Infective Endocarditis 2 emrees

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Questions and Answers

Why is urine testing performed when infective endocarditis is suspected?

  • To assess the patient's kidney function and detect renal failure.
  • To measure the level of protein in the urine, which indicates valve damage.
  • To look for microscopic haematuria, indicating blood in the urine. (correct)
  • To identify the specific type of bacteria causing the infection.

What is the primary purpose of blood cultures in the management of infective endocarditis?

  • To identify the causative organism and guide antibiotic therapy. (correct)
  • To detect the presence of anemia.
  • To assess the degree of valve damage.
  • To monitor the progression of heart failure.

A patient with infective endocarditis is likely to show which change in their blood work?

  • Decreased white blood cell count
  • Elevated white blood cell count (correct)
  • Normal C-reactive protein levels
  • Reduced erythrocyte sedimentation rate

What findings from liver function tests would suggest infective endocarditis in a patient?

<p>Raised alkaline phosphatase, serum immunoglobulins and decreased complement and C3 (A)</p> Signup and view all the answers

Which of the following findings on a chest radiograph would be most indicative of complications from infective endocarditis?

<p>Cardiomegaly and signs of heart failure. (C)</p> Signup and view all the answers

What information does an electrocardiogram (ECG) provide in the context of infective endocarditis?

<p>The origin and complications of possible organic disease such as aortic stenosis (C)</p> Signup and view all the answers

What might an echocardiogram reveal in a patient with infective endocarditis that is critical for diagnosis and management?

<p>The presence of vegetation on a valve or mural endocardium and even presence of abcesses. (B)</p> Signup and view all the answers

What is the typical duration of treatment with bactericidal antibiotics for infective endocarditis?

<p>4-6 weeks (B)</p> Signup and view all the answers

When is surgical intervention most likely required in cases of infective endocarditis?

<p>When there is extensive damage to the valve, infection of prosthetic material, worsening renal failure. (A)</p> Signup and view all the answers

Which factor indicates a worse prognosis in patients diagnosed with infective endocarditis?

<p>Organisms cannot be identified, cardiac failure is present, infection occurs on a prosthetic valve, microorganisms found are resistant to therapy. (D)</p> Signup and view all the answers

What is the recommended approach regarding antibiotic prophylaxis for patients at risk of infective endocarditis undergoing dental procedures?

<p>Antibiotic prophylaxis is not prescribed for invasive dental procedures. (D)</p> Signup and view all the answers

In the context of prophylaxis against infective endocarditis, what is the recommendation regarding chlorhexidine mouthwash?

<p>Should be offered as prophylaxis against infective endocarditis to people at risk of infective endocarditis undergoing dental procedures (B)</p> Signup and view all the answers

What preventative measure is advised for patients at risk of infective endocarditis who are considering invasive nonmedical procedures like body piercing or tattooing?

<p>Cancel patients on the risk of undergoing invasive nonmedical procedures such as body piercing and tattooing (C)</p> Signup and view all the answers

What is the most common causative organism in infective endocarditis?

<p>Streptococci (A)</p> Signup and view all the answers

Which of the following is an early clinical sign commonly associated with infective endocarditis?

<p>Fever (A)</p> Signup and view all the answers

Which of the following clinical manifestations of infective endocarditis is related to embolic events?

<p>Septic arthritis (B)</p> Signup and view all the answers

Which of the following is considered a sign of immune complex deposition in infective endocarditis?

<p>Osler's nodes (C)</p> Signup and view all the answers

What is the typical appearance of splinter hemorrhages associated with infective endocarditis?

<p>Reddish-brown lines of blood under the nails. (C)</p> Signup and view all the answers

What ocular finding is associated with infective endocarditis due to the formation of immune complexes?

<p>Roth's spots (B)</p> Signup and view all the answers

Abnormal Cardiac endothelium facilitates bacterial adherence and growth in infective endocarditis; what else is a factor in the Aetiopathogenesis?

