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Inflammatory Bowel Disease: Types and Causes

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Inflammatory Bowel Disease: Types and Causes

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Questions and Answers

Which type of drugs are aminosalicylates?

Antiviral drugs

Antifungal drugs

Anti-inflammatory drugs (correct)

Antibiotics

How do aminosalicylates like sulfasalazine work in the treatment of IBDs?

By enhancing the activity of natural killer cells

By suppressing the immune system

Systemically throughout the body

Topically in areas of diseased gastrointestinal mucosa (correct)

What is the main transcription factor that 5-ASA inhibits, leading to its anti-inflammatory effects?

NF-κB (correct)

TNF-alpha

Cyclooxygenase

Interleukin-6

What are the most common dose-related side effects of aminosalicylates like sulfasalazine?

Nausea and gastrointestinal upset (B) Signup and view all the answers

What is the optimal dose range of sulfasalazine for achieving and maintaining remission in ulcerative colitis?

$2-4 g per day (B) Signup and view all the answers

What risk is reduced by aminosalicylate maintenance therapy with doses of 1.2 g and above?

Colorectal cancer (D) Signup and view all the answers

What is the principal type of inflammatory bowel disease that affects only the colon and rectum?

Ulcerative Colitis (UC) (D) Signup and view all the answers

What is a possible cause of Ulcerative Colitis according to the text?

The immune system overreacting to normal bacteria in the digestive tract (D) Signup and view all the answers

Which part of the digestive tract can Crohn's Disease affect?

Any part from the mouth to the anus (A) Signup and view all the answers

What percentage of patients with Crohn's disease have ileocaecal disease according to the text?

45% (C) Signup and view all the answers