Podcast
Questions and Answers
Why is urine testing performed when infective endocarditis is suspected?
Why is urine testing performed when infective endocarditis is suspected?
- To assess the patient's kidney function and detect renal failure.
- To measure the level of protein in the urine, which indicates valve damage.
- To look for microscopic haematuria, indicating blood in the urine. (correct)
- To identify the specific type of bacteria causing the infection.
What is the primary purpose of blood cultures in the management of infective endocarditis?
What is the primary purpose of blood cultures in the management of infective endocarditis?
- To identify the causative organism and guide antibiotic therapy. (correct)
- To detect the presence of anemia.
- To assess the degree of valve damage.
- To monitor the progression of heart failure.
A patient with infective endocarditis is likely to show which change in their blood work?
A patient with infective endocarditis is likely to show which change in their blood work?
- Decreased white blood cell count
- Elevated white blood cell count (correct)
- Normal C-reactive protein levels
- Reduced erythrocyte sedimentation rate
What findings from liver function tests would suggest infective endocarditis in a patient?
What findings from liver function tests would suggest infective endocarditis in a patient?
Which of the following findings on a chest radiograph would be most indicative of complications from infective endocarditis?
Which of the following findings on a chest radiograph would be most indicative of complications from infective endocarditis?
What information does an electrocardiogram (ECG) provide in the context of infective endocarditis?
What information does an electrocardiogram (ECG) provide in the context of infective endocarditis?
What might an echocardiogram reveal in a patient with infective endocarditis that is critical for diagnosis and management?
What might an echocardiogram reveal in a patient with infective endocarditis that is critical for diagnosis and management?
What is the typical duration of treatment with bactericidal antibiotics for infective endocarditis?
What is the typical duration of treatment with bactericidal antibiotics for infective endocarditis?
When is surgical intervention most likely required in cases of infective endocarditis?
When is surgical intervention most likely required in cases of infective endocarditis?
Which factor indicates a worse prognosis in patients diagnosed with infective endocarditis?
Which factor indicates a worse prognosis in patients diagnosed with infective endocarditis?
What is the recommended approach regarding antibiotic prophylaxis for patients at risk of infective endocarditis undergoing dental procedures?
What is the recommended approach regarding antibiotic prophylaxis for patients at risk of infective endocarditis undergoing dental procedures?
In the context of prophylaxis against infective endocarditis, what is the recommendation regarding chlorhexidine mouthwash?
In the context of prophylaxis against infective endocarditis, what is the recommendation regarding chlorhexidine mouthwash?
What preventative measure is advised for patients at risk of infective endocarditis who are considering invasive nonmedical procedures like body piercing or tattooing?
What preventative measure is advised for patients at risk of infective endocarditis who are considering invasive nonmedical procedures like body piercing or tattooing?
What is the most common causative organism in infective endocarditis?
What is the most common causative organism in infective endocarditis?
Which of the following is an early clinical sign commonly associated with infective endocarditis?
Which of the following is an early clinical sign commonly associated with infective endocarditis?
Which of the following clinical manifestations of infective endocarditis is related to embolic events?
Which of the following clinical manifestations of infective endocarditis is related to embolic events?
Which of the following is considered a sign of immune complex deposition in infective endocarditis?
Which of the following is considered a sign of immune complex deposition in infective endocarditis?
What is the typical appearance of splinter hemorrhages associated with infective endocarditis?
What is the typical appearance of splinter hemorrhages associated with infective endocarditis?
What ocular finding is associated with infective endocarditis due to the formation of immune complexes?
What ocular finding is associated with infective endocarditis due to the formation of immune complexes?
Abnormal Cardiac endothelium facilitates bacterial adherence and growth in infective endocarditis; what else is a factor in the Aetiopathogenesis?
Abnormal Cardiac endothelium facilitates bacterial adherence and growth in infective endocarditis; what else is a factor in the Aetiopathogenesis?
Flashcards
Infective Endocarditis
Infective Endocarditis
Infection of the endocardial surface of the heart or valves, usually bacterial or fungal in origin.
IE Aetiopathogenesis: Endothelium
IE Aetiopathogenesis: Endothelium
Abnormal cardiac endothelium facilitates bacterial adherence.
Streptococci in IE
Streptococci in IE
The most common cause of infective endocarditis, accounting for ~63% of cases.
Staphylococci in IE
Staphylococci in IE
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Fungi in IE
Fungi in IE
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Heart Murmur in IE
Heart Murmur in IE
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Late Signs of IE
Late Signs of IE
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Signs of Embolism in IE
Signs of Embolism in IE
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Antibiotic Prophylaxis
Antibiotic Prophylaxis
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Chlorhexidine Mouthwash in IE
Chlorhexidine Mouthwash in IE
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Urine Testing
Urine Testing
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Blood cultures
Blood cultures
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Full blood count (FBC)
Full blood count (FBC)
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Erythrocyte sedimentation rate or C-reactive protein (CRP)
Erythrocyte sedimentation rate or C-reactive protein (CRP)
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Liver function tests
Liver function tests
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Chest radiograph
Chest radiograph
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Electrocardiogram (ACG)
Electrocardiogram (ACG)
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Echocardiogram
Echocardiogram
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Phamacotherapy Treatment
Phamacotherapy Treatment
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Treatment via surgery is required if...
Treatment via surgery is required if...
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Study Notes
Infective Endocarditis
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Infective endocarditis refers to a bacterial or fungal infection of the endocardial surface of the heart or valves
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It can manifest as an acute, rapidly progressing infection or more commonly as a subacute bacterial endocarditis (SBE)
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The annual incidence is 6-7 cases per 100,000 in the UK
Aetiopathogenesis
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Mainly due to abnormal cardiac endothelium
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Facilitates bacterial adherence and growth
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Presence of organisms in the blood
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Abnormal endothelium creates non-laminar blood flow
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Eddy current - circular flow - and jet streams promote fibrin and platelet deposition
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Small thrombi allow organisms to adhere and grow, eventually leading to characteristic infected vegetation
Microbiological Spectrum
- Streptococci account for 63%, primarily of the Viridans group at 50%
- Staphylococci accounts for 26%
- Fungi account for 4%
Clinical Signs
- Signs of heart disease include development or change of murmur and potential heart failure
- Early signs of infection might include fever, sweats, loss of appetite, weight loss, and malaise
- Late signs of infection include splenomegaly, clubbing and anaemia
- Signs of embolism (aka embolic seculay) include septic arthritis, osteomyelitis, and splenic abscess
- Possible effects on the central nervous system include meningitis, military brain abscess, TIA and stroke
- Signs of immune complex include skin lesions (osler's nodes, splinter haemorrhage), renal involvement (haematuria)
- Eye-related issues include Roth's spots (exudative oedematous haemorrhagic lesions in the retina)
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