<p>Presence of organisms in the blood (A)</p> Signup and view all the answers

Flashcards

Infective Endocarditis

Infection of the endocardial surface of the heart or valves, usually bacterial or fungal in origin.

IE Aetiopathogenesis: Endothelium

Abnormal cardiac endothelium facilitates bacterial adherence.

Streptococci in IE

The most common cause of infective endocarditis, accounting for ~63% of cases.

Staphylococci in IE

Accounts for approximately 26% of infective endocarditis cases.

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Fungi in IE

Fungal infections account for about 4% of infective endocarditis cases.

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Heart Murmur in IE

Indicative of heart disease in the context of infective endocarditis.

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Late Signs of IE

Include splenomegaly, clubbing, and anemia

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Signs of Embolism in IE

Indicate infective endocarditis and include septic arthritis and splenic abscess.

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Antibiotic Prophylaxis

Antibiotic prophylaxis is generally NOT prescribed for invasive dental procedures.

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Chlorhexidine Mouthwash in IE

Should be avoided as a prophylaxis against infective endocarditis in individuals at risk undergoing dental procedures because they are ineffective.

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Urine Testing

Looking for microscopic haematuria, which indicates blood in the urine.

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Blood cultures

Main guide for future antibiotic therapy and is positive in 75% of cases.

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Full blood count (FBC)

Will show a raised white cell count and patients also tend to develop normochromic normocytic anemia.

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Erythrocyte sedimentation rate or C-reactive protein (CRP)

Markers of inflammation.

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Liver function tests

May show mild disturbances such as raised alkaline phosphatase, serum immunoglobulins, and decreased complement and C3.

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Chest radiograph

May show enlargement of the heart (aka cardiomegaly) and signs of heart failure(such as pleural effusions).

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Electrocardiogram (ACG)

Provides information on the origin and complication of possible organic disease(such as aortic stenosis or left ventricular hypertrophy LVH) - however majority of patients present with non-specific ECG changes

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Echocardiogram

May show the presence of vegetation on a valve or mural endocardium - and may even show any presence of absesses.

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Phamacotherapy Treatment

Treated with bactericidal antibiotics, treatment continues for 4-6 weeks and based on blood culture and antibiotic sensitivity assessment.

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Treatment via surgery is required if...

Extensive damage to the valve, infection of prosthetic material and persistent infection but failure to culture an organism.

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Study Notes

Infective Endocarditis

  • Infective endocarditis refers to a bacterial or fungal infection of the endocardial surface of the heart or valves

  • It can manifest as an acute, rapidly progressing infection or more commonly as a subacute bacterial endocarditis (SBE)

  • The annual incidence is 6-7 cases per 100,000 in the UK

Aetiopathogenesis

  • Mainly due to abnormal cardiac endothelium

  • Facilitates bacterial adherence and growth

  • Presence of organisms in the blood

  • Abnormal endothelium creates non-laminar blood flow

  • Eddy current - circular flow - and jet streams promote fibrin and platelet deposition

  • Small thrombi allow organisms to adhere and grow, eventually leading to characteristic infected vegetation

Microbiological Spectrum

  • Streptococci account for 63%, primarily of the Viridans group at 50%
  • Staphylococci accounts for 26%
  • Fungi account for 4%

Clinical Signs

  • Signs of heart disease include development or change of murmur and potential heart failure
  • Early signs of infection might include fever, sweats, loss of appetite, weight loss, and malaise
  • Late signs of infection include splenomegaly, clubbing and anaemia
  • Signs of embolism (aka embolic seculay) include septic arthritis, osteomyelitis, and splenic abscess
  • Possible effects on the central nervous system include meningitis, military brain abscess, TIA and stroke
  • Signs of immune complex include skin lesions (osler's nodes, splinter haemorrhage), renal involvement (haematuria)
  • Eye-related issues include Roth's spots (exudative oedematous haemorrhagic lesions in the retina)

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