Infectious Diseases - Transmission and Virulence
20 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which mechanism is primarily responsible for the adherence of Gram-positive bacteria to host cells?

  • Receptor-mediated endocytosis
  • Fimbriae binding
  • Peptidoglycan interactions (correct)
  • Flagella attachment
  • What is a common feature of toxins produced by Gram-negative bacteria?

  • Endotoxins causing septic shock (correct)
  • Only A-B toxins
  • Directly damage host DNA
  • Exclusively excreted in the urine
  • Which characteristic is used by HIV to specifically adhere to host cells?

  • CD4 cell antigen (correct)
  • Flagella antigens
  • Peptidoglycan
  • Pili interactions
  • Which method do bacteria commonly use to survive within a host's phagocyte?

    <p>Inhibit endosome-lysosome fusion (B)</p> Signup and view all the answers

    Which of the following is a mechanism of antibiotic resistance?

    <p>Induction of penicillinase (D)</p> Signup and view all the answers

    What role do exogenous sources have in infectious disease transmission?

    <p>Include transmission through fomites, vectors, and other humans (A)</p> Signup and view all the answers

    Which bacterial species is known for producing an A-B toxin that disrupts synaptic transmission?

    <p>Clostridium tetani (D)</p> Signup and view all the answers

    What is the key feature of multidrug-resistant transporters in bacteria?

    <p>Extrusion of multiple antibiotic compounds (D)</p> Signup and view all the answers

    Which process can bacteria employ to avoid phagocytosis?

    <p>Coating with IgA antibodies (A)</p> Signup and view all the answers

    What type of sources can be classified as endogenous in relation to infectious diseases?

    <p>Internal normal flora like Staphylococcus from skin or Streptococcus from the throat (D)</p> Signup and view all the answers

    What factor has been suggested to help differentiate between pre- and post-capillary causes of exercise pulmonary hypertension (PH)?

    <p>PAWP/CO slope with a threshold &gt;2 mmHg/L/min (B)</p> Signup and view all the answers

    Which statement best describes the classification of pulmonary hypertension (PH)?

    <p>PH is categorized by similar haemodynamic characteristics and pathophysiology. (C)</p> Signup and view all the answers

    What is the global prevalence of pulmonary hypertension (PH), as stated in the content?

    <p>Roughly 1% of the global population (C)</p> Signup and view all the answers

    What recommendation was made regarding the clinical classification of PH after the 6th World Symposium on Pulmonary Hypertension?

    <p>Maintain the core structure but with necessary clarifications. (D)</p> Signup and view all the answers

    In the context of pulmonary hypertension, what does the term 'common condition' refer to?

    <p>A hemodynamic state with various underlying causes (D)</p> Signup and view all the answers

    What percentage of PH cases worldwide are accounted for by groups 2 and 3 PH?

    <p>90–95% (A)</p> Signup and view all the answers

    Which phrase indicates the change made in the 2022 ESC/ERS guidelines regarding PH groups 2, 3, and 4?

    <p>PH associated with (D)</p> Signup and view all the answers

    What is a characteristic of patients with severe PH in the context of underlying conditions?

    <p>They account for about 1–10% of patients with left heart or lung diseases. (A)</p> Signup and view all the answers

    What proportion of PAH patients might have cardiopulmonary comorbidities in current clinical registries?

    <p>60–85% (A)</p> Signup and view all the answers

    What is a significant reason for maintaining the current clinical classification of PH as proposed in the content?

    <p>To help nonspecialists understand all possible causes. (A)</p> Signup and view all the answers

    Flashcards

    Pathogen Encounter

    The initial contact between a pathogen and a host.

    Adherence

    A pathogen's ability to attach to host cells.

    Immune Evasion

    Pathogens' strategies to avoid the host's immune system.

    Pathogen Multiplication

    The process by which pathogens increase their numbers.

    Signup and view all the flashcards

    Cell/Tissue Damage

    The harm pathogens cause to host cells and tissues.

    Signup and view all the flashcards

    Exogenous Source

    Pathogens that originate from outside the host.

    Signup and view all the flashcards

    Endogenous Source

    Pathogens originating from within the host, often commensal.

    Signup and view all the flashcards

    Bacterial Adherence (gram +)

    Gram-positive bacteria adhere to surfaces by peptidoglycans.

    Signup and view all the flashcards

    Bacterial Adherence (gram -)

    Gram-negative bacteria adhere by components like flagella, pili, and fimbriae

    Signup and view all the flashcards

    Pathogen Toxin Production

    The production of harmful substances by pathogens that cause disease.

    Signup and view all the flashcards

    What is pulmonary hypertension?

    Pulmonary hypertension (PH) is a condition where the pressure in the blood vessels of the lungs is abnormally high. This makes the heart work harder to pump blood through the lungs.

    Signup and view all the flashcards

    Why is mPAP not always the best indicator of exercise PH?

    Mean Pulmonary Artery Pressure (mPAP) can change depending on how much someone is exercising. This makes it less reliable in diagnosing exercise-related PH.

    Signup and view all the flashcards

    What are the subgroups of the PH classification?

    The PH classification divides the condition into 5 subgroups based on similar causes, symptoms, and treatment.

    Signup and view all the flashcards

    What is the general prevalence of PH?

    PH is a relatively common condition with a global prevalence of approximately 1%.

    Signup and view all the flashcards

    What are PAH and CTEPH?

    Pulmonary Arterial Hypertension (PAH) and Chronic Thromboembolic Pulmonary Hypertension (CTEPH) are rare but severe forms of PH.

