venules
  • Causes irregular dilation and constriction of arterioles and venules
  • Has no effect on arterioles and venules
  • Causes dilation of arterioles and increases the permeability of venules (correct)

Which receptors does histamine bind to on microvascular endothelial cells?

<p>H1 receptors (B)</p> Signup and view all the answers

What type of drugs are H1 receptor antagonists?

<p>Antihistamine drugs (C)</p> Signup and view all the answers

Which of the following triggers the release of histamine from mast cells?

<p>Products of complement called anaphylatoxins (D)</p> Signup and view all the answers

Which of the following is NOT a trigger for the release of histamine from mast cells?

<p>Binding to H1 receptors (D)</p> Signup and view all the answers

Which of the following is a function of histamine?

<p>Causes dilation of arterioles (D)</p> Signup and view all the answers

What triggers the release of histamine from mast cells in immediate hypersensitivity (allergic) reactions?

<p>Binding of antibodies to mast cells (D)</p> Signup and view all the answers

Which of the following is a source of histamine?

<p>Mast cells (B)</p> Signup and view all the answers

Flashcards

Mast Cells

Cells that are rich in histamine stores and play a key role in allergic reactions.

Histamine Release Trigger

The process initiated by antibody binding to mast cells, leading to histamine release.

Histamine Effect on Blood Vessels

Histamine causes dilation of arterioles and increases venule permeability, leading to inflammation.

H1 Receptors

Specific receptors on microvascular endothelial cells that bind histamine and mediate its effects.

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Antihistamine Drugs

Medications known as H1 receptor antagonists that block the action of histamine.

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Anaphylatoxins

Products of complement that can trigger histamine release from mast cells.

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Non-Triggers for Histamine Release

Binding to H1 receptors does NOT trigger the release of histamine from mast cells.

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Function of Histamine

One role of histamine is to cause dilation of arterioles, affecting blood flow and inflammation.

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Immediate Hypersensitivity Trigger

In allergic reactions, histamine release is triggered by the binding of antibodies to mast cells.

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Source of Histamine

Mast cells are considered primary sources of histamine in the body.

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