30 Questions
Which of the following is a common symptom of asthma?
Shortness of breath
What is the prevalence of asthma in the United States?
7.9%
Which gender has a higher prevalence of asthma in childhood?
Boys
What is the most common type of airway inflammation in asthma?
Eosinophilic
Which cytokine has a critical role in regulating eosinophils?
IL-5
Which type of inflammation is commonly seen in severe asthma that has not responded to corticosteroids?
Neutrophilic inflammation
Which chemical substance is produced by mast cells and upregulates type 2 inflammation?
Prostaglandins
Which fatty acid mediator is responsible for the resolution of inflammation?
Interleukins
Which of the following is NOT a mediator involved in type 2 and non-type 2 inflammation?
Resolvins
What is the percentage range of heritability suggested by family and twin studies?
25-50%
Which of the following is NOT a gene consistently identified in association studies with asthma?
IL-12
What proportion of asthma risk can be explained by the currently identified 31 single nucleotide polymorphisms associated with asthma?
2%
Which country had the highest asthma mortality rate in 2006?
Unknown
What is the estimated economic cost of asthma in the United States in 2016?
$1.8 million
Which race is associated with greater case morbidity in asthma?
Unknown
What is the most common trigger of airway narrowing in asthma?
Exercise
Which type of inflammation is associated with the production of cytokines interleukin (IL) 4, IL-5, and IL-13?
Type 2 inflammation
What is the main characteristic of airway inflammation in most asthmatics?
Eosinophilic inflammation
What can contribute to airway obstruction in asthma?
All of the above
What can the deposition of collagen and matrix in the airway result in?
Exaggerated responses to increased circumferential tension
What is the estimated percentage of adult-onset asthma that is attributed to occupational exposures?
25%
Which of the following is NOT a recognized type of occupational asthma?
Immunologic stimuli
Which of the following is associated with increased risk of children developing asthma symptoms?
Air pollution
Which of the following is believed to cause oxidative injury to the airways, producing airway inflammation and leading to remodeling and increased risk of airway sensitization?
Air pollution
Which of the following has been suggested as a risk factor for childhood and adult asthma?
All of the above
What is the association between H2 blockers and proton pump inhibitors use in pregnancy and the risk of asthma in children?
Increased risk of asthma
What did a study from NHANES II find regarding the association between obesity and asthma?
Association with dyspnea but not with airway obstruction
What is the association between perinatal acetaminophen use and the risk of asthma?
No association found
Which of the following has been suggested as playing a pathobiologic role in the development of asthma?
Both adipokines and IL-6
What is the association between maternal polyunsaturated fatty acid supplementation and childhood asthma risk?
Decreased risk of asthma
Test your knowledge of key molecules and receptors involved in inflammation and immune response with this quiz. Challenge yourself to identify the functions and roles of BLT2, CRTH2, CXCL8, CXCR2, GATA3, GM-CSF, IFN-γ, ILC2, KIT, LTB4, and MPO.
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