    Signup and view all the flashcards

    Group 2 and 3 PH

    These groups of pulmonary hypertension (PH) are the most common, accounting for 90-95% of cases worldwide. They are often linked to left heart disease, lung disease, and blood clots.

    Signup and view all the flashcards

    Severe PH

    Severe pulmonary hypertension is less common, affecting only 1-10% of patients. It involves significant damage to the blood vessels in the lungs.

    Signup and view all the flashcards

    PH Associated with

    The term "PH associated with" highlights that certain conditions like heart disease or lung disease are risk factors for PH, but don't always directly cause it.

    Signup and view all the flashcards

    PAH with Comorbidities

    Many patients with pulmonary arterial hypertension (PAH) also have other health problems like heart or breathing conditions.

    Signup and view all the flashcards

    Pulmonary Vascular Diseases

    These diseases affect the blood vessels in the lungs, sometimes leading to pulmonary hypertension. They involve damage to the vessels.

    Signup and view all the flashcards

    Study Notes

    Infectious Diseases - Transmission and Virulence

    • Mechanisms of infection: Encounter, Adherence, Evasion of Immune System, Multiplication and Spread, Cell/Tissue Damage, and Shedding.
    • Sources of infection:
      • Exogenous: Fomites (Listeria, E. coli, Salmonella), Animal and insect vectors (viruses, malaria, encephalitis, typhus, leptospirosis, tularemia, parasites), Other humans (Strepto pneumoniae, viruses, STDs, tuberculosis). Airborne and bodily fluids are also transmission vectors.
      • Endogenous: Commensalism or mutualism, Skin-Staph, Intestines-gram negatives, anaerobes, fungi, Nasal/Oropharynx-Staph, Strep, anaerobes.
    • Transmission: Most organisms have a defined survival outside of hosts, except some fungi and bacteria (like anthrax) which can form spores.
    • Adherence:
      • Viruses adhere and enter cells by specific receptors or proteins. Examples include Covid-19 (angiotensin II converting enzyme receptor), HIV (CD4 cell antigen).
      • Gram-positive bacteria adhere through peptidoglycans in their cell walls.
      • Gram-negative bacteria adhere through antigens on flagella, pili, or fimbriae.

    Bacterial Characteristics and Biological Relevance (E. coli)

    • Bacterial Characteristics: H (flagella) antigen, K (cell wall) antigen, glycocalyx, lipid A, lipopolysaccharide/endotoxin, haemagglutination, haemolysis, enterochelin, aerobactin, fimbriae, hydrophobicity, urease production, resistance to cidal effect of serum, biotin production, phase variation.
    • Biological Relevance: Motility, inhibition of phagocytosis by polymorphs, ureteric paralysis, impairment of kidney growth, renal scar formation, access to iron source, adhesion to urothelium, mediators of inflammation, scar formation, stone formation, impairment of polymorph function and complement-mediated lysis, hematogenous spread, protection against high urine osmolality, continued survival of bacteria in changing conditions.

    Virus Replication (HIV)

    • Virus Entry: gp120 binds CD4, conformational change, gp41 membrane penetration, fusion of HIV membrane with host cell membrane.
    • Replication: Reverse transcriptase-mediated synthesis of proviral DNA, integration of provirus into host cell genome, cytokine activation, transcription of HIV genome, transport of viral RNAs to cytoplasm, synthesis of HIV proteins, assembly of virion core structure.
    • Virus Release: Budding and release of mature virion, new HIV virion.

    Spread/Multiplication

    • Production of toxins: E. coli, Clostridium difficile, Super antigens-Staph.
    • Secretion of enzymes: Streptolysin, proteases, Lipoprotein saccharide.

    Toxin Production

    • Gram-negative organisms: Endotoxin, LPS of cell wall, fever, permeability changes, vasodilation-septic shock.
    • A-B toxins: Clostridium tetani, synaptic transmission, Vibrio cholera, ADP ribosylation.

    Evading Host Immune Response

    • Inhibition of chemotaxis: C5a-Strep, killing of phagocyte, A-toxin-Staph.
    • Avoiding ingestion: LPS, k-capsule of Strep.
    • Avoiding complement lysis: Coating with IgA antibodies-Nisseria.
    • Surviving within phagocyte: Inhibition of endosome-lysosome fusion—Chlamydia, inhibition of NADPH oxidase—Salmonella, inhibition of H+-ATPase—tuberculosis.

    Survival within Host Phagocyte

    • Inhibition of Endosome—lysosome fusion—Chlamydia
    • Inhibition of NADPH Oxidase—Salmonella
    • Inhibition of endosomal H+-ATPase—tuberculosis

    Phagocytosis

    • Recognition and Attachment: Microbes bind to phagocyte receptors.
    • Engulfment: Phagocyte membrane surrounds the microbe.
    • Killing and Degradation: Phagosome fuses with lysosome, degradation by lysosomal enzymes.

    Antibiotic Resistance

    • Induction or Modification of Enzymes: Inactivating drugs, such as penicillinase cleaving β-lactam ring structure.
    • Multidrug Resistant Transporter.
    • Alteration of Metabolic Function.
    • Phage Transfer.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Description

    Explore the mechanisms of infection, sources, and transmission of various pathogens. Understand how viruses and bacteria adhere to host cells and the role of different vectors in spreading diseases. This quiz covers essential concepts in infectious disease dynamics.

    More Like This

    Use Quizgecko on...
    Browser
    Browser