Inflammatory Bowel Disease
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Questions and Answers

What is the main difference between Crohn’s disease (CD) and ulcerative colitis (UC)?

  • UC affects any part of the GI tract, while CD is confined to the rectum and colon
  • UC is caused by genetic factors, while CD is caused by environmental factors
  • UC is confined to the rectum and colon, while CD can affect any part of the GI tract from mouth to anus (correct)
  • UC is a transmural inflammation of the GI tract, while CD is a mucosal inflammatory condition

    • What are some contributing factors to the continuing inflammation of the GI mucosa in IBD?

  • High intake of vitamin C and fiber
  • Regular physical exercise and adequate sleep
  • Excessive consumption of spicy food and caffeine
  • Defects in the intestinal epithelial barrier and immune system (correct)

    • Which of the following is associated with improvement in UC symptoms but worsens CD?

  • NSAIDs
  • Smoking (correct)
  • Luminal bacteria
  • Dietary antigens

    • What are some of the proinflammatory cytokines contributing to the ongoing inflammatory process in IBD?

    <p>Interleukin-1, interleukin-6, tumor necrosis factor-α (TNF-α)</p> Signup and view all the answers

    What is the genetic association with respect to first-degree relatives of affected patients?

    <p>First-degree relatives have a 4 to 20-fold greater risk of developing IBD</p> Signup and view all the answers

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